Article
Materials Science, Multidisciplinary
He Li, Jiayi Cui, Zhibin Yan, Mingliang Jin, Yu Zheng, Guofu Zhou, Lingling Shui
Summary: Paper-based microfluidic devices based on electrowetting principle were fabricated using cellulose paper and paraffin wax, with key fabrication parameters optimized. Devices fabricated by the spray-coating method showed larger contact angle changes under DC electric field.
RESULTS IN PHYSICS
(2021)
Article
Thermodynamics
Israr Ahmad, Atul Ranjan, Manabendra Pathak, Mohd Kaleem Khan
Summary: This study integrates the electrowetting technique to solve the bubble departure problem in pool boiling under low gravity conditions. Using a phase-field-based numerical method with a dynamic contact angle model in COMSOL Multiphysics (V5.3), the bubble dynamics in electrowetting integrated pool boiling for low gravity conditions are analyzed. The electrowetting technique significantly increases the bubble departure frequency and heat transfer rate compared to conventional pool boiling, with the sinusoidal voltage waveform showing the best performance, achieving 119.3% higher bubble departure frequency and a 74.3% heat transfer enhancement.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2023)
Article
Materials Science, Ceramics
Jian Wang, Xinyu Pei, Jianwen Zhang, Yan Li, Jianbiao Chen, Chengwei Wang
Summary: This paper successfully prepared Fe doped ZnO memristors with reversible electronic resistive switching behavior by a simple hydrothermal method. The hierarchical dual-layer nanorod array on the surface of the memristors enables reversible electrowetting-on-dielectric (EWOD) response with low energy consumption. The study found that the prepared Fe doped ZnO memristors have stable high and low resistive states with distinct surface wetting properties, which can be intelligently controlled for resistive-switching EWOD devices. This work provides a new approach for the development of excellent artificial intelligence liquid switch and devices.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Physical
Xin-Yu Pei, Jian Wang, Jian-Wen Zhang, Xianggang Dai
Summary: In this study, a superhydrophobic Ag-ZnO@STA/Zn composite device was prepared to address the disadvantages of slow responsiveness, low sensitivity, and poor reproducibility in dynamic blood glucose detection. The device exhibited a large contact angle modulation and low threshold voltage, enabling successful application in diabetes detection. Additionally, it demonstrated high sensitivity detection ability to low concentration glucose and excellent anti-corrosion and bactericidal functions.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Thermodynamics
Israr Ahmad, Manabendra Pathak, Mohd Kaleem Khan
Summary: The recent advancement in electrowetting technique using an interdigitated electrode (IDE) configuration for producing oscillating droplets has shown to be an effective method for heat dissipation in electronic devices. The oscillation frequency is higher with IDE than with wire electrode and the heat transfer performance is maximum at the first resonant frequency.
EXPERIMENTAL THERMAL AND FLUID SCIENCE
(2021)
Article
Engineering, Electrical & Electronic
Seungmin Lee, Daeyoung Lee, Minsuk Choi, Sang Kug Chung
Summary: This paper presents a method for efficiently manipulating droplets on a 2-D plane using low-frequency electrowetting-on-dielectric (EWOD) and asymmetric oscillation characteristic of droplets. The study investigates the behavior of droplets actuated by low-frequency EWOD and their horizontal transportation. It also demonstrates droplet transference to adjacent electrodes and successfully manipulates droplets using a limited number of patterned electrodes.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Physical
Israr Ahmad, Manabendra Pathak, Mohd Kaleem Khan
Summary: This work presents numerical and experimental techniques for studying electrowetting-induced oscillating water droplets on surfaces with different hydrophobicity. The results show that the hydrophobicity of the surface affects the deformation, internal flow structures, amplitude, and frequency of the oscillating droplets. Additionally, a simplified analytical model is developed to establish the correlation between the maximum amplitude of the oscillating droplets and the static contact angle.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Multidisciplinary Sciences
Haiyang Zhan, Zichao Yuan, Yu Li, Liang Zhang, Hui Liang, Yuhui Zhao, Zhiguo Wang, Lei Zhao, Shile Feng, Yahua Liu
Summary: Using a photopyroelectric slippery surface (PESS), bubble splitting, merging, and detachment can be achieved with high flexibility and precision. This method also extends bubble control capabilities to microrobots and transmission of gear structures. It provides a valuable platform for various bubble-involved processes.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Ali Reza Bahari, Mobin Abdar Esfahani, Mojtaba Taghipoor
Summary: Transparent electrowetting is a branch of EWOD devices that use transparent electrodes for optical applications. This paper introduces a transparent EWOD with permanent liquid electrodes. Liquid electrodes were used instead of conventional solid-state ones. The concept of Liquid Electrode EWOD (LEWOD) is successfully implemented on both rigid and flexible substrates. Results show promising performance similar to PCBs, indicating potential future applications of liquid electrodes in EWOD systems.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Article
Thermodynamics
Run Yan, Kai-Hao Cheng, Robin Pham, Chung -Lung Chen
Summary: This paper discusses the distinct droplet distribution patterns of open-plate grid-wire-patterned EWOD devices under low and high frequencies of AC-EWOD. It found that at low frequencies, droplets stayed inside the grid, while at high frequencies, droplets adhered to the grid wires. The dynamics of single droplets were studied, revealing two different oscillation modes and their impact on droplet coalescence mechanisms and distribution patterns.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Article
Multidisciplinary Sciences
Haiyang Zhan, Zichao Yuan, Yu Li, Liang Zhang, Hui Liang, Yuhui Zhao, Zhiguo Wang, Lei Zhao, Shile Feng, Yahua Liu
Summary: A sandwich-structured photopyroelectric slippery surface (PESS) is developed to achieve high-efficiency manipulation of underwater bubbles. It enables various bubble maneuvers, such as splitting, merging, detachment, and control of microrobots for cargo transportation and micropart assembly.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Mingzhen Chen, Shanling Lin, Ting Mei, Ziyu Xie, Jianpu Lin, Zhixian Lin, Tailiang Guo, Biao Tang
Summary: This paper proposes a new driving waveform for improving the response speed and aperture ratio of electrowetting display systems. By analyzing the characteristics of fluids with different viscosities, the suitable range of viscosity and voltage was determined. Model simulations and experimental results demonstrate that the proposed driving waveform enhances the performance of electrowetting.
Article
Chemistry, Analytical
Matin Torabinia, Udaya Sree Dakarapu, Parham Asgari, Junha Jeon, Hyejin Moon
Summary: This study demonstrates the use of an electrowetting-on-dielectric digital microfluidic device as an efficient in-line work-up tool for organic chemical synthesis reactions, showing the device's capability to optimize operational parameters and adapt to various processes.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Electrical & Electronic
Vandana Jain, Raghvendra Kumar Dwivedi, K. Muralidhar
Summary: Electrowetting-on-Dielectric (EWOD) is a powerful technology for biological and chemical diagnostics. This study developed a closed EWOD device integrated with thermal cycling and optical diagnostics. The device achieves precise thermal cycling needed in clinical and medical diagnostics, and has demonstrated effectiveness in glucose detection and liquid drop transportation. It shows reliability and potential for low-cost point-of-care applications.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Engineering, Electrical & Electronic
Johannes Strassner, Christoph Doering, Emerson Oliveira, Henning Fouckhardt
Summary: This article discusses the phenomena and techniques of electrowetting on dielectric (EWOD) and optoelectrowetting (OEW), and explores the operating points of OEW through discussion and modification.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Review
Optics
Guanyu Chen, Yu Yu, Yang Shi, Nanxi Li, Wei Luo, Lin Cao, Aaron J. Danner, Ai-Qun Liu, Xinliang Zhang
Summary: This review introduces the basic metrics and key process technologies for high-speed photodetectors (PDs) on silicon photonics platform, and reviews and discusses various types of high-speed PDs. These detectors continue to set new speed records and open an era of ultrahigh-speed optical interconnect. This review provides readers with insights into recent advances and contributes to further development.
LASER & PHOTONICS REVIEWS
(2022)
Article
Chemistry, Analytical
Wenshuai Wu, Binh Thi Thanh Nguyen, Patricia Yang Liu, Gaozhe Cai, Shilun Feng, Yuzhi Shi, Boran Zhang, Yuzhi Hong, Ruozhen Yu, Xiaohong Zhou, Yi Zhang, Eric Peng Huat Yap, Ai Qun Liu, Lip Ket Chin
Summary: Single cell analysis is vital for disease diagnosis by searching for rare biomarkers. Microfluidic technology enables single cell analysis, but current devices have limitations such as low throughput and the need for external instruments. In this study, a self-driven high-density microwell array was developed, which significantly improved the efficiency of single-cell metabolic activity analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Physics, Applied
Yuzhi Shi, Qinghua Song, Ivan Toftul, Tongtong Zhu, Yefeng Yu, Weiming Zhu, Din Ping Tsai, Yuri Kivshar, Ai Qun Liu
Summary: Optical tweezers are important manipulation tools used in various fields of physics. This review explores recent advances in optical manipulation using metamaterials, which offer unprecedented control of light. The study also discusses the potential for future developments in this emerging field.
APPLIED PHYSICS REVIEWS
(2022)
Article
Quantum Science & Technology
Yuan Li, Lingxiao Wan, Hui Zhang, Huihui Zhu, Yuzhi Shi, Lip Ket Chin, Xiaoqi Zhou, Leong Chuan Kwek, Ai Qun Liu
Summary: This study presents a scheme for implementing three-qubit Fredkin and Toffoli gates on a programmable quantum photonic chip, which is experimentally demonstrated. The scheme can also be used to realize other two-qubit quantum gates, providing a new approach for advanced quantum chip processors.
NPJ QUANTUM INFORMATION
(2022)
Article
Multidisciplinary Sciences
Hui Zhang, Lingxiao Wan, Tobias Haug, Wai-Keong Mok, Stefano Paesani, Yuzhi Shi, Hong Cai, Lip Ket Chin, Muhammad Faeyz Karim, Limin Xiao, Xianshu Luo, Feng Gao, Bin Dong, Syed Assad, M. S. Kim, Anthony Laing, Leong Chuan Kwek, Ai Qun Liu
Summary: This paper proposes an approach to reduce the resource costs for quantum teleportation of subspaces in high-dimensional systems using quantum autoencoders and demonstrates it experimentally on an integrated photonic platform. By training the on-chip autoencoder with unsupervised machine learning, compression and teleportation of any state from a high-dimensional subspace are achieved.
Article
Optics
Hui Zhang, Jonathan Wei Zhong Lau, Lingxiao Wan, Liang Shi, Yuzhi Shi, Hong Cai, Xianshu Luo, Guo-Qiang Lo, Chee-Kong Lee, Leong Chuan Kwek, Ai Qun Liu
Summary: This study demonstrates the capability of photonic neural networks in predicting the quantum mechanical properties of molecules and shows that multiple properties can be learned simultaneously in a photonic chip through a multi-task regression learning algorithm. It is the first application of photonics technology in machine learning for computational chemistry and molecular sciences, such as drug discovery and materials design, which is of great significance.
LASER & PHOTONICS REVIEWS
(2023)
Article
Multidisciplinary Sciences
Haoye Qin, Yuzhi Shi, Zengping Su, Guodan Wei, Zhanshan Wang, Xinbin Cheng, Ai Qun Liu, Patrice Genevet, Qinghua Song
Summary: Polarization singularities and topological vortices are observed in photonic crystal slabs centered at bound states in the continuum (BICs), which can be attributed to zero amplitude of polarization vectors. Optical forces around BICs exhibit similar topological features, with force vectors winding in the momentum space. These topological forces can be used to trap and repel nanoparticles, providing opportunities for manipulating nanoparticles and fluid flow.
Article
Optics
Cong Xiong, Wei Jiang, Caoyuan Wang, Ruowei Yu, Jun He, Runxiao Chen, Xuan Li, Kang Ying, Haiwen Cai, Aiqun Liu, Limin Xiao
Summary: The nanobore fiber (NBF) is a promising nanoscale optofluidic platform with long nanochannels and unique optical properties. In this study, NBF-based fiber Bragg gratings (FBGs) were introduced using femtosecond (fs) laser direct writing or ultraviolet (UV) laser phase mask techniques for the first time. The optimized UV laser fabricated FBG achieved a high reflectivity of 96.89% while preserving the open nanochannel. The NBF-based FBGs showed high potential for nanofluidic applications.
Article
Chemistry, Multidisciplinary
Ahmed A. Elsayed, Ahmed M. Othman, Yasser M. Sabry, Frederic Marty, Haitham Omran, Diaa Khalil, Ai-Qun Liu, Tarik Bourouina
Summary: In Raman analysis, the substrate material can enhance or interfere with the signal depending on its properties. By tilting the supporting substrate, the Raman signal of the substrate material, in this case, silicon, can be drastically reduced, making it easier to observe the target analyte, such as microplastic particles.
Review
Optics
Wei Luo, Lin Cao, Yuzhi Shi, Lingxiao Wan, Hui Zhang, Shuyi Li, Guanyu Chen, Yuan Li, Sijin Li, Yunxiang Wang, Shihai Sun, Muhammad Faeyz Karim, Hong Cai, Leong Chuan Kwek, Ai Qun Liu
Summary: Recent years have seen significant progress in quantum communication and quantum internet through the use of quantum photonic chips, which offer scalability, stability, and low cost in a compact form. This article provides an overview of the advancements in quantum photonic chips for quantum communication, including the main fabrication platforms and key components. It discusses various applications such as quantum key distribution and quantum teleportation. The article also highlights the challenges for achieving high-performance chip-based quantum communication and provides insights into future opportunities for integrated quantum networks.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Optics
Yuan Shen, Wai-Keong Mok, Changsuk Noh, Ai Qun Liu, Leong-Chuan Kwek, Weijun Fan, Andy Chia
Summary: This article proposes a new approach to quantum synchronization by using an approximate model of the Duffing-van der Pol oscillator. It captures interesting phenomena in the deep-quantum strongly nonlinear regime, such as amplitude death on resonance and nonlinearity-induced position correlations.
Proceedings Paper
Engineering, Electrical & Electronic
Cong Xiong, Wei Jiang, Caoyuan Wang, Ruowei Yu, Jun He, Xuan Li, Kang Ying, Haiwen Cai, Aiqun Liu, Limin Xiao
Summary: A fiber Bragg grating based on a novel nanobore fiber, fabricated using femtosecond laser direct writing and ultraviolet phase mask exposure techniques, is presented. The proposed nanobore fiber Bragg grating is temperature-insensitive and incorporates a nanochannel embedded in the fiber core, making it suitable for nanofluidic applications.
2022 ASIA COMMUNICATIONS AND PHOTONICS CONFERENCE, ACP
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Yuxing Chen, Cong Xiong, Jie Zhu, Caoyuan Wang, Ruowei Yu, Hanbing Yue, Zhende Zhai, Yuzhi Shi, Aiqun Liu, Limin Xiao
Summary: This study demonstrates the fabrication of an all-solid light-induced self-writing waveguide using photopolymer material, which provides a new scheme for interconnecting optical fibers and can potentially be extended to fiber-waveguide interconnection and photonic chip integration.
2022 ASIA COMMUNICATIONS AND PHOTONICS CONFERENCE, ACP
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Hui Zhang, Ai Qun Liu
Summary: This article introduces the advantages of optical neural networks and complex-valued neural networks over their electronic and real-valued counterparts, respectively. It proposes an optical neural network that implements complex-valued neural networks and presents an efficient on-chip training protocol applicable for various types of chip structures. The results demonstrate the potential for smaller chip size, stronger performance, and flexible reconfiguration in realistic applications.
2022 PHOTONICS & ELECTROMAGNETICS RESEARCH SYMPOSIUM (PIERS 2022)
(2022)
Review
Optics
Guanyu Chen, Nanxi Li, Jun Da Ng, Hong-Lin Lin, Yanyan Zhou, Yuan Hsing Fu, Lennon Yao Ting Lee, Yu Yu, Ai-Qun Liu, Aaron J. Danner
Summary: Lithium niobate (LN) has undergone significant developments due to its versatile properties, particularly its large electro-optic coefficient. The availability of high-quality thin-film LN on insulator (LNOI) has paved the way for integrated LN photonics, enabling the demonstration of various high-performance devices. This review provides a comprehensive summary of advances in LN photonics, including both bulk LN devices and recently developed thin-film LN devices.
ADVANCED PHOTONICS
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
