Article
Chemistry, Multidisciplinary
Jie-Yu Yue, Xiu-Li Ding, Ling Wang, Run Yang, Jing-Shu Bi, Ya-Wei Song, Peng Yang, Yu Ma, Bo Tang
Summary: A novel COF-enzyme composite glucose colorimetric biosensor was developed, showing a wide linear range and low detection limit. The biosensor demonstrated good selectivity, recoverability, and storage stability in real sample glucose quantification, indicating its potential in colorimetric biosensing and medical diagnostics.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Multidisciplinary Sciences
Muhammad Asif Ahmad Khushaini, Nur Hidayah Azeman, Ahmad Ghadafi Ismail, Chin-Hoong Teh, Muhammad Mat Salleh, Ahmad Ashrif A. Bakar, Tg Hasnan Tg Abdul Aziz, Ahmad Rifqi Md Zain
Summary: This study utilized the RS mechanism, formed by electrochemical redox-reactions, and a novel organic molecule, BOBzBT(2), to modify the SPE electrode for creatinine sensing. By optimizing the concentration of BOBzBT(2) during CV measurements, the sensor's sensitivity was enhanced, showing potential for practical application in detecting creatinine levels.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Nataliya Stasyuk, Olha Demkiv, Galina Gayda, Oksana Zakalska, Wojciech Nogala, Mykhailo Gonchar
Summary: The aim of this research is to design alcohol oxidase-based amperometric biosensors using metallic nanoparticles as artificial peroxidases or peroxidase-like nanozymes. Various metallic peroxidase-like nanozymes were synthesized and tested for their ability to replace natural peroxidase. The most effective nanomaterials were coupled with alcohol oxidase on graphite electrodes and showed high sensitivities and low limits of detection for ethanol, as well as satisfactory storage stabilities. The bioelectrode with the highest sensitivity was used as a biosensor for ethanol determination in real samples, demonstrating its practical feasibility.
Article
Environmental Sciences
Vinita Hooda, Anjum Gahlaut, Vikas Hooda
Summary: The research aimed to fabricate an improved enzyme-based biosensor for rapid quantification of ethanol. The biosensor displayed optimal response in a short time span with a wide working range and high reliability.
ENVIRONMENTAL TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ismael Babeli, Anna Puiggali-Jou, Joan Josep Roa, Maria-Pau Ginebra, Jose Garcia-Torres, Carlos Aleman
Summary: The newly developed conducting nanocomposite hydrogel shows outstanding capability for detecting hydrogen peroxide, making it suitable for detecting the oxidation of L-lactate. The sensor works in two linear regimes for different concentrations of L-lactate, with good detection limits. This biosensor, functionalized with lactate oxidase, has a potential wide application in biological fluids due to its linear range interval.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Electrochemistry
Merih Zeynep Cetin, Roxana-Mihaela Apetrei, Nese Guven, Pinar Camurlu
Summary: In this study, novel biosensing matrices based on electrospun nanofibers coated with conducting polymers (PEDOT or PPy) were used for immobilization of Tyrosinase enzyme and evaluated for phenol detection. The results showed that the biosensors developed using PEDOT and PPy exhibited high sensitivity and low detection limits.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Energy & Fuels
Xue-Yong Li, Jia-Ying Huang, Qiang Zhou, Yuan-Yuan Xu, Ponnandy Prabhu, Ye-Wang Zhang
Summary: This study successfully achieved efficient conversion of ethanol to acetoin through cascade enzymatic reactions by immobilizing and optimizing the conditions of three enzymes.
Article
Polymer Science
Canan Altunbas, Ahmet Aslan, Kevser Kusat, Mehtap Sahiner, Sinan Akgol, Nurettin Sahiner
Summary: Cryogels offer advantages such as mechanical and chemical stability, ease of production, superior porosity, and low cost for enzyme immobilization applications. By altering parameters such as pH, enzyme concentration, and flow rate, the best reaction conditions for immobilizing catalase onto cryogel matrices were determined. Repeated useability tests showed that the cryogel matrix remained stable and maintained its adsorption capacity with a high recovery ratio. Therefore, cryogels have promising potential for various industrial applications.
Article
Chemistry, Analytical
Yihui Ma, Nianzu Liu, Zhenying Xu, Jingjing Wang, Xiliang Luo
Summary: A promising electrochemical biosensor based on three-dimensional nanoporous conducting polymer PEDOT decorated with gold nanoparticles was developed for selective and ultrasensitive detection of miRNA24 using methylene blue as redox indicator. The biosensor exhibited significantly enlarged specific surface area and enhanced sensitivity compared to planar PEDOT-based biosensors, achieving a detection range from 1 fM to 10 nM with high stability, selectivity, and low limit of detection. The strategy of using porous conducting polymers decorated with AuNPs proved to be effective in increasing the electroactive surface area of sensing interfaces and enhancing sensitivity.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
B. Kim, Y. J. Cho, D. -g. Kim, J. -h. Seo
Summary: Developing ion conducting elastomers (ICE) with reprocessing capability is important for resource conservation and environmental protection. However, elastomers with covalent cross-linking are challenging to reprocess due to their thermoset properties. To overcome this challenge, a thiourea-based dynamic covalent network was utilized to design the ICE. The analysis of the interaction between lithium salt and polymer chain led to the selection of LiTFSI. It was found that the dynamic covalent network's formation and behavior were influenced by the interaction between the polymer chain and lithium salts. The resulting dynamic covalent elastomer can be reprocessed through various methods and exhibits dimensional stability and ionic conductivity. (c) 2023 Elsevier Ltd. All rights reserved.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Physical
Minying Wu, Qian Zhang, Yuanyuan Fang, Chao Deng, Fangzhou Zhou, Yi Zhang, Xingdong Wang, Yi Tang, Yajun Wang
Summary: Two-dimensional nanoreactors with cascade catalytic activity for glucose oxidation and hydrogen peroxide decomposition were prepared by immobilizing GOx on Ti3C2 MXene nanosheets. The GOx-conjugated Ti3C2-PLL nanosheets exhibited excellent enzymatic activities and were further deposited on glassy carbon electrode to construct a high-performance biosensor with a low glucose detection limit.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Xiuyu Jin, Quanhui Ye, Chien-Wei Wang, Ying Wu, Kangling Ma, Sihan Yu, Na Wei, Haifeng Gao
Summary: Protein immobilization on magnetic nanoparticles using the SpyTag-SpyCatcher chemistry is an effective method to enhance stability and facilitate separation. The SpyTag peptide incorporated into MNPs improves loading capacity and water dispersity, allowing for efficient and stable conjugation without the need for additional enzymes or cross-linkers. The platform offers protection and improved shelf life for immobilized proteins, with fast magnetophoresis for easy recovery under external magnetic fields.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biotechnology & Applied Microbiology
Rumysa S. Khan, Anjum H. Rather, Taha U. Wani, Sami-ullah Rather, Touseef Amna, M. Shamshi Hassan, Faheem A. Sheikh
Summary: This review article systematically discusses the recent trends and applications of enzyme immobilization using natural polymers to prepare nanofibers. Nanostructured supports have been proven to exhibit better catalytic performance and immobilization efficiency.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Heru Agung Saputra, Khatun A. Jannath, Kwang Bok Kim, Deog-Su Park, Yoon-Bo Shim
Summary: This review highlights the importance of electrochemical biosensors in the early detection of lung cancer and discusses in detail the design and development of biosensors using conducting polymer composite materials. The review covers various electrochemical sensing methods for lung cancer markers using composite electrodes, including conducting polyterthiophene, poly(3,4-ethylenedioxythiophene), polyaniline, polypyrrole, molecularly imprinted polymers, and others. The potential of combining electrochemical biosensors with other techniques is emphasized. The outlook for the development of conducting polymer composite-based electrochemical biosensors for point-of-care diagnostic devices is also briefly discussed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Analytical
Zhen Song, Yihui Ma, Aoife Morrin, Caifeng Ding, Xiliang Luo
Summary: Porous conducting polymers (PCPs) are unique materials that integrate excellent electrochemical properties with a porous structure, providing larger surface area and higher electrocatalytic activity. They have received increasing attention as sensing materials and are widely applied in electrochemical sensing applications.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Asma Khurshid, Aamer Saeed, Mauricio F. Erben, Tuncer Hokelek, Erum Jabeen
Summary: This study aims to investigate the effect of substitution on the reactivity of newly synthesized crystalline azomethine linked aromatic compounds/Schiff bases. Crystalline compounds were obtained in good yields through condensation reaction between 2-iodo-4-chloro substituted aniline and suitably substituted aromatic aldehydes. The reactivity of the azomethine pharmacophore was explained based on the electronic features of the attached substituents. DFT calculations and frontier molecular orbital calculations were used to support the reactivity profile and understand the mechanistic aspects.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Aamer Saeed, Hafiza Zara Tariq, Ghulam Shabir, Tuncer Hokelek, Michael Bolte, Syeda Abida Ejaz, Aftab Ahmed
Summary: A green synthesis method was used to successfully synthesize the novel symmetrical molecule 1,3-bis(4-ethylphenyl)triazene (3) via the self-coupling of 4-ethylaniline in water at room temperature. The structure of 3 was determined using spectroscopic data, elemental analysis, and single crystal X-ray crystallography. The crystal structure of 3 was found to be stabilized by intermolecular hydrogen bonds and van der Waals interactions. The evaluation of the energy frameworks indicated that dispersion energy played a dominant role in the stabilization of the crystal packing. The HOMO and LUMO energies were determined to be -0.19401 and -0.5546, respectively. (C) 2022 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Resit Cemaloglu, Nuran Asmafiliz, Zeynel Kilic, Bunyemin Cosut, Busra Nur Sabah, Leyla Acik, Nebahat Aytuna Cerci, Tuncer Hokelek
Summary: This study synthesized organic-inorganic hybrid multi-heterocyclic unsymmetrical cis/trans dispirocyclotriphosphazenes with different pendant arms and investigated their spectral, stereogenic, photophysical, and bioactivity properties.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Hamid Aziz, Aamer Saeed, C. John McAdam, Jim Simpson, Tuncer Hokelek, Erum Jabeen, Asma Khurshid, Muhammad Saleem, Hesham R. El-Seedi
Summary: The current research focuses on the synthesis, crystal structure determination, Hirshfeld surface analysis, interaction energies, and density functional theory calculations of functionalized 1,3-thiazoles (5a and 5b). The synthesized compounds crystallized in monoclinic crystal systems with the P 2 1 /c space group. Intermolecular interactions were analyzed using Hirshfeld surface analysis. The study also investigated the energy contributions, redox behavior, and electrophilic characteristics of the compounds (5a and 5b).
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Azer Ozen, Elif Ozturkkan, Guventurk Ugurlu, Giray Bugra Akbaba, Mustafa Sertcelik, Tuncer Hokelek, Hacali Necefoglu
Summary: The current study synthesized a new ligand and its cobalt and nickel complexes. Their structures were determined using various spectroscopic techniques and X-ray diffraction. The crystal structures revealed the formation of three-dimensional architectures through hydrogen bonding and π-π interactions. The synthesized compounds showed significant antibacterial effects on K. pneumoniae bacteria.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Huseyin Akbas, Aysegul Senocak, Zeynel Kilic, Secil Erden Tayhan, Sema Bilgin, Asli Yildirim, Tuncer Hokelek
Summary: Schiff bases prepared from condensation reactions of furfural with N-ethyl-1,2-diaminoethane and N-methyl-1,3-diaminopropane were successfully reduced to obtain the starting diamines. Regioselective formation of tetrachloro(2-furanylmethyl)spiro-(N/N)cyclotriphosphazenes was achieved when reacting hexachlorocyclotriphosphazene with the diamines. Furthermore, the Cl replacement reactions with pyrrolidine and piperidine resulted in the synthesis of tetrapyrrolidino and tetrapiperidino cyclotriphosphazenes. The compounds exhibited varying degrees of success in inhibiting the growth and migration of various cancer cells, with the most effective phosphazene derivatives being the five-membered N-ethyl phosphazenes (3a and 3b).
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Hamid Aziz, Aamer Saeed, Jim Simpson, Tuncer Hokelek, Erum Jabeen
Summary: The research focuses on the convenient synthesis, molecular and crystal structures of C-2 symmetric N,N'-(cyclohexane-1,4-dicarbonothioyl)bis(4-methylbenzamide). The crystal structure exhibits three-dimensional architecture with hydrogen bonding and van der Waals contacts as the dominant interactions. Analysis of the crystal voids suggests the absence of any large cavity in the crystal. The optimized molecular structure and molecular electrostatic potential surface provide insights into the nucleophilic and electrophilic behavior of the bis-amide.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Tolga Gokturk, Talip Zengin, Tuncer Hokelek, Cansu Gokce Topkaya, Ramazan Gup
Summary: In this study, a novel 1,2,4-triazine derivative, 2-(6-(4-chlorophenyl)-1,2,4-triazin-3-yl)quinoline, was synthesized and characterized by various analytical techniques. The molecular and crystal structures were determined using X-ray crystallography, revealing the involvement of hydrogen bonding and van der Waals interactions in the crystal packing. The compound exhibited binding activity with CT-DNA via the minor groove and with BSA via subdomain IIIB.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Huseyin Akbas, Aysegul Senocak, Zeynel Kilic, Secil Erden Tayhan, Sema Bilgin, Asli Yildirim Kocaman, Tuncer Hokelek
Summary: In this study, the condensation reaction of hexachlorocyclotriphosphazene with N-1,N-3-bis(furan-2-ylmethyl)-1,3-diamino-propane yielded a new phosphazene compound. The structures of the phosphazenes were confirmed by various analysis methods. The antiproliferative and antimigratory effects of the phosphazenes on prostate and colon cancer cell lines were evaluated, and compound 2a showed higher effectiveness than compound 2b.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2023)
Article
Chemistry, Multidisciplinary
Tolga Gokturk, Esin Sakalli Cetin, Tuncer Hokelek, Hanife Pekel, Ozge Sensoy, Ebru Nur Aksu, Ramazan Gup
Summary: A new 1,2,3-triazole derivative was synthesized and its structure was analyzed using multiple techniques. The compound exhibited significant DNA and protein binding activity both in vitro and in vivo, and showed high cytotoxicity against Caco-2 cancer cell lines, possibly by inducing apoptosis.
Article
Crystallography
Seqqat Yousra, Lhoussaine El Ghayati, Tuncer Hokelek, Fouad Ouazzani Chahdi, Joel T. Mague, Youssef Kandri Rodi, Nada Kheira Sebbar
Summary: The title compound exhibits two molecules with slightly different conformations in the crystal, which are connected by hydrogen bonds and stacking interactions. Hirshfeld surface analysis reveals that H···H and H···O/O···H interactions are the major contributions to the crystal packing. The density functional theory calculations agree well with the experimental results.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Crystallography
Ezaddine Irrou, Younesse Ait Elmachkouri, Ahmed Mazzah, Tuncer Hokelek, Amal Haoudi, Joel T. Mague, Mohamed Labd Taha, Nada Kheira Sebbar
Summary: The crystal structure and energy characteristics of a molecule containing a nitrogen-sulfur heterocyclic structure were studied, and hydrogen bonding and π-π interactions were found in the crystal. The crystal packing was analyzed through experimental and theoretical calculations.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Crystallography
Nohaila Rharmili, Omar Abdellaoui, Amal Haoudi, Joel T. Mague, Tuncer Hokelek, Fouad Ouazzani Chahdi, Youssef Kandri Rodi, Ahmed Mazzah, Nada Kheira Sebbar
Summary: The title compound possesses an almost planar indoline portion and an all-trans conformation for the 12-bromododecyl chain, except for the gauche terminal C-C-C-Br fragment. The crystal structure forms a micellar-like structure through C-H center dot center dot center dot O hydrogen bonds and pi-stacking interactions between the indolinedione head groups and intercalation of the 12-bromododecyl tails. The most important contributions for crystal packing come from H...H (58.9%), H center dot center dot center dot O/O center dot center dot center dot H (17.9%), and H center dot center dot center dot Br/Br center dot center dot center dot H (9.5%) contacts, as indicated by Hirshfeld surface analysis. A density functional theory (DFT) optimized structure at the B3LYP/6-311 G(d,p) level agrees well with the experimentally determined molecular structure in the solid state.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Cansu Gokce Topkaya, Sema Aslan, Tolga Goturk, Sultan Kincal, Tuncer Hokelek, Ramazan Gup
Summary: This paper reports a metal catalyst-free synthesis method for the one-step synthesis of 6-(4-chlorophenyl)-3,3-dimethyl-4-(Noxide)-1,2,3,4-tetrahydro-1,2,4-triazine. The compound's molecular and crystal structures were characterized, and various interactions were identified in the crystal packing. Additionally, the electrochemical characterizations and supercapacitor performances of the compound were investigated.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Multidisciplinary
Tolga Gokturk, Esin Sakalli Cetin, Tuncer Hokelek, Hanife Pekel, Ozge Sensoy, Ebru Nur Aksu, Ramazan Gup
Summary: In this study, a new 1,2,3-triazole derivative was synthesized and its structure was characterized using various analysis techniques. The compound exhibited hydrogen bonding and van der Waals interactions in the crystal packing, and demonstrated binding activity to DNA and bovine serum albumin. Furthermore, the compound showed significant anticancer activity and induced apoptosis in Caco-2 cells.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)