Article
Chemistry, Analytical
Ya-Mei Peng, Jian-Zhang Pan, Qun Fang
Summary: Miniaturized LIF detectors with three optical configurations were developed and tested for detection limits of sodium fluorescein. A handheld orthogonal LIF detector was successfully built with small size, moderate cost, and low detection limit for field analysis applications.
Article
Chemistry, Multidisciplinary
Serban Dobroiu, Falco C. M. J. M. van Delft, Ayyappasamy Sudalaiyadum Perumal, Shantoshini Dash, Jenny Aveyard, Jeroen van Zijl, Jaap Snijder, Eric van den Heuvel, Jurgen van Berkum, Marie Pierre Blanchard, Cyril Favard, Dan Nicolau
Summary: One challenge in biosensing technology is detecting very low concentrations of analytes. The fluorescence interference contrast (FLIC) technique improves sensitivity by selectively amplifying or suppressing the emission of a fluorophore-labeled biomolecule. FLIC's extreme sensitivity to wavelength can be a problem due to variations in the fluorophore's vertical position.
Article
Chemistry, Analytical
Lipeng Pan, Mingye Zou, Fangxing Ma, Lingqing Kong, Changnan Zhang, Likun Yang, Anna Zhu, Feng Long, Xiang-Yang Liu, Naibo Lin
Summary: A compact evanescent wave detection platform is developed for the detection of fluorescence gold nanoclusters. The platform employs a simple optical system and a Si-based photodetector assembly, improving the optical efficiency and detection sensitivity. It has potential applications for fast detection of dopamine in microsamples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Hanieh Mardani, Hossein Roghani-Mamaqani, Mehdi Salami-Kalajahi
Summary: Stimuli-responsive block copolymers were synthesized for high-sensitivity detection of copper ions based on a fluorescence quenching mechanism. The self-assembled micellar structures showed fast reaction rates and high detection limits, making them suitable for sensing applications.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Optics
Jennifer D. T. Kruschwitz, Michael Trubetskov, Jason Keck
Summary: The paragraph introduces the design problems for the Optical Interference Coating (OIC) 2022 Topical Meeting, which include black box coatings for reverse engineering and white-balanced, multi-bandpass filters for three-dimensional cinema projection in outdoor environments. Fourteen designers from China, France, Germany, Japan, Russia, and the United States submitted a total of 32 designs for the problems. The design problems and the submitted solutions are described and evaluated.
Article
Engineering, Chemical
Jing Lv, Qing-xian Yue, Rui Ding, Wei-hua Li, Xiao Wang, Tai-jiang Gui, Xiao-dong Zhao
Summary: A material for detecting metal corrosion was developed, which could accurately locate corrosion sites and enhance the shielding performance of coatings.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Article
Engineering, Electrical & Electronic
Jing Lu, Tingting Duan, Lina Wang, Youfu Geng, Duo Yi, Zhifeng Tong, Xiaojian Zhu, Xuejin Li, Xueming Hong
Summary: In this article, a phasedemodulated high-order intermodal interference based on exposed-core microstructure fiber (ECF) is demonstrated for low-concentration in situ deafness gene DNA detection. The high-order interference mode (LP01-LP(21)a) shows a phase sensitivity about 6 times higher than the low-order mode (LP01-LP(11)b), differing from traditional wavelength-coded demodulation methods. Hybridization experiments confirm that the sensing system can detect complementary gene fragments with concentrations as low as 1 nM, with a corresponding phase variation of 7.394. The detection limit (LOD) is as low as 0.046 nM. The experiment and theoretical analyses prove that this fiber optic biosensor provides a high sensitivity and signal-to-noise ratio for high-sensitivity and high-precision sensors.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Tiange Zhang, Shuai Wu, Haifeng Qin, Huaying Wu, Xiaoshuai Liu, Baojun Li, Xianchuang Zheng
Summary: The OCViM technique allows for noninvasive and precise control of nanoprobe for multipoint detection in vivo, providing valuable insights for biomarker research and antithrombotic drug evaluation.
ADVANCED MATERIALS
(2022)
Article
Materials Science, Coatings & Films
Jeremy Grace, Samad Edlou, Joseph Foss, Craig Hodgson, Jean-Philippe Rheault, Jake Rosvold, Kurt Sieber, Sarah Walters
Summary: In fluorescence microscopy, autofluorescence from optical elements in the system can limit background levels. Although weaker than fluorescence from organic dyes, detailed spectral information about autofluorescence comes at the cost of sensitivity. The study presents an approach using a chopped laser and phase-lock detection scheme for sensitive fluorescence measurements, controlling the trade-off between spectral information and sensitivity through filter edge locations and bandwidths.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Katerina Nikolaidou, Pedro G. M. Condelipes, Catarina R. F. Caneira, Maximilian Krack, Pedro M. Fontes, Hugo M. Oliveira, Milan Kovacic, Janez Krc, Marko Topic, Susana Cardoso, Paulo P. Freitas, Virginia Chu, Joao Pedro Conde
Summary: Highly selective optical interference filters are integrated with photosensors for fluorescence measurements in lab-on-chip applications. The filters are designed to match the requirements of each application and fabricated as nitride-oxide multilayers. They are combined with hydrogenated amorphous silicon-carbon alloys to serve as absorption filters for different spectral requirements. These integrated filters enable simplified and portable measurement setups for fluorescence applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Electrical & Electronic
Lishuai Zhao, Guoqiang Li, Jiulin Gan, Zhongmin Yang
Summary: The flexible hydrogel optical fiber with a permeable core/clad structure and a step-index profile is designed for efficient light guiding and fluorescence emission. It shows great potential for real-time, highly sensitive detection of pH in aqueous environments through integration of fluorescent materials as pH probes. This design eliminates external disturbances and allows linear responses over a wide pH range.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Physics, Applied
Kalipada Chatterjee, Rakesh Kumar Singh, Rajan Jha
Summary: This study proposes and utilizes a wavefront division interferometry method for determining the topological charge of vortex beams and detecting beam displacement. The method uses a single Fresnel biprism to determine the vortex charge and utilizes interference pattern configuration to detect displacement in orthogonal directions. A fringe scanning algorithm based on image correlation is proposed for accurately determining beam displacement. The proposed method achieves a sensitivity of 80 px/0.5 mm beam displacement along the x-direction. It can be integrated with optical assemblies for fast vortex beam recognition and can be used for precision alignment, propagation analysis, and monitoring physical fields.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yating Chen, Zhonghang Chen, Jiming Wang, Xuandi Ma, Linyu Yuan, Shuhua Zhang, Fushun Tang
Summary: A zinc supracluster and a 1D zinc supracluster chain with molecular diameters of 2 nm were synthesized. The fluorescence-quenching effects of various ions were investigated, and the zinc supracluster showed excellent efficiency in selectively detecting Ce3+ ions.
Article
Environmental Sciences
Brij Mohan, Tiantian Xing, Sandeep Kumar, Suresh Kumar, Shixuan Ma, Feiyun Sun, Dingyu Xing, Peng Ren
Summary: A molecular probe was developed in this study to detect metal cations in wastewater using various spectroscopy techniques. The probe showed high sensitivity and a wide linear range, making it a reusable sensor.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Electrical & Electronic
Gopikrishnan Gopalakrishnan Meena, Joel G. Wright, Aaron R. Hawkins, Holger Schmidt
Summary: The study introduced a new optofluidic platform based on silicon photonics, achieving higher detection efficiency and lower detection limits. This platform demonstrated ultra-high sensitivity for analyzing pathogens at clinical concentrations, marking a significant step towards developing an ultrasensitive biosensor system.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Article
Physics, Applied
Giulia Laghi, Domenico Franco, Guglielmo Guido Condorelli, Riccardo Gallerani, Salvatore Guglielmino, Romolo Laurita, Dario Morganti, Francesco Traina, Sabrina Conoci, Matteo Gherardi
Summary: The validity of the Yasuda parameter W/FM as a controlling parameter for plasma polymerization is demonstrated using an atmospheric pressure single electrode plasma jet. Thin films deposited under different W/FM values exhibit different chemical and physical properties. Coatings with similar characteristics can be obtained regardless of the power and feed rate values adopted. Preliminary results show that the deposited coatings have antiadhesive activity against Pseudomonas aeruginosa and Staphylococcus aureus.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Chemistry, Analytical
Laura Sola, Laura Abdel Mallak, Francesco Damin, Alessandro Mussida, Dario Brambilla, Marcella Chiari
Summary: We conducted a detailed investigation on the effect of a polymeric coating's functional group concentration on probe density immobilization, aiming to find the optimal formulation for specific microarray applications. The performance of a microarray is known to be influenced by the way probes are attached to the surface, and our N, N-dimethylacrylamide-based polymeric coating has shown great flexibility for customizing surface properties. Through synthesizing polymers with increasing concentrations of N-acryloyloxysuccinimide (NAS) and optimizing the coating procedure accordingly, we tested their performance in DNA and protein microarray assays to determine the formulation that improves assay performance in specific applications. The flexibility of this polymeric platform also allowed us to explore different immobilization chemistries, specifically click chemistry reactions, and assess the potential differences generated by this modification.
Article
Chemistry, Multidisciplinary
Simona Filice, Stefano Boscarino, Mario Scuderi, Sebania Libertino, Clelia Galati, Antonio Terrasi, Silvia Scalese
Summary: Nanocomposites formed by aluminum-doped zinc oxide nanoparticles (AZO-NP) and multiwall carbon nanotubes (CNT) are proposed as a promising material for UV light sensing applications. The nanocomposite operates in air, at room temperature, and at low voltage. The electrical response to UV light is characterized by a sudden current increase, with good repeatability and stability.
Article
Biochemical Research Methods
Carola Romani, Paola Gagni, Mattia Sponchioni, Alessandro Volonterio
Summary: In this study, we successfully functionalized PAMAM G2 and PAMAM G4 with fluorinated arginine-based building blocks, resulting in a novel PAMAM-based gene delivery vector. The conjugates showed improved binding capacity to plasmid DNA, reduced cytotoxicity, and enhanced gene transfection efficiency compared to undecorated PAMAM dendrimers. These findings are of great importance for gene delivery research and also have the potential for future application in F-19 magnetic resonance imaging.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Physical
Giuseppe Tranchida, Rachela Gabriella Milazzo, Marco Leonardi, Silvia Scalese, Luca Pulvirenti, Guido G. Condorelli, Corrado Bongiorno, Salvatore Lombardo, Stefania M. S. Privitera
Summary: In this study, Fe-based nanoparticles with different morphology were deposited on carbon cloth via drop-casting and chemical reduction. The catalyst activity was evaluated and optimized, resulting in a significant increase in ammonia production. The optimized catalysts produced ammonia with a yield of 26.44 μg mgcat-1h-1 and a Faradaic efficiency of 20.4%, more than five times higher than without activation.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Biochemistry & Molecular Biology
Anna Lange-Consiglio, Giulia Gaspari, Federico Funghi, Emanuele Capra, Marina Cretich, Roberto Frigerio, Giampaolo Bosi, Fausto Cremonesi
Summary: In this study, a novel approach of using extracellular vesicles derived from amniotic mesenchymal stromal cells (AMSC-EVs) was investigated to prevent and alleviate persistent post-breeding induced endometritis (PPBIE) in mares. The supplementation of AMSC-EVs to stallion semen resulted in a reduction in neutrophil infiltration and intrauterine fluid accumulation, and modulation of the post-insemination inflammatory response was observed. This procedure may be beneficial for susceptible mares with PPBIE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Francesco Damin, Silvia Galbiati, Nicola Clementi, Roberto Ferrarese, Nicasio Mancini, Laura Sola, Marcella Chiari
Summary: Since the emergence of the COVID-19 pandemic, monitoring and tracking the distribution of SARS-CoV-2 variants is crucial for adjusting public health interventions. However, genome sequencing is not cost-effective and rapid. We have developed a microarray-based assay that can accurately detect known viral variants present in clinical samples by detecting mutations in the Spike protein gene. This assay can genotype the WHO-reported variants of concern (VOCs) in patient samples.
Article
Electrochemistry
Cigdem Tuc Altaf, Tuluhan Olcayto Colak, Emre Erdem, Ugur Unal, Feray Bakan Misirlioglu, Guglielmo Guido Condorelli, Nurdan Demirci Sankir, Mehmet Sankir
Summary: Photo-supercapacitors (PSCs) can convert and store solar energy into electricity, providing a sustainable solution to reduce reliance on the grid. In this study, a lithiated biphenol-based disulfonated poly (arylene ether sulfone) random copolymer (BPS) membrane was integrated into a PSC to improve efficiency and design. Under UV illumination, the PSC with BPS-Li(+) showed 2.8-fold increase in specific capacitance (Cp) and 2.7-fold increase in energy density (Ed) compared to dark conditions. Additionally, at elevated temperatures and 100% relative humidity, Cp and Ed of the PSC increased to 23.61 Fg(-1) and 47.22 Whkg(-1) at 85 degrees C, respectively, due to the enhanced ionic conductivity of the membrane.
ELECTROCHIMICA ACTA
(2023)
Article
Materials Science, Multidisciplinary
Ameen Uddin Ammar, Feray Bakan-Misirlioglu, Mohamad Hasan Aleinawi, Giorgia Franzo, Guglielmo Guido Condorelli, Fatma Nur Tuzluca Yesilbag, Yasar Ozkan Yesilbag, Salvo Mirabella, Emre Erdem
Summary: In this study, high-performance supercapacitor devices were developed using manganese-doped zinc oxide nanowires and copper-doped zinc oxide nanoparticles as a positive electrode, with MXene as a negative electrode. The performance of transition metal-based electrodes in combination with MXene was found to significantly enhance the supercapacitors' performance. The highest-performance supercapacitor achieved a specific capacitance of 151 F/g, an energy density of 84 Wh/kg, and a power density of 75 kW/kg. The presence of intrinsic and extrinsic defects in the Mn/Cu-doped ZnO was found to optimize the intrinsic properties and improve reaction kinetics, leading to enhanced electrochemical activity and superior supercapacitor device performance.
MATERIALS RESEARCH BULLETIN
(2023)
Article
Chemistry, Physical
Anna L. Pellegrino, Cristina Tudisco, Francesca Lo Presti, Emil Milan, Adolfo Speghini, Guglielmo G. Condorelli, Graziella Malandrino
Summary: For the first time, a gas-phase route called molecular layer deposition (MLD) was used to create a monolayer of metalorganic Eu(III) molecules on a NiO oxide layer. The NiO layer was activated using H2O/O2 vapors and then functionalized with molecules of the Eu complex at different temperatures to promote the chemisorption process. The effects of activation process and MLD temperature on the chemisorption of the Eu complex were evaluated using X-ray photoelectron and luminescence spectroscopy. The research findings defined the stoichiometry of the chemisorbed Eu moiety and optimized a strategy for synthesizing hybrid metalorganic/inorganic systems. The luminescence properties of the hybrid system confirmed energy conversion phenomena of the monolayer and provided information about the local environment of the Eu(III) complex anchored on the NiO surface.
Article
Biology
Marta Brambilla, Roberto Frigerio, Alessia Becchetti, Alessandro Gori, Marina Cretich, Maria Conti, Antonella Mazza, Martino Pengo, Marina Camera
Summary: The concentration of tissue factor (TF) positive small extracellular vesicles (sEVs) is significantly higher than that of large EVs (lEVs), but the TF-dependent procoagulant potential is primarily sustained by lEVs. In thromboinflammatory conditions such as COVID-19, the enhanced procoagulant potential is predominantly supported by lEVs, with both TF-positive sEVs and lEVs increasing during the acute phase of the disease.
Article
Materials Science, Multidisciplinary
Vincenzo Paratore, Domenico Franco, Salvatore Guglielmino, Francesca Lo Presti, Francesco Traina, Sabrina Conoci, Guglielmo Guido Condorelli
Summary: In this study, a silver terephthalate-based metal organic framework (MOF) was successfully synthesized using a new synthetic method. The obtained MOF showed efficient antibacterial activity against various bacteria and exhibited good stability in different environments. Therefore, it has the potential to be a new antibacterial agent.
MATERIALS ADVANCES
(2023)
Article
Nanoscience & Nanotechnology
Luca Pulvirenti, Cinzia Lombardo, Mario Salmeri, Corrado Bongiorno, Giovanni Mannino, Francesca Lo Presti, Maria Teresa Cambria, Guglielmo Guido Condorelli
Summary: In this paper, a new hybrid photocatalytic material activated by natural sunlight irradiation was synthesized. The material is composed of multiferroic nanoparticles of bismuth ferrite (BFO) modified by the growth of the Fe-based MIL-101 framework. The study found that MIL-101 modification significantly enhances the photo-degradative properties of BFO nanoparticles. Antibacterial experiments under natural sunlight exposure showed that the MIL-modified BFO exhibits stronger antimicrobial activity compared to bare nanoparticles.
Article
Materials Science, Multidisciplinary
Quentin Micard, Samuel Margueron, Ausrine Bartasyte, Guglielmo G. Condorelli, Graziella Malandrino
Summary: This study optimized the MOCVD process to deposit Dy-doped bismuth ferrite thin films and systematically investigated the effects of doping on the morphology, growth rate, and structure of the films. The results showed that the films exhibit good ferroelectric and piezoelectric responses with a significant reduction in the optical bandgap at a Dy-doping level of 0.08.
MATERIALS ADVANCES
(2022)
Article
Engineering, Electrical & Electronic
Emanuela Schiliro, Patrick Fiorenza, Giuseppe Greco, Francesca Monforte, Guglielmo Guido Condorelli, Fabrizio Roccaforte, Filippo Giannazzo, Raffaella Lo Nigro
Summary: This paper presents a comparative study of the early growth stages of aluminum oxide thin dielectric layers deposited by thermal- and plasma-enhanced atomic layer deposition on AlGaN/GaN heterostructures. The study revealed two different ALD growth mechanisms and provided evidence of the efficiency of the PE-ALD process for ideal layer-by-layer growth. Additionally, the investigation quantified oxide trap charges and their effects on insulating properties, highlighting the importance of the proper deposition process.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)