Article
Chemistry, Multidisciplinary
Hafiz Muhammad Junaid, Madeeha Batool
Summary: Optical sensors are being widely studied for their ability to quickly and easily detect metal ions. In this research, a Schiff base 4-(Benzylideneamino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one (V-AAP) was found to have chemosensing abilities for Fe2+, Fe3+ and AsO2- ions. The colorimetric probe showed color changes for these ions and had low detection limits.
Article
Infectious Diseases
Gustavo Pretelin-Castillo, Mayra Silva Miranda, Clara Espitia, Rosa Maria Chavez-Santos, Abel Suarez-Castro, Luis Chacon-Garcia, Rodrigo Aguayo-Ortiz, Roberto Martinez
Summary: This study investigated the role of substituents attached to the phenyl ring of a 3-hydroxy-3-phenyl-prop-2-enedithioic acid scaffold in inhibiting the growth of M. tuberculosis strain H37Rv. It was found that compounds with electron-donating or electron-withdrawing substituents on the aromatic ring showed potential antituberculosis activities, with compound 11e showing promising results for further development. Docking studies also revealed potential interactions between synthesized compounds and the HadAB enzyme, providing insights for future drug design.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Chemistry, Physical
B. Saranya, M. Gowri
Summary: In this study, the Schiff base and its metal complexes were synthesized and characterized using various techniques. The potential activity of these compounds against T-cells and coronavirus was studied, and their drug-like nature and pharmacokinetic properties were evaluated.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Wei Liu, Zhifei Hu, Peng Xu, Biao Yu
Summary: Here, we presented a convenient procedure to prepare EPP glycosides and their application in the synthesis of the clinically approved anticoagulant fondaparinux. Additionally, we successfully achieved the synthesis of heparin-like tetrasaccharides using EPP glycosides in a one-pot orthogonal glycosylation reaction.
Article
Pharmacology & Pharmacy
Jing Chen, Zhenghuan Rao, Qinqin Li, Tao Jiang, Yuan Chen, Xia Gu, Mengyue Miao, Daifeng Hu, Hui Zhou, Alexander Tobias Teichmann, Youzhe Yang
Summary: The study demonstrates the beneficial effects of FK-morph on a surgically induced endometriosis rat model. FK-morph effectively reduces the volumes and adhesion scores of implants, downregulates inflammatory cytokines and chemokines levels, mediates cell apoptosis of endometriosis foci, and attenuates angiogenesis by decreasing the expression of VEGF. The underlying mechanism involves blocking the activation of the PI3K/Akt and NF-xB signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Ramachandran Rajamanickam, Senthan Sivakolunthu, Jayanthi Sampathkumar
Summary: In this study, the compound BPZ was synthesized using Ce-MCM-48 catalyst and characterized by various spectroscopic techniques. Molecular structure was optimized using DFT, and the compound's interactions with the COVID-19 protein structure were investigated through molecular docking study, revealing significant hydrogen bonding interactions.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Medicinal
Marta A. A. Wazynska, Roberto Butera, Marta Requesens, Annechien Plat, Tryfon Zarganes-Tzitzikas, Constantinos G. G. Neochoritis, Jacek Plewka, Lukasz Skalniak, Justyna Kocik-Krol, Bogdan Musielak, Katarzyna Magiera-Mularz, Ismael Rodriguez, Simon N. N. Blok, Marco de Bruyn, Hans W. W. Nijman, Philip H. H. Elsinga, Tad A. A. Holak, Alexander Domling
Summary: In search of a potent small molecular PD-L1 inhibitor, a compound based on a 2-hydroxy-4-phenylthiophene-3-carbonitrile moiety was designed and synthesized. The ligand's performance in vitro was compared with a known PD-L1 antagonist, BMS1166, and modifications were made to allow F-18 labeling for PET imaging. The resulting inhibitor demonstrated comparable biological activity to BMS1166 towards hPD-L1, while possessing enhanced pharmacological properties.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dima A. Sabbah, Rawan A. Haroon, Sanaa K. Bardaweel, Rima Hajjo, Kamal Sweidan
Summary: Cancer, the second leading cause of death globally, is a multifactorial disease. A series of newly synthesized derivatives demonstrated promising anti-cancer activity against human epithelial colorectal adenocarcinoma and colon carcinoma cells, with studies showing their interactions with key binding residues in PI3Kα.
Article
Biochemistry & Molecular Biology
Shikha Kamboj, Samridhi Thakral, Sunil Kumar, Vikramjeet Singh
Summary: A series of 3-hydroxy-N-(2-(substituted phenyl)-4-oxothiazolidin-3-yl)-2-napthamide derivatives were synthesized and evaluated for their antimicrobial, antioxidant and anti-inflammatory activities. The compounds were synthesized by condensation reaction and cyclization reaction. Among them, 3-hydroxy-N-(4-oxo-2-(3,4,5-trimethoxyphenyl)thiazolidin-3-yl)-2-naphthamide (S20) exhibited the highest antimicrobial potential.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Multidisciplinary
Victor Kesternich, Marcia Perez-Fehrmann, Victor Quezada, Marina Castroagudin, Ronald Nelson, Rolando Martinez
Summary: This paper presents a method for synthesizing rafoxanide 6, a halogenated salicylanilide used as an efficient anthelmintic in sheep and cattle. The synthesis involves three steps starting from readily available 4-chlorophenol, with an overall yield of 74%. The key stages of the synthesis are salicylic acid iodination achieving a yield of 95% and the reaction of 3,5-diiodosalicylic acid 5 with aminoether 4, resulting in a yield of 82%. The intermediates and final product were characterized using physical and spectroscopic techniques.
Article
Electrochemistry
S. R. Priyanka, K. P. Latha
Summary: A new class Copper (II) complex was designed and successfully used for electrochemical analysis; HQ and CC were effectively separated using CV and DPV methods; Poly(Cu-PABC)/MCPE achieved the voltammetric separation of dihydroxy benzene isomers in a binary relationship.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2021)
Article
Chemistry, Physical
Hisakazu Miyamoto, Hiroki Takahashi
Summary: The title compounds, 3-(p-phenylphenyl)-3-hydroxy-N-isopropyl-4,4-dimethylazetidin-2-one (2d) and 3-phenyl-3-hydroxy-N-isopropyl-4,4-dimethylazetidin-2-one (2a), were synthesized by photoreaction of N,N-diisopropyl(p-phenylphenyl)glyoxylamide 1d and N,N-diisopropylphenylglyoxylamide 1a, respectively, in solution. The formation of the compounds was confirmed by various spectroscopic techniques and X-ray diffraction. The crystal structures of compounds 2d and 2a belong to the orthorhombic and monoclinic systems, with space groups Pna2(1) and P2(1)/c, respectively.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Martin Porubsky, Kristyna Vychodilova, David Milicevic, Milos Budesinsky, Jarmila Stankova, Petr Dzubak, Marian Hajduch, Jan Hlavac
Summary: Combining cytotoxic amino-BODIPY dye and 2-phenyl-3-hydroxy-4(1H)-quinolinone (3-HQ) derivatives into one molecule resulted in selective activity against leukemia cells while sparing normal cells. The conjugation of both compounds can be cleaved in cancer cells, releasing the individual components which can be monitored through fluorescence techniques. Additionally, similar cytotoxic activity was observed with a non-cleavable linker, showcasing the potential of these conjugates in cancer therapy.
Article
Optics
Xucong Zhou, Huiting Li, Yu Zhao, Xixi Cui, Changzhe Zhang, Qingtian Meng
Summary: In this study, the solvent effect mechanism of the fluorescent probe DPPHC molecule was systematically investigated using density functional theory and time-dependent density functional theory. The results revealed that the DPPHC molecule exhibited significant intramolecular charge transfer characteristics instead of intramolecular proton transfer reactions in the excited state. With increasing solvent polarity, the hydrogen bond strength of the DPPHC molecule decreased, leading to a reduced likelihood of intramolecular proton transfer reactions.
JOURNAL OF LUMINESCENCE
(2022)
Article
Biochemical Research Methods
Gabriel E. Gomez Pinheiro, Heiko Ihmels
Summary: The study investigated the suitability of 3-hydroxy-4-pyridylisoquinoline as a fluorescent chemosensor for detecting metal ions. Interactions with selected metal ions were studied using absorption and emission spectroscopy, revealing characteristic optical responses for Zn2+, Fe2+, and Mg2+ complexes with 1:1 and 2:1 stoichiometry, allowing for the identification and detection of specific metal cations under different solvent conditions.
JOURNAL OF FLUORESCENCE
(2021)
Article
Engineering, Electrical & Electronic
K. K Bindu, S. Rajbala, Girish Kumar, Anil K. Singh
Summary: This paper proposes a technique using directly coupled stacked patches to increase impedance bandwidth and reduce cross-polarization. By employing metallic shorting posts between the metallic patches, the stacked configurations achieve a bandwidth of 25.8% and a gain of 8.8 dBi with low cross-polarization levels. A symmetrically direct-coupled stacked design further suppresses cross-polar components, resulting in a bandwidth of 26.1% and a gain of 9.3 dBi.
IETE JOURNAL OF RESEARCH
(2023)
Review
Food Science & Technology
Avtar Singh, Ajay Mittal, Soottawat Benjakul
Summary: This article provides insights into the applications of chitosan and its derivatives in the food industry, specifically for enhancing shelf-life and antimicrobial activity.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Ajay Mittal, Avtar Singh, Hui Hong, Soottawat Benjakul
Summary: Chitooligosaccharides (COS) prepared from shrimp shell chitosan using different concentrations of H2O2 or AsA/H2O2 redox pair were characterized. COS-RP produced by AsA/H2O2 redox pair showed higher antioxidant and antimicrobial activities compared to COS-HP, with lower degree of polymerisation and average molecular weight.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Horticulture
Sandhya Thapa, Kalyan Barman, Anil K. Singh
Summary: The study found that postharvest putrescine (PUT) treatment has significant effects on delaying senescence and maintaining quality of guava fruits. Among the different doses of PUT treatment, 1.0 mM was the most effective in reducing weight loss and decay of the fruits.
Article
Chemistry, Applied
Ajay Mittal, Avtar Singh, Soottawat Benjakul
Summary: The inhibitory effects of chitooligosaccharide-epigallocatechin gallate (COS-EGCG) conjugate on alpha-amylase were studied and found to be significant. The conjugate could reduce starch digestibility and could be used as a food additive with low glycemic index.
Article
Food Science & Technology
Avtar Singh, Kartik Sharma, Pornpot Nuthong, Soottawat Benjakul
Summary: In this study, the emulsifying properties of psyllium husk powder at various concentrations in natural actomyosin extracted from threadfin bream mince were investigated. The addition of psyllium husk powder at 1.25 g/100 mL and 2.50 g/100 mL resulted in increased emulsion activity and stability indexes. Furthermore, the gel properties and consumer acceptability of fish tofu with different levels of psyllium husk powder were examined.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Ajay Mittal, Avtar Singh, Hui Hong, Soottawat Benjakul
Summary: The aim of this study was to determine the optimum condition for preparing chitooligosaccharide-catechin conjugate (COS-CAT) liposomes using different stabilising agents. COS-CAT liposomes were prepared using soy phosphatidylcholine (SPC) and either glycerol or cholesterol, and their encapsulation efficiency, loading capacity, physicochemical characteristics, FTIR spectra, thermal stability, and structure were assessed. The results showed that COS-CAT loaded liposome stabilised by cholesterol (COS-CAT-CHO) exhibited higher stability, with the highest encapsulation efficiency and loading capacity, and the lowest zeta potential, polydispersity index, and releasing efficiency.
JOURNAL OF MICROENCAPSULATION
(2023)
Article
Food Science & Technology
Natchaphol Buamard, Avtar Singh, Bin Zhang, Hui Hong, Prabjeet Singh, Soottawat Benjakul
Summary: The quality of surimi gel can be improved by using protein cross-linkers, especially those from plant extracts like Duea ching fruit. The fruit extract, rich in phenolic compounds and calcium, can activate transglutaminase and enhance the gel's properties. Different media for the extraction of Duea ching were studied and its application in sardine surimi gel was investigated.
Article
Biotechnology & Applied Microbiology
Khurshid Ahmed Baloch, Avtar Singh, Khamtorn Pudtikajorn, Soottawat Benjakul
Summary: Enrichment of n-3 polyunsaturated fatty acids (PUFA) in skipjack tuna eyeballs oil (STEO) was investigated using lipases from different yeast strains. Among all lipases tested, Candida rugosa extracellular lipase (Cr-ECL) showed promising enrichment of EPA and DHA in STEO. RSM was used to optimize reaction conditions and resulted in a significant increase in DHA and EPA concentration in STEO. The established hydrolysis protocol successfully converted fish oil from tuna waste to valuable fish oil enriched with n-3 fatty acids.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Avtar Singh, Saumya Mehta, Umesh Patil, Pornpot Nuthong, Soottawat Benjakul
Summary: The effects of adding hyperoside (HyS) at various levels (0%-4%; w/w) on the textural, rheological, structural, and sensory properties of threadfin bream surimi were investigated. The addition of 1% and 2% HyS resulted in surimi gel with the highest breaking force and deformation. HyS also improved the water-holding capacity and increased hardness, springiness, gumminess, and chewiness of the gel. The addition of HyS enhanced the connections between surimi proteins and improved the gel network.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Avtar Singh, Umesh Patil, Ajay Mittal, Prabjeet Singh, Anuj Tyagi, Soottawat Benjakul
Summary: The gelling behaviors of partially purified myofibrillar proteins (PPMP) extracted from Indian mackerel (IM) and threadfin bream (TB) were compared at different heating temperatures. The results demonstrated that IM-MP exhibited lower turbidity, surface hydrophobicity, and disulfide bond content compared to TB-MP. The amino acid profile showed no significant difference between the two species, except for lysine and glutamine. Structural analysis confirmed these differences, and the transmission analysis revealed lower aggregation and crosslinking ability of IM-MP. Therefore, the gelling behavior of IM-MP was poorer compared to TB-MP.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ajay Mittal, Avtar Singh, Bin Zhang, Qiancheng Zhao, Soottawat Benjakul
Summary: The inhibitory effects of chitooligosaccharide (CHOS) conjugates, including CHOS-catechin (CHOS-CAT), CHOS-epigallocatechin gallate (CHOS-EGCG), and CHOS-gallic acid (CHOS-GAL), on Pacific white shrimp cephalothorax polyphenoloxidase (PPO) were studied. CHOS-CAT showed the strongest inhibitory activity against PPO and exhibited mixed-type inhibition. Molecular docking analysis revealed that CHOS-CAT interacts with various amino acid residues near the active site of PPO. Therefore, CHOS-CAT could serve as an anti-melanosis agent to prevent discoloration in crustaceans.
Article
Fisheries
Wattana Temdee, Avtar Singh, Hui Hong, Bin Zhang, Ahmet Faruk Yesilsu, Soottawat Benjakul
Summary: The effects of epigallocatechin gallate (EGCG) at 200 or 400 ppm on the quality changes of cooked Harpiosquillid mantis shrimp (Harpiosquilla raphidea) (CHMS) meat subjected to varying freeze-thaw cycles (F-T-C; 0, 1, 3, and 5) were studied. With increasing F-T-C, the CHMS meat deteriorated to a higher extent, indicated by increased exudate loss, tougher texture, and higher microbial counts. The addition of EGCG could dose-dependently retard these changes, as well as prevent microbial growth and lipid oxidation. The alterations in disulfide bond content and surface hydrophobicity of CHMS added with EGCG were more pronounced with higher EGCG concentration.
TURKISH JOURNAL OF FISHERIES AND AQUATIC SCIENCES
(2023)
Review
Food Science & Technology
Ajay Mittal, Avtar Singh, Jirayu Buatong, Jirakrit Saetang, Soottawat Benjakul
Summary: Chitooligosaccharide (CHOS), a depolymerized chitosan, has various applications as alternative additives or bioactive compounds in food and biomedical fields. Derivatives of CHOS with enhanced bioactivities, such as anti-inflammatory, anti-obesity, neuroprotective, and anti-cancer effects, have been prepared and characterized. These CHOS derivatives also exhibit improved antibacterial and antioxidant activities, which are beneficial for shelf-life extension and food safety.
Proceedings Paper
Materials Science, Multidisciplinary
Surendra Poonia, A. K. Singh, Dilip Jain
Summary: In the water-stressed Thar desert of Rajasthan, a concentrating solar thermal desalination device was developed to address the limited surface water resources and brackish groundwater. The use of paraffin as a phase change material increased the system productivity and the economic analysis showed cost-efficiency. This device can effectively desalinate water for rural areas in the Thar desert.
MATERIALS TODAY-PROCEEDINGS
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
