Article
Chemistry, Analytical
Andrea Rescalli, Davide Marzorati, Simone Gelosa, Francesco Cellesi, Pietro Cerveri
Summary: This study explores the potential of temperature modulation in improving the sensitivity of gas sensors in electronic nose devices for exhaled breath analysis. The results demonstrate successful discrimination of different analytes and concentrations, with the square and triangular combination pattern achieving optimal accuracy. The findings highlight the potential for further advancements in the field of disease diagnosis through exhaled breath analysis.
Article
Chemistry, Multidisciplinary
Matteo Tonezzer, Cristina Armellini, Laura Toniutti
Summary: Thermal electronic noses are an important type of sensor in modern applications, capable of distinguishing different gases and volatiles. Research shows that thermal electronic noses based on SnO2 nanowires outperform in detection and classification.
Article
Chemistry, Analytical
Andreas Voss, Rico Schroeder, Steffen Schulz, Jens Haueisen, Stefanie Vogler, Paul Horn, Andreas Stallmach, Philipp Reuken
Summary: The purpose of this exploratory study was to determine whether liver dysfunction can be generally classified using a wearable electronic nose based on semiconductor metal oxide (MOx) gas sensors, and whether the extent of this dysfunction can be quantified. The study found that the wearable, non-invasive system could detect liver dysfunctions and accurately distinguish different degrees of cirrhosis patients and healthy controls.
Article
Chemistry, Organic
Peng Zhang, Tianhong Wu, Hui Cao, Jie Zhang, Tony D. James, Xiaolong Sun
Summary: In this article, a gas sensor named CA-SCH3 was developed for real-time/on-site and quantitative detection of volatile amines. The sensor exhibited a turn-on fluorescence signal and a blue shift in the UV-vis absorbance signal in the presence of ammonia. A paper-based gas sensor loaded with the probe enabled the quantification of ammonia gas and detection of volatile amines from fish spoilage. A polyethylene glycol film interlinked by the CA-SCH3 reagent provided a dual response of macroscopic degradation and fluorescence readout towards ammonia vapors. The fluorescent probe offers extensive possibilities for developing additional photoluminescent detection systems.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Agronomy
Eduardo Gonzalez Maria, Antonio Madueno Luna, Agustin Conesa Celdran, Gemma Martinez Munoz, Martin John Oates, Antonio Ruiz-Canales
Summary: This article presents a case study on the characterisation of honey based on floral origin. By using a low-cost electronic nose prototype consisting of metal oxide sensors, the aim was to discriminate Iberian honeys from local beekeepers in Madrid, Spain. The results showed that honey with higher pollen content triggered a clear response in the sensors, while those with lower pollen values did not show a noticeable reaction. By applying Support Vector Machines (SVM) for data analysis, a classification model with 87.5% accuracy was achieved, with lavender and chestnut honeys having the highest precision at 90% and 100% respectively.
Review
Chemistry, Multidisciplinary
Matteo Tonezzer, Dang Thi Thanh Le, Lai Van Duy, Nguyen Duc Hoa, Flavia Gasperi, Nguyen Van Duy, Franco Biasioli
Summary: Metal oxides are ideal for gas sensors due to their sensitivity and simplicity, but they lack selectivity. This review analyzes scientific articles on electronic noses based on metal oxide nanowires, which address the issue of selectivity by using multivariate statistical algorithms. The review covers various applications such as health, agrifood, and security.
NANOTECHNOLOGY REVIEWS
(2022)
Article
Agriculture, Multidisciplinary
Chang Liu, Hui Hou, Xiaoshuo Lu, Xin Chen, Donglu Fang, Qiuhui Hu, Liyan Zhao
Summary: The innovative mixedQu developed in this study can be considered as an excellent fermentation starter for brewing waxy maize wine. It is more suitable for making maize wine by the raw-starch brewing method compared to three kinds of commercialQu. Significant differences were observed among maize wines fermented by different types ofQu in terms of bitterness, umami, richness, saltiness, and sourness, as analyzed by electronic tongue and electronic nose.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Chemistry, Multidisciplinary
Salih Okur, Peng Qin, Abhinav Chandresh, Chun Li, Zejun Zhang, Ulrich Lemmer, Lars Heinke
Summary: Chirality plays a crucial role in nature, especially in biological information transfer through odor messenger molecules. A sensor array coated with metal-organic framework (MOF) films of different homochiral and achiral structures has been developed to selectively identify and discriminate chiral odor molecules, demonstrating the potential of chiral-MOF e-nose for advanced odor sensing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Xiaofang Pan, Jiebin Chen, Xiaolin Wen, Jiacheng Hao, Wei Xu, Wenbin Ye, Xiaojin Zhao
Summary: In order to address the performance issues of gas sensor systems in complex gas mixtures, we propose a comprehensive algorithm called HATN-DA. This algorithm utilizes multi-head transformers and channelwise attention mechanisms for feature extraction, and encodes gas species into concentration information using capsule vectors. It also achieves label-free drift compensation and transfer calibration effects through a domain discriminator.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Sayed A. M. Marzouk, Abdallah J. Abu Namous
Summary: This paper describes an experimental system for simultaneous permeation of different gases through gas permeable membranes and provides a proof of concept for gas identification. The system records the rate of gas pressure accumulation behind each membrane as a measure of gas permeation rate. The results show promising potential for using simultaneous permeation rates through different membranes as characteristic fingerprints for gas identification.
ANALYTICAL CHEMISTRY
(2022)
Review
Agriculture, Multidisciplinary
Zichen Zheng, Chao Zhang
Summary: The detection of pests and diseases is crucial for agricultural production. The traditional methods have negative impacts on the environment and health, while electronic nose technology offers an environmentally friendly alternative.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2022)
Article
Chemistry, Analytical
Hannaneh Mahdavi, Saeideh Rahbarpour, Seyed-Mohsen Hosseini-Golgoo, Hamidreza Jamaati
Summary: Despite the successful detection performance of electronic nose in laboratories, challenges exist for their industrial use due to accuracy reduction caused by variable ambient properties, especially relative humidity (RH) variation. Classifier models designed to detect studied gases showed that when humidity level deviates from training conditions, detection accuracy decreases to less than 60%.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yixu Huang, Iyll-Joon Doh, Euiwon Bae
Summary: Volatile organic compounds (VOCs) are emitted chemicals from various sources, detected through odor tests or gas chromatography-mass spectrometry. Utilizing machine learning algorithms and metal-oxide gas sensors, VOCs can be effectively detected and classified.
Article
Food Science & Technology
Ruocen Tian, Zhiming Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai
Summary: This study investigated the application of Bifidobacterium longum CCFM5871 as an adjunct starter culture for the production of fermented milk. Genome analysis revealed that CCFM5871 possesses various carbohydrate metabolic pathways, and comparative genomic analysis showed similar functional genes in other bifidobacteria strains used in dairy fermentation. The results demonstrated that supplementation with CCFM5871 increased acidification and solidification of fermented milk, without significantly affecting flavor and taste compared to the control group.
Article
Nanoscience & Nanotechnology
Li Yang, Guanghao Zheng, Yaoqian Cao, Chuizhou Meng, Yuhang Li, Huadong Ji, Xue Chen, Guangyu Niu, Jiayi Yan, Ye Xue, Huanyu Cheng
Summary: This study presents the design and demonstration of a moisture-resistant, stretchable NOx gas sensor based on laser-induced graphene (LIG). The gas sensor exhibits a large response, an ultralow detection limit, fast response/recovery, and excellent selectivity. It can be stretched by 30% and has been demonstrated to monitor the personal local environment and analyze human breath samples for disease diagnostics.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Parasitology
Emmanuel Edwar Siddig, Annelies Verbon, Sahar Bakhiet, Ahmed Hassan Fahal, Wendy W. J. van de Sande
Summary: Mycetoma can be caused by bacteria or fungi, resulting in actinomycetoma or eumycetoma. Molecular techniques, such as MALDI-TOF MS and DNA sequencing, enable rapid and accurate identification of causative organisms for guiding patient management and treatment.
Article
Infectious Diseases
Wilson Lim, Mickey Konings, Florianne Parel, Kimberly Eadie, Nikolaos Strepis, Ahmed Fahal, Annelies Verbon, Wendy W. J. van de Sande
Summary: This study discovered that Madurella mycetomatis produces DOPA-, pyomelanin and DHN-melanin in vivo. Inhibiting the DHN-melanin biosynthesis of M. mycetomatis increased the therapeutic value of the antifungal itraconazole in vivo.
Article
Infectious Diseases
Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de Sande
Summary: Eumycetoma is a chronic subcutaneous neglected tropical disease caused by various fungal agents. Current antifungal drugs have low cure rates, and there is a need for novel treatments. In this study, four compounds (fenbendazole, carbendazim, tafenoquine, and MMV1578570) were found to inhibit the growth of five species of fungi that cause eumycetoma. These compounds showed promising results in in vivo experiments as well.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
S. O. Abd Algaffar, A. Verbon, S. A. Khalid, W. W. J. van de Sande
Summary: An in vitro susceptibility assay for Actinomadura madurae was developed, and the minimum inhibitory concentrations (MICs) of commonly used antibacterial agents were determined. The results showed that trimethoprim/sulfamethoxazole, amikacin, doxycycline, and linezolid had high susceptibility against Actinomadura madurae, while amoxicillin and rifampicin had low susceptibility.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Dermatology
Bertrand Nyuykonge, Emmanuel Siddig, Najwa A. Mhmoud, Sahar Bakhiet, Eduard Zijlstra, Annelies Verbon, Ahmed H. Fahal, Wendy W. J. van de Sande
Summary: This study compared the performance of Wako and Fungitell beta-D-glucan assays in patients with eumycetoma. The results showed that when using the optimized cut-off value, the Wako assay and Fungitell assay had comparable performance in terms of sensitivity and specificity. Therefore, the Wako assay can be used in combination with current diagnostic tools.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Emmanuel Edwar Siddig, Bertrand Nyuykonge, Najwa Adam Mhmoud, Omnia Babekir Abdallah, Mustafa El Nour Bahar, Eiman Siddig Ahmed, Borna Nyaoke, Eduard E. Zijlstra, Annelies Verbon, Sahar Mubarak Bakhiet, Ahmed Hassan Fahal, Wendy W. J. van de Sande
Summary: This study compared the diagnostic performance of ultrasound, histopathology, culture, and two species-specific PCRs in identifying the causative organism of mycetoma. The results showed that the two PCR methods were the most sensitive and specific, while ultrasound was the least specific. The evaluation concluded that PCR directly on DNA isolated from grains is the most rapid and reliable diagnostic tool.
Article
Dermatology
Emmanuel Edwar Siddig, Ayman Ahmed, Omnia Babekir Hassan, Sahar Mubarak Bakhiet, Annelies Verbon, Ahmed Hassan Fahal, Wendy W. J. van de Sande
Summary: PCR performed on ultrasound-guided fine-needle aspiration (US-FNA) material has similar sensitivity and specificity as PCR performed on deep-seated biopsies.
Article
Public, Environmental & Occupational Health
Noah Fongwen, Kingsley B. Asiedu, Sahar Bakhiet, Alexandro Bonifaz, Israel Cruz, Daniel Argaw, Guadalupe Estrada-Chavez, Ahmed H. Fahal, Ana Litvintseva, Michael Marks, Mario C. Salinas-Carmona, Doudou Sow, Wendy W. J. van de Sande
Summary: This study discusses the development of two TPPs for mycetoma, one for diagnosing the causative agent and another for determining treatment cessation. Challenges included the multitude of agents causing mycetoma and the lack of specific biomarkers for most of them.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Jingyi Ma, Matthew Todd, Wendy W. J. van de Sande, Bernhard Biersack
Summary: In this study, a series of natural naphthoquinones and anthraquinones were evaluated for their activity against the most common causative agent of eumycetoma. Naphthazarin was identified as a considerably active antifungal compound against Madurella mycetomatis, with reduced toxicity to Galleria mellonella larvae.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Medicinal
Tariq A. Khan, Ibrahim S. Al Nasr, Waleed S. Koko, Jingyi Ma, Simon Eckert, Lucas Brehm, Ridha Ben Said, Ismail Daoud, Riadh Hanachi, Seyfeddine Rahali, Wendy W. J. van de Sande, Klaus Ersfeld, Rainer Schobert, Bernhard Biersack
Summary: Synthetic derivatives of the natural alkaloid piperlongumine, N-acylpyrrolidones and -piperidones, were prepared and tested against Leishmania major and Toxoplasma gondii parasites. Replacement of an aryl meta-methoxy group with halogens increased antiparasitic activities. Some compounds showed strong activity against L. major promastigotes and high activity against T. gondii parasites. QSAR studies and docking calculations revealed binding differences between 2-pyrrolidone and 2-piperidone derivatives. Compound 4 b exhibited microtubules-destabilizing effects in T. b. brucei cells.
Review
Pharmacology & Pharmacy
David J. Chandler, Alexandro Bonifaz, Wendy W. J. van de Sande
Summary: Eumycetoma, a chronic subcutaneous mycosis, has limited treatment options and often requires extensive surgery. This article discusses the need for better treatments, current developments, and future challenges.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Jingyi Ma, Mickey Konings, Annelies Verbon, Wendy W. J. van de Sande
Summary: Eumycetoma is a common subcutaneous implantation mycosis with the formation of black or white grains. In this study, a grain model of F. senegalensis was established in G. mellonella larvae, and the efficacy of antifungal therapy was evaluated. The results showed that amphotericin B can prolong larval survival. This model can be used to monitor grain formation and study the effectiveness of antifungal drugs.
Article
Dermatology
Bertrand Nyuykonge, Emmanuel E. Siddig, Borna A. Nyaoke, Eduard E. Zijlstra, Annelies Verbon, Sahar M. Bakhiet, Ahmed H. Fahal, Wendy W. J. van de Sande
Summary: The study measured and evaluated (1,3)-beta-D-glucan concentrations in 104 patients with eumycetoma, showing stability before treatment, significant drop after surgery, and low predictive accuracy for recurrence, suggesting limited value in determining treatment response to azoles.
Review
Microbiology
Emmanuel Edwar Siddig, Ayman Ahmed, Hala Fathi Eltigani, Sahar Mubarak Bakhiet, Wendy W. J. van de Sande, Ahmed Hassan Fahal
Summary: This is a case report on a fungal infection caused by Fusarium falciforme, resulting in a recurrent eumycetoma. This is the first report of Fusarium falciforme causing eumycetoma in Sudan, highlighting the need for increased awareness among healthcare providers and improved diagnostic and surveillance systems in at-risk areas to improve case management and reduce the threat of further spread.
Article
Infectious Diseases
Mickey Konings, Kimberly Eadie, Nikolaos Strepis, Bertrand Nyuykonge, Ahmed H. Fahal, Annelies Verbon, Wendy W. J. van de Sande
Summary: Mycetoma is a neglected tropical disease caused by the fungus Madurella mycetomatis. This study evaluated the potential of a novel antifungal agent, manogepix, for the treatment of mycetoma. In vitro tests showed synergy between manogepix and itraconazole, but no efficacy was observed in an in vivo grain model using clinically relevant dosages. The therapeutic potential of manogepix for mycetoma caused by M. mycetomatis appears to be limited.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)