Article
Environmental Sciences
S. P. Sreekanth, Abdullah Alodhayb, Abdulaziz K. Assaifan, Khalid Eidah Alzahrani, Muthumareeswaran Muthuramamoorthy, Hend Alkhammash, Saravanan Pandiaraj, Abdullah M. Alswieleh, Quyet Van Le, R. Mangaiyarkarasi, Andrews Nirmala Grace, Vimala Raghavan
Summary: The prevalence of cadmium in the ecosystem due to industrial and agricultural processes can lead to inadvertent consumption of hazardous concentrations in food and water. Environmental contamination of cadmium poses a substantial threat to human and animal life. Developing a reliable method for detecting Cd (II) ions, such as the DNA-based electrochemical method discussed in this study, can help reduce exposure and complement existing conventional methods, with potential applications for detecting other heavy metals in environmental samples.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biophysics
Xiaoli Wang, Xinyu He, Zhiheng He, Liwei Hou, Chuang Ge, Li Wang, Shunbo Li, Yi Xu
Summary: This paper proposes a microfluidic chip integrated with DEP separation, electrochemical nanoprobes binding, and DPV detection for sensitive and rapid detection of PSA in whole blood. The chip demonstrates high efficiency in cell separation and PSA detection, and achieves excellent performance in quantitative detection of PSA.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Arzum Erdem, Ece Eksin
Summary: A Zip nucleic acid (ZNA)-based genomagnetic assay was developed for the detection of microRNA-34a (miR-34a), which is associated with neurological disorders and cancer. The assay involved hybridization between the ZNA probe and miR-34a target, followed by immobilization on magnetic beads and pencil graphite electrodes for electrochemical measurement. Experimental parameters were optimized, and cross-selectivity was tested against other miRNAs. The assay successfully detected miR-34a in real samples from a hepatocellular carcinoma cell line (HUH-7).
Article
Chemistry, Physical
Chittatosh Pal, Subrata Majumder
Summary: This paper proposes a sensitive, selective, and facile electrochemical biosensor based on non-covalent ssDNA-MWNT hybridization for the detection of Ag+ ions in an aqueous medium. The biosensor achieved selective detection of Ag+ metal ions with a lowest concentration of 1 pM in the aqueous medium, and showed potential for trace amount determination in real sample studies for environmental monitoring purposes.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Analytical
Nina Lokar, Borut Pecar, Matej Mozek, Danilo Vrtacnik
Summary: This study presents the development and characterization of a microfluidic electrochemical glucose biosensor. The biosensor uses thin-film metal electrodes on a glass substrate as the transducer part. The pyrroloquinoline quinone-glucose dehydrogenase (PQQ-GdhB) enzyme is selectively immobilized via microcontact printing on a gold working electrode, and the microfluidic part of the device is made of polydimethylsiloxane (PDMS) elastomer. The biosensor's electrode properties and response to glucose concentration and analyte flow rate were evaluated using cyclic voltammetry and chronoamperometry. The results showed a measurement range of up to 10 mM in glucose concentration and a detection limit of 30 μM.
Article
Chemistry, Analytical
Fatih Turk, Abdullah Atilgan, Nimet Yildirim-Tirgil
Summary: Molecularly imprinted polymer (MIP) and DNA aptamers with the ability to detect targets with high sensitivity and specificity by simulating the structure and function of antibodies and biological receptors have been combined to create hybrid alternatives with enhanced attributes and desirable properties. A new method has been developed to produce aptamer/MIP hybrids for protein biomarkers that is simple and reproducible. Multi-walled carbon nanotubes (MWCNTs) were used to develop sensitive sensor/biosensors due to their outstanding chemical/mechanical stability. The MWCNTs/Aptamer/MIP system was characterized using various techniques and showed satisfactory results in terms of sensitivity, selectivity, stability, and practical analysis when tested with thrombin as a model peptide.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Chenyi Hu, Guanghua Wei, Fengjuan Zhu, Aiming Wu, Liuxuan Luo, Shuiyun Shen, Nengqin Jia, Junliang Zhang
Summary: Electrochemical immunosensors have been widely used in various fields such as food industry, clinical medicine, biomonitoring, and environmental protection due to their high specificity, superior analysis sensitivity, low cost, and convenient operations. In this study, a specific immunosensor was designed using the Pt@BSA nano-composite with affinity-purified antibody molecules, to detect Escherichia coli O157:H7. The immunosensor showed amplified signal responses and favorable biocompatibility for bacteria attachment at the Pt@BSA biosensing interface. By forming immune complexes, the immunosensor could detect E. coli O157:H7 cells at different levels using electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The DPV technique allowed the quantitative monitoring of E. coli O157:H7 cells in a linear concentration range from 2.5 x 101 to 5.0 x 108 cfu mL-1, with a low detection limit of 9 cfu mL-1. This fabricated bacteria immunosensor demonstrated high specificity, selectivity, storage stability, preparation reproducibility, and detection accuracy in practical food samples, providing a promising approach for ultrasensitive monitoring of hazardous substances and disease markers in clinical diagnosis at an extremely low level.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Analytical
Franziska Beck, Carina Horn, Antje J. Baeumner
Summary: The microfluidic biosensor has key characteristics of desirable home-tests, including low limits of detection, small sample volume, simple detection strategies, and long-term stable reagents. It can accurately assess the severity and progression of diseases.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Yuliang Zhao, Hongyu Zhang, Yang Li, Xiaoai Wang, Liang Zhao, Jianghong Xu, Zhikun Zhan, Guanglie Zhang, Wen Jung Li
Summary: An electrochemical HbA1c sensor with high sensitivity and good specificity is proposed, which is based on the electrochemical immune principle. The sensor's properties were characterized and analyzed, and the experimental results demonstrated its satisfactory performance in terms of detection limit, sensitivity, repeatability, stability, and anti-interference capabilities.
Article
Chemistry, Physical
S. Keerthana, A. Rajapriya, S. Amirthapandian, C. Viswanathan, N. Ponpandian
Summary: The study introduces a hydrothermally prepared WS2/rGO nanocomposite for selective detection of Mesalazine. The electrode exhibits a low detection limit, good sensitivity, and anti-interference capability, as well as remarkable repeatability, reproducibility, and stability. Experimental results demonstrate excellent recovery rates of Mesalazine in analytical samples.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Analytical
Ummama Saeed, Batool Fatima, Dilshad Hussain, Muhammad Imran, Maryam Jamil, Muhammad Naeem Ashiq, Muhammad Najam-ul-Haq
Summary: Uric acid metabolism is associated with diseases such as acute myeloid leukemia. Electrochemical sensing is a specific, rapid, automatic, and economical method for uric acid analysis. This study developed a Ce-MOF sensor for uric acid determination, showing good linearity and detection limit.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Ruizhuo Ouyang, Lan Jiang, Xianjin Xie, Ping Yuan, Yuefeng Zhao, Yuhao Li, Abel Ibrahim Balbin Tamayo, Baolin Liu, Yuqing Miao
Summary: In this study, an ultra-sensitive electrochemical biosensor was constructed for miRNA-21 detection based on a dual signal amplification strategy of novel accordion-like Bi2O3-decorated Ti3C2 nanocomposites and hybridization chain reaction (HCR). The biosensor demonstrated high sensitivity for miRNA-21 detection in a wide linear range with a low detection limit. The detection of miRNA-21 in human blood plasma showed promising applications in clinical diagnosis.
Article
Chemistry, Analytical
Azeema Munir, Burcin Bozal-Palabiyik, Gokcen Eren, Afzal Shah, Saqib Ali, Noor Uddin, Bengi Uslu
Summary: This study demonstrated the sensing of a Schiff base by a DNA biosensor, investigating the binding mechanisms between 5-DDMP and dsDNA. The efficiency of the dsDNA biosensor was determined through UV-vis spectrophotometry and differential pulse voltammetry, while molecular docking simulations revealed hydrogen bonding and pi-pi contacts between 5-DDMP and specific bases of the dsDNA. These findings could potentially aid in the design and development of new anticancer drugs.
Article
Chemistry, Analytical
Simone Fortunati, Ilaria Vasini, Marco Giannetto, Monica Mattarozzi, Alessandro Porchetta, Alessandro Bertucci, Maria Careri
Summary: This study provides design rules for programming dynamic DNA structures on the surface of single-walled carbon nanotube electrodes and demonstrates the measurement of current signal to monitor specific DNA interactions. The use of pyrene as a backfilling agent reduces nonspecific adsorption and enables controlled formation of DNA duplexes on the electrode surface. Additionally, the development of amperometric hybridization platforms based on small molecule melamine templated DNA structures is reported.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Elhameh Saeb, Karim Asadpour-Zeynali
Summary: In this study, a sensitive electrochemical sensor for hydrazine oxidation was developed using a TiO2@PANI@Au nanocomposite on a glassy carbon electrode. The sensor displayed high electrocatalytic activity and good stability, repeatability, and reproducibility for hydrazine measurements in water samples. The synthesized nanoparticles were characterized using XRD, FESEM, EDX, and electrochemical techniques, demonstrating efficient detection and quantification of hydrazine in a linear range of 0.9 x 10(-6) M to 1.2 x 10(-3) M.
MICROCHEMICAL JOURNAL
(2021)
Article
Engineering, Biomedical
Susan Wojtalewicz, Jonathon Vizmeg, Sierra Erickson, Caleb Lade, Jill Shea, Himanshu Sant, Jules Magda, Bruce Gale, Jayant Agarwal, Brett Davis
Summary: This study evaluated the material properties of a novel local anesthetic delivery system for controlled release of bupivacaine for 72 hours. The results showed that hot homogenized particles had a slower and more controlled release, and hyaluronic acid hydrogel was important for lowering injection forces and minimizing clogging events.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Multidisciplinary Sciences
Farhad Shiri, Haidong Feng, Kevin E. Petersen, Himanshu Sant, Gina T. Bardi, Luke A. Schroeder, Michael L. Merchant, Bruce K. Gale, Joshua L. Hood
Summary: Nanoscale and microscale cell-derived extracellular vesicles types and subtypes have significant importance in biology and medicine. Researchers have developed a miniaturized device that uses elasto-inertial effect to separate different types of extracellular vesicles, which can be applied in microfluidic applications. The device has successfully re-isolated and recovered extracellular vesicles in the experiment.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Analytical
Haidong Feng, Alexander R. Jafek, Bonan Wang, Hayden Brady, Jules J. Magda, Bruce K. Gale
Summary: This paper studies particle focusing in viscoelastic flow and predicts the focusing position by analyzing the force balance. The research finds that particle separation resolution can be improved in viscoelastic flows.
Article
Chemistry, Physical
Zifei Hu, Dan Shi, Guohong Wang, Tengyuan Gao, Juan Wang, Lianying Lu, Jun Li
Summary: In recent years, the coupling of TiO2 with other narrow bandgap semiconductors to improve the photocatalytic hydrogen generation rate has been widely studied. In this study, carbon dots decorated g-C3N4/TiO2 all-solid-state Z-scheme heterojunction photocatalysts were fabricated using a facile solvothermal and calcination method. The dosage of carbon dots greatly influenced the microstructure and the visible-light photocatalytic H2 evolution rate. Under the optimal condition, the ternary composites exhibited the highest HER. The excellent photocatalytic performance was attributed to stronger light absorption, higher specific surface area, and faster charge transportation.
APPLIED SURFACE SCIENCE
(2022)
Article
Electrochemistry
Jiayi Xu, Ayyappan Elangovan, Cong Liu, Jun Li, Bin Liu
Summary: This study investigates the origin and mechanism of the oxygen reduction reaction (ORR) activity of platinum catalysts on vertically aligned carbon nanofibers (VACNFs) using a multiscale modeling approach. The results show that as the size of platinum nanoparticles decreases, the percentage of low coordination sites increases, leading to a decrease in ORR activity. Additionally, the binding energies of OOH and OH on VACNF-supported platinum nanoparticles are significantly higher than on Pt (111), resulting in a lower limiting potential for the ORR.
Article
Engineering, Environmental
Zhiqiang Tan, Weichen Zhao, Yongguang Yin, Ming Xu, Wenxiao Pan, Yanwanjing Liu, Qinghua Zhang, Bruce K. Gale, Yukui Rui, Jingfu Liu
Summary: This study evaluated the separation ability of biased cyclical electrical field-flow fractionation (BCyElFFF) for polyvinyl pyrrolidone-coated and poly(ethylene glycol)-coated silver nanoparticles (AgNPs) with different electrophoretic mobilities, and elucidated the mechanism behind the formation of NOM corona on these AgNP surfaces. Furthermore, it was observed that the survival rates of E. coli exposed to AgNPs with or without NOM corona collected during repeated BCyElFFF runs increased with increasing NOM concentration, indicating the negative effect of NOM coronas on the bioavailability of AgNPs. These findings highlight the powerful capability of BCyElFFF in studying the fate and transformation of nanoparticles in aqueous environments.
Article
Chemistry, Multidisciplinary
Kamalambika Muthukumar, Sabari Rajendran, Archana Sekar, Ya Chen, Jun Li
Summary: In this study, a novel cathode material for aqueous zinc-ion batteries (AZIBs) was synthesized using divalent metal cation-mediated coprecipitation. The hybrid material, consisting of V2O5 nanoribbons and reduced graphene oxide nanosheets, showed improved performance in terms of specific capacity, stability, and rate performance.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Physical
Ahmed Al Mayyahi, Archana Sekar, Sabari Rajendran, Shusil Sigdel, Lianying Lu, Juan Wang, Guohong Wang, Jun Li, Placidus B. Amama
Summary: This study demonstrates a new photocatalyst that has high adsorption capacity and low band gap, enabling efficient NOx oxidation and conversion to non-toxic NO 3 through visible light. Compared to traditional photocatalysts, this hybrid catalyst shows higher NO conversion rate and less formation of harmful NO2, making it a promising approach for NOx abatement.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Zachary Estlack, Matin Golozar, Anna L. Butterworth, Richard A. Mathies, Jungkyu Kim
Summary: A programmable microfluidic organic analyzer was developed for detecting life signatures beyond Earth and clinical monitoring of astronaut health. The functionality of the analyzer was confirmed to be minimally affected by significant changes in the gravitational field under various gravitational environments, paving the way for its use in space missions.
Article
Chemistry, Physical
Sabari Rajendran, Archana Sekar, Jun Li
Summary: The use of three dimensional (3D) conductive hosts is a promising strategy to alleviate dendrite formation in lithium metal anodes. However, the fundamental issues associated with the 3D hosts, such as formation of excessive solid electrolyte interphase (SEI) and complicated Li deposition morphologies, have not been well studied. This study focuses on understanding these critical issues using vertically aligned carbon nanofiber (VACNF) array as a model 3D host. Various characterization tools are employed to elucidate the morphology and composition of electrodeposited Li (e-Li) and its associated SEI.
Article
Chemistry, Multidisciplinary
Christopher J. Lambert, Harikrishnan Jayamohan, Bruce K. Gale, Lars B. Laurentius, Dhruv Patel, Madison Hansen, Tawsif Mahmood, Himanshu Jayant Sant
Summary: This study presents an electrochemical immunoassay-based method for the precise, simple, quick, and cost-effective detection of SARS-CoV-2 nucleocapsid protein. By immunomagnetic capture of the protein in nasal samples, followed by electrochemical detection using gold nanoparticle labels on a screen-printed carbon electrode, the researchers determined optimal conditions to maximize the electrochemical signal and successfully detected the nucleocapsid protein in SARS-CoV-2-positive samples with a low viral load.
APPLIED SCIENCES-BASEL
(2023)
Article
Materials Science, Multidisciplinary
Shusil Sigdel, Justin P. Wright, Jose Covarrubias, Archana Sekar, Kamalambika Mutthukumar, Stefan H. Bossmann, Jun Li, Arjun Nepal, Stephen Corkill, Christopher M. Sorensen
Summary: Explosions of benzene, toluene, and xylenes in the presence of O2 at different fuel-rich molar ratios were conducted, resulting in the production of graphene. The study also revealed the existence of two types of products: amorphous soot at a lower explosion temperature and few-layer graphene at a higher explosion temperature.
Article
Biochemical Research Methods
Matt D. Nelson, Brady L. Goenner, Bruce K. Gale
Summary: ChatGPT is a generative AI model that has attracted significant attention due to its advanced reasoning and analysis capabilities. It can solve various problems by creating and debugging code. In this study, GPT-4 was utilized to design functional microfluidic components using the open-source CAD software OpenSCAD through iterative dialogue. This concept has the potential to advance CAD usage for both technical and non-technical users and can be extended to other fields.
Article
Chemistry, Multidisciplinary
John C. Douglin, Archana Sekar, Ramesh K. Singh, Zihua Chen, Jun Li, Dario R. Dekel
Summary: This study develops a core-shell catalyst support based on hydrogenated TiO2/carbon for the hydrogen oxidation reaction in anion-exchange membrane fuel cells. The catalyst exhibits improved oxophilicity and HOR activity, as well as greater size control of the catalyst nanoparticles. The synthesized PtRu/TiO2/C-400 electrocatalyst demonstrates respectable performance and short-term voltage stability in AEMFCs.
Article
Materials Science, Multidisciplinary
Taehwan Lim, Seoyeon Won, Minju Kim, Marshall A. Trout, Jungkyu Kim, Jacob A. George, Huanan Zhang
Summary: This study presents a rationally designed material engineering approach to overcome challenges in liquid metal bioelectronics, resulting in the development of stretchable, leak-free, and highly conductive gallium-based bioelectronic devices with exceptional biostability and electrochemical properties. The devices demonstrated the ability to conform to stretching deformation and maintain high electrical properties, and were used to monitor physiologic parameters and control robots for mimicking hand gestures.
ACS MATERIALS LETTERS
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
