Review
Materials Science, Multidisciplinary
Aleksandr S. Oshchepkov, Maxim S. Oshchepkov, Margarita Oshchepkova, Ammar Al-Hamry, Olfa Kanoun, Evgeny A. Kataev
Summary: The intensive development of fiber-optic sensors marked the beginning of the 21st century, requiring new functional materials and specifically fluorescent probes for their design. Despite continuous development, successfully incorporating probes into functional sensing polymers remains a challenge, particularly in retaining the sensing properties of the probes in a polymer matrix.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Chemistry, Analytical
Wei Qi, Shufang Liu, Menghao Li, Qing Su, Qiaolin Wu
Summary: Heavy metal pollution poses a significant threat to public health and the environment. Covalent organic frameworks (COFs) with well-defined pore structures and specific functional units are used as an effective platform for fluorescent sensing. This research synthesized hydrozone-linked framework material SH-COF, which exhibited excellent hydrophilicity and abundant chelating sites. SH-COF was found to have specific binding sites for detecting and removing Cu2+ and Hg2+, with high selectivity, sensitivity, and realtime response.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Pavel A. Panchenko, Anastasija Efremenko, Anna S. Polyakova, Alexey Feofanov, Maria A. Ustimova, Yuri Fedorov, Olga A. Fedorova
Summary: In this study, a Dyad compound NI-SP with 1,8-naphthalimide (NI) and styrylpyridine (SP) photoactive units was evaluated as a ratiometric fluorescent chemosensor for mercury (II) ions in living cells. The compound selectively responds to the presence of Hg2+ by enhancing the emission intensity of NI while the fluorescence of SP remains virtually unchanged. This allows for self-calibration of the optical response. The compound shows potential for the detection and quantitative analysis of intracellular Hg2+ ions.
Article
Chemistry, Physical
Sasiwimon Kraithong, Nirumon Chailek, Jitnapa Sirirak, Kullatat Suwatpipat, Nantanit Wanichacheva, Pattanawit Swanglap
Summary: A new Hg2+-selective fluorescent sensor with high selectivity and low detection limit was successfully synthesized, demonstrating improved sensitivity when combined with purple silver nanoparticles. The sensor showed excellent performance in real samples and can be applied for Hg2+ detection in aqueous matrices.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Optics
Wen-Li Guan, Yun-Fei Zhang, Qin-Peng Zhang, You-Ming Zhang, Tai-Bao Wei, Hong Yao, Qi Lin
Summary: Developing a simple and low-cost method for detecting toxic ions is a crucial challenge. This study presents a novel fluorescent sensor that shows high sensitivity and specific selectivity towards Hg2+ and CN-. The sensor also functions as a fluorescence turn-on selective sensor for CN- with high anti-interference ability. The mechanisms of ion recognition were investigated through experiments and quantum chemical calculations, providing insights into the collaboration of the fluorescent signal groups and confirming charge transfer. Additionally, logic gates and test kits for detecting Hg2+ and CN- were prepared.
JOURNAL OF LUMINESCENCE
(2022)
Review
Chemistry, Inorganic & Nuclear
Xiaojing Nan, Yuchen Huyan, Hongjuan Li, Shiguo Sun, Yongqian Xu
Summary: Transition metal ions play crucial roles in medicine, life sciences, and environmental science, but some like mercury, copper, and iron ions pose serious health and environmental risks due to biomagnification. Monitoring metal ion levels in organisms and the environment is urgent, and reaction-based fluorescent probes offer higher sensitivity and selectivity than traditional methods. Research on these probes for Hg2+, Cu2+, and Fe2+/Fe2+ detection has advanced in the past decade, with potential for interdisciplinary development in the future.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Pan He, Xianyu Huang, Pingting Zhuang, Hongyu Guo, Fafu Yang
Summary: Although some Pd2+ sensors have been developed, the in-situ and real-time examination of Pd2+ using a fluorescent sensor remains challenging. In this study, a novel thiourea-cyanostilbene derivative (TCS) was successfully synthesized and used as an effective fluorescent sensor for in-situ and real-time sensing of Pd2+ in aqueous media. TCS exhibited good AIE fluorescence and selective quenching by Pd2+ among various metallic ions.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Catia Correia, Jose Martinho, Ermelinda Macoas
Summary: Carbon dots doped with Eu3+ ions were synthesized and their interaction and luminescence properties were characterized by vibrational spectroscopy and UV-vis excitation spectroscopy. The Eu3+ ions are strongly coordinated with the carboxylate groups at the surface of the Cdots and incorporated within the nanographene network in the carbon core. The luminescence of the Cdots is strongly quenched by Hg2+ and Ag+, and a ratiometric sensor can be built using their luminescence intensities ratio.
Article
Biochemical Research Methods
Fenghua Geng, Dandan Wang, Congying Shao, Guixin Li, Maotian Xu, Li Feng
Summary: A simply constructed fluorescent Hg2+ sensor based on the intrinsic fluorescence quenching power of G-quadruplex was developed using inexpensive reagents and low toxicity. Two components, AGRO 100 and AMT, were used to construct the sensor. AMT served as the fluorescent probe while AGRO 100 acted as both the quencher and the capture sequence. The sensing system showed good performance for detecting Hg2+ in human serum.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jin-jin Tian, Dian-dian Deng, Long Wang, Zhao Chen, Shouzhi Pu
Summary: A tetraphenylethene-modified rhodanine derivative was designed and synthesized, exhibiting excellent fluorescence properties and multiple applications such as aggregation-induced emission enhancement, solvatochromic fluorescence effect, reversible mechanochromic fluorescence behavior, and sensitive detection of Hg2+.
FRONTIERS IN CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
M. Ranjana, Dhanya Sunil
Summary: Gasotransmitters are a promising and less-explored area of research, as they have significant biological impacts and can act as both friend and foe in mammalian systems. This review highlights the physiological and pathophysiological roles of these endogenous gas transmitters, as well as their synergistic interactions. It also discusses various detection approaches, with a focus on the usage of 1,8-naphthalimide as a fluorescent probe for the detection and monitoring of these small signaling molecules.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Spectroscopy
H-L Wu, J-P Dong, F-G Sun, R. X. Li, Y-X Jiang
Summary: A new fluorescent turn-on sensor for Hg2+ has been designed, showing high selectivity and good quantitative detection performance. The complex between HL and Hg2+ is formed by a 2:1 complex ratio.
JOURNAL OF APPLIED SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Nirawit Kaewnok, Nirumon Chailek, Watsamon Muansrichai, Sirilak Wangngae, Anuwut Petdum, Waraporn Panchan, Anyanee Kamkaew, Jitnapa Sirirak, Pattanawit Swanglap, Thanasat Sooksimuang, Nantanit Wanichacheva
Summary: A novel fluorescence sensor (M201NHP) was developed for rapid and sensitive detection of Hg2+. The sensor has a low detection limit of 1.94 ppb and low cytotoxicity, making it promising for preventing health risks and environmental impacts caused by mercury pollution.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Spectroscopy
Liangyu He, Qi Li, Yaqing Zhang, Kun Huang, Bingxin Du, Lijuan Liang
Summary: A naphthalimide functionalized fluoran dye NAF has been prepared, which exhibits a red-shift in emission at 550 nm in a water-CH3CN mixture due to aggregating induced emission (AIE) effect. NAF can function as a selective and sensitive sensor for Hg2+ ions by displaying a ratiometric fluorescence signal change and visible color change. It shows fast response time, wide pH range, and low detection limit, making it suitable for ratiometric imaging of Hg2+ ions in living HeLa cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Pramod Kumar Mehta, Hyojin Park, Eun-Taex Oh, Heon Joo Park, Keun-Hyeung Lee
Summary: In this study, a reversible fluorescent sensor was synthesized for the turn-on monitoring of Hg2+ in water, and a fluorescent sensing method was developed for the selective detection of CH3Hg+ over Hg2+. The sensor showed rapid response (<30 s), high sensitivity and/or selectivity, low detection limits (107 nM), and significant enhancement of fluorescence for CH3Hg+.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)