Article
Nanoscience & Nanotechnology
Hai-Tao Deng, Zhi-Yong Wang, Yi-Lin Wang, Dan-Liang Wen, Xiao-Sheng Zhang
Summary: In this study, an elastic hybrid triboelectric-electromagnetic microenergy harvester (EHTE) was developed, which integrates hybrid sensing and microenergy. By combining a triboelectric nanogenerator (TENG) and an electromagnetic nanogenerator (EMG), the EHTE achieved enhanced electrical output and demonstrated potential for microelectronics powering and wearable electronic applications.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Avisek Roy, Bao Q. Ta, Mehdi Azadmehr, Knut E. Aasmundtveit
Summary: Carbon nanotubes (CNTs) were successfully grown on custom-designed CMOS microheaters by a thermal chemical vapour deposition (CVD) process. A two-step reactive ion etching (RIE) method and design improvements were employed to achieve high selectivity, uniform etching, and a good etch rate. The CMOS-MEMS microheaters fabricated through this process were utilized for synthesizing CNTs by a local thermal CVD process.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Computer Science, Information Systems
Andrea Boni, Michele Caselli, Alessandro Magnanini, Matteo Tonelli
Summary: This paper presents the design and implementation of electronic interfaces and acquisition circuits for typical high-voltage signals in an automotive context. The novel co-design of voltage clamps and electro-static discharge (ESD) protections achieves on-chip high-voltage compatibility while minimizing off-chip components.
Article
Chemistry, Analytical
Michael Yampolsky, Evgeny Pikhay, Ruth Shima Edelstein, Yakov Roizin
Summary: We introduce novel UVC sensors based on the floating gate discharge principle, which exhibit enhanced sensitivity to ultraviolet light through a special design featuring low FG capacitance and long gate periphery. These low-cost integrated sensors are optimized for use in UVC sterilization systems, providing feedback on the radiation dose required for disinfection. The sensors can be reprogrammed up to 10,000 times and accurately measure UVC radiation doses typically employed for surface or air disinfection.
Article
Engineering, Electrical & Electronic
Do Thi Thu, Zong-Han Liu, Ya-Chu Lee, Tzu-Wen Kuo, Wei-Lun Sung, Yen-Chang Chu, Yu-Lun Chueh, Weileun Fang
Summary: This study designs and implements a chip-scale amperometric ethanol sensor using the standard commercially available CMOS process and post-CMOS micromachining processes. The sensor consists of a suspended plate with a microhole structure as the working electrode, a fully anchored plate with a microhole structure as the counter electrode, and a microcavity as the electrolyte reservoir. By exploiting the metal and dielectric layers in the CMOS process, the sensor achieves enhanced sensitivity and response time. Measurements show that the sensor has a sensing range of ppm (20-1000 ppm) at room temperature, with a sensitivity of 0.01 nA/ppm and a response time of 6 s. The presented design demonstrates the potential of CMOS-MEMS for amperometric ethanol sensing.
IEEE SENSORS JOURNAL
(2023)
Review
Engineering, Electrical & Electronic
Rafel Perello-Roig, Jaume Verd, Sebastia Bota, Jaume Segura
Summary: Volatile organic compounds (VOCs) have attracted attention in the biomedical community for noninvasive disease diagnosis through breath analysis. Current commercially available equipment for VOCs detection is bulky, expensive, and lacks portability. Resonant inertial mass sensing has emerged as a promising technique to achieve high-resolution VOCs identification and fulfill portability requirements. This article reviews the state of the art in resonator topologies, electromechanical transduction techniques, and coating materials and procedures, providing design guidelines and foreseeing future trends.
IEEE SENSORS JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Sara Garbolino, Sorin Martoiu, Manuel D. Da Rocha Rolo, Giulio Dellacasa, Giovanni Mazza, Angelo Rivetti, Richard Wheadon
Summary: The precise measurement of the time associated with the passage of quantum radiation through matter is crucial in scientific research. This article presents two detector systems based on constant-fraction-discriminators (CFDs) and discusses their performance in terms of area occupation, power consumption, and timing accuracy.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2023)
Review
Nanoscience & Nanotechnology
Xavier X. Chia, Dawn T. H. Tan
Summary: Silicon nitride (SiN) has become a popular choice for photonic-integrated circuits (PICs) due to its broadband transparency, compatibility with CMOS fabrication processes, and high optical bandgap. However, current fabrication methods result in trade-offs between low thermal budgets and low losses. Recent research has focused on using deuterated silicon nitride (SiNx:D) to achieve low-loss PICs through a low-temperature, CMOS-compatible process. These devices show promise for both linear and nonlinear applications and have the potential to enable highly efficient chips with co-packaged electronics and photonics devices.
Article
Engineering, Electrical & Electronic
Rakesh Tirupathi, Sougata Kumar Kar
Summary: This brief introduces a switched-capacitor based low offset differential output sensor interface for MEMS capacitive accelerometers, which employs an improved demodulation scheme to reduce zero-g offset. The interfacing ASIC is designed and fabricated using UMC 180 nm CMOS process technology, achieving a maximum sensitivity of 1.45 V/g with less than 2% non-linearity error, a zero-g offset less than 3 milli-g, and a noise floor of approximately 200 mu g/root Hz.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2021)
Article
Engineering, Electrical & Electronic
F. Piro, G. Aglieri Rinella, A. Andronic, M. Antonelli, M. Aresti, R. Baccomi, P. Becht, S. Beole, J. Braach, M. D. Buckland, E. Buschmann, P. Camerini, F. Carnesecchi, L. Cecconi, E. Charbon, G. Contin, D. Dannheim, J. de Melo, W. Deng, A. di Mauro, M. Dimitrova Vassilev, S. Emiliani, J. Hasenbichler, H. Hillemanns, G. H. Hong, A. Isakov, A. Junique, A. Kluge, A. Kotliarov, F. Krizek, T. Kugathasan, L. Lautner, C. Lemoine, M. Mager, D. Marras, P. Martinengo, S. Masciocchi, M. W. Menzel, M. Munker, A. Rachevski, K. Rebane, F. Reidt, R. Russo, I. Sanna, V. Sarritzu, S. Senyukov, W. Snoeys, J. Sonneveld, M. Suljic, P. Svihra, N. Tiltmann, G. Usai, J. B. van Beelen, C. Vernieri, A. Villani
Summary: This article presents the design of a front-end circuit for monolithic active pixel sensors. The circuit operates with a sensor featuring a small, low-capacitance collection electrode and is integrated into the DPTS chip. The chip, implemented in 65-nm imaging technology, was developed to explore this technology for particle detection. The front-end circuit has a small area and low power consumption.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Jose A. Hidalgo-Lopez, Julian Castellanos-Ramos
Summary: This article presents a new type of capacitive DIC that is simple in terms of hardware, needing only two resistors of known value and the DP in order to make the capacitance estimation. The design has been tested for a wide range of capacitances, showing good performance with an average relative error of 0.41%, linearity errors below 0.3%, and a minimum signal-to-noise ratio of 64 dB.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Instruments & Instrumentation
P. Kmon, R. Szczygiel, R. Kleczek, D. Gorni, G. Wegrzyn, A. Niedzielska, K. Sitko, P. Drwal
Summary: We present a multichannel integrated circuit of pixel architecture designed in CMOS 40 nm technology, which can work in single photon counting mode and has the ability to store the energy spectrum information of particles.
JOURNAL OF INSTRUMENTATION
(2022)
Article
Engineering, Electrical & Electronic
Joost Romijn, Sten Vollebregt, Vincent G. de Bie, Luke M. Middelburg, Brahim El Mansouri, Henk W. van Zeijl, Alexander May, Tobias Erlbacher, Johan Leijtens, Guoqi Zhang, Pasqualina M. Sarro
Summary: The next generation of satellites will tackle future challenges by increasing the number of satellites in orbit, forming smart constellations, and miniaturizing individual satellites. Proper navigation is vital for these satellites, which starts with attitude measurement using sun position sensors. However, current sensors face signal distortions caused by Earth's albedo and the trend of satellite miniaturization. This study presents a microfabricated albedo insensitive sun position sensor with integrated optics, reaching a mean angular accuracy of 5.7 degrees in a +/- 37 degrees field-of-view and including an on-chip temperature sensor.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Engineering, Electrical & Electronic
Jiacheng Guo, Yizhu Shen, Kai Ye, Sanming Hu
Summary: This communication presents a differential retrodirective array (RDA) with circular polarization for real-time tracking. The RDA, enabled by specifically designed low-cost CMOS chips, has a large beamwidth and is suitable for tracking free moving targets.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2022)
Article
Biochemical Research Methods
Rafel Perello-Roig, Jaume Verd, Sebastia Bota, Bartomeu Soberats, Antonio Costa, Jaume Segura
Summary: CMOS-MEMS microresonators are promising for portable chemical VOC sensing systems due to their large mass sensitivity, miniaturization capabilities, and integration with CMOS circuitry. This study presents MEMS plate resonators coated with P4V for acetone detection, showing increased response and a sensitivity of -0.012 ppm Hz(-1) with a detection limit of 20 ppb. An alternative resonator design with folded flexure anchors is also proposed to reduce sensor temperature sensitivity and mitigate fluid flow impact.
Article
Instruments & Instrumentation
F. Ceraudo, I. Dedolli, D. Cirrincione, E. Del Monte, F. Mele, F. Ambrosino, P. Bellutti, G. Bertuccio, G. Borghi, R. Campana, M. Caselle, Y. Evangelista, M. Feroci, F. Ficorella, M. Fiorini, F. Fuschino, M. Gandola, M. Grassi, C. Labanti, P. Loffredo, P. Malcovati, A. Picciotto, A. Rachevski, I. Rashevskaya, A. Tobia, A. Vacchi, A. Volpe, G. Zampa, N. Zampa, N. Zorzi
Summary: This paper presents the radiation tests performed on the ASIC RIGEL within the PixDD project. The results show that the device can be safely operated on an equatorial orbit but requires protection in a Sun-synchronous orbit.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2022)
Article
Chemistry, Analytical
Elisabetta Moisello, Maria Eloisa Castagna, Antonella La Malfa, Giuseppe Bruno, Piero Malcovati, Edoardo Bonizzoni
Summary: This paper presents a detailed analysis of a micromachined thermopile detector with high responsivity and a versatile mosaic structure. Two versions of the detector, featuring different series/parallel connections, were characterized and compared to other sensors. The application of these detectors as proximity detectors was verified.
Article
Instruments & Instrumentation
Massimo Gandola, Marco Grassi, Filippo Mele, Irisa Dedolli, Piero Malcovati, Giuseppe Bertuccio
Summary: This study presents an ASIC called RIGEL, designed for the sparse readout of a Silicon Pixel Drift Detector (PixDD) for space applications. The ASIC features low leakage current, low-noise electronics readout, and high spectroscopic resolution performance even at room temperature.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2022)
Review
Chemistry, Analytical
Antonio Aprile, Edoardo Bonizzoni, Piero Malcovati
Summary: This paper presents an extensive review of the main highlights in the Temperature-to-Digital Converters (TDCs) field and analyzes the key techniques and approaches that have led to its evolution. It highlights the pros and cons of different design methods and summarizes the trends in this field.
Article
Engineering, Electrical & Electronic
Lara Novaresi, Piero Malcovati, Andrea Mazzanti, Edoardo Bonizzoni
Summary: The brief presents a design solution for a compact and power efficient bipolar return to zero (RZ) 3-level high-voltage TX pulser for high-performance portable ultrasound medical imaging systems. The pulser is integrated in the front end of a 1-10 MHz PMUT probe and ensures high transmitting linearity with minimum power transistors. It features programmable variable delays and rise/fall times controlled through a digital interface and achieves a small R-eq of 2.24 ohm.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Review
Chemistry, Analytical
Samuele Fusetto, Antonio Aprile, Piero Malcovati, Edoardo Bonizzoni
Summary: InfraRed Focal Plane Arrays (IRFPAs) are essential components in a wide range of applications, and micro-bolometer-based ones have gained significant attention due to their high sensitivity, low noise, and low cost. However, their performance heavily relies on the readout interface, which converts analog signals into digital signals for further analysis.
Review
Chemistry, Analytical
Alessandro Gemelli, Marco Tambussi, Samuele Fusetto, Antonio Aprile, Elisabetta Moisello, Edoardo Bonizzoni, Piero Malcovati
Summary: In recent years, MEMS technology has had a significant impact in the field of acoustic transducers, enabling the development of smart, low-cost, and compact audio systems. This review analyzes the main integrated sound transduction principles and surveys the State-of-the-Art scenario of MEMS microphones and speakers. It also addresses the interface Integrated Circuits (ICs) needed for signal processing and actuation in these systems.
Article
Computer Science, Information Systems
Nima Shahpari, Mehdi Habibi, Piero Malcovati, Jose M. M. De La Rosa
Summary: This paper proposes a low-power SAR ADC with low-input capacitance, which overcomes the drawback of high input capacitance in many applications. By using a separated DAC and sample-and-hold blocks structure, a closed-loop low-power offset cancellation technique and complementary-clocked dynamic branches at the input of the comparator, the proposed ADC achieves high performance with reduced power consumption.
Article
Engineering, Electrical & Electronic
Elisabetta Moisello, Calogero Marco Ippolito, Giuseppe Bruno, Piero Malcovati, Edoardo Bonizzoni
Summary: This article introduces a MOS-based on-chip temperature sensor system that meets both high-resolution and low inaccuracy requirements, with only one temperature calibration point. Therefore, the proposed temperature sensor system is a low-cost solution that can effectively address the needs of the expanding market for system-on-chips (SoCs), mobile and wearable devices, and consumer electronics. The temperature sensor utilizes a two-phase time-domain architecture, with a single NMOS transistor as the sensing element biased alternately with different currents to achieve inherent inaccuracy reduction. The proposed sensory system, fabricated in a standard 130-nm CMOS process, includes a switched-capacitor analog interface circuit and a 1-bit second-order sigma-delta (ΣΔ) analog-to-digital converter (ADC) in addition to the sensor core.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Computer Science, Information Systems
Elisabetta Moisello, Maria Eloisa Castagna, Antonella La Malfa, Giuseppe Bruno, Piero Malcovati, Edoardo Bonizzoni
Summary: This paper introduces a temperature sensor system that provides the reference temperature for TMOS-based thermal detectors, enabling contactless absolute temperature measurements. The system uses a few pixels of the TMOS detector as the sensing element to detect the local TMOS temperature, while the readout circuit is integrated on a separate chip. The readout circuit features a two-phase time-domain architecture, which provides biasing to the sensing element by switching between two different bias current values. The temperature reading is converted to the digital domain using a switched-capacitor 1-bit second-order sigma-delta analog to-digital converter. The proposed system was fabricated and tested using a 130-nm CMOS process, demonstrating its suitability for contactless human body temperature measurements with high resolution and accuracy.
Proceedings Paper
Acoustics
Alessandro S. Savoia, Lara Novaresi, Edoardo Bonizzoni, Andrea Mazzanti, Piero Malcovati, Marco Terenzi, Stefano Ottaviani, Davide Ugo Ghisu, Fabio Quaglia
Summary: This paper reports on the development of a fully integrated 4-channel analog front-end transceiver designed for 1-D PMUT arrays. The electrical and acoustic characteristics of the transceiver are described based on chip prototypes and experiments.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
M. M. Abdevand, D. Livornesi, A. E. Vergani, P. Malcovati, E. Bonizzoni
Summary: This paper proposes an analog front-end circuit for low-resistance sensors based on a closed-loop bias circuit with high-impedance output, eliminating the need for calibration. Furthermore, a noise canceling technique is introduced to significantly reduce bias noise in the complete interface circuit.
PRIME 2022: 17TH INTERNATIONAL CONFERENCE ON PHD RESEARCH IN MICROELECTRONICS AND ELECTRONICS
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Andrea Gallone, Piero Malcovati
Summary: This paper presents a new approach for suppressing ringing in CAN BUS by placing an equalizer in front of the comparator in the CAN receiver. The proposed equalizer topology consists of two RC branches and a voltage resistive divider connected through op-amps in feedback to the RC network. The method offers five configurations to remove ringing at different frequencies, and has low power consumption.
2022 29TH IEEE INTERNATIONAL CONFERENCE ON ELECTRONICS, CIRCUITS AND SYSTEMS (IEEE ICECS 2022)
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Antonio Aprile, Elisabetta Moisello, Edoardo Bonizzoni, Piero Malcovati
Summary: This study presents an extensive comparison of temperature-related performance between two types of test chips. The comparison covers sensitivity, susceptibility to mismatch variations, inaccuracy, linearity, and noise.
2022 29TH IEEE INTERNATIONAL CONFERENCE ON ELECTRONICS, CIRCUITS AND SYSTEMS (IEEE ICECS 2022)
(2022)
Article
Computer Science, Hardware & Architecture
D. Livornesi, A. E. Vergani, F. Piscitelli, E. Mammei, M. M. Abdevand, E. Bonizzoni, P. Malcovati, P. Pulici
Summary: This letter presents an analog interface circuit for resistive sensor arrays, which achieves low noise and high performance signal readout.
IEEE SOLID-STATE CIRCUITS LETTERS
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
