Article
Biochemical Research Methods
Kenia Chavez Ramos, Maria del Pilar Canizares Macias
Summary: This study developed an innovative microdevice for on-line whole blood dilution with a phosphate buffer solution (PBS) and separation of plasma. The microdevice, utilizing unique design and manufacturing techniques, demonstrated high purity and efficiency in separating plasma.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yanfang Guan, Xiaoliang Wang, Guangyu Liu, Wujie Li, Kun Zhang, Baoshuo Sun, Feifan Shi, Yanbo Hui, Bingsheng Yan, Jie Xu, Zaihui Wu, Zhiyong Duan, Ronghan Wei
Summary: This study introduces 2D and 3D platforms driven by BAW and LCBE in liquid crystal solutions for efficient microparticle manipulation, allowing for precise control of microparticles and alteration of their moving direction.
Article
Engineering, Electrical & Electronic
Ming-Jing Lee, Yu-Jen Chang, Che-Jung Cheng, Yi-Chun Yeh, Chien-Fu Chen, Yi-Ju Chou
Summary: The separation of blood plasma by centrifugation can be accelerated by tilting the sample relative to the direction of the centrifugal force. This is due to the Boycott effect and buoyancy-induced convection, resulting in enhanced sedimentation of red blood cells. Flow instability invalidates the traditional predictive model, but our new model accounts for these factors and predicts the optimal tilt angle for highest separation efficiency. Experimental data confirms the accuracy of our theoretical prediction, and sensitivity analysis investigates the influence of blood sample variation on physical parameters.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Chemistry, Multidisciplinary
Seyong Kwon, Jieung Oh, Min Seok Lee, Eujin Um, Joonwoo Jeong, Joo H. Kang
Summary: A hemolysis-free and highly efficient plasma separation platform has been developed using enhanced diamagnetic repulsion of blood cells. By supplementing blood with superparamagnetic iron oxide nanoparticles, complete removal of blood cells from blood plasma is achieved, allowing for successful collection of plasma without losing plasma proteins, platelets, or exosomes.
Article
Chemistry, Analytical
Shaohua Ding, Shengbao Duan, Yezhou Chen, Jinsong Xie, Jingjing Tian, Yong Li, Hongmei Wang
Summary: This study presents a portable microfluidic device for parallel and digital analysis of red cell antigen typing. The device allows for fast and accurate identification of multiple red blood cell antigens through a zigzag-shaped precise metering channel and sequential-step spinning protocol.
Article
Biochemistry & Molecular Biology
Angeles Ivon Rodriguez-Villarreal, Manuel Carmona-Flores, Jordi Colomer-Farrarons
Summary: This study demonstrates the widening of the cell-free area (CFA) in a microfluidic device based on experimental results of red blood cell (RBC) flow, showing that temperature and flow rate modifications can significantly alter RBC response.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Chemistry, Analytical
Yuchen Dai, Haotian Cha, Michael J. Simmonds, Hedieh Fallahi, Hongjie An, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang, Antony P. McNamee
Summary: This study investigates the effects of altering fluid viscoelasticity on blood plasma extraction. Poly (ethylene oxide) (PEO) was added to increase blood viscoelasticity, resulting in improved cell focusing performance. The optimal PEO concentration was found to be in the range of 100 to 200 ppm, and the optimal flow rate was determined to be between 1 and 15 mu L/min.
Article
Biochemical Research Methods
Philippe Vachon, Srinivas Merugu, Jaibir Sharma, Amit Lal, Eldwin J. Ng, Yul Koh, Joshua E. -Y. Lee, Chengkuo Lee
Summary: This study presents microfabricated piezoelectric thin film membranes made via silicon diffusion for guided flexural wave generation as promising acoustofluidic actuators with low frequency, voltage, and power requirements. The guided wave propagation can be dynamically controlled to tune and confine the induced acoustofluidic radiation force and streaming. The membrane acoustic waveguide actuators offer a promising pathway for acoustofluidic applications such as biosensing, organoid production, and in situ analyte transport.
Article
Biochemical Research Methods
Shadi Karimi, Mohammad Mojaddam, Sahand Majidi, Pouya Mehrdel, Josep Farre-Llados, Jasmina Casals-Terre
Summary: This study focuses on optimizing the design of a microfluidic blood plasma separator for portable blood plasma separation with high purity and reasonable yield. The experimental results show that the design can achieve a 19% yield with 77.1% purity, which can be adjusted based on the point-of-care application requirements.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Haizhen Sun, Yukun Ren, Ye Tao, Tianyi Jiang, Hongyuan Jiang
Summary: The study introduces a technique called alternating current electrothermal-flow field-effect transistor (ACET-FFET) for in-droplet cell/particle concentration. By tuning the electric field and splitting droplets, cells/particles can be flexibly and efficiently concentrated. This technology demonstrates broad applications in droplet microfluidics.
Article
Multidisciplinary Sciences
Amir Shamloo, Amin Naghdloo, Mohsen Besanjideh
Summary: The study focused on isolating rare cancer cells using two centrifugal microfluidic devices. The passive design isolates cells through inertial effects and bifurcation law, while the hybrid design captures magnetically labeled cells using permanent magnets at the end of the microchannel. The hybrid design offers better separation efficiency and purity, while the passive one is simpler and cost-effective without the need for cell labeling.
SCIENTIFIC REPORTS
(2021)
Review
Nanoscience & Nanotechnology
Anamika Maurya, Janani Srree Murallidharan, Atul Sharma, Amit Agarwal
Summary: Significant advancements have been made in the field of diluted and whole blood plasma separation in the last two decades. Microfluidic devices with different geometries are used for this purpose, and a comparative analysis of these geometries is conducted to improve separation efficiency.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Review
Nanoscience & Nanotechnology
Yanping Fan, Xuan Wang, Jiaqi Ren, Francis Lin, Jiandong Wu
Summary: Acoustofluidic separation technology integrates acoustics and microfluidics to achieve the separation of cells and particles, and it has the characteristics of biocompatibility, contactless operation, and label-free nature, showing great potential in various applications.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Biochemical Research Methods
Maede Momeni, Amir Shamloo, Mojtaba Hasani-Gangaraj, Rasool Dezhkam
Summary: Cancer diagnosis is a major focus of current medical research, and one promising method is the detection of Circulating Tumor Cells (CTCs) in blood samples. This study presents a centrifugal microfluidic platform that separates CTCs from other blood cells using both active and passive methods, including an external magnetic field. Experimental tests and numerical studies determined the optimum parameters for the device, and results showed that curved channel geometries performed better in terms of separation efficiency. Including an external magnetic field improved the direction of the net force and enhanced separation efficiency. Comparing numerical and experimental results, the curved expansion-contraction channel was found to have the highest CTC separation efficiency.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemical Research Methods
Yongjun Choi, Vijaya Sunkara, Yeojin Lee, Yoon-Kyoung Cho
Summary: Dendritic cells (DCs) play essential roles in immune responses, with exhausted matured DCs (xmDCs) showing significantly different cellular migration behavior compared to active matured DCs (amDCs) and immature DCs (iDCs). Although xmDCs exhibit slower, less persistent, and less diffusive random motility, their CCR7-dependent chemotactic motility remains well-preserved.
Article
Chemistry, Analytical
Snehan Peshin, Derosh George, Roya Shiri, Lawrence Kulinsky, Marc Madou
Summary: Compact disc (CD)-based centrifugal microfluidics is a popular choice for portable biological and chemical assays. This study presents two new multiple-use wax valve designs driven by capillary or magnetic forces. The capillary-driven wax valve was analyzed through numerical simulations and experimental results, and the parameters of the valve were measured and analyzed theoretically.
Article
Chemistry, Multidisciplinary
Reyna Berenice Gonzalez-Gonzalez, Lucy Teresa Gonzalez, Marc Madou, Cesar Leyva-Porras, Sergio Omar Martinez-Chapa, Alberto Mendoza
Summary: In this study, carbon dots were synthesized from activated and non-activated pyrolytic carbon black obtained from waste tires and chemically oxidized with HNO3. The effects on carbon dot properties were analyzed using various characterization techniques. The results showed that carbon dots from activated precursors exhibited different photoluminescence properties compared to those from non-activated precursors. Additionally, a dialysis method was proposed to purify the carbon dots.
Article
Biochemical Research Methods
Yujia Liu, Lawrence Kulinsky, Roya Shiri, Marc Madou
Summary: In this study, a novel method of inward pumping using elastic membranes was introduced to centrifugal microfluidic platforms, allowing the liquid to be returned from the periphery to the center of the disk. By controlling the disk's angular velocity and the fluidic resistance in two channels, efficient inward pumping was achieved, demonstrating enhanced fluid mixing and the utility for multi-step assays on the disk.
Article
Chemistry, Analytical
Masoud Madadelahi, Javid Azimi-Boulali, Marc Madou, Sergio Omar Martinez-Chapa
Summary: The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept that is used for making multiple emulsions and microparticles. This study focuses on the application of particle generation to better understand this method. Theoretical models are used to explain how liquid polymeric droplets pass through a fluidic barrier, and experimental investigations are conducted to explore the effects of different parameters on the size and aspect ratio of the particles. The concept is further extended to two-source fluids, and the importance of source channel geometry, barrier length, and rotational speed in generating two-fluid droplets is studied.
Review
Chemistry, Multidisciplinary
Sumit Kumar, Mamata Karmacharya, Yoon-Kyoung Cho
Summary: Cells are the fundamental units of life and contain the necessary information for building living creatures. Advances in synthetic biology and cell engineering allow for the redesign of biological systems, but creating life-like structures from nonliving building blocks remains challenging. Cell membrane-engineered micro or nanoreactors have promising applications.
Article
Oncology
Jisu Lee, Hyun Sik Park, Seung Ro Han, Yun Hee Kang, Ji Young Mun, Dong Wook Shin, Hyun-Woo Oh, Yoon-Kyoung Cho, Myung-Shin Lee, Jinsung Park
Summary: Extracellular vesicles derived from urine, specifically urinary EVs (uEVs), have shown promise as diagnostic biomarkers for urogenital cancers. This study identified uEV-derived alpha-2-macroglobulin (a2M) as a novel diagnostic biomarker for bladder cancer (BC) and validated its upregulation in patient uEVs. The use of the centrifugal microfluidic tangential flow filtration device ExoDisc was found to be more effective for uEV protein analysis compared to classical differential centrifugation. These findings suggest that this approach for EV analysis can lead to the identification of clinically meaningful uEV-based biomarkers for cancer diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Rehabilitation
Caroline Mills, Danielle Tracey, Simone Nash, Robert Gorkin
Summary: This study explores the feasibility of implementing a VR sensory room for adults with neurodevelopmental disabilities and examines future improvements for the product and process. The findings suggest that the VR sensory room is well-received by most participants with consistent usage, but modifications and training may be required based on individual variations and support needs.
DISABILITY AND REHABILITATION
(2023)
Article
Chemistry, Analytical
Snehan Peshin, Marc Madou, Lawrence Kulinsky
Summary: Over the past 20 years, numerous immunoassays have been successfully integrated on CD platforms, enabling portable POC platforms with sample-to-answer capabilities. This study demonstrates the simultaneous integration of blood plasma separation (BPS) and reciprocation on a CD platform, allowing for the separation of plasma from red blood cells without inflow into the reciprocation chamber. Experimental results showed that the integrated design had significantly higher fluorescent signal compared to the standard design when the reciprocation time was increased to 7 minutes.
Article
Biophysics
Jonathan Sabate del Rio, Jooyoung Ro, Heejeong Yoon, Tae-Eun Park, Yoon-Kyoung Cho
Summary: Organs-on-chips (OoCs) are biomimetic in vitro systems that mimic the physicochemical microenvironments, physiologies, and key functional units of specific human organs using microfluidic cell cultures. These systems have the potential to replace animal models, enable personalized medicine, and require continuous monitoring of quality parameters. Integration of biosensing technologies into OoCs allows for monitoring of their physiologies, functions, and microenvironments. Future directions involve the application of artificial intelligence for process optimization, self-regulation, and data analysis in OoCs and cyber-physical systems.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Biomedical
Mamata Karmacharya, Sumit Kumar, Yoon-Kyoung Cho
Summary: Membrane fusion is an important phenomenon for cellular function. Extracellular vesicles (EVs) have the ability to transfer information between cells through fusion and can be used in diagnostics and therapeutics. This study explores the potential applications of EVs and their fusion with liposomes and cells, as well as methods to enhance the fusion process. EVs have high loading capacity, bio-compatibility, and stability, making them ideal for drug production and diagnostics. The unique properties of fused EVs and the necessary design and development procedures are also examined. The promise of EVs in disease management highlights their potential role in future healthcare.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Chemistry, Analytical
Masoud Madadelahi, Marc J. Madou
Summary: The pandemic has provided financial and regulatory support for the improvement of limit of detection (LOD), speed, and cost of important diagnostic tools such as lateral flow assays (LFA), enzyme-linked immunosorbent assays (ELISA), and polymerase chain reaction (PCR). Among these tools, PCR has shown the most progress in overall performance. However, implementing PCR in point of care (POC) settings remains challenging due to strict requirements for low LOD, multiplexing, accuracy, selectivity, robustness, and cost. This article introduces three parameters to guide the design of the next generation of PCR reactors based on POC requirements: the overall sample-to-answer time (t), lambda (?), which determines the minimum number of copies required per reactor volume, and gamma (?), the system's thermal efficiency. Evaluation: 8/10.
Article
Biochemical Research Methods
Junyoung Kim, Vijaya Sunkara, Jungmin Kim, Jooyoung Ro, Chi-Ju Kim, Elizabeth Maria Clarissa, Sung Wook Jung, Hee Jin Lee, Yoon-Kyoung Cho
Summary: Tumor-educated platelets play a critical role in tumorigenesis, cancer development, and metastasis. Researchers found that interleukin-8 (IL-8) in cancer-derived extracellular vesicles (EVs) contributed to platelet activation, resulting in increased platelet adhesion and potentially leading to tumor metastasis. Platelet adhesion levels can differentiate breast cancer patients with and without metastasis.
Review
Chemistry, Analytical
Jooyoung Ro, Junyoung Kim, Yoon-Kyoung Cho
Summary: Three-dimensional multicellular spheroid models can accurately recapitulate the tumor microenvironment and microfluidic platforms are extensively used to study spheroids and understand cellular interactions and discover cancer therapeutics.
Article
Biochemical Research Methods
Tanya Narahari, Joshua Dahmer, Alexandros Sklavounos, Taehyeong Kim, Monika Satkauskas, Ioana Clotea, Man Ho, Julian Lamanna, Christopher Dixon, Darius G. Rackus, Severino Jefferson Ribeiro da Silva, Lindomar Pena, Keith Pardee, Aaron R. Wheeler
Summary: This paper introduces a digital microfluidic platform for portable, automated, and integrated Zika viral RNA extraction and amplification. The platform features reconfigurable DMF cartridges and programmable control instrumentation, and it can be coupled with paper-based analysis for amplified Zika RNA. Blinded laboratory evaluation and field evaluation in Brazil showed high sensitivity and specificity of the platform.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
