Article
Chemistry, Multidisciplinary
Sunil Kumar Mahobiya, Sapna Balayan, Nidhi Chauhan, Manika Khanuja, Naresh K. Kuchhal, S. S. Islam, Utkarsh Jain
Summary: Diabetes is a global threat that leads to various diseases. Traditional methods for diagnosing diabetes based on glycated hemoglobin level have limitations. A new electrochemical biosensor has been developed in this study to rapidly and accurately detect glycated hemoglobin protein, showing potential application value.
Article
Chemistry, Analytical
Bohdan Josypcuk, Jan Langmaier, Sofiia Tvorynska
Summary: Silver amalgam screen-printed electrodes (AgA-SPEs) were designed, prepared, and tested as representatives among SPEs for measuring at high negative potentials, showing superior PHE values compared to traditional silver-SPEs. The practical application of AgA-SPEs was demonstrated by analyzing iodine content in table salt, with consistent results as declared by the manufacturer.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Giti Paimard, Ehsan Ghasali, Mireia Baeza
Summary: As electrochemical measuring instruments, screen-printed electrodes (SPEs) are simple, inexpensive, and rapid to analyze substances with high reproducibility, sensitivity, and accuracy. The latest research has focused on expanding SPE electrochemical biosensors, such as aptasensors, immunosensors, DNA sensors, and enzymatic biosensors, to identify, distinguish, and quantify various biocompounds. This review discusses the use of different nanomaterials in manufacturing on-screen electrode methods and strategies for stable diagnosis of biorecognition elements in the future.
Article
Environmental Sciences
Ting Zhang, Juan Han, Houjin Zhang
Summary: A novel electrochemical method was developed for rapid screening of saline-alkali tolerant bacteria using a hydrogel/gold nanoparticles-modified screen-printed electrode. Compared to traditional bacterial culture methods, this method has the clear advantages of rapidity, high efficiency, and low cost.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Mustafa Sen, Merve Oguz, Ipek Avci
Summary: A non-toxic, flexible, low-cost, and disposable multiwalled carbon nanotube (MWCNT)-based screen-printed electrode (SPE) was developed for non-invasive health monitoring applications. The electrode demonstrated excellent electrochemical behavior and is expected to contribute to wearable sensor technology.
Review
Biotechnology & Applied Microbiology
Gang Liang, Zhaoying He, Jianhui Zhen, Hao Tian, Lianfeng Ai, Ligang Pan, Wenwen Gong
Summary: Periodically excessive use of pesticides in agricultural production has led to ecotoxicity and environmental pollution. Biosensing technique is a complementary tool to classical chromatographic methods for rapid, in situ analysis. Screen-printed electrode (SPE) is a widely used method for pesticides detection due to its low cost, easy integration, versatility, and portability. This review provides an overview of the screen-printing technique and SPE, including their definition, preparation procedure, advantages, and discusses the utilization of SPE in detecting pesticides using various bioreceptors and nanomaterials. The sensing principles, analytical performance, advantages, and shortcomings of SPE-based sensors are summarized, and the current challenges and future directions for SPE and SPE-based electrochemical sensors for pollutants are outlined.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Chemistry, Multidisciplinary
Daniel A. Smith, Kate Simpson, Matteo Lo Cicero, Lucy J. Newbury, Philip Nicholas, Donald J. Fraser, Nigel Caiger, James E. Redman, Timothy Bowen
Summary: This paper introduces a straightforward electrochemical method for quantifying urinary miRNA using disposable biosensors to distinguish between DKD patients and control subjects. Aberrant miRNA expression has been observed in several major human disorders, and a urinary miRNA signature for DKD has been identified. The method shows great clinical and commercial potential for quantitative miRNA detection in liquid biopsies and may serve as a platform for non-invasive high-throughput screening.
Article
Chemistry, Analytical
Noelia Felipe Montiel, Marc Parrilla, Victoria Beltran, Gert Nuyts, Filip Van Durme, Karolien De Wael
Summary: The study presents a rapid analysis method based on the enriched electrochemical fingerprint of heroin, allowing for selective detection in street samples. By using electrochemical pretreated screen printed electrodes (p-SPE), the sensitivity and reproducibility of detection are improved, while the detection limits are lowered. The method also includes testing against common cutting agents for validation.
Article
Chemistry, Analytical
Cong Wang, Tan Wang, Zhen Li, Xianbao Xu, Xiaoshuan Zhang, Daoliang Li
Summary: A SPEC/AuNPs/PMB modified electrode was prepared and used for indirect measurement of ammonia nitrogen content in water samples. The biosensor exhibited good sensitivity and stability under certain conditions.
Article
Chemistry, Analytical
H. F. El-Sharif, S. Patel, E. N. Ndunda, S. M. Reddy
Summary: This study reports the use of electropolymerised molecularly imprinted polymers (E-MIPs) for the determination of dioctyl phthalate (DOP). E-MIPs with high affinity for DOP were produced using commercially available screen printed electrodes (SPEs). The E-MIPs showed rapid and accurate detection of DOP in freshwater samples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Tzong-Jih Cheng, Hsien-Yi Hsiao, Pei-Chia Tsai, Richie L. C. Chen
Summary: Electrochemical impedance spectroscopy (EIS) is a sensitive analytical method for surface and bulk properties. Here, we demonstrated redoxless ECS for directly determining surfactant adsorption on screen-printed carbon electrodes (SPCEs), providing excellent capacitance plot loci for quantifying the interfacial permittivity of dielectric layers on electrode surfaces. Our proposed approach may serve as a starting point for future probeless and label-free biosensors based on electrochemistry, eliminating disturbance with surface charge properties and minimizing forced potential bias by avoiding redox couples.
Article
Chemistry, Multidisciplinary
Muhammad Abdurrahman Munir, Khairiah Haji Badri, Lee Yook Heng, Ahlam Inayatullah, Eva Nurinda, Daru Estiningsih, Annisa Fatmawati, Veriani Aprilia, Nur Syafitri
Summary: Histamine detection in fish mackerel is important for assessing allergic reactions and food freshness. This study developed a histamine sensor based on electrodes modified with polyurethane-LiClO4, which showed satisfactory selectivity and sensitivity. The sensor has great potential for analyzing histamine content in fish mackerel.
Article
Chemistry, Analytical
Rui S. Gomes, Blanca Azucena Gomez-Rodriguez, Ruben Fernandes, M. Goreti F. Sales, Felismina T. C. Moreira, Rosa F. Dutra
Summary: This work reports the design of a novel plastic antibody for the biomarker Cys-C in acute kidney injury and its application in point-of-care testing. The synthetic antibody was tailored on a carbon screen-printed electrode using molecularly imprinted polymer, and its binding ability was evaluated using electrochemical techniques and Raman spectroscopy. The device showed promising features for AKI diagnosis in terms of simplicity, cost, and sensitivity.
Article
Biotechnology & Applied Microbiology
Nan Wang, Guiying Pan, Shimin Guan, Shaofeng Rong, Dapeng Wang, Zhiyong Gao, Peng Tian, Qianqian Li
Summary: In this study, an electrochemical biosensor based on a screen-printed carbon electrode was developed for the rapid detection of human noroviruses (HuNoVs). The biosensor showed high sensitivity and specificity, and could detect different genogroups and genotypes of HuNoVs. The detection limit of HuNoVs in clinical fecal samples was 10(4) genomic copies/mL. The results could be obtained within 1 hour.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Alejandro Fidel Alba, Roberto Fernandez-de Luis, Joseba Totoricaguena-Gorrino, Leire Ruiz-Rubio, Julia Sanchez, Jose Luis Vilas-Vilela, Senentxu Lanceros-Mendez, Francisco Javier Del Campo
Summary: Screen printed graphite electrodes are commonly used in electroanalysis and electrochemiluminescence (ECL) applications. This study investigates the ECL of the Ru(bpy)32+/TPrA system on different graphite electrodes printed from various graphite pastes. The ECL intensity of the graphite electrodes is found to depend on electrode kinetics and wettability, which are influenced by paste composition.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
J. Bujes-Garrido, D. Izquierdo-Bote, A. Heras, A. Colina, M. J. Arcos-Martinez
ANALYTICA CHIMICA ACTA
(2018)
Article
Chemistry, Analytical
F. Pires, M. Julia Arcos-Martinez, A. Cristina Dias-Cabral, Juan C. Vidal, Juan R. Castillo
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2018)
Article
Chemistry, Analytical
B. Molinero-Abad, D. Izquierdo, L. Perez, I. Escudero, M. J. Arcos-Martinez
Article
Chemistry, Analytical
Hugo Cunha-Silva, M. Julia Arcos-Martinez
Article
Chemistry, Analytical
Hugo Cunha-Silva, M. Julia Arcos-Martinez
SENSORS AND ACTUATORS B-CHEMICAL
(2019)
Article
Chemistry, Analytical
Olga Dominguez-Renedo, A. Marta Navarro-Cunado, Eduardo Ventas-Romay, M. Asuncion Alonso-Lomillo
Article
Chemistry, Analytical
Olga Dominguez-Renedo, A. Marta Navarro-Cunado, Victor Arnaiz-Lozano, M. Asuncion Alonso-Lomillo
Article
Electrochemistry
M. Asuncion Alonso-Lomillo, Sheila Lopez-Gil, F. Javier del Campo Garcia, Olga Dominguez-Renedo
Summary: An environmentally friendly electrochemical sensor was developed for the detection of mercaptans in wine samples, using glassy carbon and screen-printed carbon electrodes modified with gold nanoparticles. The sensitivity and selectivity of the sensor were enhanced due to a strong covalent bond formed between sulfur and gold atoms. The reduction of ethanethiol was found to be dependent on both pH and adsorption time.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Jerson Gonzalez-Hernandez, Colby Edward Ott, Maria Julia Arcos-Martinez, Alvaro Colina, Aranzazu Heras, Ana Lorena Alvarado-Gamez, Roberto Urcuyo, Luis E. Arroyo-Mora
Summary: This study explores the spectroelectrochemical response of synthetic cathinones using cyclic voltammetry and Raman spectroscopy for the first time. The proposed method allows for rapid and reliable determination of these substances, making it applicable for forensic analysis of real drug samples and spiked synthetic urine.
Article
Chemistry, Analytical
Paula Portugal-Gomez, M. Asuncion Alonso-Lomillo, Olga Dominguez-Renedo
Summary: This work demonstrates the potential of modified screen-printed carbon electrodes for sensitive and selective detection of 4-ethylphenol in wine. The study compares gold nanoparticles and fullerene C60 as modified sensors, and optimizes the pH, deposition time, and working temperature to achieve the best performance. The activated C60/SPCE shows the highest detection capability under the optimal measurement conditions.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Olga Dominguez-Renedo, A. Marta Navarro-Cunado, M. Asuncion Alonso-Lomillo
Summary: Cholesterol is an important biomarker for diseases such as heart and coronary artery diseases or arteriosclerosis, and its fast determination in blood is crucial for early diagnosis. Electrochemical sensors and biosensors have emerged as potential tools for selective and sensitive detection of cholesterol, combining the analytical advantages of electrochemical techniques with modified electrodes' selective recognition abilities. This review focuses on the development of electrochemical sensors for cholesterol, distinguishing between enzymatic biosensors and non-enzymatic systems, with emphasis on lab-on-a-chip devices. Different electrode modification procedures and the role of functional materials are also discussed.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Analytical
M. Asuncion Alonso-Lomillo, Olga Dominguez-Renedo
Summary: This work presents a molecularly imprinted (MIP) sensor for the determination of ethanethiol. The MIP/GCE sensor showed a linear range of 6.1-32.4 mg L-1 with good detection capability and reproducibility. The sensitivity of the sensor was enhanced by incorporating gold nano-particles. The sensor was successfully applied to determine ethanethiol in spiked wine samples.
Article
Chemistry, Analytical
Paula Portugal-Gomez, A. Marta Navarro-Cunado, M. Asuncion Alonso-Lomillo, Olga Dominguez-Renedo
Summary: This article describes an electrochemical method for determining 4-ethylguaiacol and its application in wine analysis. Modified screen-printed carbon electrodes (AC(60)/SPCEs) with fullerene C-60 (C-60) have shown high efficiency in this analysis. Under optimized conditions, AC(60)/SPCEs demonstrated a linear range of 200 to 1000 μg/L for 4-ethylguaiacol determination, with a reproducibility of 7.6% and a detection capability (CCb) value of 200 μg/L. The selectivity of AC(60)/SPCE sensors was evaluated in the presence of potentially interfering compounds, and their practical applicability in analyzing different wine samples was demonstrated with recoveries ranging from 96% to 106%.
Article
Chemistry, Analytical
Paula Portugal-Gomez, Olga Dominguez-Renedo, M. Asuncion Alonso-Lomillo
Summary: This study reports the use of different cobalt phthalocyanine/nanomaterials-based sensors for the headspace detection of volatile thiols. The best performance was achieved by using carbon sensors modified with cobalt phthalocyanine. The optimized amperometric procedure showed good reproducibility, capability of detection, and decision limit for ethanethiol quantification in white and red wines.
Review
Chemistry, Analytical
Olga Dominguez-Renedo, A. Marta Navarro-Cunado, M. Elena Melendez-Alvarez, M. Asuncion Alonso-Lomillo
Summary: The development of electrochemical sensors for analyzing various analytes in wine has been driven by the need to ensure its quality in terms of taste and food safety, as well as compliance with regulations. Certain components in wine can affect its stability and organoleptic properties, and some may have harmful effects on consumers. Therefore, early diagnosis is crucial in wine samples. Enzymatic and non-enzymatic electrochemical sensors, utilizing nanostructured materials or chemically modified electrodes, have been explored to enhance sensitivity and selectivity. These miniaturizable sensors are ideal for point-of-care devices.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
