Article
Engineering, Electrical & Electronic
Soumendu Sinha, Tapas Pal, Prashant Sharma, Dheeraj Kharbanda, P. K. Khanna, Amit Tanwar, Rishi Sharma, Ravindra Mukhiya
Summary: The study focused on the fabrication, characterization, and electrochemical modeling of an Al2O3-gate ISFET-based pH sensor. The sensor, made using established MOS processes, demonstrated high sensitivity, low drift, and hysteresis properties. This was achieved through the deposition of Al2O3 sensing film and packaging technology, resulting in a capable pH sensor with superior performance.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Chemistry, Analytical
Yonghao Jia, Jianyu Wang, Shari Yosinski, Yuehang Xu, Mark A. Reed
Summary: In this paper, a potentiometric method using silicon nanowire biosensors is used to monitor the concentration of glutamine in the bioprocess. A more convenient hydrolyzation reaction is used, and the Al2O3 sensing layer and the Sigmoidal function are employed to achieve consistent and fast monitoring results.
Article
Chemistry, Analytical
Olga Naumova, Vladimir Generalov, Dmitry Shcherbakov, Elza Zaitseva, Yuriy Zhivodkov, Anton Kozhukhov, Alexander Latyshev, Alexander Aseev, Alexander Safatov, Galina Buryak, Anastasia Cheremiskina, Julia Merkuleva, Nadezhda Rudometova
Summary: Quick label-free virus screening and highly sensitive analytical tools/techniques are crucial in a pandemic. In this study, a biosensing device based on silicon nanoribbon sensors was developed for the detection and characterization of viruses and their protein components. The sensors demonstrated subattomolar sensitivity and a dynamic range of 4 orders, with the ability to distinguish between specific and nonspecific interactions. Dielectrophoretic controlled sensors allowed for estimating the effective charge of individual viruses at the sensor surface, separate from the charge associated with protein binding.
Article
Chemistry, Analytical
Tae-Hwan Hyun, Won-Ju Cho
Summary: In this study, a high-performance dopamine-sensitive biosensor platform based on a dual-gate FET on a silicon-on-insulator substrate was proposed, which overcame the limitations of conventional approaches and increased the sensitivity of dopamine sensors. The biosensor platform consisted of a dual-gate FET transducer unit and a dopamine-sensitive extended gate sensing unit. The capacitive coupling between the top- and bottom-gate of the transducer unit allowed for self-amplification of dopamine sensitivity, resulting in an increased sensitivity of 373.98 mV/log[DA] from concentrations 10 fM to 1 mu M. Therefore, the proposed FET-based dopamine sensor is expected to be widely applied as a highly sensitive and reliable biosensor platform, enabling fast and accurate detection of dopamine levels in various applications such as medical diagnosis and drug development.
Article
Chemistry, Physical
Kemin Wang, Xiaofeng Liu, Zijun Zhao, Luyao Li, Qian Shang, Yiwei Liu, Zhiyong Zhang
Summary: This paper reports a carbon nanotube (CNT)-FET pH sensor with enhanced environmental stability by introducing HfO2 film into the gate insulator. The proposed sensor shows immunity to environmental interference and demonstrates high-performance pH sensing.
Article
Chemistry, Multidisciplinary
Gangrong Li, Qianhui Wei, Shuhua Wei, Jing Zhang, Qingxi Jin, Guozhi Wang, Jiawei Hu, Yan Zhu, Yun Kong, Qingzhu Zhang, Hongbin Zhao, Feng Wei, Hailing Tu
Summary: In this study, a pH-responsive hydrogel-modified silicon nanowire field-effect transistor was developed for pH sensing. The hydrogel sensor demonstrated stable and repeatable measurement of buffer pH in the range of 3-13, with a high pH sensitivity. The design of the sensor shows promise for future biosensing applications utilizing the excellent biocompatibility of hydrogels.
Article
Computer Science, Information Systems
Anastasia Bulgakova, Anton Berdyugin, Olga Naumova, Boris Fomin, Dmitrii Pyshnyi, Alexey Chubarov, Elena Dmitrienko, Alexander Lomzov
Summary: Nanowire or nanobelt sensors based on silicon-on-insulator field-effect transistors (SOI-FETs) are a leading direction for label-free biosensors. Reproducible results from electrochemical measurements are important for this device construction type, and are affected by factors including the measuring solution and sensor design parameters. The pH value should be chosen to minimize surface charge for maximum sensitivity and effect from charged molecule interactions. The study found that 3 μm wide nanobelt sensing elements are most suitable for reliable analysis of biomolecules at pH values over 7.
Article
Engineering, Electrical & Electronic
Sihyun Kim, Ryoongbin Lee, Daewoong Kwon, Tae-Hyeon Kim, Tae Jung Park, Sung-Jin Choi, Hyun-Sun Mo, Dae Hwan Kim, Byung-Gook Park
Summary: In this study, silicon nanowire FET and TFET biosensors were integrated with CMOS circuits, demonstrating the capability of multiplexed sensing and independent detection of different biomolecules. The use of different sensing materials and bio-receptors allowed for successful monitoring of changes in saturation and GIDL currents in the FET sensor, as well as the use of tunneling and ambipolar currents in the TFET biosensor.
IEEE SENSORS JOURNAL
(2021)
Article
Engineering, Electrical & Electronic
Praveen Dwivedi, Rohit Singh, Yogesh Singh Chauhan
Summary: This work investigates the underlap structure of a TFET with electrolyte/watery solution to enhance sensitivity beyond the Nernst limit, achieving a voltage sensitivity of 180 mV/pH and a current sensitivity greater than one decade per pH. Results show that the TFET outperforms the IM device, demonstrating its potential as a promising alternative for future biosensors.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Yu Luo, Ruizhi Lin, Yimei Zuo, Ziyi Zhang, Yi Zhuo, Ming Lu, Shu Chen, Hui Gu
Summary: In this study, an electrochemical microsensor was designed for the selective and accurate measurement of hydrogen peroxide (H2O2) in the living brain. By tuning the structure of the probe and using a stable internal reference material, the sensor was able to track the concentration of H2O2 in real-time. The sensor was successfully applied to measure H2O2 in the Parkinson's disease mouse brain. This research provides insights into the role and impact of H2O2 in Parkinson's disease.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
I. Novodchuk, M. Kayaharman, I. Prassas, A. Soosaipillai, R. Karimi, I. A. Goldthorpe, E. Abdel-Rahman, J. Sanderson, E. P. Diamandis, M. Bajcsy, M. Yavuz
Summary: Researchers have developed a graphene-based FET biosensor with high sensitivity and fast detection capabilities for detecting SARS-CoV-2 nucleocapsid protein. The biosensor can detect the viral protein within four minutes with a wide detection range.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Yann Sprunger, Luca Capua, Thomas Ernst, Sylvain Barraud, Didier Locca, Adrian Ionescu, Ali Saeidi
Summary: In this paper, a novel approach utilizing silicon nanowires as high-sensitivity pH sensors is proposed. The approach works by fixing the current bias of ISFETs and monitoring the resulting drain voltage as the sensing signal. This method is highly suitable for real-time and continuous measurements of biomarkers in human biofluids, achieving exceptional accuracy in a complex matrix.
Article
Materials Science, Multidisciplinary
Mohammad K. Anvarifard, Zeinab Ramezani, Iraj Sadegh Amiri
Summary: The study utilizes a multi-layer perceptron to predict the drain current of GNRFET, achieving a simple and efficient simulation with excellent match and correlation compared to the NEGF method. The model proves to be a suitable tool for different spice levels, saving running time and enhancing efficiency in nanoscale circuits based on the GNRFET structure.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Samran Durrani, Zihuayuan Yang, Jie Zhang, Zihao Wang, Haiyan Wang, Faran Durrani, Fu-Gen Wu, Fengming Lin
Summary: This article reports a fluorescent sensor that can directly monitor changes in nucleus pH, which is of great significance in understanding nucleus-related biological events.
Article
Chemistry, Analytical
Hiroaki Satoh, Koki Isogai, Shohei Iwata, Taiki Aso, Ryosuke Hayashi, Shu Takeuchi, Hiroshi Inokawa
Summary: This paper proposes a new optical biosensor composed of a SOI p-n junction PD with an SP antenna, which demonstrates sharp peaks in the spectroscopic light sensitivity when the phase-matching condition is satisfied. The RI detection limit is found to be 1.11 x 10(-5) RIU, comparable to an SPR sensor. Moreover, electromagnetic simulations using the FDTD method confirm the ability of the biosensor to detect biomolecular interactions.
Article
Chemistry, Multidisciplinary
Ali Abdelhafiz, Adam Vitale, Parker Buntin, Ben deGlee, Corey Joiner, Alex Robertson, Eric M. Vogel, Jamie Warner, Faisal M. Alamgir
ENERGY & ENVIRONMENTAL SCIENCE
(2018)
Article
Engineering, Electrical & Electronic
P. Wang, C. Perini, A. O'Hara, B. R. Tuttle, E. X. Zhang, H. Gong, L. Dong, C. Liang, R. Jiang, W. Liao, D. M. Fleetwood, R. D. Schrimpf, E. M. Vogel, S. T. Pantelides
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2018)
Article
Nanoscience & Nanotechnology
Christopher J. Perini, Pradip Basnet, Matthew P. West, Eric M. Vogel
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Chemistry, Analytical
Sepideh Rastegar, Justin Stadlbauer, Twinkle Pandhi, Lynn Karriem, Kiyo Fujimoto, Kyle Kramer, David Estrada, Kurtis D. Cantley
Article
Engineering, Electrical & Electronic
Pan Wang, Christopher J. Perini, Andrew O'Hara, Huiqi Gong, Pengfei Wang, En Xia Zhang, Michael W. McCurdy, Daniel M. Fleetwood, Ronald D. Schrimpf, Sokrates T. Pantelides, Eric M. Vogel
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2019)
Article
Physics, Applied
Decarle S. Jin, Eleanor L. Brightbill, Eric M. Vogel
JOURNAL OF APPLIED PHYSICS
(2019)
Article
Chemistry, Physical
Katherine T. Young, Shelly S. Phillips, Jasmine T. T. Coley, Christopher J. Perini, Dale A. Hitchcock, Steve M. Serkiz, Eric M. Vogel
APPLIED SURFACE SCIENCE
(2019)
Article
Computer Science, Artificial Intelligence
Robert C. Ivans, Sumedha Gandharava Dahl, Kurtis D. Cantley
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2020)
Article
Computer Science, Information Systems
Sumedha Gandharava, Robert C. Ivans, Benjamin R. Etcheverry, Kurtis D. Cantley
Summary: Biological neural networks show remarkable resilience and compensation for neuron loss. This study investigates the ability of electronic spiking networks to compensate for sudden neuron failures and highlights the importance of non-participating neurons in improving the learning ability and stability of the network.
Article
Multidisciplinary Sciences
Sumedha Gandharava Dahl, Robert C. Ivans, Kurtis D. Cantley
Summary: This study investigates the impact of radiation interactions on synaptic devices in an electronic spiking neural network, finding that radiation tends to strengthen synaptic connections, distort the STDP learning curve, and make synaptic weight evolution unstable.
SN APPLIED SCIENCES
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Sumedha Gandharava Dahl, Rober C. Ivans, Kurtis D. Cantley
2019 IEEE 62ND INTERNATIONAL MIDWEST SYMPOSIUM ON CIRCUITS AND SYSTEMS (MWSCAS)
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Robert Ivans, Kurtis D. Cantley
2019 IEEE 62ND INTERNATIONAL MIDWEST SYMPOSIUM ON CIRCUITS AND SYSTEMS (MWSCAS)
(2019)
Article
Nanoscience & Nanotechnology
Hossein Taghinejad, Ali A. Eftekhar, Philip M. Campbell, Brian Beatty, Mohammad Taghinejad, Yao Zhou, Christopher J. Perini, Hesam Moradinejad, Walter E. Henderson, Eric V. Woods, Xiang Zhang, Pulickel Ajayan, Evan J. Reed, Eric M. Vogel, Ali Adibi
NPJ 2D MATERIALS AND APPLICATIONS
(2018)
Article
Engineering, Electrical & Electronic
Christopher J. Perini, Michael J. Muller, Brent K. Wagner, Eric M. Vogel
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B
(2018)
Article
Materials Science, Multidisciplinary
Philip M. Campbell, Christopher J. Perini, Johannes Chiu, Atul Gupta, Hunter S. Ray, Hang Chen, Kevin Wenzel, Eric Snyder, Brent K. Wagner, Jud Ready, Eric M. Vogel
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
