Article
Chemistry, Physical
G. Martinez-Saucedo, M. Ugalde-Reygadas, J. J. Alcantar Pena, G. Lastra-Medina, J. Marquez-Marin, G. Torres-Delgado, R. Castanedo-Perez, I. R. Chavez-Urbiola
Summary: The glucose sensitivity of a non-enzymatic sensor is affected by the thickness of the thin-film, which depends on the conductivity and roughness of the film. Copper oxide films grown by spray pyrolysis were used to study the effect of thin-film thickness. It was found that increasing the film thickness up to 434 nm improved the signal stability and sensitivity, but beyond that thickness, the sensitivity started to decrease gradually.
SURFACES AND INTERFACES
(2023)
Article
Biophysics
Nicole L. Walker, Jeffrey E. Dick
Summary: The development of a new electrochemical technique - open circuit potential, has been aimed at stable and reliable monitoring of biological metabolites. By immobilizing oxidase enzyme in chitosan hydrogel, the method achieves specificity in monitoring metabolites. This approach can effectively detect metabolites such as glucose and can be extended to detect other analytes.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
I. R. Chavez-Urbiola, A. Y. Resendiz-Jaramillo, F. J. Willars-Rodriguez, G. Martinez-Saucedo, L. G. Arriaga, Jesus Alcantar-Pena, Ricardo A. Escalona-Villalpando, J. Ledesma-Garcia
Summary: This study investigates the influence of ZnO semiconductor thin film on enzymatic immobilization in a glucose biosensor. The results suggest that the combination of ZnO thin film and enzymes enhances the immobilization process, leading to improved performance of the glucose biosensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Computer Science, Artificial Intelligence
Alcebiades Dal Col, Fabiano Petronetto
Summary: This paper presents a novel multidimensional projection method called Graph Regularization Multidimensional Projection (GRMP), which utilizes the graph regularization technique from the graph signal processing theory. The method constructs a similarity graph in the high-dimensional space and creates a two-dimensional distribution using a phyllotactic distribution in the visual space. The graph regularization reorganizes the distribution by bringing together similar data points. The effectiveness of the method is demonstrated using synthetic and real datasets, and its computational efficiency is highlighted by its fast approximation mechanism based on Chebyshev polynomials.
PATTERN RECOGNITION
(2022)
Article
Materials Science, Multidisciplinary
Guan-Kai Huang, Shivam Gupta, Chi -Young Lee, Nyan-Hwa Tai
Summary: In this study, a noninvasive saliva glucose sensor was developed using polypyrrole (PPy) and acid-treated carbon nanotubes (acid-CNTs) deposited on a fluorine-doped tin oxide (FTO) conductive glass substrate. The sensor exhibited high sensitivity, selectivity, and stability, making it suitable for noninvasive diagnosis of diabetes.
DIAMOND AND RELATED MATERIALS
(2022)
Review
Chemistry, Analytical
Flavio M. Shimizu, Anerise de Barros, Maria L. Braunger, Gabriel Gaal, Antonio Riul
Summary: This review discusses the convergence of impedimetric biosensing technologies and computational methods for data information visualization. Various methodologies and analytical techniques associated with impedance measurements for biosensing are presented, including versatile testing platforms and management decisions based on detection level. The application of multivariate methods in data analysis, particularly machine learning methods, has seen steady growth in determining biosensing parameters. These methods have been applied to calibration, analysis, classification, regression procedures, and optimization of device performance. As a result, there has been significant improvement in data automation, accuracy, and its impact on diagnostics and protocols.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Valdes-Ramirez, Laura Galicia
Summary: The biosensing membrane based on ferulic acid and glucose oxidase synthesized via cyclic voltammetry shows a linear response to glucose concentration, with high sensitivity and stability. The developed glucose biosensors exhibit a broader linear response compared to other polymer-based glucose biosensors.
Article
Chemistry, Analytical
Yue Wang, Jifan Zhao, Tian Yang, Yan Zhang, Dongping Tao, Yasushi Hasebe, Zhiqiang Zhang
Summary: Sulfide minerals were employed as a matrix for glucose oxidase immobilization in biosensors, showing good linear range, detection limits, and detection performance for glucose sensing. The results suggest that sulfide minerals are promising platforms for enzyme immobilization in biosensor applications.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yu Cai, Tingting Tu, Tianyu Li, Shanshan Zhang, Bin Zhang, Lu Fang, Xuesong Ye, Bo Liang
Summary: The study on the application of nanomaterials in glucose biosensors demonstrates excellent electrochemical performance, taking a step towards the development of the third-generation glucose biosensor.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Minying Wu, Qian Zhang, Yuanyuan Fang, Chao Deng, Fangzhou Zhou, Yi Zhang, Xingdong Wang, Yi Tang, Yajun Wang
Summary: Two-dimensional nanoreactors with cascade catalytic activity for glucose oxidation and hydrogen peroxide decomposition were prepared by immobilizing GOx on Ti3C2 MXene nanosheets. The GOx-conjugated Ti3C2-PLL nanosheets exhibited excellent enzymatic activities and were further deposited on glassy carbon electrode to construct a high-performance biosensor with a low glucose detection limit.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biophysics
Matias Regiart, Ana Ledo, Eliana Fernandes, German A. Messina, Christopher M. A. Brett, Mauro M. Bertotti, Rui Barbosa
Summary: Highly sensitive and selective nanostructured lactate and glucose microbiosensors were developed for simultaneous determination in rat brain. The microbiosensors, based on carbon fiber microelectrodes modified with nanoporous gold, exhibited enhanced sensitivity and electrocatalytic properties towards H2O2 detection. The selective measurements were achieved by enzyme immobilization, permselective layer, and a null sensor. The microbiosensor platform was used to determine lactate and glucose in blood serum samples, as well as in vivo measurements of basal extracellular concentrations in different rat brain structures.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Laura Sakalauskiene, Benediktas Brasiunas, Anton Popov, Asta Kausaite-Minkstimiene, Almira Ramanaviciene
Summary: The development of a first-generation reagentless amperometric glucose biosensor based on the combination of AuNS, PB, and GOx has been achieved, enabling convenient and intuitive glucose detection. The biosensor exhibits a wide linear range, good repeatability, and high selectivity.
Article
Chemistry, Analytical
Cheng-Ju Sung, Szu-Han Chao, Shih-Chieh Hsu
Summary: This report summarizes the development of biosensors for Rhodamine 6G and in vitro glucose detection based on surface-enhanced Raman scattering technology. The use of NPS-AuFON as the sensor platform, combined with potentiostatic technique and electrochemical adsorption, allowed for optimal detection of low concentrations of glucose. The surface modification technology achieved the goal of detecting a glucose concentration of 11.1 mmol/L (mg/dL) to determine diabetic status, as set by the World Health Organization.
Article
Nanoscience & Nanotechnology
Artur Huseinov, Chaminda P. Nawarathne, Noe T. Alvarez
Summary: This paper introduces the first application of a covalently attached carbon nanotube film to a nanostructured gold electrode for electrochemical detection of hydrogen peroxide. The introduction of properly aligned carbon nanotubes significantly enhances the electroactive surface area and current response, leading to a stable signal under oxidative conditions. In addition, the functional groups on the carbon nanotube surface offer possibilities for simple functionalization.
ACS APPLIED NANO MATERIALS
(2023)
Article
Computer Science, Software Engineering
Tacito Trindade de Araujo Tiburtino Neves, Rafael Messias Martins, Danilo Barbosa Coimbra, Kostiantyn Kucher, Andreas Kerren, Fernando Paulovich
Summary: Streaming data applications are becoming more common, but existing visualization methods have limitations. This paper presents a novel incremental dimensionality reduction technique called Xtreaming, which can continuously update visual representations without revisiting the data.
COMPUTERS & GRAPHICS-UK
(2022)
Article
Computer Science, Interdisciplinary Applications
Martha Dais Ferreira, Gabriel D. Cantareira, Rodrigo F. de Mello, Fernando V. Paulovich
Summary: This paper introduces neural network training fingerprint (NNTF), a visual analytics approach to investigate the training process of any neural network performing classification. NNTF can help understand how classification decisions change along the training process, displaying information about convergence, oscillations, and training rates. Its usefulness is demonstrated through case studies and its ability to support the analysis of training parameters.
JOURNAL OF VISUALIZATION
(2022)
Article
Materials Science, Biomaterials
Thalita J. Bondancia, Andrey Coatrini Soares, Mario Popolin-Neto, Nathalia O. Gomes, Paulo A. Raymundo-Pereira, Hernane S. Barud, Sergio A. S. Machado, Sidney J. L. Ribeiro, Matias E. Melendez, Andre L. Carvalho, Rui M. Reis, Fernando Paulovich, Osvaldo N. Oliveira Jr
Summary: In this study, an immunosensor was developed for the detection of the cancer biomarker p53 antigen in MCF7 lysates. The immunosensor showed high sensitivity and selectivity, and a supervised machine learning approach based on decision trees was used for sample classification.
BIOMATERIALS ADVANCES
(2022)
Article
Chemistry, Analytical
Daniel C. Braz, Mario Popolin Neto, Flavio M. Shimizu, Acelino C. Sa, Renato S. Lima, Angelo L. Gobbi, Matias E. Melendez, Lidia M. R. B. Arantes, Andre L. Carvalho, Fernando Paulovich, Osvaldo N. Oliveira Jr
Summary: This study demonstrates the potential of using data from an electronic tongue to diagnose oral cancer through machine learning algorithms. Supervised learning techniques can distinguish between healthy individuals and oral cancer patients, with an accuracy above 80%.
Article
Engineering, Environmental
Andrey Coatrini-Soares, Juliana Coatrini-Soares, Mario Popolin Neto, Suelen Scarpa de Mello, Danielle Dos Santos Cinelli Pinto, Wanessa Araujo Carvalho, Michael S. Gilmore, Maria Helena Oliveira Piazzetta, Angelo Luiz Gobbi, Humberto de Mello Branda, Fernando Vieira Paulovich, Osvaldo N. Oliveira Jr, Luiz Henrique Capparelli Mattoso
Summary: An electronic tongue based on impedance spectroscopy was developed to detect Staphylococcus aureus and diagnose bovine mastitis. The sensing units were optimized with layer-by-layer films and the capacitance data was processed using machine learning algorithms. The combination of electronic tongues and machine learning showed promising results for the low-cost diagnosis of mastitis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Computer Science, Software Engineering
A. Chatzimparmpas, F. Paulovich, A. Kerren
Summary: Despite advances in machine learning, imbalanced data still poses challenges. This paper presents HardVis, a visual analytics system designed to handle instance hardness in imbalanced classification scenarios. It allows users to visually compare data distributions, select instances based on local characteristics, and validate undersampling or oversampling techniques for the ML model.
COMPUTER GRAPHICS FORUM
(2023)
Article
Ecology
Lais Petri, Evelyn M. Beaury, Jeffrey Corbin, Kristen Peach, Helen Sofaer, Ian S. Pearse, Regan Early, David T. Barnett, Ines Ibanez, Robert K. Peet, Michael Schafale, Thomas R. Wentworth, James P. Vanderhorst, David N. Zaya, Greg Spyreas, Bethany A. Bradley
Summary: The movement of plant species across the globe exposes native communities to new species introductions. While introductions are pervasive, variability exists in the invasiveness of introduced species across different locations, impacting ecosystems to varying degrees. Understanding these phenomena is crucial for accurately interpreting patterns of plant invasion and the diverse outcomes observed in the literature.
Article
Materials Science, Multidisciplinary
Andre L. Oliveira, Amanda de S. M. de Freitas, Jessica S. Rodrigues, Karina P. P. do Carmo, Marystela Ferreira, Vagner R. R. Botaro
Summary: By adding tannin from black wattle to polystyrene, the photodegradation process can be significantly reduced. The film with 5% tannin additive showed the highest antioxidant protection among all compositions, indicating its potential application in the packaging market.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Lucas Felipe de Lima, Andre Lopes Ferreira, Amanda de Sousa Martinez de Freitas, Jessica de Souza Rodrigues, Ana Paula Lemes, Marystela Ferreira, William Reis de Araujo
Summary: This study reports a novel biodegradable composite material based on PHBV:Ecoflex and graphite microparticles for sensitive and selective electrochemical detection of CK-MB. The material exhibited a homogeneous and synergistic distribution of graphite microparticles, providing high electrical conductivity and electron transfer kinetics. Portable and disposable devices using electrochemical impedance spectroscopy (EIS) were able to detect CK-MB in a relevant clinical concentration range. The method showed good selectivity and accuracy, and the devices demonstrated potential for rapid and decentralized tests of AMI.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Ecology
Ines Ibanez, Lais Petri, David T. Barnett, Evelyn M. Beaury, Dana M. Blumenthal, Jeffrey D. Corbin, Jeffrey Diez, Jeffrey S. Dukes, Regan Early, Ian S. Pearse, Cascade J. B. Sorte, Montserrat Vila, Bethany Bradley
Summary: Invasive species science has historically focused on the invasive agent, while neglecting the vulnerability of resident communities to invasion impacts. This study introduces an analytical framework that accounts for factors acting across scales to quantify the scale-dependent impact of biological invasions on native richness. By analyzing vegetation data from the U.S. National Ecological Observatory Network, the researchers found that native richness was compromised only at high levels of non-native plant cover. Additionally, colder and wetter ecoregions were found to be most vulnerable at the local level, while warmer and wetter regions were most susceptible at the landscape level.
ECOLOGICAL APPLICATIONS
(2023)
Article
Computer Science, Cybernetics
Sherlon Almeida da Silva, Evangelos E. Milios, Maria Cristina F. de Oliveira
Summary: Users have positive views on the potential of visual analytics systems in retrieval tasks, but they also face practical difficulties in using it effectively and show considerable variation in their assessment of specific functionalities. This highlights the potential of visual analytics systems and the importance of informing users about the underlying conceptual models and limitations.
INTERACTING WITH COMPUTERS
(2023)
Article
Biochemistry & Molecular Biology
Jessica S. Rodrigues, Amanda de S. M. Freitas, Henrique S. M. Lopes, Ariane A. F. Pires, Ana Paula Lemes, Marystela Ferreira, Vagner R. Botaro
Summary: This study investigates the effect of different fractions of kraft lignin on the structure and performance of thermoplastic starch (TPS) matrix during photooxidative degradation. Kraft lignin from Eucalyptus urograndis wood was fractionated in ethyl acetate (EtOAc), and the fractions were added to TPS matrix films. The samples were exposed to UV-C light for accelerated aging, and their structural, thermal, morphological, and mechanical properties were analyzed. It was found that the fraction of lignin with higher phenolic hydroxyl group content provided the best photoprotection and stabilizing effect on TPS matrix.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biodiversity Conservation
Lais Petri, Ines Ibanez
Summary: The encroachment of invasive shrubs in forest understories can have detrimental effects on native plant recruitment. Removal of invasive species is a common practice, but long-lasting success is rare. Understanding the mechanisms that drive shrub invasion is crucial for effective conservation and management of invaded forests.
JOURNAL OF APPLIED ECOLOGY
(2023)
Article
Chemistry, Analytical
Stefanny F. Amaro, Cristiane C. Maciel, Jessica S. Rodrigues, Amanda de S. M. de Freitas, Lucas V. B. V. Fre, Anerise de Barros, Marystela Ferreira
Summary: This research aims to study flexible sensors based on a biodegradable polymer PBAT and graphite. The sensors were modified using the layer-by-layer technique to improve their electrochemical behavior for detecting paraquat. Nanostructured films were created by alternating layers of anionic and cationic materials, carbon nanotubes, and polypyrrole. The sensors showed good stability, reproducibility, and repeatability for paraquat detection.
Article
Biotechnology & Applied Microbiology
Juliana Coatrini Soares, Andrey Coatrini Soares, Mario Popolin-Neto, Fernando Vieira Paulovich, Osvaldo N. Oliveira Jr, Luiz Henrique Caparelli Mattoso
Summary: Early diagnosis of cattle diseases, such as mastitis caused by S. aureus, can be effectively achieved through on-site detection methods using immunosensors with high sensitivity. The immunosensors fabricated in this study showed detection limits as low as 2.6 CFU/mL in milk, enabling early detection of mastitis. Additionally, machine learning techniques and rules calibration space were utilized to enhance the selectivity and predictability of the sensors towards various interferents.
SENSORS AND ACTUATORS REPORTS
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
