Article
Chemistry, Inorganic & Nuclear
Sonkeshriya Dhanshri, Suban K. Sahoo
Summary: This study introduces a fluorescent nanoprobe PLP@l-Cyst-Mn-ZnS obtained through post-functionalization of lcysteine capped Mn-doped ZnS quantum dots (l-Cyst-Mn-ZnS QDs) with pyridoxal 5'-phosphate (PLP). The nanoprobe serves as a highly sensitive fluorescent turn-on probe for ALP and ATP, with the ability to accurately quantify their concentrations in human serum and plasma.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Yanxia Song, Siyu Lu, Shihao Sun, Wenting Guo, Junxia Su, Genping Meng, Jun Hai, Baodui Wang
Summary: The study utilized NPCN-222-ATP for the quantitative determination of ALP activity, showing excellent selectivity and sensitivity. It successfully monitored and imaged ATP activity in living cells, offering a new approach for the use of chiral MOFs in biological analysis and detection platforms.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Zhi Zhang, Hwa Kyung Nam, Spencer Crouch, Nan E. Hatch
Summary: TNAP deficiency plays a crucial role in bone and muscle progenitor cells, impacting bone formation, mineralization, and mitochondrial function. TNAP deficiency also results in decreased trabecular bone volume fraction, trabeculation, and muscle coordination deficiencies similar to hypophosphatasia, highlighting the importance of TNAP in influencing mitochondrial respiration and ATP production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Fang Liu, Jundong Zhu, Peipei Dai, Jian Deng, Juan Qin, Zhiguang Yuchi, Aiping Fan, Zheng Wang, Yanjun Zhao
Summary: A hybrid nanocarrier is developed to deliver chemotherapy drugs selectively to tumor cells, reducing off-target adverse effects. The two-step unlocking process enables enhanced intracellular uptake of the drug within tumor cells, promising efficacy enhancement and side-effect reduction in chemotherapeutics.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Pengbo Zhang, Ke Qin, Anand Lopez, Zhengping Li, Juewen Liu
Summary: In this study, a cationic conjugated polymer (CCP)-based binding assay was developed for aptamer binding. The conformational change of aptamer after binding with a target was reflected by the fluorescence change of the CCP. Four aptamers for different targets were characterized, and the longer stem of the stem-loop structured aptamer facilitated target binding and enlarged the detection signal. This label-free and cost-effective method showed high specificity and sensitivity, making it a useful tool for aptamer binding evaluation and target detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yang Xu, Chongqi Zhou, Dongmei Li, Cuixia Guo, Zhangyan Li, Xinhui Xing, Shaoxin Li, Tian Guan, Le Liu, Yonghong He
Summary: In this study, a novel aptamer biosensor based on weak value amplification is proposed, which demonstrates feasibility, selectivity, robustness, and high detection accuracy. The research finds that the aptamer biosensor, utilizing weak value amplification, offers precise and specific detection of biological molecules.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Han-Wen Zhang, Qian-Qian Zhu, Rongrong Yuan, Hongming He
Summary: The UiO-66-NH2@COF composite, constructed through a covalent linking approach, significantly enhances the electrochemical detection performance, showing promising applications in the field.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Li Li, Zheng Zhou, Xinmin Li, Dandan Li, Min Zhao, Changjin Liu, Haiping Wu, Wei Yang, Shijia Ding, Bo Shen
Summary: A novel 3D walking nanomachine-based biosensor utilizing strand displacement for ultrasensitive detection of ATP was successfully developed, demonstrating a low limit of detection and practical application in human serum samples. This biosensing strategy holds great potential for biochemical studies and clinical diagnosis.
Article
Chemistry, Analytical
Fuchun Si, Yaping Zhang, Jing Lu, Mengyuan Hou, Huaixia Yang, Yanju Liu
Summary: Alkaline phosphatase (ALP) is an important enzyme with significant implications in biomedical research and clinical diagnosis. A novel electrochemical biosensor based on photoinduced atom transfer radical polymerisation (photoATRP) has been developed for the analysis of ALP. This biosensor demonstrates a wide linear range, low detection limits, and excellent selectivity and interference resistance in human serum samples.
Article
Chemistry, Analytical
Shuhao Hu, Yuting Liu, Liu Liu, Zhenzhong Yu, Ning Gan
Summary: In this study, an ultrasensitive photoelectrochemical bioanalysis was developed using endogenous adenosine triphosphate (ATP) to measure Escherichia coli O157:H7 in food. Through the synergy of two signal amplification mechanisms, accurate detection of E. coli O157:H7 was achieved.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Yufen Lai, Mengyan Li, Xiaofei Liao, Li Zou
Summary: In this study, a DNAzyme-regulated CRISPR/Cas12a cascade signal amplification strategy was developed for sensitive and selective detection of ALP activity and inhibition. The proposed method overcomes the shortcomings of conventional methods and shows great potential in clinical diagnosis and biomedical research.
ANALYTICA CHIMICA ACTA
(2022)
Article
Immunology
Chenzhe Gao, Marwa Yagoub Farag Koko, Mingxing Ding, Weichen Hong, Jianping Li, Na Dong, Mizhou Hui
Summary: This study investigated the effects of intestinal alkaline phosphatase (IAP) in controlling intestinal inflammation and alleviating associated insulin resistance (IR). The researchers found that IAP can be used as a natural anti-inflammatory agent to reduce intestinal inflammation-induced IR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biophysics
Xianfeng Wang, Shiying Zhou, Chengxiang Chu, Mei Yang, Danqun Huo, Changjun Hou
Summary: An ultra-sensitive ALP sensing strategy (TITAC-Cas) is developed using target-induced transcription amplification to trigger the trans-cleavage activity of Cas13a. This method achieves ultra-sensitive detection of ALP activity with a wide linear range through triple signal amplification.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Yuanyuan Liu, Bangyan Liu, Lian Xia, Hongyan Yu, Qiaodie Wang, Yuangen Wu
Summary: A novel visual aptamer-based chromatographic strip was developed for rapid paraquat detection, showing good response, low detection limit, stability, and specific selectivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemical Research Methods
Wenbin Wang, Jing Lu, Lulu Hao, Huaixia Yang, Xuejie Song, Fuchun Si
Summary: A novel electrochemical method utilizing aminoferrocene as an electroactive probe for alkaline phosphatase (ALP) activity detection was described in this study. The approach demonstrated good linear relationship and sensitivity in detecting ALP activity, with high selectivity and applicability.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)