Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 160, Issue 1, Pages 441-447Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2011.08.006
Keywords
Biosensor; DNA; Finite-element; Lab-on-chip; Label-free; Simulation
Funding
- Canada Research Chair program
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- S Korean Ministry of Education, Science, and Technology [R31-2008-000-10100-0]
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As the design of label-free DNA biosensors matures, and their sizes reduced to enhance their sensitivity, not much has been researched about the variations in the received signal with the positioning of the probes on the sensitive surface. We approach this issue computationally in this paper. By adopting the finite-element model on a three-dimensional biological field-effect transistor (BioFET) slice, and running Monte-Carlo simulations on the positions of the DNA molecules, we extract the expected variations in the signal. Then, we show that signal-to-noise (SNR) ratio can be low enough to hinder the functionality of the device, placing a limitation on how low the sensitivity of a sensor of a certain size can be. (C) 2011 Elsevier BM. All rights reserved.
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