Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 159, Issue 1, Pages 142-147Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2011.06.062
Keywords
Glutathione (GSH); Colorimetric; Ratiometric fluorescent; Probe; Piazselenole
Funding
- National Nature Science Foundation of China [20975012]
- 111 Project [B07012]
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A naphthalene derivate containing piazselenole (NDP) has been developed as an example of colorimetric and ratiometric fluorescent probes for glutathione (GSH) at physiologically relevant concentration. Upon addition of GSH, the probe displayed a ratiometric fluorescent response with an enhancement of the ratios of emission intensities at 436 and 615 nm, accompanied with the solution color change from jacinth to colorlessness. The detection range is 0-80 mM with the detection limit of 0.178 mm. moreover, the probe showed good selectivity and satisfying results in the determination of GSH. As the linear response range covers the concentration range of biological samples, the probe may have the potential to determine GSH directly in biological samples in the future. (C) 2011 Elsevier B.V. All rights reserved.
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