Article
Chemistry, Analytical
Satit Rodphukdeekul, Miyuki Tabata, Chindanai Ratanaporncharoen, Yasuo Takeuchi, Pakpum Somboon, Watcharee Boonlue, Yuji Miyahara, Mana Sriyudthsak
Summary: In this study, a quartz crystal microbalance (QCM) immunoassay was demonstrated for quantitative assessment of periodontal bacteria, A. actinomycetemcomitans. The immunosensor constructed using a self-assembled monolayer showed a lower detection limit of 800 cells and a dynamic range up to 2.32 x 10(6) cells. This label-free method provides a sensitive approach for quantitative analysis of periodontal bacteria.
Article
Chemistry, Analytical
Wei Pan, Xianhe Huang, Qiao Chen
Summary: This study theoretically analyzes the impact of different sizes of dot ring and dot double-ring electrodes on the mass sensitivity distribution of the quartz crystal microbalance (QCM), and proposes a dot triple-ring electrode to enhance uniformity. The research provides a new direction for improving the uniformization of QCM mass sensitivity distribution.
ANALYTICAL CHEMISTRY
(2021)
Article
Optics
Mirit Hen, Leroy Dokhanian, Etai Grunwald, Matan Slook, Moshe Katzman, Maayan Priel, Olga Girshevitz, Avi Zadok
Summary: In this work, the analysis of elastic properties of thin layers deposited on surface acoustic wave-photonic devices is proposed and demonstrated. By measuring the changes in the group velocity of surface acoustic waves after deposition of thin layers, estimates for Young's modulus of these layers can be obtained.
Article
Chemistry, Analytical
Di Jiang, Xiaona Zhao, Yi-Nan Liu, Hai-Bo Chen, Wen-Li Lv, Chen Qian, Xian-Wei Liu
Summary: The study introduces a label-free optical imaging technology that can detect molecule binding kinetics by tracking charge-sensitive variations in the oscillation amplitude with sub-nanometer precision, allowing for the measurement of small molecules and metal ions binding to the surface as well as protein-protein binding kinetics. This capability offers a promising platform for screening small-molecule drugs, probing conformational changes in proteins, and detecting environmental pollutants.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Philipp Ortner, Maren Umlandt, Nino Lomadze, Svetlana Santer, Marek Bekir
Summary: The quartz crystal microbalance with dissipation (QCM-D) has been widely used for investigating the external stimuli responsiveness at solid-liquid interfaces. However, in light responsive adsorption investigation, the quartz crystal itself reacts to optical stimulation, which poses challenges in data interpretation. This article introduces a simple guideline for correcting the measurement artifacts and minimizing the impact of light induced detuning (LID).
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Minoru Yoshimoto, Shigeru Kurosawa, Mutsuo Tanaka
Summary: The study found that under different temperatures and oscillation frequencies, the nanoscale dynamics of soft materials can be described linearly by the relationship between resonant length or molecular weight and the logarithm of QCM angular frequency, and converged to a single point independently of temperature within a certain temperature range.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Biochemistry & Molecular Biology
Gergely Stankovits, Agnes Abraham, Eva Kiss, Zoltan Varga, Anil Misra, Andras Szilagyi, Benjamin Gyarmati
Summary: The type and concentration of charged groups in polymers play a crucial role in mucoadhesive interactions. This study investigated the correlation between chemical structure and mucin-polymer interactions by designing cationic poly(amino acid)s with different charge densities. The results showed that the interactions between mucin and polyaspartamides with at least 50% cationic groups displayed a non-linear change, causing increased light scattering. The analysis further revealed that fully cationic polyaspartamide is not necessarily superior, and the maximum adsorbed mass of polymers on mucin occurred at medium cationic group contents. This highlights the importance of cationic polyaspartamides as mucoadhesive excipients due to their multiple functionalities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Sandeep Kumar, Poonam Singh, Sanjay Kumar Verma
Summary: In this study, a novel aptamer candidate for specific and sensitive arsenic detection was identified using Graphene Oxide-SELEX (GO-SELEX). A QCM-based biosensing platform was designed for target-triggered release of aptamer, and the sensor exhibited excellent selectivity.
Article
Chemistry, Physical
Jugal Suthar, Alberto Alvarez-Fernandez, Esther Osarfo-Mensah, Stefano Angioletti-Uberti, Gareth R. Williams, Stefan Guldin
Summary: Extracellular vesicles (EVs) are released from various cell types and contain biomolecular content for health and disease identification. However, the heterogeneity of EVs and complexity of biofluids pose challenges to current analytical approaches. This study explores nanostructuring the sensor electrode surface to enhance detection capabilities and achieves significant improvement.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Sanjeeb Lama, Bong-Gyu Bae, Sivalingam Ramesh, Young-Jun Lee, Namjin Kim, Joo-Hyung Kim
Summary: This study synthesized hybrid composite materials for the detection of chemical warfare agents (CWAs) and evaluated their performance using quartz crystal microbalance (QCM) and surface acoustic wave (SAW) sensors. The findings showed that NGO@MnO2 and NGO@MnO2/PPy demonstrated high sensitivities and repeatability, making them potential candidates for CWA detection.
Article
Polymer Science
Nisha Hollingsworth, Ronald G. Larson
Summary: This study investigates the swelling/deswelling and hysteresis behavior of weakly ionizable polyanion poly(acrylic acid) (PAA) brushes and bilayers containing PAA and poly(ethylene imine) (PEI) using a quartz crystal microbalance with dissipation (QCM-D) system. The results demonstrate that the brush height is influenced by grafting density, chain length, ion charge distribution, and pH value, leading to hysteresis phenomena under different conditions. The findings highlight the complex thermodynamics and kinetics of polyelectrolyte films, even at the monolayer and bilayer level.
Article
Chemistry, Analytical
Vasiliy S. Chernyshev, Mikhail Skliar
Summary: This article introduces a method for quantifying extracellular vesicles (EVs) using a quartz crystal microbalance (QCM) as a biosensor. This method has the advantages of high sensitivity, small sample volume, and low cost, and is of great importance for research in cell-to-cell signaling, disease modeling, and drug development.
Article
Chemistry, Physical
Sanjeeb Lama, Sumita Subedi, Sivalingam Ramesh, Kyeongho Shin, Young-Jun Lee, Joo-Hyung Kim
Summary: A hybrid nanostructured composite was synthesized to detect simulant of nerve agents. The MnO2@CE/PPy composite showed high sensitivity, excellent linearity, and reversible adsorption and desorption phenomenon.
Article
Chemistry, Analytical
Ieva Plikusiene, Ernesta Buzavaite-Verteliene, Vincentas Maciulis, Audrius Valavicius, Almira Ramanaviciene, Zigmas Balevicius
Summary: Low-cost 1D plasmonic photonic structures were used to enhance the optical signal of a modified quartz crystal microbalance with dissipation (QCM-D) sensor chip, achieving significant improvements in refractive index sensitivity compared to standard spectroscopic ellipsometry. The sensitivity of Tamm plasmon polaritons and cavity modes in optical biosensing signal readout is comparable to or even higher than that of the standard QCM-D sensor chip. The different origins of Tamm plasmon polaritons (TPP) and cavity mode (CM) offer further advantages in determining the dominating process on the sensing surface.
Article
Polymer Science
Charlotte Frost, Sandra Wiedbrauk, Elizabeth Graham, Nageshwar R. Yepuri, Andrew R. J. Nelson, Nathan R. B. Boase
Summary: Amphipathic copolymers are synthesized and studied for their interactions with model lipid membranes using complementary techniques. The results show that these materials can interact with Langmuir lipid monolayers, and neutron reflectometry confirms the intercalation of polymers with the monolayers due to hydrophobic interactions. In situ quartz crystal microbalance (QCM) model is used to study more complex models of lipid bilayers, and it is found that the composition and hydrophobic comonomer affect the stability of these interactions, but have no effect on the viscoelasticity of the lipid membranes. This in-depth understanding of the interfacial interactions is crucial for further research on complex copolymers in nanomedicine, providing insights into important processes such as cellular entry and endosomal escape.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Microbiology
David Chauvin, Michael Hust, Mark Schuette, Adelaide Chesnay, Christelle Parent, Gustavo Marcal Schmidt Garcia Moreira, Javier Arroyo, Ana Belen Sanz, Martine Pugniere, Pierre Martineau, Jacques Chandenier, Nathalie Heuze-Vourch, Guillaume Desoubeaux
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Immunology
Jerome Granel, Roxane Lemoine, Eric Morello, Yann Gallais, Julie Mariot, Marion Drapeau, Astrid Musnier, Anne Poupon, Martine Pugniere, Seda Seren, Dalila Nouar, Valerie Gouilleux-Gruart, Herve Watier, Brice Korkmaz, Cyrille Hoarau
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Chemistry, Medicinal
Florie Desriac, Abderrafek El Harras, Matthieu Simon, Arnaud Bondon, Benjamin Brillet, Patrick Le Chevalier, Martine Pugniere, Patrice Got, Delphine Destoumieux-Garzon, Yannick Fleury
Article
Immunology
Coraline Cheneau, Karsten Eichholz, Tuan Hiep Tran, Thi Thu Phuong Tran, Oceane Paris, Corinne Henriquet, Jeffrey J. Bajramovic, Martine Pugniere, Eric J. Kremer
Summary: Despite limited understanding of our innate immune response to human adenoviruses (HAdVs) and their vectors, this study found that lactoferrin can redirect HAdV types and induce an NLRP3-associated response in human phagocytes, impacting the immunogenicity of HAdVs and potentially enhancing the efficacy of HAdV-based vectors/vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Floriane Gibault, Manon Sturbaut, Mathilde Coevoet, Martine Pugniere, Ashley Burtscher, Frederic Allemand, Patricia Melnyk, Wanjin Hong, Brian P. Rubin, Ajaybabu V. Pobbati, Jean-Francois Guichou, Philippe Cotelle, Fabrice Bailly
Summary: Synthesized compounds were found to inhibit the activity of the YAP/TAZ-TEAD complex, with some displaying cytotoxic effects on cells. Despite this, they serve as promising starting points for the development of effective YAP-TEAD disruptors in the future.
Article
Chemistry, Medicinal
Manon Sturbaut, Fabrice Bailly, Mathilde Coevoet, Pasquale Sileo, Martine Pugniere, Maxime Liberelle, Romain Magnez, Xavier Thuru, Marie-Christine Chartier-Harlin, Patricia Melnyk, Muriel Gelin, Frederic Allemand, Jean-Francois Guichou, Philippe Cotelle
Summary: The Hippo pathway regulates organ size and tissue homeostasis through controlling cell growth, proliferation, and apoptosis. Dysregulation of YAP, TAZ, and TEADs in cancer makes YAP/TAZ-TEAD interaction a new emerging anti-cancer target. Compound 6 is the first inhibitor of YAP/TAZ-TEAD targeting interface 2 and has the potential to inhibit cell proliferation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Virology
Karsten Eichholz, Tuan Hiep Tran, Coraline Cheneau, Thi Thu Phuong Tran, Oceane Paris, Martine Pugniere, Eric J. Kremer
Summary: This study examines the interactions between danger-associated molecular patterns and human adenoviruses and their impact on vaccines. The interaction between human adenoviruses and HNP-1 can modify the response of antigen-presenting cells, influencing vaccine efficacy. HNP-1 binds to the capsids of human adenoviruses and directs them to Toll-like receptor 4 (TLR4), leading to internalization, inflammasome response, and IL-1β release.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Raquel Gutierrez-Climente, Margaux Clavie, Jeremie Gouyon, Giang Ngo, Yoann Ladner, Pascal Etienne, Pascal Dumy, Pierre Martineau, Martine Pugniere, Catherine Perrin, Gilles Subra, Ahmad Mehdi
Summary: The immobilization of novel silylated amino acid derivatives onto SBA-15 materials under biocompatible conditions yielded amino acid-functionalized materials with improved enzyme adsorption properties. Characterization of the resulting materials revealed differences in physical properties while maintaining structural integrity. The presence of various functional groups on the modified materials led to enhanced enzyme adsorption compared to bare SBA-15, showing potential for developing stable and cost-effective biocatalysts.
Article
Multidisciplinary Sciences
Stella Cesari, Yuxuan Xi, Nathalie Declerck, Veronique Chalvon, Lea Mammri, Martine Pugniere, Corinne Henriquet, Karine de Guillen, Vincent Chochois, Andre Padilla, Thomas Kroj
Summary: This study demonstrates that the recognition spectrum of plant nucleotide-binding and leucine-rich repeat domain proteins (NLRs) can be extended to new pathogen effectors through molecular engineering. By introducing specific binding residues into the integrated decoy domain (ID) of an NLR, the researchers created a high-affinity binding surface for a new effector, providing proof of concept for designing new effector recognition specificities in NLRs.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Philippe Billiald, Alexandre Slater, Martin Welin, Joanne C. Clark, Stephane Loyau, Martine Pugniere, Isabella G. Jiacomini, Nadia Rose, Kristell Lebozec, Elie Toledano, Deborah Francois, Steve P. Watson, Martine Jandrot-Perrus
Summary: This study shows that glenzocimab, a humanized antibody fragment, blocks the binding of GPVI to vascular collagen and fibrin through steric hindrance and structural change. This finding is significant for the development of new antiplatelet molecules with a low bleeding risk.
Article
Chemistry, Multidisciplinary
R. Gutierrez-Climente, G. Ngo, M. Clavie, J. Gouyon, Y. Ladner, P. Etienne, P. Dumy, C. Perrin, A. Mehdi, P. Martineau, M. Pugniere, G. Subra
Summary: This study presents a method for preparing bio-mimetic and functionalized protein imprints without protein denaturation in biocompatible conditions. The imprints were made almost entirely of amino acids to mimic the paratope surfaces of antibodies. The resulting hybrid materials showed high adsorption capacity, specificity, and selectivity, representing a significant breakthrough in sol-gel-based molecular imprinting materials.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Christophe Dumet, Martine Pugniere, Corinne Henriquet, Valerie Gouilleux-Gruart, Anne Poupon, Herve Watier
Summary: Monoclonal antibodies with improved half-life properties can be generated using a machine learning approach by training algorithms with a dataset of Fc variants affecting the affinity for FcRn. The best prediction was achieved with a support vector regressor using six features, with an error of less than 0.17 on log(K-D). This approach provides a potential avenue for discovering novel antibody variants with improved pharmacokinetic properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Malvina Schatz, Laetitia Marty, Camille Ounadjela, Phuoc Bao Viet Tong, Ilaria Cardace, Clement Mettling, Pierre-Emmanuel Milhiet, Luca Costa, Cedric Godefroy, Martine Pugniere, Jean-Francois Guichou, Jean-Michel Mesnard, Mickael Blaise, Bruno Beaumelle
Summary: A tripartite complex consisting of Tat, CypA, and CA was found to be assembled in HIV-1-infected cells, allowing Tat to be encapsidated into HIV virions. Encapsidated Tat is required for efficient viral transcription and enhanced infectivity.
JOURNAL OF VIROLOGY
(2023)
Article
Neurosciences
Adrien Tassou, Maxime Thouaye, Damien Gilabert, Antoine Jouvenel, Jean-Philippe Leyris, Corinne Sonrier, Lucie Diouloufet, Ilana Mechaly, Sylvie Mallie, Juliette Bertin, Myriam Chentouf, Madeline Neiveyans, Martine Pugniere, Pierre Martineau, Bruno Robert, Xavier Capdevila, Jean Valmier, Cyril Rivat
Summary: Acute pain can lead to chronic pain, and the FLT3-tyrosine kinase receptor plays a crucial role in pain chronification after peripheral nerve injury. This study aimed to investigate whether injury-induced pain sensitization can also contribute to long-term mood disorders. The results showed that mice with double paw incisions exhibited an anxiodepressive-like phenotype and increased pain sensitivity compared to those with single incisions. These behavioral changes were associated with peripheral and spinal changes, including increased microglia activation. Blocking FLT3 and microglia activation alleviated the exaggerated pain sensitivity and anxiodepressive behaviors induced by double incisions. Humanized antibodies against FLT3 also reduced behavioral and microglia changes. Overall, this study suggests that peripheral lesions can not only cause exaggerated pain behaviors but also induce anxiodepressive disorders, and targeting peripheral FLT3 may provide a potential therapeutic approach.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Immunology
Thomas Cnudde, Zineb Lakhrif, Justine Bourgoin, Fanny Boursin, Catherine Horiot, Corinne Henriquet, Anne di Tommaso, Matthieu Olivier Juste, Isabella Gizzi Jiacomini, Isabelle Dimier-Poisson, Martine Pugniere, Marie-Noelle Mevelec, Nicolas Aubrey
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
