Review
Chemistry, Analytical
Seunghun Lee, Hyerin Song, Heesang Ahn, Seungchul Kim, Jong-ryul Choi, Kyujung Kim
Summary: This article discusses the latest research methods and experimental results of fiber-optic LSPR sensors, confirming their potential applications in the fields of chemistry, physics, and biology with the ability to achieve high sensitivity target measurements.
Article
Chemistry, Analytical
Hong Lei, Shenghu Zhu, Chang Liu, Wei Zhang, Chong Chen, Hui Yan
Summary: In this study, the signal strength of a localized surface plasmon resonance (LSPR) biosensor based on optical fiber end-face was enhanced by designing an AuNP multimer structure. The biosensor showed higher sensitivity and lower limit of detection compared to biosensors with AuNPs alone. This strategy can be applied in the research and development of various biosensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Nanoscience & Nanotechnology
Zilun Tang, Jianyu Wu, Xiaofeng Yu, Rui Hong, Xihong Zu, Xiaofeng Lin, Hongsheng Luo, Wenjing Lin, Guobin Yi
Summary: AuNP arrays on SMPU substrates were used for tunable LSPR, with LSPR increasing with negative bending and decreasing with positive bending. Mechanical uniaxial tension led to an initial increase followed by a decrease in LSPR. The resulting films showed excellent performance in SERS applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Electrical & Electronic
Bharathi Raj Muthu, Ewins Pon Pushpa, Vaithiyanathan Dhandapani, Anuj K. Sharma
Summary: This study investigates the potential of an Si-SiO2-ZnO-Au nanoparticles (NPs) structure based plasmonic multilayer FET design for sensing applications. The effects of design parameters such as the diameter of Au NPs, obliqueness of light incidence, and spacing between Au NPs on the sensor's sensitivity are studied. The incorporation of 3-mercapto propionic acid (3-MPA) with Au NPs is also examined for increased sensitivity. The results show that the size of NPs and angle of light incidence have a coupled effect on the sensitivity.
OPTICAL AND QUANTUM ELECTRONICS
(2022)
Article
Chemistry, Physical
Mengwei Gao, Yuanbo Song, Yidan Liu, Wentao Jiang, Jianchao Peng, Liyi Shi, Rongrong Jia, Yaseen Muhammad, Lei Huang
Summary: In this study, a novel approach was proposed to fabricate Au@MnO2 core/shell assembled nanosheets utilizing the localized surface plasmon resonance (LSPR) effect of gold nanoparticles. The reduction of KMnO4 to MnO2 on Au NPs under 520 nm light resulted in the gradual assembly into thin sheeted morphology. The significance of irradiation conditions and surface functional groups, particularly the 520 nm light and citrate group, in the formation of stable Au@MnO2 core-shell assembled nanosheets was systematically studied. The controllable, green, and facile nature of this approach allows for its extension to synthesize other complex nanomaterials for various applications.
APPLIED SURFACE SCIENCE
(2021)
Article
Biophysics
Jin Wang, Dan Luo, Yandi Cai, Xiang-Ling Li, Hong-Yuan Chen, Jing-Juan Xu
Summary: In this study, an ingenious gold-silver Janus plasmonic nanoprobe was developed for the detection of intracellular hydrogen sulfide (H2S). The nanoprobe exhibited good anti-interference capability, low detection limit, and the ability to monitor real-time variations of H2S in cells. This work provides a promising tool for studying H2S-related biological processes.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Zetao Chen, Fenni Zhang, Yaru Li, Jianzhen Shan, Yanli Lu, Qingjun Liu
Summary: The analysis of reactant at different regions of the bioreaction interface is important for studying the impact of interface conditions on bioreactions. In this study, a localized surface plasmon resonance (LSPR) biosensing platform was proposed for monitoring local charge density and detecting corresponding analytes. The researchers synthesized core-shell nanocomposites and modified tin-doped indium oxide (ITO) substrates for optical and electrochemical measurements. By immobilizing glucose oxidase (GOD) on the LSPR chips, the researchers demonstrated monitoring of charge transfer during the bioreaction of glucose catalysis. The charge density of the LSPR chip was detected using optical extinction peak shifts.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Yun Wang, Jia Jia, Jie Zhang, Ruixue Xiao, Wenjia Xu, Yuhua Feng
Summary: This work reports the colloidal synthesis of extraordinary bridged Au core-satellite structures by exploiting the buffer effect of polydopamine shell on Au core for Au atom diffusion, in which the Au bridge is well controlled in terms of width and length. Benefiting from the tunable Au bridges, the resonance energy of the CTP can be readily controlled. As a result, the LSPR absorptions of the core-satellite structures are continuously tuned within the NIR spectral range (from 900 to >1300 nm), demonstrating their great potentials for ultrafast nano-optics and biomedical applications.
Article
Engineering, Electrical & Electronic
Devi Taufiq Nurrohman, Nan-Fu Chiu
Summary: Gold nanoparticles (AuNPs) have unique properties and are widely used. This study investigates the signal characteristics of AuNPs-based localized surface plasmon resonance (LSPR) immunosensor through theoretical and experimental approaches. Simulation results show that the particle distance and the presence of dielectric material greatly affect the extinction and scattering spectra, while experimentally, the detection range of the sensor is limited by the enhanced electric field and the occurrence of the Hook effect at higher concentrations.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Zhao Li, Jiangzhi Zi, Xue Luan, Yueqi Zhong, Minghan Qu, Yuzhe Wang, Zichao Lian
Summary: Combining metal nanoparticles with localized surface plasmon resonance (LSPR) with metal-organic framework (MOF)-based photocatalysts is an effective way to enhance the separation of electron-hole pairs. In this study, Au@NH2-UiO-66/CdS composites were synthesized by encapsulating Au nanoparticles with LSPR into NH2-UiO-66 nanocages and growing CdS nanoparticles on the surface. The composites exhibited higher photocatalytic activity in hydrogen evolution reaction compared to NH2-UiO-66/CdS and CdS alone under visible-light irradiation. The study also revealed the important role of MOF in transferring electrons and receiving hot electrons generated from plasmonic Au in Au@MOF/CdS composites to enhance the photocatalytic performance.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Devendra Bhandari, Fur-Chi Chen, Roger C. Bridgman
Summary: This study developed a method utilizing magnetic nanoparticles and surface plasmon resonance for rapid detection of Salmonella. The results showed that the sequential two-step sandwich assay and preincubation one-step sandwich assay had higher detection signals compared to the direct assay, with detection limits reaching a high level.
Article
Biotechnology & Applied Microbiology
Jingru Liang, Hang Dong, Fei Xu, Baowei Li, Haimei Li, Limei Chen, Mei Li, Yingchu Liu, Guosheng Jiang, Jinhua Dong
Summary: In this study, a monoclonal antibody named ESC9 was developed, and an immunosensor called ESC9 Quenchbody (Q-body) was generated for rapid and sensitive detection of estradiol. The ESC9 Q-body showed potential for clinical applications due to its excellent detection speed and sensitivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Roshni S. Babu, Hamish R. Colenso, Gideon J. Gouws, Baptiste Auguie, Ciaran P. Moore
Summary: This study investigated Ag-Au bimetallic surface plasmon resonance (SPR) sensors in the Kretschmann configuration. Ag-based sensors have high sensitivity but poor stability, while the addition of an Au capping layer improves chemical resistance and analyte bonding. Numerical modeling and experiments evaluated sensors with different Ag-Au thickness ratios, showing that the best SPR response was achieved with 45 nm Ag and 5 nm Au. The fabricated Ag-Au sensors were characterized, and the results were compared to single-layer Ag and Au sensors. The sensitivity of the thickness-optimized bimetallic layer was 1.5 times higher than that of the single-layer Au sensor.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Fatemeh Maleki, Mohammad-Reza Rashidi, Habib Razmi, Marjan Ghorbani
Summary: A novel electrochemical immunosensor based on immobilization of monoclonal antibody on PAN/Zein-rGO nanofibers was developed for ultrasensitive determination of IGF-1. The PAN/Zein nanofibers provided flexibility and high specific surface area, while rGO nanoparticles improved detection sensitivity and anti-IGF-1 immobilizing. The proposed method showed good selectivity, stability, reproducibility, and acceptable results in the analysis of IGF-1 in human plasma samples.
Article
Chemistry, Analytical
Jingon Yoo, Soobin Han, Bumjun Park, Sonam Sonwal, Munirah Alhammadi, Eunsu Kim, Sheik Aliya, Eun-Seon Lee, Tae-Joon Jeon, Mi-Hwa Oh, Yun Suk Huh
Summary: The developed peptide-coated gold nanoparticles (AuNPs) based on localized surface plasmon resonance (LSPR) sensor chips have demonstrated high sensitivity and selectivity for detecting fipronil. The sensor offers features such as rapid analysis, cost-effectiveness, and the potential for mass production, making it a promising on-site detection tool for fipronil estimation.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)