Article
Polymer Science
Haonan Wang, Qian Li, Yongchao Jiang, Xiaofeng Wang
Summary: This study designed gelatin-based hydrogels loaded with chondroitin sulfate (CS) to regulate the angiogenesis behaviors of endothelial cells (ECs). The hydrogels exhibited excellent biocompatibility and hemocompatibility, and significantly promoted ECs angiogenesis behaviors. However, excessive loading of CS weakened the effect.
Article
Polymer Science
Tien Thinh Nguyen, Le Hang Dang, Phuong Nguyen, Truc Le-Buu Pham, Hai Khoa Le, Minh-Ty Nguyen, Tran Thi Yen Nhi, Sijia Feng, Jun Chen, Ngoc Quyen Tran
Summary: Hydrogels with bone biomimetic microenvironment are prepared using biopolymer and biphasic calcium phosphate nanoparticles, which have great potential for bone-graft materials development.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Yaqi Zhao, Yan Li, Tianchan Lan, Baowei Wang, Ming Huang, He Huang, Changming Qiao, Jingxin Sun
Summary: The physicochemical properties and microstructure of hybrid hydrogels prepared using sodium alginate and chondroitin sulfate extracted from two animal sources were investigated. The results showed that the addition of different sources of sulfate greatly influenced the properties and microstructure of the hydrogels.
Article
Polymer Science
Rubina Qaiser, Fahad Pervaiz, Hanasul Hanan, Hina Shoukat, Muhammad Nadeem
Summary: In this research, a mucoadhesive hydrogel loaded with captopril was developed using chondroitin sulfate (CHS), polyvinylpyrrolidone (PVP), and 2-acrylamide-2-methylpropane sulphonic acid (AMPS). The hydrogel showed efficient sustained release of the drug and demonstrated enhanced mucoadhesive characteristics. The study also analyzed the influence of different formulation ingredients and quantities on the swelling behavior and mucoadhesion capacity of the hydrogel. The findings suggest that this CHS/PVP-co-poly (AMPS)-based hydrogel system is a viable option for sustained delivery of captopril.
Article
Polymer Science
Batuhan Unver, Onder Pekcan, Gulsen Akin Evingur
Summary: The aim of this study was to investigate the effects of drying, swelling, elastic properties, and optical band gap energies on the performance of PNIPAm-MWCNTs and PNIPAm-GO composites. The composites were prepared through free radical crosslinking copolymerization. Drying and swelling were analyzed using steady state fluorescence technique, while elastic properties and optical band gap energies were calculated using various models and spectroscopy. The findings showed that the composites with different contents of MWCNTs and GO exhibited different desorption coefficients, diffusion coefficients, modulus, and band gap values.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shengsheng He, Huijuan Li, Baiyi Chi, Xingjiang Zhang, Yuzhe Wang, Jianxin Wu, Qing Huang
Summary: The main challenge in the field of 3D biomimetic skin is to find a suitable hydrogel matrix that can support the adhesion and proliferation of skin cells. In this study, a photo-crosslinked dual-component hydrogel matrix was constructed using photocurable chondroitin sulfate methacrylate (CSMA) and collagen methacrylate (CoLMA). The hydrogel showed improved mechanical properties and good biocompatibility, making it a promising matrix for constructing 3D biomimetic skin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Engineering, Biomedical
Yan Zhou, Min Ye, Hongyu Zhao, Xiaopu Wang
Summary: In this work, thermosensitive poly-N-acryloyl glycinamide (PNAGA) hydrogels-based microrobots were developed using two-photon polymerization printing technology. The performance of thermosensitivity in relation to N-acryloyl glycinamide (NAGA) concentration was investigated and the swelling behavior of PNAGA-100 was found to be the highest among all PNAGA hydrogels at 45 degrees C. These PNAGA-100-based thermosensitive hydrogels also showed higher drug release amount at 45 degrees C, indicating their potential for drug delivery. Furthermore, the PNAGA-100-based thermosensitive microrobots were able to swim along a specified path under magnetic actuation after incubation with Fe@ZIF-8 crystals.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Engineering, Biomedical
Yansha Qiao, Qian Zhang, Qian Wang, Yan Li, Lu Wang
Summary: This study introduced a hydrogel layer with anti-inflammatory effects anchored on PP mesh, which significantly reduced inflammation and promoted tissue regeneration. The hydrogel layer inhibited immunological attack through a biomimetic microenvironment and served as an effective scavenger for reducing pro-inflammatory factors. This innovative approach has potential applications in hernia repair and the design of other anti-inflammatory implants.
ACTA BIOMATERIALIA
(2021)
Article
Biotechnology & Applied Microbiology
Sandra Escalante, Gustavo Rico, Jose Becerra, Julio San Roman, Blanca Vazquez-Lasa, Maria Rosa Aguilar, Ivan Duran, Luis Garcia-Fernandez
Summary: Articular cartilage is an important avascular tissue that provides support, shock absorption, and facilitates joint motion. Current surgical treatments for cartilage damage have limitations in restoring fully functional cartilage. This study presents the development of hydrogels based on hyaluronic acid and chitosan loaded with chondroitin sulfate, which have the potential to improve the microfracture procedure and promote the colonization of articular cartilage by chondrocytes. These hydrogels act as delivery systems for chondroitin sulfate and have mucoadhesive properties, making them promising for next-generation therapies against articular cartilage damage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Ya Zhang, Zi-Li Wang, Ze-Peng Deng, Zi-Lin Wang, Fei Song, Li-Li Zhu
Summary: Diabetes often leads to difficult-to-heal wounds, but platelet rich plasma (PRP) has great potential for diabetic wound treatment. An injectable, self-healing, and non-specific tissue-adhesive hydrogel was designed as an encapsulation and delivery platform for PRP. The hydrogel inhibits PRP enzymolysis and enables sustained release of growth factors, which enhances cell proliferation and migration in vitro, and accelerates healing of full thickness wounds of diabetic skins in vivo.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Shumin Wang, Xiaoguo Ji, Shumin Chen, Chunyue Zhang, Yibing Wang, Haodong Lin, Liming Zhao
Summary: A novel hemostatic dressing, Me-CMC/CSS, developed using thiol-ene click chemistry, showed rapid water absorption and transformation into soft hydrogels for wound sealing. The dressing achieved good hemostasis with significantly reduced blood clotting index and total blood loss in a rat liver hemorrhage model compared to untreated or gelatin sponge-treated groups. The excellent platelet adhesion ability of Me-CMC/CSS dressing suggests its potential application as a rapid hemostatic material.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Vincenzo Ruzzi, Stefano Buzzaccaro, Roberto Piazza
Summary: The weak absorption of a laser beam in a fluid generates an inhomogeneous refractive index profile, acting as a negative lens. This effect, known as Thermal Lensing (TL), is widely used in sensitive spectroscopic techniques and all-optical methods for assessing thermal properties of fluids. Using the Lorentz-Lorenz equation, we demonstrate that the TL signal is directly proportional to the sample's thermal expansivity alpha, enabling high sensitivity detection of density changes in a small volume using a simple optical setup. We applied this method to investigate the compaction of PniPAM microgels during their volume phase transition temperature and the temperature-driven formation of poloxamer micelles, observing a significant peak in the solute contribution to alpha for both structural transitions.
Article
Materials Science, Multidisciplinary
Jiarui Lu, Ruoman Xu, Yanan Chen, Laiting Chan, Xin Feng, Lichieh Lin, Yichen Yao, Xiaoli Hu, Xiaolei Zhang
Summary: This study developed a thermosensitive hybrid hydrogel scaffold based on collagen and chondroitin sulfate, which showed promising results in promoting bone regeneration. In both in vitro and in vivo evaluations, the presence of the hydrogel enhanced osteogenic differentiation and mineralization, leading to improved healing of bone defects, even in the case of genetically impaired osteogenesis.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Seongwon Lee, Joohee Choi, Jina Youn, Younghun Lee, Wooyoup Kim, Seungho Choe, Jeongeun Song, Rui L. Reis, Gilson Khang
Summary: This study investigated a ternary hydrogel composed of gellan gum, silk fibroin, and chondroitin sulfate as a biomaterial for cartilage tissue engineering. The hydrogel showed enhanced mechanical properties with higher gellan gum content, but exhibited harsh conditions for cell encapsulation at certain concentrations. The ternary hydrogel exhibited positive cell growth and expression of cartilage-specific ECM and genes, indicating its potential for promoting articular cartilage defect repair in cartilage tissue engineering.
Article
Polymer Science
Karina L. Bierbrauer, Roxana Alasino, Fernando E. Barclay, Eduardo M. Belotti, Hugo H. Ortega, Dante M. Beltramo
Summary: The functional capability of a cross-linked hydrogel composed of sulfated glycosaminoglycans and a cationic cellulose for treating osteoarthritis was demonstrated in experimental animal models. In long-term follow-up after implantation, the hydrogel showed superior safety, permanence, and reduced cartilage damage compared to commercial hyaluronic acid.
Article
Materials Science, Composites
Roopasri Rajamany, Sivakrishna Prakash, Yahya A. Ismail
Summary: The composites of polyaniline and polyvinyl alcohol prepared through in-situ polymerization exhibit high electrical conductivity and superior electrochemical performance as supercapacitor electrode materials. SEM analysis confirms the growth of coral-like nanowires of polyaniline within the polyvinyl alcohol matrix, allowing efficient electrochemical reactions. These composites show excellent stability and specific capacitance, making them promising materials for energy storage applications.
PLASTICS RUBBER AND COMPOSITES
(2022)
Article
Materials Science, Multidisciplinary
Madari Palliyalil Sidheekha, Lijin Rajan, Yahya A. Ismail
Summary: This article presents the reaction driven biomimetic sensing characteristics of a highly electroactive polyaniline/chitosan hybrid film. The SEM analysis, galvanostatic and potentiodynamic methods were used to study the sensing signals generated by the hybrid film in different chemical reaction environments.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Engineering, Electrical & Electronic
Jung Gi Choi, Geoffrey M. Spinks, Seon Jeong Kim
Summary: Soft robotics is a promising field that aims to create robot systems with versatile and complex movements similar to natural organisms. In this study, composite fibers made from shape memory polymers and thermo-sensitive hydrogels were used to create various types of actuators such as tensile, torsional, and flexural actuators. The fibers could be programmed and reprogrammed by heating and cooling, and they demonstrated reversible actuation. The optimized fibers showed significant strokes in torsion, bending, and tensile movements, offering a convenient means for generating different actuation types in soft robotics.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Nanoscience & Nanotechnology
Yongwoo Jang, Ji Hwan Moon, Chanho Lee, Sung Min Lee, Heesoo Kim, Gyu Hyeon Song, Geoffrey M. Spinks, Gordon G. Wallace, Seon Jeong Kim
Summary: This article introduces a surface electromyogram (sEMG) device that utilizes nanotechnology to recognize the strength, direction, and degree of muscle movement. By combining sEMG with nanoelectrodes, complementary information can be provided for monitoring human motion.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Eunyoung Kim, Yongwoo Jang, Hyunsoo Kim, Dong Yeop Lee, Jung Gi Choi, Seon Jeong Kim
Summary: DNA artificial muscle can undergo reversible movement under calcium stimulation, similar to the contraction mechanism of natural muscle. This artificial muscle has high work performance and has great potential for biomedical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Materials Science, Biomaterials
Dong Yeop Lee, Yongwoo Jang, Eunyoung Kim, Tao Li, Seon Jeong Kim
Summary: The tissue-engineered vascular graft (TEVG) is a promising alternative for small-diameter blood vessel replacement, and a bioresorbable polyglycolic acid (PGA) fiber-knitted tubular scaffold shows potential as a flexible and durable support for vascular cells. The PGA tubular knit serves as a porous three-dimensional matrix for cell attachment and growth, and it can withstand mechanical damage and maintain suturability.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Multidisciplinary
Tao Li, Yongwoo Jang, Jung Gi Choi, Dong Yeop Lee, Jae Sang Hyeon, Seon Jeong Kim
Summary: In this study, a high water content hydrogel fiber with increased stretchability was developed through biomimetic design. The fiber self-coiled under aqueous conditions, resulting in high water content and stretchability. This has potential implications for various medical applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Wonkyeong Son, Jae Myeong Lee, Sungwoo Chun, Seongjun Yu, Jun Ho Noh, Hyeon Woo Kim, Sung Beom Cho, Seon Jeong Kim, Changsoon Choi
Summary: A facile strategy of electrochemical inner-bundle activation (EIBA) is reported to enhance the properties of CNT yarns. The EIBA-treated yarns exhibit enhanced wettability, improved torsional actuation, and increased capacitance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Lijin Rajan, Aranhikundan Shabeeba, Madari Palliyalil Sidheekha, Yahya A. Ismail
Summary: Conducting polymers can mimic the sensing characteristics of biological muscles. A polyindole-coated polyvinyl alcohol film can respond to changes in temperature and electrical energetic condition.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Aranhikundan Shabeeba, Madari Palliyalil Sidheekha, Lijin Rajan, Yahya A. Ismail
Summary: A polypyrrole/hydrogel hybrid film composed of macromolecular electrochemical machines was fabricated through in situ chemical polymerization of pyrrole. This flexible model material of the intracellular matrix of ectothermic muscle cells can sense ambient thermal energy. The hybrid film exhibits excellent electroactivity and good electronic conductivity, and it can undergo consecutive and reversible conformation changes under electrochemical control, acting as a multi-step macromolecular motor.
Review
Chemistry, Multidisciplinary
Deepak Joshy, Soumya B. Narendranath, Yahya A. Ismail, Pradeepan Periyat
Summary: TiO2 nanomaterials have been widely studied as photoanode materials in dye-sensitized solar cells due to their non-toxicity, high electron transport rates, and fine tuneable band gap. This review focuses on the modification of TiO2 photoanodes through doping and morphological variations, and highlights the impact of various morphologies on photoanode design.
NANOSCALE ADVANCES
(2022)
Article
Materials Science, Multidisciplinary
Deepak Joshy, Chamundi P. Jijil, Sheethu Jose, Yahya A. Ismail, Pradeepan Periyat
Summary: A new class of near-infrared reflecting yellow and orange cool pigments based on TiZn2O4 inverse spinels were synthesized. By adjusting the composition, a series of pigment compositions with colors ranging from greenish-yellow to reddish-brown were obtained. These pigments exhibited high NIR reflectance and had the ability to reduce indoor temperature, resulting in energy conservation.
MATERIALS ADVANCES
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Madari Palliyalil Sidheekha, Kurikkalath Nufaira, A. K. Shabeeba, Lijin Rajan, Yahya A. Ismail
Summary: The influence of pH value on the synthesis of polyaniline was studied, revealing that the performance of polyaniline-based supercapacitors decreases when synthesized from higher pH media, while the highest specific capacitance is obtained from the pH = 0 medium. Additionally, the synthesized polyanilines are capable of sensing their electrical working energetic conditions, and the current sensing ability of polyaniline shows a linear relationship with the consumed electrical energy and applied current.
MATERIALS TODAY-PROCEEDINGS
(2022)
Article
Chemistry, Multidisciplinary
Lijin Rajan, Madari Palliyalil Sidheekha, Aranhikundan Shabeeba, Yahya A. Ismail
Summary: This article validates the reactive sensing characteristics of polyindole as a sensor for changing electrical and chemical conditions through a flexible polyindole/polyvinyl alcohol hybrid film. The reversible conformational movement of polyindole generates volume changes that mimic biological muscles under electrical stimulus.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Review
Materials Science, Multidisciplinary
Anjitha Thadathil, Hareesh Pradeep, Deepak Joshy, Yahya A. Ismail, Pradeepan Periyat
Summary: This review highlights the importance of conducting polymers and the applications of nanoparticle-incorporated composites in the fields of chemistry and material science. It focuses on the synthesis of two main types of conducting polymer nanocomposites and their applications in contaminant treatment, sensing, and green chemistry. Different strategies to improve the performance and applications of conducting polymers are also discussed.
MATERIALS ADVANCES
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
