Article
Engineering, Chemical
Fahizan Mahmud, Khairul Fikri Tamrin, Shahrol Mohamaddan, Nobuo Watanabe
Summary: This study simplifies the manufacturing process and improves mixing performance by externally applying ultrasound and thermal energy upstream of the micromixer. The Dean micromixer shows higher mixing performance compared to T- and Y-micromixers, with about 27% improvement for Reynolds numbers between 40 and 100.
Article
Chemistry, Analytical
Mojtaba Zeraatkar, Marco D. de Tullio, Gianluca Percoco
Summary: The demand for accessible and affordable microfluidic devices has led to the development of new manufacturing methods like 3D printing to replace traditional techniques. Through fused filament fabrication (FFF) 3D printing, microfluidic micromixers were created to address the challenge of enhancing the mixing process in microfluidic devices. A design of experiment demonstrated the impact of different parameters on mixing performance in printed devices, showing the inherent property of ridges formed on microchannels due to the FFF process.
Article
Mechanics
Ekta Tripathi, Promod Kumar Patowari, Sukumar Pati
Summary: In this study, the influence of the shapes of passive micromixers on the mixing efficiency of fluids in microfluidic devices such as Lab on a chip and mu-total analysis systems was investigated. The mixing efficiency of straight, serpentine, and spiral micromixers was compared, while keeping the same axial length of each channel to compact the size of the microfluidic device. Numerical simulations were performed for a range of Reynolds numbers in each micromixer. The results showed that the spiral micromixer had the highest mixing efficiency among all the considered micromixers.
Article
Chemistry, Analytical
Fang Yang, Wei Zhao, Cuifang Kuang, Guiren Wang
Summary: In this study, a quasi T-channel electrokinetics-based micromixer with electrically conductive sidewalls was investigated. It was found that this micromixer configuration achieved faster mixing compared to another widely studied micromixer configuration. The effects of Re numbers, applied AC voltage and frequency, and conductivity ratio of the two fluids on mixing results were explored. The study of this micromixer could provide new insights into electrokinetic phenomena and offer new tools for sample preparation in applications requiring fast mixing.
Article
Chemistry, Analytical
Wenpeng Guo, Li Tang, Biqiang Zhou, Yingsing Fung
Summary: This paper presents the first report on the simple and rapid fabrication of an on-chip compact micromixer using laser-ablated irregular microspheric surfaces on a polymethyl methacrylate (PMMA) microfluidic chip for continuous mixing in modular microfluidics. The micromixer is designed for sequential mixing of nanoliter fluids in about 1 second, and can achieve up to 90% fluid mixing in a short channel under optimized conditions. Computational flow dynamics simulations and experimental results demonstrate good agreement.
Article
Engineering, Chemical
Fang Yang, Wei Zhao, Guiren Wang
Summary: Electrokinetic (EK) micromixers have been widely studied, but they usually require different electrical conductivity between the fluids to be mixed. This study presents a method to enhance mixing between fluids with identical conductivity using an EK micromixer with conductive sidewalls. The results show that the mixing becomes stronger with increased conductivity value. This method provides a novel and convenient strategy for mixing fluids with the same or similar electrical conductivity in microfluidic systems.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Engineering, Environmental
Xin Dong, Kentaro Yaji, Xiaomin Liu
Summary: This paper investigates the design of the mixing unit in a T-shape micromixer considering non-Newtonian fluid effects using topology optimization. The optimized structures exhibit superior performance in maximizing mixing quality, especially for non-Newtonian fluids.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Thermodynamics
Junsheng Wang, Qiaoyu Feng, Junzhu Yao, Kai Zhao
Summary: A novel T-type electromagnetic micromixer was proposed by combining the effects of laminar flow with Lorentz force. The effects of various parameters on the fluid mixing in the micromixer were numerically investigated, and the mixing efficiency achieved as high as approximately 97% by adjusting these parameters.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Chemistry, Multidisciplinary
Dariush Bahrami, Afshin Ahmadi Nadooshan, Morteza Bayareh
Summary: In this study, a two-dimensional combined active/passive micromixer was designed and evaluated, and the results showed that the magnetic field improved the mixing quality. The micromixer with sinusoidal walls had better performance compared to the one with a straight channel.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Engineering, Electrical & Electronic
Dezhao Jiao, Ruirong Zhang, Hantian Zhang, Shuang Ren, Huicheng Feng, Honglong Chang
Summary: This paper proposes a three-dimensional split-and-recombination (SAR) micromixer inspired by the horseshoe transform principle, and reveals the optimal size through computational fluid dynamics simulations and experimental tests. The results show that the SAR micromixer achieves high mixing efficiency and has potential applications in the field of microchip-based biochemical analysis.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Reza Karimi, Sajad Rezazadeh, Mohammad Raad
Summary: This paper presents a three-dimensional study of the nitrogen and oxygen mixing process in a T-type micromixer, and validates the improvement of mixing quality by introducing SAR structures. It is found that at low Reynolds numbers, the mixing quality is high, and increasing the cross-section area of mixing units can enhance mixing quality.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Engineering, Chemical
Amin Lotfiani, Ghader Rezazadeh
Summary: Micromixers are crucial components in microfluidic systems, with numerous passive designs proposed. In this study, a new efficient micromixer design with low complexity is introduced, based on SAR and vortex mixing principles. The design was chosen through CFD simulations and showed promising results compared to existing designs.
INTERNATIONAL JOURNAL OF CHEMICAL REACTOR ENGINEERING
(2021)
Article
Chemistry, Analytical
Ranjitsinha R. Gidde
Summary: This paper analyzed the mixing performance of three types of baffle-based passive micromixers using numerical simulation, finding different mixing mechanisms at different Reynolds numbers and their suitability for chemical, biochemical, and medical applications.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Aoba Ota, Ayaka Mochizuki, Keitaro Sou, Shinji Takeoka
Summary: This paper investigates the potential of a static mixer (SM) in liposome formulation compared to a commonly used microfluidic device (SHM). The results indicate that liposomes prepared with SM have larger particle size but better size control, while liposomes prepared with SHM have higher encapsulation efficiency. Moreover, SM demonstrates significant advantages in user-friendliness, allowing for thorough cleaning of the mixing elements and device.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Chemical
William L. N. Buglie, Khairul Fikri Tamrin, Nadeem Ahmed Sheikh, Mohd Fairus Mohd Yasin, Shahrol Mohamaddan
Summary: A two-dimensional Tesla micromixer was experimentally characterized to analyze its performance under different Reynolds numbers and valve stages. The study found that the low Reynolds number regime showed steady incremental mixing, while the high Reynolds number regime displayed enhanced mixing, particularly at the first valve. This was primarily due to the amplified opposing flow from the helix branch, resulting in stronger chaotic advection in the main microchannel. Interestingly, the measured mixing performance of the two-dimensional micromixer was comparable to that of three-dimensional passive micromixers reported in previous literature.
CHEMICAL ENGINEERING & TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Su Jeong Yeom, Tae-Ung Wi, Sangho Ko, Changhyun Park, Khayala Bayramova, Sunghwan Jin, Seok Woo Lee, Hyun-Wook Lee
Summary: This study proposes a simple method of using nitrogen gas plasma to surface treat silicon-based electrodes, which can improve the reversibility and reaction kinetics of silicon anodes and achieve higher specific capacity in silicon/graphite anodes with high silicon content.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Xiaoya Li, Jia Li, Jeonghun Yun, Angyin Wu, Caitian Gao, Seok Woo Lee
Summary: Thermally regenerative electrochemical cycle (TREC) system is a promising technology for low-grade heat recovery, achieving high energy conversion efficiency. This continuously operated system converts heat to electricity by alternately operating two electrochemical cells at different temperatures. With a copper hexacyanoferrate cathode and a Cu/Cu2+ anode, the system achieves an energy conversion efficiency of 1.76% (14.19% of Carnot efficiency) between 10 and 50 degrees C. Even at a low temperature difference of 10 degrees C vs room temperature, the efficiency is 0.98%. The proposed system allows flexibility in electrode material selection, improving the practicality of low-grade heat harvesting with TREC systems.
Article
Chemistry, Physical
Angyin Wu, Xiaoya Li, Donghoon Lee, Jia Li, Jeonghun Yun, Cheng Jiang, Zongkang Li, Seok Woo Lee
Summary: In this study, a thermoresponsive ionic liquid (TRIL) was added to the electrolyte in a TREC system for ultralow-grade heat harvesting, resulting in high energy density and conversion efficiency. The solvation states of ions changed during charging and discharging across the phase change critical point, achieving significant improvement in energy efficiency compared to conventional systems. The tunable phase change temperature of the TRIL enhances the feasibility and resilience of the TREC system, providing a novel perspective for electrolyte design in electro-chemical cells.
Article
Chemistry, Physical
Jia Li, Peihua Yang, Xiaoya Li, Cheng Jiang, Jeonghun Yun, Wenqi Yan, Kang Liu, Hong Jin Fan, Seok Woo Lee
Summary: In this study, dual-function battery and supercapacitor devices for skin-interfaced wearable electronics are developed, which have high performance and large capacity. These ultra-thin energy devices have good flexibility and adaptability and can be applied to various surfaces. The results of this study contribute to the development of versatile electronic skins and next-generation wearable electronics.
ACS ENERGY LETTERS
(2022)
Article
Chemistry, Physical
Xiaoya Li, Angyin Wu, Caitian Gao, Zongkang Li, Seok Woo Lee
Summary: In this study, a copper hexacyanoferrate (CuHCFe) electrode was introduced into AAIBs with an aluminum triflate electrolyte, showing excellent rate performance and cycling stability. The results highlight the compatibility and potential of CuHCFe cathodes and aluminum triflate electrolytes for AAIBs.
MATERIALS TODAY ENERGY
(2023)
Article
Chemistry, Multidisciplinary
Zongkang Li, Jeonghun Yun, Xiaoya Li, Moobum Kim, Jia Li, Donghoon Lee, Angyin Wu, Seok Woo Lee
Summary: Recent advancements in wearable devices have made noninvasive healthcare monitoring possible. This study introduces a power-free smart contact lens that can detect glucose levels through color changes of multiple electrochromic electrodes, eliminating the need for external wireless systems. The device demonstrates high accuracy and reproducibility, making it a potential tool for daily health monitoring without additional power supply or devices.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Jeonghun Yun, Zongkang Li, Xinwen Miao, Xiaoya Li, Jae Yoon Lee, Wenting Zhao, Seok Woo Lee
Summary: Smart contact lenses require miniaturized power supplies, and integrated batteries offer promising options. Charging them is challenging due to the difficulty of transferring electrical power through miniaturized wired connections or wireless units. Therefore, we developed tear-based batteries for contact lenses that are charged by biofuel during storage.
Article
Chemistry, Multidisciplinary
Ahreum Choi, You-Yeob Song, Juyoung Kim, Donghyeon Kim, Min-Ho Kim, Seok Woo Lee, Dong-Hwa Seo, Hyun-Wook Lee
Summary: Low-grade heat (<100℃) is difficult to convert into usable energy with conventional systems. This study investigates the role of structural vibration modes in thermally regenerative electrochemical cycles (TREC) and discovers that changes in bonding covalency influenced by water molecules impact the vibration modes. Leveraging these insights, a highly efficient TREC system with a sodium-ion-based aqueous electrolyte is designed and implemented.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jia Li, Xiaoya Li, Donghoon Lee, Jeonghun Yun, Angyin Wu, Cheng Jiang, Seok Woo Lee
Summary: The thermally regenerative electrochemical cycle (TREC) is an efficient method to convert low-grade heat into electricity, with a high temperature coefficient (& alpha;) being crucial for its energy conversion efficiency. This study demonstrates a significant improvement in the & alpha; of a Prussian blue analogue (PBA)-based electrochemical cell by incorporating poly(4-styrenesulfonic acid) (PSS) into the electrolyte. The addition of PSS influences the ion hydration structure and increases the entropy change (& UDelta;S) during ion intercalation in PBA, resulting in a high & alpha; of -2.01 mV K-1 and a heat-to-electricity conversion efficiency of 1.83% in the temperature range of 10-40 & DEG;C. This research provides insights into the origin of & alpha; and offers a simple approach to enhance the temperature coefficient for developing highly efficient low-grade heat harvesting systems.
Article
Chemistry, Physical
Ji-Eun Jang, Ryeong-ah Kim, S. Jayasubramaniyan, Chanhee Lee, Jieun Choi, Youngdae Lee, Sujin Kang, Jaechan Ryu, Seok Woo Lee, Jaephil Cho, Dong Woog Lee, Hyun-Kon Song, Wonyoung Choe, Dong-Hwa Seo, Hyun-Wook Lee
Summary: This work introduces a new chromium-based negative electrode material that can mitigate strong Jahn-Teller effects, resulting in low redox potential, high stability, and rapid kinetics. The balanced full-cell configuration exhibits a stable lifetime of 500 cycles with an energy density of 14 Wh L-1. Under excessive positive electrode conditions, the full-cell can achieve a high energy density of 38.6 Wh L-1 as a single electron redox process. Consequently, the proposed system opens new avenues for the development of high-performance RFBs.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Ji-Eun Jang, S. Jayasubramaniyan, Seok Woo Lee, Hyun-Wook Lee
Summary: Aqueous redox flow batteries (RFBs) are promising large-scale energy storage devices due to their scalability, safety, and flexibility. Manganese-based redox materials are particularly attractive for use in RFBs due to their abundance, affordability, and range of oxidation states. However, the instability of Mn redox couples has been a challenge. In this study, the addition of NaCN supporting electrolyte was found to improve the reversibility, stability, and reaction kinetics of [Mn(CN)(6)](5-/4-/3-) negolyte, leading to high performance and stable multielectron reactions.
ACS ENERGY LETTERS
(2023)
Article
Chemistry, Physical
Xiaoya Li, Angyin Wu, Jia Li, Zongkang Li, Donghoon Lee, Seok Woo Lee
Summary: The thermopower improvement is essential for enhancing the energy conversion efficiency of a thermally regenerative electrochemical cycle (TREC). In this study, the researchers utilized the coordinating nature of anions to modulate the desolvation and reorganization entropy changes during the redox reaction in the aqueous electrochemical system. They found that the preference of anions for increased thermopower roughly follows the reverse order of the Hofmeister series, with the noncoordinating chaotropic anion ClO(4)(-) enabling the highest thermopower. By leveraging this finding, they demonstrated a TREC system with high thermopower and highlighted the promising potential of TREC for low-grade energy harvesting.
ACS ENERGY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Ahreum Choi, You-Yeob Song, Juyoung Kim, Donghyeon Kim, Min-Ho Kim, Seok Woo Lee, Dong-Hwa Seo, Hyun-Wook Lee
Summary: This study investigates the role of structural vibration modes in enhancing the efficacy of TREC systems and analyzes how changes in bonding covalency, influenced by the number of structural water molecules, impact the vibration modes. It is discovered that even small amounts of water molecules can induce strong structural vibration energy, contributing significantly to a larger temperature coefficient (alpha) in a TREC system. Leveraging these insights, a highly efficient TREC system using a sodium-ion-based aqueous electrolyte is designed and implemented. This study provides valuable insights into the potential of TREC systems in enhancing energy-harvesting capabilities.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Sangho Ko, Myung-Jin Baek, Tae-Ung Wi, Juyoung Kim, Changhyun Park, Daegyun Lim, Su Jeong Yeom, Khayala Bayramova, Hyeong Yong Lim, Sang Kyu Kwak, Seok Woo Lee, Sunghwan Jin, Dong Woog Lee, Hyun-Wook Lee
Summary: This study reports the development of a multifunctional polymeric binder with a three-dimensional network structure for silicon-based anodes. The binder provides greater structural integrity, stronger adhesion, and higher ionic conductivity compared to traditional binders. Operando observations show that the novel binder mitigates microstructural changes in silicon, resulting in high electrochemical performance even after 1000 cycles.
ACS MATERIALS LETTERS
(2022)
Article
Green & Sustainable Science & Technology
Yezhou Liu, Caitian Gao, Jeonghun Yun, Yeongae Kim, Moobum Kim, Jia Li, Seok Woo Lee
Summary: This study aims to improve the α value in high-efficiency, low-grade heat harvesting by tuning the hydration status of cations, and by mixing solvents to enhance the efficiency of the electrochemical cell.
ADVANCED ENERGY AND SUSTAINABILITY RESEARCH
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
