Article
Physics, Multidisciplinary
Lodovico Ratti, Paolo Brogi, Gianmaria Collazuol, Gian-Franco Dalla Betta, Pier Simone Marrocchesi, Lucio Pancheri, Arta Sulay, Gianmarco Torilla, Carla Vacchi
Summary: This paper reports the characterization of SPAD arrays in a 150 nm CMOS technology for the detection of charged particles. The study focused on breakdown voltage and dark count rate (DCR) in both single- and dual-layer structures, highlighting the advantage of the coincidence readout architecture.
FRONTIERS IN PHYSICS
(2021)
Article
Engineering, Electrical & Electronic
Hiwa Mahmoudi, S. Saman Kohneh Poushi, Bernhard Steindl, Michael Hofbauer, Horst Zimmermann
Summary: This article presents a comprehensive modeling and experimental characterization of photon detection probability (PDP) of single-photon avalanche diodes (SPADs), highlighting the necessity of the approach especially when anti-reflection coating layer is not available. The obtained results show excellent agreement with measurements, indicating the reliable use of the model for accurate design and optimization of SPAD-based detectors.
IEEE SENSORS JOURNAL
(2021)
Article
Instruments & Instrumentation
Peter Fischer, Robert K. Zimmermann, Benedict Maisano
Summary: This article introduces a "Digital SiPM" solution that combines Single Photon Sensitive Avalanche Diodes (SPADs) and CMOS readout electronics for light detection in optical fibers. By assigning individual SPADs to programmable groups, the solution offers flexibility and provides timing and amplitude information through purely digital output signals. Initial tests show that this solution can significantly reduce the complexity and cost of fiber readouts, and possibly improve their performance.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2022)
Article
Engineering, Electrical & Electronic
Hui-Chen Tsai, Chun-Hsien Liu, Sheng-Di Lin, Chia-Ming Tsai, Jau-Yang Wu
Summary: In this study, a wide radiation temperature measurement is demonstrated using a single-photon avalanche diode image array. The detection temperature window ranges from 280 degrees C to 1050 degrees C with a noise equivalent temperature difference below 1 degrees C. The thermal image obtained has a high detection rate and a spatial resolution of 80 μm.
IEEE SENSORS JOURNAL
(2022)
Article
Polymer Science
Ming-Lin Yeh, Geng-Ming Chang, Yi-Je Juang
Summary: This study proposed and demonstrated the conformal coating of microparticles with a positively charged polyelectrolyte using an acoustofluidic microchip. The results showed that the microfluidic approach achieved rapid and uniform coating of microparticles. The zeta potentials of the coated microparticles exhibited charge reversal, with little variation influenced by the microchannel width or PAH concentration.
Article
Biotechnology & Applied Microbiology
Brandon Ashley, Umer Hassan
Summary: The novel signal averaging algorithm effectively reduces noise in microfluidic impedance cytometry data, improving counting accuracy and lowering the detection limit. This technique enhances signal-to-noise ratio and accuracy across all experiments conducted, showing potential for next-generation devices with an expanded dynamic range and improved enumeration accuracy in biomedical applications.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Quan-Wei Cai, Da-Wei Pan, Xiao-Jie Ju, Chen Chen, Li-Ping Zhang, Shi-Hao Yang, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: In this paper, a simple microfluidic strategy is introduced for the controlled fabrication of monodisperse amphiphilic Janus microparticles. The strategy utilizes online UV curing and phase separation to produce the desired morphologies. The functionalization of the microparticles can also be easily achieved by introducing certain elements into the dispersed phase. The versatility and efficiency of this strategy make it highly applicable in various fields.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Optics
Peiwen Li, Haibo Yu, Xiaoduo Wang, Yangdong Wen, Wenxiu Zhao, Hao Luo, Zhixing Ge, Lianqing Liu
Summary: The study introduces a novel method combining femtosecond laser two-photon polymerization micromachining technology with optical tweezers operation to achieve selective and targeted capture of single particles and cells. Diverse ordered microcages were self-assembled, allowing selective transport of single microparticles and cells to desired locations. The captured microparticles and cells were kept trapped without additional forces.
Article
Engineering, Biomedical
Gabriel M. Ferreira, Vitoria Baptista, Vitor Silva, Maria I. Veiga, Graca Minas, Susana O. Catarino
Summary: This study presents the design, simulation, and fabrication of a CMOS microelectronic detection system for automatically quantifying the presence of malaria parasites in a blood sample. The system consists of an array of photodiodes and current to frequency converters. The microsystem demonstrated high linearity and sensitivity, successfully distinguishing between infected and healthy red blood cells.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Sundar Hengoju, Oksana Shvydkiv, Miguel Tovar, Martin Roth, Miriam A. Rosenbaum
Summary: Droplet microfluidics using optical fiber as a light guiding medium has revolutionized analytical possibilities by providing a simpler, more flexible, lower-cost, and sensitive setup for the detection of various parameters. This technology has great potential in biochemistry and biotechnology research.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Materials Science, Multidisciplinary
Zhuo Chen, Yang Lan, Si-Da Ling, Yu-Hang Dong, Yun-Dong Wang, Jian-Hong Xu
Summary: Droplet microfluidics allows precise and simultaneous control of multiple fluids, leading to the synthesis of diverse microparticles in drug delivery applications. The morphology and functionality of these microparticles can be well designed by modulating the hydrodynamic profile and geometric structures. Future research directions include utilizing biodegradable microparticles for on-demand drug delivery.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Multidisciplinary Sciences
Chaoyu Yang, Yunru Yu, Yuanjin Zhao, Luoran Shang
Summary: A piezoelectric microfluidic system is developed to generate complex flow configurations and fabricate jellyfish-like microparticles with precise control over size and morphology. By modifying the injecting channel geometry, multi-compartmental microparticles with a dual-layer structure can be achieved. These jellyfish-like microparticles exhibit flexible motion ability, especially when incorporating stimuli-responsive materials.
Article
Instruments & Instrumentation
G. Torilla, J. Minga, P. Brogi, G. Collazuol, G. -f. Dalla Betta, P. S. Marrocchesi, L. Pancheri, L. Ratti, C. Vacchi
Summary: This paper presents the results from the crosstalk and dark count rate (DCR) characterization of a 24 x 72 single photon avalanche diode (SPAD) array, fabricated in a 150 nm CMOS technology. The chip under test consists of a dual layer detection system developed in view of applications to charged particle tracking. A three step procedure used for the crosstalk characterization is presented. The crosstalk probability, taking place in 5 x 5 sub arrays built around noisy pixels, has been computed. Eventually, random telegraph signal (RTS) fluctuations in DCR, at different bias conditions, are briefly discussed.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2023)
Article
Chemistry, Analytical
Ruiting Xu, Leixin Ouyang, Rubia Shaik, Heyi Chen, Ge Zhang, Jiang Zhe
Summary: Rapid and accurate analysis of micro/nano bio-objects is crucial in clinical diagnostics and drug discovery. A unique bipolar pulse-width, multiplexing-based resistive pulse sensor is presented for high-throughput analysis of microparticles. The accuracy of particle counting and sizing was validated and its accuracy for cell analysis was demonstrated.
Article
Materials Science, Multidisciplinary
Shuai Zhang, Bo Wang, Chenmu Xue, Xiaodong Chen
Summary: This paper presents a reusable and adjustable microfluidic device composed of glass capillaries and polydimethylsiloxane, which allows for the generation of compound microdroplets with different morphologies. The device can be used for rapid prototyping and high-throughput generation of droplets or particles.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Engineering, Electrical & Electronic
Mohammad Azim Karami, Lucio Carrara, Cristiano Niclass, Matthew Fishburn, Edoardo Charbon
IEEE ELECTRON DEVICE LETTERS
(2010)
Article
Engineering, Electrical & Electronic
Cristiano Niclass, Claudio Favi, Theo Kluter, Marek Gersbach, Edoardo Charbon
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2008)
Article
Engineering, Electrical & Electronic
Cristiano Niclass, Claudio Favi, Theo Kluter, Frederic Monnier, Edoardo Charbon
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2009)
Article
Physics, Multidisciplinary
D. L. Boiko, N. J. Gunther, N. Brauer, M. Sergio, C. Niclass, G. B. Beretta, E. Charbon
NEW JOURNAL OF PHYSICS
(2009)
Article
Optics
D. L. Boiko, N. J. Gunther, N. Brauer, M. Sergio, C. Niclass, G. B. Beretta, E. Charbon
Article
Optics
Cristiano Niclass, Kota Ito, Mineki Soga, Hiroyuki Matsubara, Isao Aoyagi, Satoru Kato, Manabu Kagami
Article
Optics
M. Gersbach, D. L. Boiko, C. Niclass, C. C. H. Petersen, E. Charbon
Article
Engineering, Electrical & Electronic
Marek Gersbach, Justin Richardson, Eric Mazaleyrat, Stephane Hardillier, Cristiano Niclass, Robert Henderson, Lindsay Grant, Edoardo Charbon
SOLID-STATE ELECTRONICS
(2009)
Article
Engineering, Electrical & Electronic
Cristiano Niclass, Marek Gersbach, Robert Henderson, Lindsay Grant, Edoardo Charbon
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2007)
Article
Instruments & Instrumentation
Eugene Grigoriev, Alexander Akindinov, Marco Breitenmoser, Stefano Buono, Edoardo Charbon, Cristiano Niclass, Iris Desforges, Roberto Rocca
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2007)
Article
Engineering, Electrical & Electronic
Cristiano Niclass, Alexis Rochas, Pierre-Andre Besse, Radivoje Popovic, Edoardo Charbon
SENSORS AND ACTUATORS A-PHYSICAL
(2006)
Article
Engineering, Electrical & Electronic
C Niclass, A Rochas, PA Besse, E Charbon
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2005)
Article
Engineering, Electrical & Electronic
C Niclass, A Rochas, PA Besse, E Charbon
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2004)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)