4.6 Article

Acoustic Devices for Particle and Cell Manipulation and Sensing

Journal

SENSORS
Volume 14, Issue 8, Pages 14806-14838

Publisher

MDPI
DOI: 10.3390/s140814806

Keywords

ultrasonic manipulation; high frequency; array; piezocrystals; screen-printing

Funding

  1. UK Engineering and Physical Sciences Research Council through the Electronic Sonotweezers programme
  2. BBSRC [BB/L00271X/1] Funding Source: UKRI
  3. EPSRC [EP/G012075/1, EP/G01213X/1] Funding Source: UKRI
  4. Engineering and Physical Sciences Research Council [EP/G012075/1, EP/G01213X/1] Funding Source: researchfish

Ask authors/readers for more resources

An emerging demand for the precise manipulation of cells and particles for applications in cell biology and analytical chemistry has driven rapid development of ultrasonic manipulation technology. Compared to the other manipulation technologies, such as magnetic tweezing, dielectrophoresis and optical tweezing, ultrasonic manipulation has shown potential in a variety of applications, with its advantages of versatile, inexpensive and easy integration into microfluidic systems, maintenance of cell viability, and generation of sufficient forces to handle particles, cells and their agglomerates. This article briefly reviews current practice and reports our development of various ultrasonic standing wave manipulation devices, including simple devices integrated with high frequency (>20 MHz) ultrasonic transducers for the investigation of biological cells and complex ultrasonic transducer array systems to explore the feasibility of electronically controlled 2-D and 3-D manipulation. Piezoelectric and passive materials, fabrication techniques, characterization methods and possible applications are discussed. The behavior and performance of the devices have been investigated and predicted with computer simulations, and verified experimentally. Issues met during development are highlighted and discussed. To assist long term practical adoption, approaches to low-cost, wafer level batch-production and commercialization potential are also addressed.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Engineering, Biomedical

High-frequency quantitative ultrasound for the assessment of the acoustic properties of engineered tissues in vitro

Joseph A. Sebastian, Eric M. Strohm, Emmanuel Cherin, Bahram Mirani, Christine E. M. Demore, Michael C. Kolios, Craig A. Simmons

Summary: High-frequency ultrasound can non-invasively characterize and monitor the acoustic properties of biomaterials and engineered tissues. A new method is proposed to accurately measure the speed of sound, acoustic impedance, and acoustic attenuation of cell-laden hydrogels, taking into account the frequency-dependent effects of attenuation in coupling media, hydrogel thickness, and interfacial transmission/reflection coefficients of ultrasound waves. The acoustic attenuation coefficients were found to increase with increasing cell concentration, reflecting the cellularity of the hydrogel independent of its thickness.

ACTA BIOMATERIALIA (2023)

Article Chemistry, Analytical

The 0-3 Lead Zirconate-Titanate (PZT)/Polyvinyl-Butyral (PVB) Composite for Tactile Sensing

Eun-Bee Jo, Yoon-A Lee, Yoon-A Cho, Paul A. Guenther, Sylvia E. Gebhardt, Holger Neubert, Hyun-Seok Kim

Summary: In this study, a 0-3 piezoelectric composite based on lead zirconate-titanate (PZT)/polyvinyl-butyral (PVB) was fabricated and characterized for its potential application in tactile sensing. The sensitivity and response time of the sensor were measured, and the results showed that the composite had high sensitivity and fast response time.

SENSORS (2023)

Article Instruments & Instrumentation

Simultaneous direct measurement of the electrocaloric and dielectric dynamics of ferroelectrics with microsecond temporal resolution

J. Fischer, J. Doentgen, C. Molin, S. E. Gebhardt, Y. Hambal, V. V. Shvartsman, D. C. Lupascu, D. Haegele, J. Rudolph

Summary: A contactless technique is introduced for direct time-resolved measurements of the full dynamics of the adiabatic temperature change in electrocaloric materials. The technique detects the infrared radiation emitted by the electrocaloric sample with μs time resolution and mK temperature resolution. Time-resolved measurements of the electrocaloric effect are presented at kHz frequencies and small field strengths. The technique allows for the simultaneous recording of transient behaviors in the applied electric field and induced polarization, providing a comprehensive understanding of the correlation between electrocaloric and ferroelectric properties. Additionally, it can be used for continuous fatigue measurements for >10(6) electric field cycles.

REVIEW OF SCIENTIFIC INSTRUMENTS (2023)

Article Chemistry, Multidisciplinary

Directional Suppression of Monotone Noises with A Parametric Array Loudspeaker

Han Wang, Jingxiao Zhang, Lin Gan, Yu Liu

Summary: This paper proposes a directional monotone noise reduction method using a feedforward active noise control (ANC) structure with filtered-x least mean square (FxLMS) algorithms. The system utilizes a parametric array loudspeaker (PAL) as the active noise-canceling source with high audio directivity for directional noise suppression. Compared to traditional ANC methods with a voice coil loudspeaker (VCL), our PAL-based system achieves similar noise suppression performance with improved source-to-target distance and audio main lobe beam width reduction.

APPLIED SCIENCES-BASEL (2023)

Article Chemistry, Inorganic & Nuclear

Influence of Sintering Additives on Modified (Ba,Sr)(Sn,Ti)O3 for Electrocaloric Application

Zhenglyu Li, Christian Molin, Sylvia E. Gebhardt

Summary: This paper investigates the influence of sintering additives CuO and MgO on the lead-free electrocaloric material BSSnT-18-6.5. The addition of 2% CuO significantly reduces the sintering temperature, while the addition of 1% MgO reduces the grain size and improves the dielectric breakdown strength. The results show that BSSnT-18-6.5 with MgO addition achieves significant EC temperature changes within a broad temperature range, making it suitable for future electrocaloric applications.

INORGANICS (2023)

Article Acoustics

Single-Fiber Transducer Arrays for 3-D Ultrasound Computed Tomography: From Requirements to Results

Martin Angerer, Michael Zapf, Sylvia E. Gebhardt, Holger Neubert, Nicole V. Ruiter

Summary: A potential method for future breast cancer screening is 3-D ultrasound computed tomography (USCT). In this article, a new transducer array design is presented to be utilized in a third generation 3-D USCT system. The design provides random transducer positioning, isotropic sound emission, large bandwidth, and wide opening angle. Characterization of the acoustic field showed isotropic fields with a mean bandwidth of 131% and an opening angle of 42 degrees.

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL (2023)

Article Engineering, Electrical & Electronic

A 99.74% Efficient Capacitor-Charging Converter Using Partial Power Processing for Electrocalorics

Stefan Moench, Richard Reiner, Kareem Mansour, Patrick Waltereit, Michael Basler, Rudiger Quay, Christian Molin, Sylvia Gebhardt, David Bach, Roland Binninger, Kilian Bartholome

Summary: This work combines two power converters, one with a high efficiency of 99.2% and the other with low losses, to create a six-level prototype with an overall efficiency of 99.74%. The high charging efficiency enables a high coefficient of performance (COP) for electrocaloric heat pumps. It is predicted that the combination of the electrical charging efficiency and electrocaloric material data can surpass 50% of the thermal Carnot limit, paving the way for future high-performance electrocaloric heat pumps.

IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS (2023)

Article Computer Science, Information Systems

Internet of Things for Diagnosis of Alzheimer's Disease: A Multimodal Machine Learning Approach Based on Eye Movement Features

Yunpeng Yin, Han Wang, Shuai Liu, Jinglin Sun, Peiguang Jing, Yu Liu

Summary: This article proposes an Internet of Things (IoT) architecture for early diagnosis of Alzheimer's disease (AD) using eye-tracking and machine learning. By collecting and analyzing eye movement data, the system can accurately identify early-stage AD patients with high accuracy.

IEEE INTERNET OF THINGS JOURNAL (2023)

Article Energy & Fuels

On the efficiency of caloric materials in direct comparison with exergetic grades of compressors

Jan Schipper, David Bach, Stefan Moench, Christian Molin, Sylvia Gebhardt, Juergen Woellenstein, Olaf Schaefer-Welsen, Christian Vogel, Robin Langebach, Kilian Bartholome

Summary: Efficiency improvements in heat pump can reduce global energy demand. Caloric heat pumps are being explored as a more efficient alternative to vapor compression systems, driven by solid-state materials with significant temperature changes when a field is applied. The efficiency of caloric cooling systems is impacted by power dissipation during phase transitions, which can be quantified by a figure of merit (FOM) derived from material properties.

JOURNAL OF PHYSICS-ENERGY (2023)

Article Engineering, Electrical & Electronic

Airborne Ultrasound Haptics From Amplitude and Spatiotemporal Modulation of Acoustic Vortices

Han Wang, Xin Liu, Peiguang Jing, Yu Liu

Summary: This letter investigates the use of acoustic radiation forces generated by air-coupled ultrasound to provide contactless tactile feedback in mid air. Simulation studies and practical experiments show that unfocused vortex beams produced by a 16-element planar transducer array offer advantages in delivering large areas of plane-like haptic sensations with naturally distributed pressure hot spots compared to traditional point-focused beams. This letter also demonstrates that mid-air haptics can be efficiently rendered through amplitude modulation (AM) or spatiotemporal modulation (STM) of the vortex beams. The results prove the feasibility of using acoustic vortices as a cost-effective method for delivering haptics with small aperture arrays.

IEEE SENSORS LETTERS (2023)

Article Engineering, Electrical & Electronic

A Novel Integrated Eye-Tracking System With Stereo Stimuli for 3-D Gaze Estimation

Jinglin Sun, Zhipeng Wu, Han Wang, Peiguang Jing, Yu Liu

Summary: This study proposes an integrated binocular eye-tracking device with stereo stimuli, which can provide highly accurate 3D point-of-gaze estimation. A regression-based eye-tracking model is built based on collected eye movement data and validated through experiments. This technology has broad application prospects in 3D vision technologies and medical applications related to neurological diseases.

IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT (2023)

Proceedings Paper Acoustics

Photoacoustic imaging of a pre-clinical tumour model with an ExactVu micro-ultrasound system

Nidhi Singh, Emmanuel Cherin, Carlos-Felipe Roa, Gang Zheng, F. Stuart Foster, Christine E. M. Demore, Yohannes Soenjaya, Ayushi Patel

Summary: This study presents a combined micro-ultrasound photoacoustic imaging system for in vivo imaging, which can simultaneously visualize oxygenated, deoxygenated hemoglobin, and an exogenous photoacoustic contrast agent called porphysome nanoparticles. Spectral unmixing is used to separate the different signals. Longitudinal imaging with porphysomes shows that the photoacoustic signal peaks at 6 hours after injection and gradually degrades.

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS) (2022)

Proceedings Paper Acoustics

Development of a 50 MHz Linear Array for Endoscopic Imaging

Carlos-Felipe Roa, Jacqueline Caminiti, Jianhua Yin, Aaron Boyes, Emmanuel Cherin, Nidhi Singh, F. Stuart Foster, Christine E. M. Demore

Summary: In this study, the authors present a method for fabricating miniaturized linear arrays for endoscopic micro-ultrasound. By limiting the area used for electrical connection and placing the signal electrodes on the back surface of the array, they achieved an endoscopic form factor and demonstrated the potential of this technique.

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS) (2022)

Proceedings Paper Acoustics

High Resolution Measurement of Coatings Inside Thick, Hot, Steel Pipes

Claire Thring, Daniel Irving, Dave Hughes

Summary: This study demonstrates the successful detection and thickness measurement of 10 to 40 μm thick silicone resin coatings from the far side of a 6 mm thick mild steel wall using a high temperature thin film sensor capable of conforming to curved surfaces.

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS) (2022)

Article Computer Science, Information Systems

Enhancing Electrocaloric Heat Pump Performance by Over 99% Efficient Power Converters and Offset Fields

Stefan Moench, Richard Reiner, Patrick Waltereit, Christian Molin, Sylvia Gebhardt, David Bach, Roland Binninger, Kilian Bartholome

Summary: This work analyzes how an over 99% efficient charging circuit and electrical offset fields enhance the coefficient of performance (COP) of electrocaloric heat pumps. The results show that the offset field can reduce material loss and improve system COP. The approach used in this work reduces charging loss by 20 times compared to state-of-the-art resonant circuits for electrocalorics, making a valuable contribution to electrocaloric heat pump systems.

IEEE ACCESS (2022)

No Data Available