Journal
SENSORS
Volume 14, Issue 11, Pages 20602-20619Publisher
MDPI
DOI: 10.3390/s141120602
Keywords
CMOS; FRET; lab-on-a-chip; microsystem; fluorescence spectroscopy; multispectral imaging; contact imaging; quantum dots; DNA analysis; point-of-care; medical diagnostics; time-resolved; TCSPC
Funding
- [6000463]
- [9667084]
- [7200381]
- [9610301]
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Instrumental limitations such as bulkiness and high cost prevent the fluorescence technique from becoming ubiquitous for point-of-care deoxyribonucleic acid (DNA) detection and other in-field molecular diagnostics applications. The complimentary metal-oxide-semiconductor (CMOS) technology, as benefited from process scaling, provides several advanced capabilities such as high integration density, high-resolution signal processing, and low power consumption, enabling sensitive, integrated, and low-cost fluorescence analytical platforms. In this paper, CMOS time-resolved, contact, and multispectral imaging are reviewed. Recently reported CMOS fluorescence analysis microsystem prototypes are surveyed to highlight the present state of the art.
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