4.6 Article

A Novel Electrochemical Sensor for Probing Doxepin Created on a Glassy Carbon Electrode Modified with Poly(4-Amino- benzoic Acid)/Multi-Walled Carbon Nanotubes Composite Film

Journal

SENSORS
Volume 10, Issue 9, Pages 8398-8410

Publisher

MDPI
DOI: 10.3390/s100908398

Keywords

poly(4-aminobenzoic acid); multi-walled carbon nanotubes; nanocomposite; doxepin; detection

Funding

  1. Shanghai Leading Academic Discipline Project [B109, 08XD14009]
  2. NSFC [20675018, 20892022]
  3. CSC
  4. CSTC [2007BB5260]
  5. Fudan University

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A novel electrochemical sensor for sensitive detection of doxepin was prepared, which was based on a glassy carbon electrode modified with poly(4-aminobenzoic acid)/multi-walled carbon nanotubes composite film [poly(4-ABA)/MWNTs/GCE]. The sensor was characterized by scanning electron microscopy and electrochemical methods. It was observed that poly(4-ABA)/MWNTs/GCE showed excellent preconcentration function and electrocatalytic activities towards doxepin. Under the selected conditions, the anodic peak current was linear to the logarithm of doxepin concentration in the range from 1.0 x 10(-9) to 1.0 x 10(-6) M, and the detection limit obtained was 1.0 x 10(-10) M. The poly(4-ABA)/MWNTs/GCE was successfully applied in the measurement of doxepin in commercial pharmaceutical formulations, and the analytical accuracy was confirmed by comparison with a conventional ultraviolet spectrophotometry assay.

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