Review
Engineering, Biomedical
Bernhard Burtscher, Pamela Allison Manco Urbina, Chiara Diacci, Simone Borghi, Marcello Pinti, Andrea Cossarizza, Carlo Salvarani, Magnus Berggren, Fabio Biscarini, Daniel T. Simon, Carlo A. Bortolotti
Summary: The overview of cytokine biosensing on organic electronic platforms highlights the importance of monitoring inflammation biomarkers in real time. The technologies provided by OECTs and EGOFETs offer low-cost point-of-care solutions that can significantly benefit the healthcare system and professionals.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Analytical
Tripti Singh, Shalini Sharma, Rajeev Singh, Dan Bahadur Pal, Irfan Ahmad, Mohammad Mahtab Alam, Nand Lal Singh, Manish Srivastava, Neha Srivastava
Summary: This review summarizes the fundamental processes and mechanisms of green synthesis approaches for TiO2 nanoparticles, with a focus on exploring the potential of using plants and microbes for preparing TiO2 nanoparticles and the role of TiO2-based nanomaterials in designing sensing platforms.
Review
Chemistry, Multidisciplinary
Sorour Darvishi, Shima Tavakoli, Mahshid Kharaziha, Hubert H. Girault, Clemens F. Kaminski, Ioanna Mela
Summary: Wound biofilms are a challenging problem in modern medicine due to their increasing antibiotic resistance and hindrance to wound healing. This review presents new chemical avenues in biofilm sensors and materials for better detection and treatment of wound biofilms, offering promising solutions for accurate detection and efficient eradication of biofilms.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Anqi Zhang, Jae-Hyun Lee, Charles M. Lieber
Summary: Bioelectronics explores the use of electronic devices in signal transduction at interfaces with biological systems. Nanowire-enabled devices offer advantages in sensitivity for biomolecule detection, and have been used in synthetic studies for creating semiconductor nanowires and field-effect transistor sensors for biomedical applications. Recent progress includes advancements in electrical recording for single cell measurements, cell network mapping, and in vivo brain mapping using nanowire electronic devices.
Review
Chemistry, Physical
Akash Prabhu, Robert D. Crapnell, Kasper Eersels, Bart van Grinsven, Aruna K. Kunhiraman, Pankaj Singla, Jake McClements, Craig E. Banks, Katarina Novakovic, Marloes Peeters
Summary: This minireview focuses on the application of chitosan and polydopamine, two commonly used biopolymers, in electrochemical sensing. Chitosan exhibits high chemical resistance and easy modification, while polydopamine has universal adhesion and self-assembling ability. The unique structural and electrochemical features of these biopolymers have a wide range of applications in electrochemical biosensing platforms.
CURRENT OPINION IN ELECTROCHEMISTRY
(2022)
Article
Energy & Fuels
Hsing-I Hsiang, Ya-Yun Chiou, Sheng-Heng Chung
Summary: Ternary metal sulfides with unique yolk-shell microstructure exhibit excellent electrochemical performance, making them suitable for supercapacitor electrodes.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Biophysics
Bhuwan Kashyap, Ratnesh Kumar
Summary: This paper proposes a novel electro-chemical method, MS-DPV, to reduce random errors and improve the precision of electrochemical sensors. The method improves precision without the need for replicating measurements and is suitable for portable or in-field sensing solutions with constraints on sampling, time, and energy use.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Dandan Men, Wenjuan Li, Ting Wu, Guihua Jiang, Honghua Zhang, Lifeng Hang, Ping Li, Hong Wang, Junhuai Xiang
Summary: The present study focuses on designing a sensor with excellent sensitivity, high stability, and low cost at room temperature for rapid and simple detection of iodine (I2) in liquid and gaseous phase. A two-dimensional Au@Ag nanoparticle ordered array was prepared using a template method combined with chemical reduction. The array exhibited plasmonic surface lattice resonances (PSLR) peak in the extinction spectrum, which changed with the reaction of the Ag shell with I2, enabling multi-mode detection of liquid and gaseous I2 without sophisticated instruments. The ordered array showed good uniformity and stability, making it suitable for detecting I2 in a large concentration region. The Au@Ag nanoparticle array also demonstrated high sensitivity to gaseous I2 at room temperature, with a detection limit reaching trace level (1 ppb), indicating great potential for real-world application.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Multidisciplinary
Jiuyun Shi, Changxu Sun, Elaine Liang, Bozhi Tian
Summary: This article introduces the potential of semiconductor nanowires in probing biological behaviors, sensing physiology or biochemistry, and modulating biological activity at the cellular level, as well as the progress in drug delivery and bioenergy production.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
Ting Wang, Ming Wang, Jianwu Wang, Le Yang, Xueyang Ren, Gang Song, Shisheng Chen, Yuehui Yuan, Ruiqing Liu, Liang Pan, Zheng Li, Wan Ru Leow, Yifei Luo, Shaobo Ji, Zequn Cui, Ke He, Feilong Zhang, Fengting Lv, Yuanyuan Tian, Kaiyu Cai, Bowen Yang, Jingyi Niu, Haochen Zou, Songrui Liu, Guoliang Xu, Xing Fan, Benhui Hu, Xian Jun Loh, Lianhui Wang, Xiaodong Chen
Summary: A chemically mediated artificial neuron is developed to detect and release dopamine neurotransmitter, utilizing a memristor and a heat-responsive hydrogel for signal processing. The artificial neuron forms a chemical communication loop with pheochromocytoma cells, triggering controllable movements of a mouse leg and robotic hand.
NATURE ELECTRONICS
(2022)
Article
Biophysics
Kamyar Behrouzi, Liwei Lin
Summary: This article introduces a virus detection scheme based on LSPR principle with gold nanoparticles aggregation, which can provide observable results by the naked eye in 5 minutes with a LOD of 150 ng/ml for N proteins. A comprehensive numerical model is developed to identify key parameters, and the linear relationship between a defined parameter and N protein concentrations is found to be useful for quantitative detection of the virus.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
John R. Aggas, Brandon K. Walther, Sara Abasi, Christian N. Kotanen, Olukayode Karunwi, Ann M. Wilson, Anthony Guiseppi-Elie
Summary: Established in 2000, the C3B has contributed new knowledge and technology in molecular bioelectronics, responsive polymers, multiplexed biosensor systems, and bioelectronic biosensors. Noteworthy contributions include direct electron transfer of enzymes enabled by carbon nanotubes and colloidal clays, integration of conductive polymers with bioactive hydrogels, development of a multi-analyte physiological status monitoring biochip, and a bioanalytical Wien-bridge oscillator for lactate and glucose measurement. The future of bioelectronics-based biosensors and systems, with a focus on multiplexed biosensor systems and data fusion for rapid decision making, is discussed.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Multidisciplinary Sciences
Nasim Ahmed, Shaikat Chandra Dey, Nusrat Mustary, Md Ashaduzzaman
Summary: This study reports a synthesis method for zinc oxide nanoparticles (ZnO NPs) using zinc nitrate hexahydrate precursor and lactose as a reducing agent. The fabricated ZnO NPs exhibited diversified morphologies and could be used for real-time glucose monitoring in biomedical science for efficient management of diabetes.
Article
Chemistry, Analytical
Nikhil Bhalla, Amir Farokh Payam, Alessio Morelli, Preetam Kumar Sharma, Rhiannon Johnson, Alan Thomson, Pawan Jolly, Francesco Canfarotta
Summary: In this study, a single sensor platform capable of detecting multiple variants of SARS-CoV-2 was developed using synthetic binders and nanoplasmonic-based sensing technology. The sensor can detect Alpha, Beta, and Gamma spike protein variants within 30 minutes, making it a rapid and efficient tool for COVID-19 detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Omid Dadras-Toussi, Milad Khorrami, Anto Sam Crosslee Louis Sam Titus, Sheereen Majd, Chandra Mohan, Mohammad Reza Abidian
Summary: By incorporating organic semiconductor materials and utilizing multiphoton lithography technology, three-dimensional OS composite microstructures with high electrical conductivity and biocompatibility were successfully fabricated, providing an efficient platform for sensitive glucose detection in biosensors.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Byron Llerena Zambrano, Csaba Forro, Erik Poloni, Robert Hennig, Pragash Sivananthaguru, Aline F. Renz, Andre R. Studart, Janos Voeroes
Summary: This research demonstrates the manipulation of nanowires using superparamagnetic iron oxide nanoparticles and vacuum filtration, resulting in different structures of oriented nanowires. The study also investigates the strain-dependent electrical properties of nanowires within composite materials.
Article
Chemistry, Physical
Akira Yasuhara, Takumi Sannomiya
Summary: Metallic nanoparticles, especially those alloyed with multiple metal elements, have been widely studied for their unique electrical, optical, and catalytic properties. Interfaces between different phases and grain boundaries play a significant role in determining the catalytic efficiency and chemical stability of the alloy nanoparticles. In this study, Au-Ag-Cu ternary alloy nanoparticles were synthesized and their atomically localized structures, particularly at the grain boundaries, were investigated. The findings provide insights into the interface structure of these nanoparticles.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Physical
John Andersson, Justas Svirelis, Gustav Ferrand-Drake del Castillo, Takumi Sannomiya, Andreas Dahlin
Summary: This study demonstrates the use of 20 nm Pd and Pt films for quantitative SPR sensing of organic films, despite their high light absorption. The Pd sensors show similarities to 50 nm gold in sensitivity and field extension, while Pt sensors have a longer extension of the evanescent field but higher noise levels. The findings highlight the advantages of SPR for studying chemical modifications of important metals in various contexts.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Neurosciences
Jens Duru, Joeel Kuechler, Stephan J. Ihle, Csaba Forro, Aeneas Bernardi, Sophie Girardin, Julian Hengsteler, Stephen Wheeler, Janos Voeroes, Tobias Ruff
Summary: Bottom-up neuroscience addresses questions on neural information processing by engineering reproducible biological neural networks of defined network topology in vitro. By using high-density CMOS MEAs, it enables high spatiotemporal resolution for sub-cellular readout and stimulation, overcoming the limitations of currently used glass MEAs.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Jose C. Mateus, Sean Weaver, Dirk van Swaay, Aline F. Renz, Julian Hengsteler, Paulo Aguiar, Janos Voeroes
Summary: This research utilizes electron beam lithography and photolithography to create microstructures that control neuronal connectivity, and demonstrates the formation of functional synapses in vitro.
Article
Biophysics
Stephan J. Ihle, Sophie Girardin, Thomas Felder, Tobias Ruff, Julian Hengsteler, Jens Duru, Sean Weaver, Csaba Forro, Janos Voros
Summary: We present a paradigm to examine the behavior of multiple neuronal networks with controlled topology in vitro. Our approach enables simultaneous electrical stimulation and recording of neuronal activity from 60 independent networks over multiple weeks. We found that the network response pattern to a stimulus remains stable for at least 12 hours and continuous stimulation does not significantly change the stimulation-induced mean spiking frequency of a circuit. We also investigated the effect of stimulation amplitude and timing on the network response and demonstrated the capability of our setup to apply complex stimulation protocols.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Nanoscience & Nanotechnology
Akira Yasuhara, Masahiro Homma, Takumi Sannomiya
Summary: Metallic nanoparticles with localized surface plasmon resonance have suitable optical properties for various applications, and the phase-separated Janus nanoparticles can be formed at high temperatures to tune the optical properties and metastructures of the nanoparticles.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Jean-Marc Von Mentlen, Jasper Clarysse, Annina Moser, Dhananjeya Kumaar, Olesya Yarema, Takumi Sannomiya, Maksym Yarema, Vanessa Wood
Summary: This article presents an easy method to reliably engineer thin Ga2O3 shells on Au nanoparticles. With the liquid-phase chemical oxidation of Au-Ga alloy nanoparticles, laminar and ultrathin Ga2O3 shells can be grown. The reaction process and Ga2O3 shell growth can be monitored using localized surface plasmon resonance.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Taeko Matsukata, Shintaro Ogura, Javier Garcia de Abajo, Takumi Sannomiya
Summary: Free-electron-based spectroscopies can reveal nanoscale optical properties of semiconductor materials and nanophotonic devices. A cathodoluminescence method is demonstrated that can access both excitation and emission spaces at the nanoscale, providing valuable information on previously inaccessible nanoscale optical properties.
Article
Materials Science, Multidisciplinary
Dung Thi Vu, Nikolaos Matthaiakakis, Takumi Sannomiya
Summary: A significant enhancement of the A- and B-exciton emission in MoS2 flakes through coupling with plasmonic Au nano-pyramid arrays fabricated by a colloidal lithography technique is reported in this study. The local emission enhancement from the structure is experimentally mapped with a nanometer spatial resolution by cathodoluminescence (CL) technique. The strongly enhanced emission intensity within the MoS2-Au pyramids is achieved due to the localized surface plasmon resonance confined in nano-pyramids and its interaction with the periodicity-based resonance of the array structure. These results provide an approach to significantly improve the luminescence intensity of MoS2 through optical interaction with the local plasmonic field, which is promising for applications in optoelectronic devices and nanophotonics.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Izzah Machfuudzoh, Tatsuki Hinamoto, F. Javier Garcia de Abajo, Hiroshi Sugimoto, Minoru Fujii, Takumi Sannomiya
Summary: This study fills the research gap in direct imaging of optical modes by demonstrating nanoscale optical-field visualization of self-interference of light extracted from excited modes through experimentally obtained photon maps that directly portray the field distributions of the excited eigenmodes. By selectively choosing specific modes using cathodoluminescence-based scanning transmission electron microscopy with angle-, polarization-, and wavelength-resolved capabilities, the internal field distributions of the whispering-gallery modes reveal the interference between multiple modes and the resulting complex patterns dependent on the detection angle and polarization. The direct visualization of internal fields enables a comprehensive understanding of WGMs and can provide insights for the design of nanophotonic applications.
Article
Biophysics
Jens Duru, Benedikt Maurer, Ciara Giles Doran, Robert Jelitto, Joel Kuchler, Stephan J. Ihle, Tobias Ruff, Robert John, Barbara Genocchi, Janos Voros
Summary: This article presents a bottom-up neuroscience approach using engineered biological neural networks to study neuronal activity. The researchers establish a platform with up to six independent networks formed by rat neurons on microelectrode arrays. They demonstrate that continuous application of a repetitive super-threshold stimulus generates a reproducible network response within a 15 ms post-stimulus window, which can be tracked with high spatiotemporal resolution across the entire network.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Microscopy
Yoshikazu Adachi, Naoki Yamamoto, Takumi Sannomiya
Summary: We developed a novel light optics system for a scanning transmission electron microscope (STEM) that accurately introduces a focused light at the electron beam irradiation position using a parabolic mirror. The position and focus of the light beam can be evaluated by imaging the angular distribution of the transmitted light. This system allows for investigating optical spectra in comparison with cathodoluminescence (CL) spectra at exactly the same location.
Article
Materials Science, Multidisciplinary
Tatsuro Yuge, Naoki Yamamoto, Takumi Sannomiya, Keiichirou Akiba
Summary: We propose a theoretical model for cathodoluminescence (CL) based on a master equation. The model describes the excitation of multiple emitters by an incoming electron and the decay of individual emitters. We investigate the second-order correlation function, g(2)(r), and derive exact and approximate formulas for different scenarios. Moreover, we discuss the radiation field state of CL and reveal the existence of a state resulting from a mixture of excited photon state and vacuum state, leading to superbunching.
Article
Biochemical Research Methods
Sophie Girardin, Blandine Clement, Stephan J. Ihle, Sean Weaver, Jana B. Petr, Jose C. Mateus, Jens Duru, Csaba Forro, Tobias Ruff, Isabelle Fruh, Matthias Mueller, Janos Voeroes, Magdalena
Summary: Building small and controlled circuits of human induced pluripotent stem cell-derived neurons holds great promise in understanding the fundamental principles of information processing and storing in the brain.
