Journal
SENSORS
Volume 9, Issue 8, Pages 6471-6503Publisher
MDPI
DOI: 10.3390/s90806471
Keywords
angiogenesis; fibroblast growth factor-2; heparan-sulfate proteoglycans; heparin; interactions; pentraxin 3; peptides; surface plasmon resonance; thrombospondin-1
Funding
- CARIPLO
- Istituto Superiore di Sanita Progetto Nazionale AIDS
- Associazione Italiana per la Ricerca sul Cancro
- Istituto Superiore di Sanita
- Ministero dell'Istruzione
- Universita e Ricerca
- Fondazione Berlucchi
- Fondazione Cariplo [2008-2264]
- NASPE
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Angiogenesis, the process of new blood vessel formation, is implicated in various physiological/pathological conditions, including embryonic development, inflammation and tumor growth. Fibroblast growth factor-2 (FGF2) is a heparin-binding angiogenic growth factor involved in various physiopathological processes, including tumor neovascularization. Accordingly, FGF2 is considered a target for antiangiogenic therapies. Thus, numerous natural/synthetic compounds have been tested for their capacity to bind and sequester FGF2 in the extracellular environment preventing its interaction with cellular receptors. We have exploited surface plasmon resonance (SPR) technique in search for antiangiogenic FGF2 binders/antagonists. In this review we will summarize our experience in SPR-based angiogenesis research, with the aim to validate SPR as a first line screening for the identification of antiangiogenic compounds.
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