Journal
SEMINARS IN THROMBOSIS AND HEMOSTASIS
Volume 37, Issue 2, Pages 97-105Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0030-1270334
Keywords
Pre-eclampsia; gene polymorphisms; PAI-1
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Funding
- Associazione Italiana Ricerca Cancro (AIRC) [IG10296]
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Pre-eclampsia (P-EC) is a multisystem disorder of pregnancy, characterized by new-onset hypertension and proteinuria. Deregulation of the coagulation cascade and hypofibrinolysis appear to play a central role in the development of this disease. After a brief review of the genetic basis of P-EC and the role of genes encoding proteins involved in coagulation, we focus on polymorphisms of the plasminogen activator inhibitor (PAI-1) gene. The most relevant association studies between PAI-1 gene polymorphisms and P-EC are reviewed. Results indicate that the 4G/4G genotype of the -675 4G/5G polymorphism represents a weak risk factor for P-EC.
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