Drug Signature-based Finding of Additional Clinical Use of LC28-0126 for Neutrophilic Bronchial Asthma

The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release

(2015) Keon-Il Im et al.   JOURNAL OF IMMUNOLOGY

The indole derivative NecroX-7 improves nonalcoholic steatohepatitis inob/obmice through suppression of mitochondrial ROS/RNS and inflammation

(2015) Hyo Kyun Chung et al.   LIVER INTERNATIONAL

Unraveling the Truth About Antioxidants: ROS and disease: finding the right balance

(2014) Hiroyuki Kawagishi et al.   NATURE MEDICINE

R&D productivity: on the comeback trail

(2014) Ulrik Schulze et al.   NATURE REVIEWS DRUG DISCOVERY

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation

(2013) So Ri Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Recombinant IGFBP-3 inhibits allergic lung inflammation, VEGF production, and vascular leak in a mouse model of asthma

(2012) S. R. Kim et al.   ALLERGY

In silico drug repositioning – what we need to know

(2012) Zhichao Liu et al.   DRUG DISCOVERY TODAY

Transcriptional data: a new gateway to drug repositioning?

(2012) Francesco Iorio et al.   DRUG DISCOVERY TODAY

A novel small molecule, NecroX-7, inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression

(2012) Hyun-Ju Kim et al.   LIFE SCIENCES

NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats

(2012) Joonghoon Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent manner

(2011) Yochai Birnbaum et al.   BASIC RESEARCH IN CARDIOLOGY

Exploiting drug-disease relationships for computational drug repositioning

(2011) J. T. Dudley et al.   BRIEFINGS IN BIOINFORMATICS

Cytosolic Phospholipase A2α Protects against Ischemia/Reperfusion Injury in the Heart

(2011) Risto Kerkelä et al.   CTS-Clinical and Translational Science

Severe asthma: Advances in current management and future therapy

(2011) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis

(2011) Jan Neckář et al.   PHYSIOLOGICAL GENOMICS

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Cardioprotective Effects of a Selective B2 Receptor Agonist of Bradykinin Post-Acute Myocardial Infarct

(2010) M. Marketou et al.   AMERICAN JOURNAL OF HYPERTENSION

NecroX as a novel class of mitochondrial reactive oxygen species and ONOO− scavenger

(2010) Hyoung Jin Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Glucocorticosteroids: current and future directions

(2010) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY

The multiple dimensions of airways disease: targeting treatment to clinical phenotypes

(2010) Philippa Shirtcliffe et al.   CURRENT OPINION IN PULMONARY MEDICINE

sscMap: An extensible Java application for connecting small-molecule drugs using gene-expression signatures

(2009) Shu-Dong Zhang et al.   BMC BIOINFORMATICS

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Mast Cells Can Mediate Vascular Permeability through Regulation of the PI3K–HIF-1α–VEGF Axis

(2008) Kyung Sun Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Superoxide Dismutase, Lipid Peroxidation, and Bell-Shaped Dose Response Curves

(2008) Joe M. McCord   Dose-Response

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE