Review
Immunology
Maheswari Muruganandam, Angie Ariza-Hutchinson, Rosemina A. Patel, Wilmer L. Sibbitt
Summary: Systemic sclerosis is a complex autoimmune disease characterized by vascular damage, inflammation, and fibrosis. Biomarkers play an important role in understanding the disease process and potential therapeutic targets. Anti-nuclear antibodies are classical biomarkers, while other proteins and pathways are also implicated. The use of biomarker panels combined with advanced analysis techniques can help determine disease activity and treatment response.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Immunology
Vikram Jain, Pratap Kumar, Prasan Kumar Panda, Mohan Suresh, Karanvir Kaushal, Anissa A. Mirza, Rohit Raina, Sarama Saha, Balram J. Omar, Vivekanandhan Subbiah
Summary: This study investigated the role of IL-6 in COVID-19 diagnosis, treatment, and prognosis, suggesting that IL-6 levels above 40 pg/mL are associated with higher rates of mortality, ICU admissions, and ventilator requirements.
Article
Immunology
Dhanasekaran Sivakumaran, Synne Jenum, Christian Ritz, Mario Vaz, Timothy Mark Doherty, Harleen M. S. Grewal
Summary: This study explored the potential of different soluble immune markers in accurately assigning household contacts of TB patients for appropriate treatment. It identified protein signatures that could distinguish between Mtb infection and Active TB with high specificity, and found that new Mtb infection induced elevated levels of soluble markers. Further validation is necessary to optimize TB case detection and treatment assignment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yanping Li, Yue Ming, Ruoqiu Fu, Chen Li, Yuanlin Wu, Tingting Jiang, Ziwei Li, Rui Ni, Li Li, Hui Su, Yao Liu
Summary: Chimeric antigen receptor (CAR)-T cell therapy is an effective treatment for refractory/relapsed hematological malignancies. However, it also causes adverse effects, with cytokine release syndrome (CRS) being the most common reaction. Severe CRS can lead to other toxicities, limiting the widespread application of CAR-T therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Jae Seok Kim, Jun Young Lee, Jae Won Yang, Keum Hwa Lee, Maria Effenberger, Wladimir Szpirt, Andreas Kronbichler, Jae Il Shin
Summary: Severe COVID-19 is characterized by systemic hyper-inflammation and cytokine storm, often leading to acute respiratory distress syndrome and multiple organ failure. Treatment of COVID-19 cytokine storm is crucial, with anti-inflammatory therapies playing a significant role. Various approaches are being used, including new cytokine-targeted therapies, to address the cytokine storm associated with COVID-19.
Review
Pharmacology & Pharmacy
Avneet Kaur, Vijay Bhalla, Mohammed Salahuddin, Syed O. Rahman, Faheem H. Pottoo
Summary: Coronavirus was first discovered in 1930, and the COVID-19 pandemic caused by SARS-CoV-2 has become a global health emergency. Efforts are being made to study the virus and develop effective treatment methods to save more lives.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Immunology
Augustina Frimpong, Ewurama D. A. Owusu, Jones Amo Amponsah, Elizabeth Obeng-Aboagye, William van der Puije, Abena Fremaah Frempong, Kwadwo Asamoah Kusi, Michael Fokuo Ofori
Summary: Sepsis is a major complication in children and often misdiagnosed due to overlapping clinical features with other infections. This study identified seven potential biomarkers that can differentiate sepsis from malaria and other febrile conditions, providing a diagnostic tool for areas burdened with infectious diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Hong-Da Wang, Zhi-Jian Wei, Jun-Jin Li, Shi-Qing Feng
Summary: This paper reviews the research progress and application prospects of recently identified biomarkers related to spinal cord injuries (SCIs). Proteins, inflammatory factors, non-coding RNAs, and trace elements have shown potential for SCI diagnosis, assessment, and prognosis. These biomarkers have the advantages of convenient sampling, low cost, and ease of dynamic tracking, but are also influenced by various factors and exhibit complex level changes.
NEURAL REGENERATION RESEARCH
(2022)
Review
Medicine, General & Internal
Robert L. Sheridan, Jeremy M. Goverman, T. Gregory Walker
Summary: Frostbite is a combination of direct cellular damage from freezing and cellular ischemia from vasospasm and small-vessel thrombosis. The severity is related to the degree of reperfusion of frozen tissues upon thawing.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jiwon Yang, Jing Jiao, Kyle M. Draheim, Guoxiang Yang, Hongyuan Yang, Li-Chin Yao, Leonard D. Shultz, Dale L. Greiner, Deepa Rajagopal, Sandrine Vessillier, Curtis C. Maier, Sunish Mohanan, Danying Cai, Mingshan Cheng, Michael A. Brehm, James G. Keck
Summary: Immuno-oncology (IO)-based therapies have been successful in treating cancer, but may lead to severe adverse events like cytokine release syndrome (CRS). Currently, there is a lack of in vivo models to evaluate dose-response relationships and safety issues. This study tested an in vivo PBMC humanized mouse model using a specific T-cell engager (BiTE) to assess treatment efficacy and cytokine release. The results show that this model accurately predicts tumor control and cytokine release, and captures variability among donors. The PBMC humanized mouse model is a reliable platform to identify effective treatments and complications.
Review
Biochemistry & Molecular Biology
Natalia A. A. Shnayder, Azamat V. V. Ashkhotov, Vera V. V. Trefilova, Zaitun A. A. Nurgaliev, Maxim A. A. Novitsky, Marina M. M. Petrova, Ekaterina A. A. Narodova, Mustafa Al-Zamil, Galina A. A. Chumakova, Natalia P. P. Garganeeva, Regina F. F. Nasyrova
Summary: Intervertebral disc degeneration (IDD) and associated conditions are a significant problem in modern medicine. IDD may start in childhood and adolescence, and progress with age, leading to various spinal conditions. The imbalance between pro-inflammatory and anti-inflammatory cytokines is a key mechanism in the development of IDD and chronic back pain. Traditional therapeutic strategies for cytokine imbalance often have limited effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xiong Liu, Qi Qiao, Xiaonan Li, Xiangjun Ou, Kexin Cui, Boning Niu, Conglian Yang, Li Kong, Zhiping Zhang
Summary: Acute respiratory distress syndrome (ARDS) is a severe respiratory disease with high mortality, but effective therapeutic drugs for clinical practice are lacking. This study constructed an apoptotic neutrophil-mediated drug delivery system for ARDS treatment. The system exhibited significant effects on reducing neutrophil infiltration, inhibiting cytokine storm, and promoting anti-inflammatory macrophage polarization.
Article
Medicine, General & Internal
Michael S. Saag
Summary: Despite extensive knowledge about HIV, incident cases have only decreased slightly in recent years. Universal screening, prompt referral for assessment, and initiation of antiretroviral therapy are crucial for improving outcomes and reducing transmission rates.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Immunology
Paola Sindaco, Hritisha Pandey, Colleen Isabelle, Nitin Chakravarti, Jonathan Edward Brammer, Pierluigi Porcu, Anjali Mishra
Summary: Cytokines play a crucial role in regulating blood cell activation and growth in the immune system. However, excessive production of cytokines can lead to malignant transformation. This review focuses on the impact of interleukin-15 (IL-15) on the development and progression of hematological malignancies, discussing its role in cell survival, proliferation, inflammation, and treatment resistance. Therapeutic approaches for inhibiting IL-15 in blood cancers will also be reviewed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ziwen Zhu, Pooja Parikh, Hongyun Zhao, Nathan T. Givens, Damien B. Beck, Conner M. Willson, Qian Bai, Mark R. Wakefield, Yujiang Fang
Summary: Tumor metabolism has emerged as a prominent research area, leading to new opportunities in metabolism-based cancer therapy. Intratumoral heterogeneity in tumors results in complex energy metabolism phenotypes in tumor cells, with metabolic reprogramming during tumor progression.
Article
Respiratory System
Catia Cilloniz, Miquel Ferrer, Juan M. Pericas, Leyre Serrano, Raul Mendez, Albert Gabarrus, Hector Jose Peroni, Luis Alberto Ruiz, Rosario Menendez, Rafael Zalacain, Antoni Torres
Summary: This study aimed to validate the accuracy of the 2007 IDSA/ATS guidelines for community-acquired pneumonia (CAP) in very elderly patients (VEP) aged 80 years and above. The results showed that the severe CAP criteria had a moderate predictive ability for ICU admission in VEP, and VEP with only minor criteria can be adequately managed in general wards.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Letter
Respiratory System
Catia Cilloniz, Juan M. Pericas, Anna Motos, Albert Gabarrus, Ricard Ferrer, Rosario Menendez, Jordi Riera, Dario Garcia-Gasulla, Osca Penuelas, Laia Fernandez-Barat, Jose Angel Lorente, David de Gonzalo-Calvo, Ferra Barbe, Antoni Torres
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Letter
Critical Care Medicine
Jessica Gonzalez, Ivan D. Benitez, Anna Motos, Antoni Torres, Ferran Barbe
INTENSIVE CARE MEDICINE
(2023)
Letter
Infectious Diseases
Catia Cilloniz, Anna Motos, Tatiana Castaneda, Albert Gabarrus, Ferran Barbe, Antoni Torres
JOURNAL OF INFECTION
(2023)
Article
Respiratory System
Ignacio Martin-Loeches, Antoni Torres, Blin Nagavci, Stefano Aliberti, Massimo Antonelli, Matteo Bassetti, Lieuwe Bos, James Chalmers, Lennie Derde, Jan de Waele, Jose Garnacho-Montero, Marin Kollef, Carlos Luna, Rosario Menendez, Michael Niederman, Dimitry Ponomarev, Marcos Restrepo, David Rigau, Marcus Schultz, Emmanuele Weiss, Tobias Welte, Richard Wunderink
Summary: The ERS, ESICM, ESCMID and ALAT have developed the first international guidelines for severe community-acquired pneumonia (sCAP). These guidelines provide evidence-based recommendations for diagnosis, empirical treatment and antibiotic therapy for sCAP.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Environmental Sciences
O. Bronte, F. Garcia-Garcia, D. -J. Lee, I. Urrutia, A. Uranga, M. Nieves, J. Martinez-Minaya, J. M. Quintana, I. Arostegui, R. Zalacain, L. A. Ruiz-Iturriaga, L. Serrano, R. Menendez, R. Mendez, A. Torres, C. Cilloniz, P. P. Espana
Summary: This study aimed to investigate the relationship between exposure to air pollution and the risk of death in COVID-19 pneumonia patients, as well as the impact on inflammation and gas exchange. The results showed a significant positive relationship between air pollution and mortality in hospitalized COVID-19 patients, and it was also related to inflammation and gas exchange.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Critical Care Medicine
James D. Chalmers, Eva Polverino, Megan L. Crichton, Felix C. Ringshausen, Anthony De Soyza, Montserrat Vendrell, Pierre Regis Burgel, Charles S. Haworth, Michael R. Loebinger, Katerina Dimakou, Marlene Murris, Robert Wilson, Adam T. Hill, Rosario Menendez, Antoni Torres, Tobias Welte, Francesco Blasi, Josje Altenburg, Michal Shteinberg, Wim Boersma, J. Stuart Elborn, Pieter C. Goeminne, Stefano Aliberti
Summary: This study aimed to describe the clinical characteristics of bronchiectasis and compare the differences between different European countries. It found that bronchiectasis shows important geographic variation in causes, microbiology, severity, and outcomes across Europe.
LANCET RESPIRATORY MEDICINE
(2023)
Review
Infectious Diseases
Jesus Ruiz-Ramos, Laura Gras-Martin, Paula Ramirez
Summary: Critically ill patients with severe infections often experience pharmacokinetic changes that lead to inadequate antibiotic serum levels. These patients also tend to have higher minimum inhibitory concentrations (MICs) of the causative pathogens. The use of extracorporeal circulation devices further complicates antibiotic dosing. It is important to optimize antibiotic pharmacokinetics to reduce the risk of antibiotic resistance.
Article
Infectious Diseases
Antoni Torres, Michele Wible, Margaret Tawadrous, Paurus Irani, Gregory G. Stone, Alvaro Quintana, Dmitri Debabov, Margaret Burroughs, Patricia A. Bradford, Marin Kollef
Summary: This post hoc analysis provides evidence of the efficacy and safety of ceftazidime/avibactam in patients with infections caused by beta-lactamase-producing Gram-negative pathogens.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Virology
Francisco Javier Candel, Pablo Barreiro, Miguel Salavert, Alfonso Cabello, Mario Fernandez-Ruiz, Pedro Perez-Segura, Jesus San Roman, Juan Berenguer, Raul Cordoba, Rafael Delgado, Pedro Pablo Espana, Ignacio Alberto Gomez-Centurion, Juan Maria Gonzalez del Castillo, Sarah Beatrice Heili, Francisco Javier Martinez-Peromingo, Rosario Menendez, Santiago Moreno, Jose Luis Pablos, Juan Pasquau, Jose Luis Pinana, MODUS Investigators Adenda
Summary: The clinical evolution of patients infected with SARS-CoV-2 depends on the interplay between viral and host factors. Virus-targeted measures, such as antiviral drugs or monoclonal antibodies, can be effective in treating COVID-19, especially for patients with risk factors or comorbidities. The findings of this study are important for establishing treatment guidelines and preventing fatal outcomes.
Review
Medicine, General & Internal
Francisco Javier Candel, Miguel Salavert, Angel Estella, Miquel Ferrer, Ricard Ferrer, Julio Javier Gamazo, Carolina Garcia-Vidal, Juan Gonzalez del Castillo, Victor Jose Gonzalez-Ramallo, Federico Gordo, Manuel Miron-Rubio, Javier Perez-Pallares, Cristina Pitart, Jose Luis del Pozo, Paula Ramirez, Pedro Rascado, Soledad Reyes, Patricia Ruiz-Garbajosa, Borja Suberviola, Pablo Vidal, Rafael Zaragoza
Summary: Nosocomial pneumonia and ventilator-associated pneumonia are significant global health problems, causing high morbidity and mortality rates. This scientific manuscript reviews important aspects of the management of these infectious respiratory syndromes, providing updates on etiological perspectives, diagnostic techniques, treatment options, and preventive strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Adrian Ceccato, Marta Camprubi-Rimblas, Lieuwe D. J. Bos, Pedro Povoa, Ignacio Martin-Loeches, Carles Forne, Aina Areny-Balaguero, Elena Campana-Duel, Luis Morales-Quinteros, Sara Quero, Paula Ramirez, Mariano Esperatti, Antoni Torres, Lluis Blanch, Antonio Artigas
Summary: The measurement and dynamics of Pancreatic Stone Protein (PSP) do not contribute to the early diagnosis of Ventilator-associated pneumonia (VAP).
Article
Respiratory System
David de Gonzalo-Calvo, Marta Molinero, Ivan D. Benitez, Manel Perez-Pons, Nadia Garcia-Mateo, Alicia Ortega, Tamara Postigo, Maria C. Garcia-Hidalgo, Thalia Belmonte, Carlos Rodriguez-Munoz, Jessica Gonzalez, Gerard Torres, Clara Gort-Paniello, Anna Moncusi-Moix, Angel Estella, Luis Tamayo Lomas, Amalia Martinez de la Gandara, Lorenzo Socias, Yhivian Penasco, Maria Del Carmen de la Torre, Elena Bustamante-Munguira, Elena Gallego Curto, Ignacio Martinez Varela, Maria Cruz Martin Delgado, Pablo Vidal-Cortes, Juan Lopez Messa, Felipe Perez-Garcia, Jesus Caballero, Jose M. Anon, Ana Loza-Vazquez, Nieves Carbonell, Judith Marin-Corral, Ruth Noemi Jorge Garcia, Carmen Barbera, Adrian Ceccato, Laia Fernandez-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Jose Angel Lorente-Balanza, Rosario Menendez, Ana Motos, Oscar Penuelas, Jordi Riera, Jesus F. Bermejo-Martin, Antoni Torres, Ferran Barbe
Summary: This study validated certain microRNAs as potential biomarkers for clinical decision-making in critically ill patients and developed a blood microRNA classifier for the early prediction of adverse outcomes in the ICU.
RESPIRATORY RESEARCH
(2023)
Article
Microbiology
Rosario Menendez, Antoni Torres, Pedro Pablo Espana, Jose Alberto Fernandez-Villar, Jose Maria Marimon, Raul Mendez, Catia Cilloniz, Mikel Egurrola, Maribel Botana-Rial, Maria Ercibengoa, Cristina Mendez, Isabel Cifuentes, Bradford D. Gessner
Summary: This study describes the evolution and distribution of serotypes in adult community-acquired pneumonia (CAP) in Spain, showing that serotypes included in the 20-valent pneumococcal conjugate vaccine (PCV20) are the predominant causes of pneumococcal CAP.