Article
Pharmacology & Pharmacy
Li Wang, Yu-fang Yang, Long Chen, Zhu-qing He, Dian-yong Bi, Lei Zhang, Yan-wu Xu, Jian-cheng He
Summary: Compound Dihuang Granule (CDG) is used in traditional Chinese medicine to treat Parkinson's disease (PD) by suppressing the JNK/AP-1 signaling pathway and thus inhibiting apoptosis in the nigrostriatal pathway, alleviating PD symptoms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura A. Struzyna, Kevin D. Browne, Justin C. Burrell, Wisberty J. Gordian Velez, Kathryn L. Wofford, Hilton M. Kaplan, N. Sanjeeva Murthy, H. Isaac Chen, John E. Duda, Rodrigo A. Espana, D. Kacy Cullen
Summary: This study successfully created a tissue-engineered nigrostriatal pathway (TE-NSP) using microtissue engineering techniques. The implanted TE-NSP showed survival, dopamine release, and integration with host tissue in a rat PD model, providing a potential strategy for replacing lost neuroarchitecture in PD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jose A. Pineda-Pardo, Alvaro Sanchez-Ferro, Mariana H. G. Monje, Nicola Pavese, Jose A. Obeso
Summary: The striatal dopaminergic deficit in Parkinson's disease follows a somatotopically related pattern, with an upper-limb onset and progression to other regions of the striatum. The denervation of the putamen was confirmed in both hemispheres and corresponding hemibodies. The findings suggest a precise somatotopic onset of nigrostriatal denervation in Parkinson's disease.
Article
Medicine, General & Internal
Jeong Pyo Seo, Dong Kyun Koo
Summary: This study used diffusion tensor tractography to investigate the effects of middle cerebral artery infarction on the nigrostriatal tract (NST). The results showed that infarction can lead to damage to the ipsilesional NST, impairing one's ability to control unwanted muscular contractions or voluntary movement.
Article
Clinical Neurology
Faezeh Vedaei, Islam Fayed, Mahdi Alizadeh, Christopher Miller, Ashley B. Zhang, Victoria Koa, Suharto Khan, Feroze B. Mohamed, Chengyuan Wu
Summary: This study demonstrated that the presence of enlarged perivascular spaces (PVS) is unlikely to affect the targeting of basal ganglia nuclei based on tractography.
Article
Cell Biology
Yanyun Sun, Xiao-jun Lu, Xinghui Fu, Ye Zhang, Yan Zhan, Jiabing Liu, Lingxia Zhao, Chun-lin Xia
Summary: Transplanting type-2 astrocytes (T2As) with high expression of FEZ1 improves symptoms and functional reconstruction in PD rats by regulating the neuronal microenvironment and supporting the survival of dopamine neurons. This study provides a theoretical basis for FEZ1 as a potential target and engraftment of T2As as a therapeutic strategy in the treatment of PD.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemical Research Methods
Hayden Wilkinson, Kristina A. Thomsson, Ana L. Rebelo, Mark Hilliard, Abhay Pandit, Pauline M. Rudd, Niclas G. Karlsson, Radka Saldova
Summary: This study provides a detailed analysis of O-glycosylation in neurodegenerative conditions such as PD and ILBD, revealing significant differences in glycosylation levels. Potential disease biomarkers are identified, highlighting the benefits of employing orthogonal techniques for glycan analysis.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Neurosciences
Vishakh Iyer, Kala Venkiteswaran, Sandip Savaliya, Christopher A. Lieu, Erin Handly, Timothy P. Gilmour, Allen R. Kunselman, Thyagarajan Subramanian
Summary: Parkinson's disease (PD) is a neurodegenerative disorder commonly treated with levodopa, which can lead to levodopa-induced dyskinesias (LID). This study found that the survival of the cross-hemispheric nigrostriatal pathway plays a crucial role in preventing the expression of LID in PD, suggesting it could be a potential target for preventing this devastating side effect.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Victor Blokhin, Maria Shupik, Ulyana Gutner, Ekaterina Pavlova, Albert T. Lebedev, Olga Maloshitskaya, Vsevolod Bogdanov, Sergey Sokolov, Alice Alessenko, Michael Ugrumov
Summary: Parkinson's disease is a neurodegenerative disease that is incurable due to late diagnosis and treatment. The study found that the expression of key sphingolipid metabolism enzyme genes and the content of sphingolipids play an important role in the preclinical and clinical stages of PD, suggesting their potential as attractive diagnostic markers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Quanquan Gu, Xiaocao Liu, Qingze Zeng, Xiaojun Guan, Cheng Zhou, Tao Guo, Baorong Zhang, Minming Zhang
Summary: This study investigated the impact of cigarette smoking on Parkinson's disease (PD) using quantified iron deposition. The results showed that smoking had a protective effect against PD movement deficits, but neuroprotection was only present when PD pathology had reached a certain stage.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carlos A. Sanchez-Catasus, Nicolaas Bohnen, Fang-Cheng Yeh, Nicholas D'Cruz, Prabesh Kanel, Martijn L. T. M. Muller
Summary: This study utilized C-11-DTBZ PET and correlational tractography to assess the integrity of nigrostriatal pathways in Parkinson's disease patients, revealing a correlation between impaired dopaminergic terminals and axonal dysfunction.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Li Zhou, Qian Xie, Quanyun Zhang, Mengxi Hu, Tengfei Ma, Hong Xie
Summary: Dexmedetomidine attenuates motor deficits and protects dopaminergic neurons in a dose-dependent manner in a PD mouse model. It acts on nigrostriatal circuit neurons, including activating dopaminergic neurons and reducing the excitabilities of striatal neurons via dopamine D2 receptors, improving motor dysfunction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
Han-Kyeol Kim, Tae Won Kim, Min Seok Baek, Eung Yeop Kim, Young Hee Sung, Jae Hoon Lee, Young Hoon Ryu, Sung Jun Ahn, Han Soo Yoo, Chul Hyoung Lyoo
Summary: In this study, the visibility of NG1 in SMwI was found to be associated with the degree of nigrostriatal degeneration in PD patients. It was concluded that SMwI can be used for diagnosing PD only after the onset of motor symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Allen P. F. Chen, Jeffrey M. Malgady, Lu Chen, Kaiyo W. Shi, Eileen Cheng, Joshua L. Plotkin, Shaoyu Ge, Qiaojie Xiong
Summary: This study reveals the involvement of the nigrostriatal system in auditory decision-making and demonstrates the modulatory effects of dopaminergic projections on striatal tone representations, which are inversely correlated with the evidence strength of tones.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Oihane Uriarte Huarte, Dimitrios Kyriakis, Tony Heurtaux, Yolanda Pires-Afonso, Kamil Grzyb, Rashi Halder, Manuel Buttini, Alexander Skupin, Michel Mittelbronn, Alessandro Michelucci
Summary: Microglia are immune cells in the CNS that rapidly respond to pathological stimuli to maintain homeostasis, but their reactions may also exacerbate neurological disorders. Studying microglia in healthy tissue can help identify specific subsets that either support or harm the neuronal network. In PD, investigating the heterogeneity of microglial cells in susceptible brain regions like the nigrostriatal pathway is crucial for understanding the disease's progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Clinical Neurology
Ling-Ling Chan, Eng-King Tan
Review
Radiology, Nuclear Medicine & Medical Imaging
Tze Phei Kee, Nanda Venkatanarasimha, Salahudeen Mohamed Haja Mohideen, Ling Ling Chan, Apoorva Gogna, Pamela Whitney Schaefer, Ghim Song Chia, Yoon Seong Choi, Robert Chun Chen
Summary: In an era of rapidly expanding knowledge and specialization, it is common to focus on one organ system. However, diseases affecting one region of the body often affect other organ systems as well. Understanding diseases from a macroscopic perspective allows for efficient and accurate diagnosis.
CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tze Phei Kee, Nanda Venkatanarasimha, Salahudeen Mohamed Haja Mohideen, Apoorva Gogna, Ling Ling Chan, Pamela Whitney Schaefer, David Wei Wen, Louis Elliott McAdory, Robert Chun Chen
Summary: This article discusses disease entities affecting both the thoracic and neurological systems, emphasizing the importance of understanding diseases from a macroscopic perspective for efficient and accurate diagnosis, rather than a narrow viewpoint. These diseases have been systematically classified, aiding in narrowing the differential considerations for timely treatment.
CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY
(2022)
Review
Cell Biology
Yuen-Fann Ng, Celeste Yan-Teng Chen, Gerald Teck-Heng Chia, Brendan Bryan Jen-Wei Tan, Ling-Ling Chan, Eng-King Tan
Summary: Sexual dysfunction is a common non-motor symptom in Parkinson's disease (PD), affecting the quality of life for both patients and their partners. Factors such as advanced age, gender, hormone deficiency, neuropsychiatric and medical comorbidities contribute to sexual dysfunction in PD. Various therapies, both pharmacological and nonpharmacological, have been suggested to improve sexual dysfunction, with evidence-based treatment available for erectile dysfunction (ED).
AGEING RESEARCH REVIEWS
(2022)
Letter
Medicine, General & Internal
Brendan Bryan Jen-Wei Tan, Ling-Ling Chan, Eng-King Tan
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Neurosciences
Thomas Welton, Yi Jayne Tan, Seyed Ehsan Saffari, Samuel Y. E. Ng, Nicole S. Y. Chia, Alisa C. W. Yong, Xinyi Choi, Dede Liana Heng, Yao-Chia Shih, Septian Hartono, Weiling Lee, Zheyu Xu, Kay Yaw Tay, Wing Lok Au, Eng-King Tan, Ling Ling Chan, Adeline S. L. Ng, Louis C. S. Tan
Summary: This study found that plasma neurofilament light chain (NfL) concentration is associated with brain white matter integrity in patients with early Parkinson's disease (PD). Higher NfL levels are correlated with a frontal pattern of neurodegeneration and poorer cognitive performance.
JOURNAL OF PARKINSONS DISEASE
(2022)
Letter
Medicine, General & Internal
Phua Hwee Tang, Alwin Yaoxian Zhang, Sean Shao Wei Lam, Marcus Eng Hock Ong, Ling Ling Chan
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Letter
Clinical Neurology
Brendan Bryan Jen-Wei Tan, Shaun Kai Kiat Chua, Qian Ying Soh, Ling-Ling Chan, Eng-King Tan
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Health Care Sciences & Services
Yi Xiang Tay, Ling Ling Chan, Shin Ru Than, Gek Hsiang Lim, Mark Bangwei Tan, May San Mak, Wenlu Hou, Jeremy Choon Peng Wee, Yeong Huei Ng, Robert Chun Chen
Summary: The demand for diagnostic imaging is increasing, prompting a shift toward value-driven patient care. Inappropriate imaging, contrary to evidence-based guidelines, contributes to rising healthcare costs. This study evaluated the appropriateness of lumbar spine X-rays in a tertiary referral Emergency Department (ED) and found that approximately one-third of the orders were inappropriate. The training and years of practice of physicians influenced the referral patterns.
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
(2023)
Editorial Material
Clinical Neurology
Brendan Jen-Wei Tan, Ling-Ling Chan, Eng-King Tan
Summary: The potential long-term neurological complications, especially cognitive impairment, of CAR T-cell therapy are receiving more attention due to its increasing availability and use.
Article
Geriatrics & Gerontology
Yao-Chia Shih, Leon Qi Rong Ooi, Hui-Hua Li, John Carson Allen, Septian Hartono, Thomas Welton, Eng-King Tan, Ling Ling Chan
Summary: In this study, longitudinal diffusion tensor imaging (DTI) was used to investigate the changes in deep nuclear pathology in Parkinson's disease (PD) over a 12-year period. The results showed progressive increase in mean diffusivity (MD) in the putamen and globus pallidus, while fractional anisotropy (FA) changes in the thalamus, putamen, and globus pallidus were complex. Caudate MD could be used as a surrogate marker to track late PD progression.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Thomas Welton, Septian Hartono, Yao-Chia Shih, Stefan T. Schwarz, Yue Xing, Eng-King Tan, Dorothee P. Auer, Noam Harel, Ling-Ling Chan
Summary: The maturation of ultra-high-field MRI has improved our capability to depict and characterise brain structures efficiently. While there is evidence for improved accuracy and precision of 7T MRI-based measurements for PD, the clinical translation is still limited. Further longitudinal studies are needed to explore the clinical potential of 7T MRI in prodromal, early-stage PD and parkinsonism cohorts.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Health Care Sciences & Services
Yi-Lin Ong, Xiao Deng, Hui-Hua Li, K. Narasimhalu, Ling-Ling Chan, Kumar M. Prakash, Wing-Lok Au, Pavanni Ratnagopal, Louis C. S. Tan, Eng-King Tan
Summary: This study investigates the interaction of caffeine intake with risk variants found in Asians and determines PD risk estimates in caffeine-drinkers carrying these variants.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Letter
Hematology
Brendan Bryan Jen-Wei Tan, Ling -Ling Chan, Eng-King Tan
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Lei Zhu, Kaiyuan Yang, Meihui Zhang, Ling Ling Chan, Teck Khim Ng, Beng Chin Ooi
Summary: In this study, a semi-supervised unpaired multi-modal learning framework was proposed to address the issue of scarce labeled data and abundant unlabeled data. By introducing a semantic consistency loss and a class-balanced deep co-training scheme, valuable complementary information from two modalities was effectively utilized to boost image segmentation performance. The framework outperformed existing methods significantly in two medical image segmentation tasks.
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2021, PT II
(2021)