Article
Obstetrics & Gynecology
Julia Lipecki, Andrew E. Mitchell, Joanne Muter, Emma S. Lucas, Komal Makwana, Katherine Fishwick, Joshua Odendaal, Amelia Hawkes, Pavle Vrljicak, Jan J. Brosens, Sascha Ott
Summary: By measuring the expression levels of six genes and using a continuous, non-categorical modelling approach, this study improves the accuracy of timing of luteal phase endometrial biopsies based on urinary ovulation testing. The method provides more accurate timing estimates and assesses the reliability of timing estimates for each sample.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Paul Pirtea, Ettore Cicinelli, Rosalba De Nola, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Chronic inflammatory processes affecting the endometrium can impact endometrial receptivity, leading to early pregnancy losses and recurrent pregnancy losses. Conditions like endometriosis may increase the risk of miscarriages, but assisted reproductive technology can mitigate these risks.
FERTILITY AND STERILITY
(2021)
Review
Plant Sciences
Kannan Maharajan, Qing Xia, Xiuying Duan, Pengfei Tu, Yun Zhang, Kechun Liu
Summary: Zishen Yutai Pill (ZYP) is a widely used Traditional Chinese Medicine in Assisted Reproductive Technology (ART) medications, and has shown potential therapeutic effects in improving fertility and pregnancy rates. Clinical studies have demonstrated its curative effects on various reproductive disorders by regulating reproductive functions such as ovulation, follicle development, and hormonal balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Pirkko Peuranpaea, Tiina Holster, Schahzad Saqib, Ilkka Kalliala, Aila Tiitinen, Anne Salonen, Hanna Hautamaki
Summary: This study found that dysbiosis of the endometrial and vaginal microbiota is associated with recurrent pregnancy loss and may represent a novel risk factor for pregnancy loss. Specifically, there was a decrease in relative abundance of Lactobacillus crispatus in endometrial samples and an increase in Gardnerella vaginalis abundance in the RPL group.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Marguerite Duane, Karen Schliep, Christina A. Porucznik, Shahpar Najmabadi, Joseph B. Stanford
Summary: Our study found no association between a short luteal phase in the three cycles prior to conception and higher rates of miscarriage in an international cohort of women tracking their cycles. Further research is warranted to determine if short luteal phases or luteal phase deficiency is associated with early pregnancy losses.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Immunology
Yutoku Shi, Hideto Yamada, Yuki Sasagawa, Kenji Tanimura, Masashi Deguchi
Summary: This study found that an increase in Ureaplasma species in the uterine endometrium microbiota of women with recurrent pregnancy loss was associated with a higher risk of miscarriage with normal chromosome karyotype and preterm delivery in subsequent pregnancies. Analyzing UEM in women with recurrent pregnancy loss before pregnancy may help identify microbiota associated with adverse pregnancy outcomes.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Kilian Vomstein, Pia Egerup, Astrid Marie Kolte, Ida Behrendt-Moller, Amalie Dyhrberg Boje, Marie-Louise Bertelsen, Cecilie Sofie Eriken, Michelle Raupelyt Reierson, Bettina Toth, Nina la Cour Freiesleben, Henriette Svarre Nielsen
Summary: This study investigated the differences in menstrual blood lymphocytes between controls, patients with recurrent pregnancy loss (RPL), and patients with unexplained infertility (uINF). The results showed that RPL patients had significantly higher numbers of CD56+ NK cells in menstrual blood compared to controls, while both RPL and uINF patients had decreased numbers of CD56dimCD16bright NK cells in menstrual blood. These findings suggest altered cytotoxicity in menstrual blood NK cell subtypes of RPL and uINF patients compared to controls.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Rene F. Frydman
Summary: Recurrent pregnancy loss (RPL) is defined as two to three spontaneous pregnancy terminations before 12 weeks of gestation, potentially caused by factors like gamete quality, uterine issues, endometrial receptivity alterations, immunologic factors, and thrombophilia.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Rima K. Dhillon-Smith, Pedro Melo, Rosinder Kaur, Emily Fox, Adam Devall, Natalie Woodhead, Arri Coomarasamy
Summary: Miscarriage can have devastating physical and psychological impacts, but there are lifestyle and therapeutic interventions available to prevent it.
FERTILITY AND STERILITY
(2023)
Review
Medicine, General & Internal
Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina, Aktoty Ilmaliyeva, Wassim Y. Almawi, Kuralay Atageldiyeva
Summary: Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. The true incidence is difficult to estimate due to inconsistency in definitions and criteria applied by international guidelines. The exact etiology remains questionable and up to 75% of cases are unexplained. This review aimed to summarize accumulated knowledge on etiology, risk factors, diagnostic options, and management approach to recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Haley G. Genovese, Dana B. Mcqueen
Summary: This manuscript reports on the prevalence of early pregnancy loss and discusses the impact of improved pregnancy diagnosis, as well as the influence of increased age and body mass index at first birth.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Dana B. McQueen, Kruti P. Maniar, Anne Hutchinson, Rafael Confino, Lia Bernardi, Mary Ellen Pavone
Summary: The study aimed to develop diagnostic criteria for chronic endometritis and compare its prevalence between women with recurrent pregnancy loss (RPL) and controls. Results showed that with strict diagnostic criteria, the prevalence of chronic endometritis was significantly higher in women with RPL, indicating an association between chronic endometritis and RPL.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Amalie Dyhrberg Boje, Pia Egerup, David Westergaard, Marie-Louise Mathilde Friis Bertelsen, Mette Nyegaard, Dorthe Hartwell, Ojvind Lidegaard, Henriette Svarre Nielsen
Summary: This nationwide historical cohort study found that endometriosis is associated with pregnancy loss and recurrent pregnancy loss (RPL), and the association strengthens with an increasing number of losses.
FERTILITY AND STERILITY
(2023)
Review
Biology
Marjanu Hikmah Elias, Nurunnajah Lazim, Zulazmi Sutaji, Mohammad Azrai Abu, Abdul Kadir Abdul Karim, Azizah Ugusman, Saiful Effendi Syafruddin, Mohd Helmy Mokhtar, Mohd Faizal Ahmad
Summary: Endometriosis is an inflammatory chronic systemic disease causing pelvic pain and infertility. The identification of the disease is insufficient, leading to a high misdiagnosis rate. Our focus is on the abnormal hypermethylation of HOXA10 in endometriosis. A comprehensive literature search was conducted to determine the DNA methylation level of HOXA10 in endometriosis patients across different populations. The gathered evidence demonstrated a higher HOXA10 DNA methylation level in the endometrium tissue of women with endometriosis in all included studies.
Article
Obstetrics & Gynecology
Jade E. Bilardi, Meredith Temple-Smith
Summary: Miscarriage and recurrent miscarriage have profound and prolonged psychological impacts, yet support for miscarriage remains inadequate. Acknowledgment and validation of grief, provision of information, and addressing the discrepancy between bereavement care offered and desired are important steps to ameliorate the impact. Collecting national miscarriage data and establishing national research funding priorities would allow for a better understanding of the socioeconomic cost and burden of miscarriage and enable targeted research for public health benefit.
FERTILITY AND STERILITY
(2023)
