Article
Oncology
Eliza R. C. Hagens, Nanke Cui, Susan van Dieren, Wietse J. Eshuis, Wytze Lameris, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz
Summary: The aim of this study was to compare the clinical judgment of surgeons using prediction models. The study found that prediction models tend to overestimate the risk of complications, while surgeons tend to underestimate this risk.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Marieke Pape, Pauline A. J. Vissers, Willemieke P. M. Dijksterhuis, David Bertwistle, Laura McDonald, Bianca Mostert, Sarah Derks, Irma M. M. Oving, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Summary: This retrospective cohort study investigated the treatment and survival of patients with advanced esophageal adenocarcinoma (EAC), gastroesophageal junction adenocarcinoma (GEJC), and gastric adenocarcinoma (GAC). Despite differences in clinical characteristics and treatment strategies, the survival of patients with advanced EAC, GEJC, and GAC was similar. Therefore, excluding EAC patients from clinical trials for patients with molecularly similar GEJC/GAC should be reconsidered.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Veena Shankaran, Hong Xiao, David Bertwistle, Ying Zhang, Min You, Pranav Abraham, Ian Chau
Summary: Management of locally advanced, unresectable, or metastatic esophageal adenocarcinoma (EAC) follows clinical guidance for gastric cancer (GC) and gastroesophageal junction cancer (GEJC). However, evidence for these guidelines is largely based on patients with adv/met GC/GEJC, and generally excludes patients with EAC. In real-world practice, patients with adv/met GC/GEJC and EAC have similar demographics and clinical outcomes, with a similar proportion receiving first-line therapy and similar median overall survival. This supports the inclusion of patients with adv/met EAC in clinical trials assessing adv/med GC/GEJC.
ADVANCES IN THERAPY
(2021)
Article
Oncology
Smita Sihag, Samuel C. Nussenzweig, Henry S. Walch, Meier Hsu, Kay See Tan, Francisco Sanchez-Vega, Walid K. Chatila, Sergio A. De la Torre, Assem Patel, Yelena Y. Janjigian, Steven Maron, Geoffrey Y. Ku, Laura H. Tang, Jaclyn Hechtman, Pari M. Shah, Abraham J. Wu, David R. Jones, Daniela Molena, David B. Solit, Nikolaus Schultz, Michael F. Berger
Summary: This study reveals that higher levels of genomic instability are associated with advanced disease in esophageal adenocarcinoma, and alterations in CDKN2A, KRAS, and SMAD4 are strongly associated with poor survival.
CLINICAL CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Jordan S. Sack, Michael Li, Stephen D. Zucker
Summary: Among cirrhotic patients, esophageal varices did not increase the risk of overt gastrointestinal bleeding following transesophageal echocardiography (TEE). The likelihood of a hemoglobin decline by at least 2 g/dL or blood transfusion within 48 hours after TEE was not significantly higher in patients with esophageal varices after adjusting for confounders. The timing of upper endoscopy relative to TEE did not impact the risk of secondary outcomes, suggesting routine preprocedural endoscopy may have limited utility.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Oncology
Zhao Cheng, Asif Johar, Magnus Nilsson, Pernilla Lagergren
Summary: A nationwide prospective cohort study in Sweden involving 331 patients who underwent esophagectomy revealed that postoperative complications, particularly medical and pulmonary complications, may be associated with increased cancer-related fatigue after surgery.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Kazuto Harada, Hyunsoo Hwang, Xuemei Wang, Ahmed Abdelhakeem, Masaaki Iwatsuki, Mariela A. Blum Murphy, Dipen M. Maru, Brian Weston, Jeffrey H. Lee, Jane E. Rogers, Irene Thomas, Namita Shanbhag, Meina Zhao, Manoop S. Bhutani, Quynh-Nhu Nguyen, Stephen G. Swisher, Naruhiko Ikoma, Brian D. Badgwell, Wayne L. Hofstetter, Jaffer A. Ajani
Summary: The study evaluated the frequency of paratracheal lymph node metastases and their prognostic impact on resectable esophageal or gastroesophageal junction adenocarcinoma patients. Results indicated that paratracheal LN metastases were associated with a shorter survival, suggesting the need for alternate approaches to prolong survival in this patient group.
Article
Surgery
Noel E. Donlon, Anitha Kammili, Ryan Roopnarinesingh, Maria Davern, Robert Power, Sinead King, Jakub Chmelo, Alexander W. Phillips, Claire L. Donohoe, Narayanasamy Ravi, Maeve Lowery, Carmen L. Mueller, Jonathan Cools-Lartigue, Lorenzo E. Ferri, John Reynolds
Summary: The study explored the outcomes of FLOT and TIE treatment for gastric, junctional, and esophageal adenocarcinoma, finding significant toxicities and varied pathological responses post-surgery, but an overall survival rate of 60%.
Article
Surgery
Bastian Dislich, Dino Kroell, Rupert Langer
Summary: The classification of adenocarcinomas in the gastroesophageal junction is hindered by morphological and phenotypic overlaps. The study found that proximally located tumors showed less aggressive behavior, better histological differentiation, and a higher association with pre-neoplastic Barrett's mucosa.
UPDATES IN SURGERY
(2023)
Review
Oncology
M. Usman Ahmad, Christopher Javadi, George A. Poultsides
Summary: Neoadjuvant and/or perioperative therapy has emerged as a treatment tool to improve patient selection and locoregional control for resectable proximal gastric, gastroesophageal junction, and distal esophageal cancer. Treatment recommendations differ based on histologic type and tumor location. Neoadjuvant chemoradiation with concurrent taxane- or fluoropyrimidine-based chemotherapy has shown efficacy for both adenocarcinoma and squamous cell carcinoma of the distal esophagus and gastroesophageal junction.
Article
Surgery
Yun-Suhk Suh, Deukchae Na, Ju-Seog Lee, Jeesoo Chae, EuiHyun Kim, Giyong Jang, Jieun Lee, Jimin Min, Chan-Young Ock, Seong-Ho Kong, Joshy George, Chengsheng Zhang, Hyuk-Joon Lee, Jong-Il Kim, Seong-Jin Kim, Woo Ho Kim, Charles Lee, Han-Kwang Yang
Summary: This study investigated the molecular characteristics of AGEJ compared with EAC and gastric adenocarcinoma, revealing that AGEJ is a combination of EAC-like and GCFB-like groups with consistently different molecular characteristics. The EAC-like group showed a significantly better response to lapatinib, indicating potential effective targeting by dual inhibition of ERBB2 and EGFR.
Article
Oncology
Thomas M. Carroll, Joseph A. Chadwick, Richard P. Owen, Michael J. White, Joseph Kaplinsky, Iliana Peneva, Anna Frangou, Phil F. Xie, Jaeho Chang, Andrew Roth, Bob Amess, Sabrina A. James, Margarida Rei, Hannah S. Fuchs, Katy J. McCann, Ayo O. Omiyale, Brittany-Amber Jacobs, Simon R. Lord, Stewart Norris-Bulpitt, Sam T. Dobbie, Lucinda Griffiths, Kristen Aufiero Ramirez, Toni Ricciardi, Mary J. Macri, Aileen Ryan, Ralph R. Venhaus, Benoit J. Van den Eynde, Ioannis Karydis, Benjamin Schuster-Bockler, Mark R. Middleton, Xin Lu
Summary: This study investigates inoperable esophageal adenocarcinoma and identifies a novel T cell inflammation signature that is correlated with tumor shrinkage induced by immune checkpoint inhibitors. The study also discovers that high tumor monocyte content is a predictive factor for higher overall survival in patients and can improve patient selection for emerging immunochemotherapy treatments in gastro-esophageal cancer.
Article
Oncology
Karen Mulder, Howard Lim, Deepti Ravi, Shahida Ahmed, Bryan Brunet, Janine Davies, Corinne Doll, Dorie-Anna Dueck, Vallerie Gordon, Pamela Hebbard, Christina A. Kim, Duc Le, Richard Lee-Ying, John Paul McGhie, Jason Park, Daniel J. Renouf, Devin Schellenberg, Ralph P. W. Wong, Adnan Zaidi, Shahid Ahmed
Summary: Immunotherapy is increasingly recognized as playing an important role in the treatment of gastro-esophageal cancer, with experts from the Western Canadian Gastrointestinal Cancer Consensus Conference giving high attention to its role.
Article
Oncology
Karol Nowicki-Osuch, Lizhe Zhuang, Tik Shing Cheung, Emily L. Black, Neus Masque-Soler, Ginny Devonshire, Aisling M. Redmond, Adam Freeman, Massimilliano di Pietro, Nastazja Pilonis, Wladyslaw Januszewicz, Maria O'Donovan, Simon Tavare, Jacqueline D. Shields, Rebecca C. Fitzgerald
Summary: Intestinal metaplasia in the esophagus (BE-IM) and stomach (GIM) are precursors for esophageal and gastric adenocarcinoma. This study constructs a single-cell RNA-sequencing atlas of the gastrointestinal tract, showing that BE-IM and GIM share molecular features and exhibit phenotypic mosaicism. Additionally, the study reveals that E-GM resembles atrophic gastritis and has a lower mutational burden than BE-IM. The findings suggest that BE-IM and GIM can be considered similar entities, enabling shared detection and treatment strategies.
Article
Multidisciplinary Sciences
Alexander Damanakis, Isabell Wahler, Hans Fuchs, Heike Loeser, Wolfgang Schroeder, Thomas Zander, Seung-Hun Chon, Christiane Bruns, Alexander Quaas, Florian Gebauer
Summary: This study demonstrates for the first time the prognostic significance of ITGB1 expression in a large population of patients with esophageal adenocarcinoma (EAC). High expression of ITGB1 is associated with tumor aggressiveness and poor survival.
SCIENTIFIC REPORTS
(2022)