Article
Radiology, Nuclear Medicine & Medical Imaging
B. H. E. Jansen, Y. J. L. Bodar, G. J. C. Zwezerijnen, D. Meijer, J. P. van der Voorn, J. A. Nieuwenhuijzen, M. Wondergem, T. A. Roeleveld, R. Boellaard, O. S. Hoekstra, R. J. A. van Moorselaar, D. E. Oprea-Lager, A. N. Vis
Summary: The study found that F-18-DCFPyL PET/CT has high specificity but limited sensitivity for detecting pelvic lymph-node metastases in primary prostate cancer patients. Therefore, current PSMA PET/CT imaging cannot fully replace diagnostic ePLND. Further research is needed to determine the exact role of PSMA PET/CT imaging in the primary staging of prostate cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haoxin Zheng, Qi Miao, Yongkai Liu, Sohrab Afshari Mirak, Melina Hosseiny, Fabien Scalzo, Steven S. Raman, Kyunghyun Sung
Summary: A radiomics-based machine learning approach was used to predict lymph node invasion (LNI) in patients with prostate cancer (PCa). The proposed integrative radiomics model (IRM) showed superior performance in predicting LNI compared to pre-existing nomograms. This model could potentially help identify PCa patients who can safely avoid extended pelvic lymph node dissection (ePLND) and reduce unnecessary surgeries.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Zhen Li, Yixin Huang, Diwei Zhao, Xin Luo, Zeshen Wu, Xinyi Zheng, Ye Xie, Yixuan Liu, Jianwei Wu, Yulu Peng, Yonghong Li, Fangjian Zhou
Summary: This study aimed to develop and validate a novel nomogram for predicting the risk of lymph node invasion in Chinese prostate cancer patients. A total of 631 patients who underwent radical prostatectomy and extended pelvic lymph node dissection were included. The proposed nomogram outperformed previous nomograms in predicting lymph node invasion risk.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Guanjie Yang, Jun Xie, Yadong Guo, Jing Yuan, Ruiliang Wang, Changcheng Guo, Bo Peng, Xudong Yao, Bin Yang
Summary: The study aimed to identify prostate cancer patients who may benefit from extended pelvic lymph node dissection (PLND). The results suggest that extensive PLND may be associated with improved survival in patients with a high risk of lymph node invasion.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Josh Gottlieb, Shu-Ching Chang, Jane Choe, Gary L. Grunkemeier, Douglas A. Hanes, David Krasne, Dave S. B. Hoon, Timothy G. Wilson
Summary: This study evaluated the significance of lymph node tumor burden in prostate cancer patients and found a significant association with biochemical recurrence-free survival. It also reported the importance of the anatomical location of tumor deposits within the lymph nodes and the extent of extranodal extension, although these factors did not show a significant association with biochemical recurrence-free survival due to a small sample size. The study emphasizes the need to consider lymph node tumor burden in nodal staging and post-operative clinical nomograms.
Review
Urology & Nephrology
Luciano Haiquel, Xavier Cathelineau, Rafael Sanchez-Salas, Petr Macek, Fernando Secin
Summary: In this critical review, we found that extended pelvic lymph node dissection (PLND) may be beneficial for accurate staging and therapeutic intent in selected patients with localized high-risk prostate cancer (PCa). Although advances in imaging and sentinel lymph node dissection have improved the detection of lymph node involvement (LNI), extended PLND remains the most accurate method for staging lymph node disease. However, extended PLND is associated with longer surgical time and potential impact on perioperative complications, hospital length of stay, rehospitalization, and healthcare costs. The therapeutic benefit of PLND, particularly in patients with high node burden, remains controversial.
INTERNATIONAL BRAZ J UROL
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Soheila Erfani, Ramin Sadeghi, Atena Aghaee, HamidReza Ghorbani, Vahid Roshanravan
Summary: This case demonstrates the feasibility of using Tc-99m-PSMA radioguided surgery for salvage lymphadenectomy in prostate cancer.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Marco Oderda, Romain Diamand, Simone Albisinni, Giorgio Calleris, Antonio Carbone, Marco Falcone, Gaelle Fiard, Giorgio Gandaglia, Alessandro Marquis, Giancarlo Marra, Cinzia Parola, Antonio Pastore, Alexandre Peltier, Guillaume Ploussard, Thierry Roumeguere, Rafael Sanchez-Salas, Giuseppe Simone, Salvatore Smelzo, John H. Witt, Paolo Gontero
Summary: The currently available nomograms for predicting lymph node invasion in prostate cancer patients have similar performances and limitations. In patients with only systematic biopsy, the MSKCC and Briganti 2012 nomograms were superior in predicting LNI.
Article
Oncology
William A. Hall, Eric Paulson, Brian J. Davis, Daniel E. Spratt, Todd M. Morgan, David Dearnaley, Alison C. Tree, Jason A. Efstathiou, Mukesh Harisinghani, Ashesh B. Jani, Mark K. Buyyounouski, Thomas M. Pisansky, Phuoc T. Tran, R. Jeffrey Karnes, Ronald C. Chen, Fabio L. Cury, Jeff M. Michalski, Seth A. Rosenthal, Bridget F. Koontz, Anthony C. Wong, Paul L. Nguyen, Thomas A. Hope, Felix Feng, Howard M. Sandler, Colleen A. F. Lawton
Summary: The study aimed to provide an updated prostate pelvic nodal consensus atlas through expert discussions and data analysis. Results showed discrepancies in CTV contours of radiation oncologists compared to the 2009 RTOG consensus atlas, leading to the development of an updated consensus contour atlas.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Surgery
Takeru Matsuda, Ryuichiro Sawada, Hiroshi Hasegawa, Kimihiro Yamashita, Masako Utsumi, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Shingo Kanaji, Taro Oshikiri, Yoshihiro Kakeji
Summary: This study demonstrates that the transanal approach for LLND in patients with rectal cancer reduces operative time, blood loss, and postoperative complication rate compared to the conventional approach alone.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Richard Choo, David W. Hillman, Cecilia Mitchell, Thomas Daniels, Carlos Vargas, Jean Claude Rwigema, Kimberly Corbin, Sameer Keole, Sujay Vora, Kenneth Merrell, Bradley Stish, Thomas Pisansky, Brian J. Davis, Adam Amundson, William Wong
Summary: The purpose of this study was to evaluate the late gastrointestinal (GI) and genitourinary (GU) toxicity of moderately hypofractionated intensity-modulated proton therapy (IMPT) targeting the prostate and pelvic lymph nodes. The results showed that moderately hypofractionated IMPT was generally well tolerated with minimal toxicity.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Naeim Nabian, Reza Ghalehtaki, Felipe Counago
Summary: The main prostate cancer treatments do not eliminate the risk of lymph node metastases. Traditional imaging methods are not sensitive enough for diagnosing lymph node metastases, while the novel PSMA PET/CT scanning provides valuable information for recurrent prostate cancer patients. Its high sensitivity enables accurate N staging in prostate cancer patients.
Article
Oncology
Karim A. Touijer, Daniel D. Sjoberg, Nicole Benfante, Vincent P. Laudone, Behfar Ehdaie, James A. Eastham, Peter T. Scardino, Andrew Vickers
Summary: This clinical trial did not find a difference in the rate of biochemical recurrence of prostate cancer between limited and extended dissection of lymph nodes in the pelvis.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Article
Oncology
Imraan Jan, Rahul R. Parikh
Summary: The Oncology Grand Rounds series aims to help readers understand how to apply academic studies to clinical practice, enhancing their understanding of clinical diagnostic and treatment challenges.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
