Article
Neurosciences
Marie Lods, Pierre Mortessagne, Emilie Pacary, Geoffrey Terral, Fanny Farrugia, Wilfrid Mazier, Nuria Masachs, Vanessa Charrier, Daniela Cota, Guillaume Ferreira, Djoher Nora Abrous, Sophie Tronel
Summary: Adult neurogenesis in the hippocampus plays a crucial role in memory processes, but its direct impact on memory performance remains uncertain. This study developed a chemogenetic method to selectively activate specific populations of adult-born neurons, and demonstrated that this activation can improve the accuracy and strength of remote memory in rats. These findings suggest that stimulating adult-born neuron activity may counteract the natural decline of memory traces over time, offering new potential for treating memory problems.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Behavioral Sciences
Rodrigo Orso, Kerstin Camile Creutzberg, Francisco Sindermann Lumertz, Luis Eduardo Wearick-Silva, Eduardo Farias Sanches, Regis Gemerasca Mestriner, Gregers Wegener, Rodrigo Grassi-Oliveira
Summary: This study demonstrates that early environmental enrichment is effective in recovering memory impairments and hippocampal volume loss caused by hypoxia-ischemia. However, the expression of Bdnf was not associated with the improvement in memory performance observed in animals exposed to EE after a hypoxic-ischemic event.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Huajie Liu, Anouk Wolters, Yasin Temel, Faisal Alosaimi, Ali Jahanshahi, Sarah Hescham
Summary: The study demonstrated that biphasic, low frequency, and intermittent NBM DBS was effective in reversing memory impairments caused by scopolamine, promoting neurogenesis and synaptic plasticity while increasing the length of cholinergic fibers in specific brain regions. The findings suggest that the memory enhancement induced by NBM DBS may be attributed to selective neuroplastic and neurochemical changes.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Bjoern Gailus, Hannah Naundorf, Lisa Welzel, Marie Johne, Kerstin Roemermann, Kai Kaila, Wolfgang Loescher
Summary: The study utilized a rat model of birth asphyxia to induce neonatal seizures, leading to impaired spatial learning and memory, increased anxiety, and spontaneous seizures in rats during a span of 14 months. This model recapitulates several adverse consequences associated with human HIE, providing an opportunity to evaluate novel therapies for prevention and alleviation of long-term adverse consequences.
Article
Neurosciences
Can Sun, Jian Fu, Zhenzhen Qu, Lijing Jia, Dongxiao Li, Junli Zhen, Weiping Wang
Summary: The study found that chronic intermittent hypobaric hypoxia treatment can rescue cognitive deficits in epileptic rats by activating the Wnt/β-catenin pathway, providing a potential therapeutic approach for epilepsy-induced cognitive impairments.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Aisling Leavy, Gary P. Brennan, Eva M. Jimenez-Mateos
Summary: Brain development occurs until adulthood, with time-sensitive processes happening during embryo development, childhood, and puberty. MicroRNAs, small non-coding RNAs that regulate gene expression, play a crucial role in brain maturation. This study analyzed the microRNA profile in the hippocampus of mice during postnatal development and after hypoxia at birth, and found that their expression may be regulated by the transcriptional regulator c-myc.
Article
Nutrition & Dietetics
Marta Portero-Tresserra, Neus Galofre-Lopez, Elisabet Pallares, Claudia Gimenez-Montes, Carlos Barcia, Roser Granero, Divka Rojic-Becker, Anna Vale-Martinez, Margarita Marti-Nicolovius, Gemma Guillazo-Blanch
Summary: Age-related changes in the brain significantly impact hippocampal structure and function, leading to cognitive impairments such as deteriorating spatial object recognition (SOR) memory. Both intrinsic factors like neuroinflammation and lifestyle factors like diet can influence aging-related brain function and cognitive performance. This study aimed to evaluate the effects of caloric restriction (CR) on SOR memory, hippocampal neuron loss, neurogenesis, and inflammation in aged male rats. The results showed that CR attenuated the decline in SOR memory, hippocampal neuron loss, and microglial activation associated with aging, while also reducing neurogenesis in the dentate gyrus.
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Artur Palasz, Aleksandra Suszka-Switek, Jacek Francikowski, Marek Krzystanek, Katarzyna Bogus, Jakub Skalbania, John J. Worthington, Inga Mrzyk
Summary: The study showed a significant increase in draxin immunoexpression in the adult rat hippocampus following long-term olanzapine administration, potentially supporting the hypothesis that olanzapine may drive adult neurogenesis via paracrine draxin-related signaling. This indicates the need for further molecular studies to fully investigate these potential novel mechanisms of neurogenesis.
Article
Biochemistry & Molecular Biology
Jia-He Zhang, Takashi Tasaki, Manabu Tsukamoto, Ke-Yong Wang, Kin-ya Kubo, Kagaku Azuma
Summary: The deletion of Wnt10a leads to decreased neurogenesis, impaired synaptic function, and neuroinflammation in the hippocampus, ultimately resulting in hippocampal neurodegeneration and memory deficits.
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Article
Cell Biology
Brina Snyder, Hua-Kang Wu, Brianna Tillman, Thomas F. Floyd
Summary: Impaired HIF-alpha activity in the hippocampus may have negative effects on aging and increase the risk of cognitive decline during hypoxic events.
Article
Biochemistry & Molecular Biology
Emily J. Camm, Christine M. Cross, Andrew D. Kane, Jane L. Tarry-Adkins, Susan E. Ozanne, Dino A. Giussani
Summary: Chronic fetal hypoxia during pregnancy can lead to long-term structural and functional impairments in the adult offspring's brain, particularly affecting neuronal number, vascular and synaptic density in the hippocampus, and memory function. Maternal supplementation with vitamin C during hypoxic pregnancy can protect against oxidative stress in the placenta and prevent adverse effects on hippocampal atrophy and memory loss in the adult offspring, indicating a potential therapeutic strategy.
Article
Neurosciences
Ye Li, Cuiqin Fan, Rui Gao, Tian Lan, Wenjing Wang, Shu Yan Yu
Summary: The study reveals that altered levels of miR-211-5p in the hippocampal DG area have a significant impact on neurogenesis, apoptosis, and depression-like behaviors in rats. Specifically, up-regulation of miR-211-5p can alleviate depression-like behaviors, reduce neuronal apoptosis, and promote neuronal regeneration; while down-regulation of miR-211-5p can induce depression-like behaviors, increase neuronal apoptosis, and decrease neuronal regeneration.
Review
Neurosciences
Orsolya Folsz, Stephanie Trouche, Vincent Croset
Summary: Although most neurons are generated embryonically, neurogenesis continues at low rates in certain brain areas throughout adulthood, such as the dentate gyrus of the hippocampus. Adult-born neurons in the dentate gyrus play a role in pattern separation and the encoding of episodic-like memories. They compete with mature neurons for input and output and regulate hippocampal activity. These neurons exhibit transient hyperexcitability and hyperplasticity during maturation, contributing to their recruitment by experiences. They support pattern separation during encoding and aid in the degradation of old connections, promoting generalization and preventing interference.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Gregory Pourie, Nicolas Martin, Carine Bossenmeyer-Pourie, Nassila Akchiche, Rosa Maria Gueant-Rodriguez, Andrea Geoffroy, Elise Jeannesson, Sarah El Hajj Chehadeh, Khalid Mimoun, Patrick Brachet, Violette Koziel, Jean-Marc Alberto, Deborah Helle, Renee Debard, Brigitte Leininger, Jean-Luc Daval, Jean-Louis Gueant
Article
Neurosciences
Andrea Geoffroy, Racha Kerek, Gregory Pourie, Deborah Helle, Jean-Louis Gueant, Jean-Luc Daval, Carine Bossenmeyer-Pourie
MOLECULAR NEUROBIOLOGY
(2017)
Article
Nutrition & Dietetics
Aude Bressenot, Shabnam Pooya, Carine Bossenmeyer-Pourie, Guillaume Gauchotte, Adeline Germain, Jean-Baptiste Chevaux, Florence Coste, Jean-Michel Vignaud, Jean-Louis Gueant, Laurent Peyrin-Biroulet
BRITISH JOURNAL OF NUTRITION
(2013)
Article
Biochemistry & Molecular Biology
Carine Bossenmeyer-Pourie, Gregory Pourie, Violette Koziel, Deborah Helle, Elise Jeannesson, Jean-Louis Gueant, Bernard Beck
Article
Cell Biology
R. Kerek, A. Geoffroy, A. Bison, N. Martin, N. Akchiche, G. Pourie, D. Helle, J-L Gueant, C. Bossenmeyer-Pourie, J-L Daval
CELL DEATH & DISEASE
(2013)
Article
Biochemistry & Molecular Biology
Andrea Geoffroy, Lynda Saber-Cherif, Gregory Pourie, Deborah Helle, Remy Umoret, Jean-Louis Gueant, Carine Bossenmeyer-Pourie, Jean-Luc Daval
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Carine Bossenmeyer-Pourie, A. David Smith, Sylvain Lehmann, Vincent Deramecourt, Bernard Sablonniere, Jean-Michel Camadro, Gregory Pourie, Racha Kerek, Deborah Helle, Remy Umoret, Rosa-Maria Gueant-Rodriguez, Valerie Rigau, Audrey Gabelle, Jeffrey M. Sequeira, Edward V. Quadros, Jean-Luc Daval, Jean-Louis Gueant
JOURNAL OF PATHOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Lynda Saber Cherif, Gregory Pourie, Andrea Geoffroy, Amelia Julien, Deborah Helle, Aurelie Robert, Remy Umoret, Jean-Louis Gueant, Carine Bossenmeyer-Pourie, Jean-Luc Daval
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Ziad Hassan, David Coelho, Tunay Kokten, Jean-Marc Alberto, Remy Umoret, Jean-Luc Daval, Jean-Louis Gueant, Carine Bossenmeyer-Pourie, Gregory Pourie
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Neurosciences
Natacha Dreumont, Khalid Mimoun, Carine Pourie, Edward V. Quadros, Jean-Marc Alberto, Remy Umoret, Deborah Helle, Aurelie Robert, Jean-Luc Daval, Jean-Louis Gueant, Gregory Pourie
Summary: This study investigated the molecular mechanisms of cognitive dysfunction in mice with Cbl deficiency, finding that impaired learning memory in Cd320KO mice could be alleviated by moderate stress and increased levels of plasma corticosterone. These findings suggest potential therapeutic targets for cognitive manifestations in patients with poor response to conventional Cbl treatment.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Jean-Marie Ravel, Mehdi Benkirane, Nadege Calmels, Cecilia Marelli, Fabienne Ory-Magne, Claire Ewenczyk, Yosra Halleb, Francois Tison, Claire Lecocq, Guillaume Pische, Philippe Casenave, Annabelle Chaussenot, Solene Frismand, Louise Tyvaert, Lise Larrieu, Morgane Pointaux, Nathalie Drouot, Carine Bossenmeyer-Pourie, Abderrahim Oussalah, Jean-Louis Gueant, Bruno Leheup, Celine Bonnet, Mathieu Anheim, Christine Tranchant, Laetitia Lambert, Jamel Chelly, Michel Koenig, Mathilde Renaud
Summary: This study reports four SCAR16 and nine SCA48 patients from two SCAR16 and five SCA48 unrelated French families. Patients presented with slowly progressive cerebellar ataxia, accompanied by cognitive decline, dystonia, parkinsonism, and swallowing difficulties. Brain MRI showed marked cerebellar atrophy. Continuum exists between recessive and dominant forms of ataxia.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arnaud Michel, Tunay Kokten, Lynda Saber-Cherif, Remy Umoret, Jean-Marc Alberto, Deborah Helle, Amelia Julien, Jean-Luc Daval, Jean-Louis Gueant, Carine Bossenmeyer-Pourie, Gregory Pourie
Summary: Vitamin B9/B12 deficiency can lead to brain retardations. Folate supplementation is discontinued after the first trimester, but adverse effects can still occur. This study investigated the effects of prolonged folate supplementation on the glucocorticoid receptor (GR) signaling in the hypothalamus. The results showed that folate and vitamin B12 deficiency during early development was associated with reduced GR expression, impaired ligand binding, and behavioral perturbations, which were improved with folic acid supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ziad Hassan, David Coelho, Carine Bossenmeyer-Pourie, Karim Matmat, Carole Arnold, Aurelie Savladori, Jean-Marc Alberto, Remy Umoret, Jean-Louis Gueant, Gregory Pourie
Summary: Impairment of one-carbon metabolism during pregnancy, either due to nutritional deficiencies in B9 or B12 vitamins or caused by specific genetic defects, is often associated with neurological defects, including cognitive dysfunction that persists even after vitamin supplementation. Using a knock-out model for the methionine synthase specifically in the brain, researchers found that the absence of methionine synthase did not lead to growth retardation in offspring. However, there were temporary retardations in vegetative functions during the suckling period and a significant reduction in cognitive performance after weaning. Investigation also showed a reduction of AMPA receptors phosphorylation and clustering in cognitive areas, indicating an epigenomic effect of the neuronal deficiency of methionine synthase on the reduction of glutamatergic synapses excitability.
Article
Genetics & Heredity
Armand Hocquel, Jean-Marie Ravel, Laetitia Lambert, Celine Bonnet, Guillaume Banneau, Bophara Kol, Laurene Tissier, Lucie Hopes, Mylene Meyer, Celine Dillier, Maud Michaud, Arnaud Lardin, Anne-Laure Kaminsky, Emmanuelle Schmitt, Liang Liao, Francois Zhu, Bronner Myriam, Carine Bossenmeyer-Pourie, Antoine Verger, Mathilde Renaud
Summary: This study reports the clinical and paraclinical features of spastic paraplegia associated with SPG3A. Patients often have cognitive impairments and abnormal PET findings, which may be related to brain abnormalities in cerebellar cognitive affective syndrome (CCAS).
Article
Biochemistry & Molecular Biology
Gregory Pourie, Nicolas Martin, Jean-Luc Daval, Jean-Marc Alberto, Remy Umoret, Jean-Louis Gueant, Carine Bossenmeyer-Pourie
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)