Journal
SEMINARS IN NEPHROLOGY
Volume 33, Issue 4, Pages 314-326Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semnephrol.2013.05.004
Keywords
Kidney development; epigenetics; intermediate mesoderm; nephrogenesis
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Funding
- National Institutes of Health [DK073722, DK082409]
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The development of the mammalian kidney has been studied at the genetic, biochemical, and cell biological level for more than 40 years. As such, detailed mechanisms governing early patterning, cell lineages, and inductive interactions have been well described. How genes interact to specify the renal epithelial cells of the nephrons and how this specification is relevant to maintaining normal renal function is discussed. Implicit in the development of the kidney are epigenetic mechanisms that mark renal cell types and connect certain developmental regulatory factors to chromatin modifications that control gene expression patterns and cellular physiology. In adults, such regulatory factors and their epigenetic pathways may function in regeneration and may be disturbed in disease processes. (c) 2013 Elsevier Inc. All rights reserved.
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