Article
Gastroenterology & Hepatology
Navine Nasser-Ghodsi, Kristin Mara, Kymberly D. Watt
Summary: This study analyzed data from 1997 to 2017 and found that gastrointestinal malignancies, especially colorectal and pancreatic cancer, are more common after liver transplantation. Specific populations, such as patients with PSC, those over 50 with NASH and HCC/CCA, and females over 50 with alcohol-associated liver disease and HCC/CCA, have a higher risk of these malignancies within 5 years post-transplant.
Article
Transplantation
Ji Eun Kim, Jina Park, Sehoon Park, Mi-Yeon Yu, Seon Ha Baek, Sang Hyun Park, Kyungdo Han, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Summary: The risk of de novo major adverse cardiovascular events (MACEs) in kidney transplant recipients (KTRs) is lower compared to dialysis patients and similar to the general population (GP). However, once such events occur, they increase the risk of mortality in KTRs.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Tine Holm Riis, Dina Leth Moller, Julie Hogh, Andreas Dehlbaek Knudsen, Andreas Arendtsen Rostved, Delal Akdag, Nikolai Kirkby, Ulrik Lassen, Allan Rasmussen, Jens G. G. Hillingso, Hans-Christian Pommergaard
Summary: This study investigated the cumulative incidence of de novo cancer in Danish liver transplant recipients. It was found that 12% of the recipients developed de novo cancer after liver transplantation, with non-melanoma skin cancer being the majority. The 5-year cumulative incidences for all cancers and non-skin cancers were 10.7% and 4.9%, respectively. Thus, further larger studies are needed to identify the risk factors for de novo cancer after liver transplantation.
Article
Endocrinology & Metabolism
Andries Heida, Nanda Gruben, Leen Catrysse, Martijn Koehorst, Mirjam Koster, Niels J. Kloosterhuis, Albert Gerding, Rick Havinga, Vincent W. Bloks, Laura Bongiovanni, Justina C. Wolters, Theo van Dijk, Geert van Loo, Alain de Bruin, Folkert Kuipers, Debby P. Y. Koonen, Bart van de Sluis
Summary: This study investigated the role of the hepatocytic NF-kB signaling pathway as a metabolic regulator in promoting the development of hepatic steatosis. The activation of hepatic NF-kB led to hepatic steatosis without inflammation, while the ablation of A20 in hepatocytes exacerbated hepatic steatosis and increased plasma cholesterol levels. These findings suggest that chronic NF-kB activation may contribute to the initiation of hepatic steatosis and cardiovascular disease risk in MAFLD patients.
MOLECULAR METABOLISM
(2021)
Article
Clinical Neurology
Max J. J. Oosterwegel, Jesse H. H. Krijthe, Melina G. H. E. den Brok, Lieneke van den Heuvel, Edo Richard, Tom Heskes, Bastiaan R. R. Bloem, Luc J. W. Evers
Summary: This study found no clinically significant effects of cardiovascular risk factors on the clinical progression of Parkinson's disease, based on the analysis of two large cohorts of de novo PD patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Urology & Nephrology
Sehoon Park, Sung Jin Kang, Jang Wook Lee, Ji Eun Kim, Yaerim Kim, Kwangsoo Kim, Minsu Park, Yong Chul Kim, Yon Su Kim, Yaeji Lim, Hajeong Lee
Summary: The study found an association between post-transplant hypertension and related antihypertensive medication use with post-transplant prognosis in kidney transplant recipients. Patients with post-transplant hypertension who required multiple medications may face higher risks.
JOURNAL OF NEPHROLOGY
(2021)
Article
Surgery
Navine Nasser-Ghodsi, Kristin Mara, Alina M. Allen, Kymberly D. Watt
Summary: This study assessed the incidence of NASH overlap and its effect on de novo malignancy in liver transplant recipients. The results showed an increasing prevalence of NASH overlap and a higher risk of de novo malignancy in patients with NASH overlapping other liver diseases. Further study of patients with overlap diagnoses is important for personalized care and cancer screening programs.
CLINICAL TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Alessandro Mantovani, Graziana Petracca, Giorgia Beatrice, Herbert Tilg, Christopher D. Byrne, Giovanni Targher
Summary: This meta-analysis shows that patients with NAFLD have a significantly increased risk of developing diabetes, and this risk rises with the severity of NAFLD. The risk is independent of age, sex, adiposity measures, and other metabolic risk factors.
Article
Urology & Nephrology
Giuseppe Cianciolo, Francesco Tondolo, Simona Barbuto, Francesca Iacovella, Guido Zavatta, Paola Altieri, Valeria Grandinetti, Giorgia Comai, Mario Cozzolino, Gaetano La Manna
Summary: This study investigates the risk factors of hypocalcemia and PTH increase after denosumab treatment in kidney transplant recipients, finding that hypocalcemia is related to lumbar osteoporosis, and PTH increase is correlated with baseline bone turnover markers, vitamin D levels, and eGFR. Continual supplementation therapy with calcitriol is necessary to control PTH levels effectively in these patients.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Gastroenterology & Hepatology
Nima Memaran, Hannes Wilke, Rizky Sugianto, Ulrich Baumann, Elena Bauer, Maxine Swallow, Esther Beuke, Norman Junge, Eva D. Pfister, Carl Grabitz, Nicolas Richter, Imeke Goldschmidt, Bernhard M. W. Schmidt, Anette Melk
Summary: Leukocyte telomere length (LTL) is associated with subclinical atherosclerosis in pediatric liver transplant patients, suggesting a negative impact of early aging on cardiovascular damage.
LIVER TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Vanisha Patel, Parth Shah, Daniel R. Ludwig, Chet W. Hammill, Motaz Ashkar
Summary: This study aimed to determine the incidence and identify peri-operative risk factors for de novo non-alcoholic fatty liver disease (NAFLD) after pancreatectomy. The overall incidence of de novo NAFLD was 17.5%, with higher rates observed in patients with malignant indications for surgery compared to benign indications. The development of hepatic steatosis occurred earlier in the malignant group and was associated with higher pre-operative body mass index.
Article
Gastroenterology & Hepatology
Magdalena Meszaros, Valerie Dubois, Nicolas Congy-Jolivet, Sarah Hamada, Celine Thevenin, Stephanie Faure, Olivier Boillot, Nassim Kamar, Georges-Philippe Pageaux, Arnaud Del Bello, Jerome Dumortier
Summary: Among liver transplant recipients, CNI-free immunosuppression regimen leads to a higher prevalence of dnDSA, which is associated with abnormal allograft histology.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Avonne E. Connor, Chester L. Schmaltz, Jeannette Jackson-Thompson, Kala Visvanathan
Summary: Women with coexisting comorbidities at the time of breast cancer diagnosis have an increased risk of breast cancer and overall mortality. Newly diagnosed comorbidities such as diabetes, hypertension, and CVD are associated with an increased risk of CVD mortality among breast cancer patients, especially those who receive chemotherapy. Monitoring for these conditions from the time of breast cancer diagnosis may help reduce CVD mortality.
Article
Orthopedics
Hao Chai, Jirong Ge, Li Li, Jianyang Li, Yunjin Ye
Summary: This study revealed that Chinese postmenopausal women with osteoporosis had a higher prevalence of hypertension, indicating a significant association between hypertension and osteoporosis.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Jie Wang, Qi Sun, Yu An, Jia Liu, Song Leng, Guang Wang
Summary: This study found that elevated remnant cholesterol is associated with a higher risk of hypertension in the Chinese population, especially among individuals with diabetes. However, with ideal management of remnant cholesterol, glucose, and other cardiovascular risk factors, the risk of hypertension can be minimized for diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)