Article
Pharmacology & Pharmacy
Wen Su, Mingji Feng, Yuan Liu, Rong Cao, Yiao Liu, Junyao Tang, Ke Pan, Rongfeng Lan, Zhuo Mao
Summary: Deficiency of ZnT8 in mice alleviates APAP-induced liver injury by inhibiting oxidative stress and promoting hepatocyte proliferation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kai Markus Schneider, Carsten Elfers, Ahmed Ghallab, Carolin Victoria Schneider, Eric J. C. Galvez, Antje Mohs, Wenfang Gui, Lena Susanna Candels, Theresa Hildegard Wirtz, Sebastian Zuehlke, Michael Spiteller, Maiju Myllys, Alain Roulet, Amirouche Ouzerdine, Benjamin Lelouvier, Konrad Kilic, Lijun Liao, Anika Nier, Eicke Latz, Ina Bergheim, Christoph A. Thaiss, Jan G. Hengstler, Till Strowig, Christian Trautwein
Summary: The study revealed an important yet unknown role of intestinal microbiota during ALF. Intestinal dysbiosis was transferable to healthy wild-type mice via fecal microbiota transfer (FMT) and aggravated liver injury, highlighting intestinal microbiota as a targetable risk factor for ALF.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Plant Sciences
Zhitao Jiang, Xiang Yang, Yi Han, Jie Li, Chen Hu, Chundi Liu, Wei Xiao
Summary: Sarmentosin protects the liver against APAP-induced injury by activating Nrf2 and inducing mitophagy.
Article
Medicine, General & Internal
Jinqiu Tao, Cailin Xue, Xiaodong Wang, Huihui Chen, Qiaoyu Liu, Chunping Jiang, Wenjie Zhang
Summary: In this study, we found that GAS1 overexpression plays a key role in exacerbating APAP-induced acute liver injury by promoting ferroptosis-induced accumulation of lipid peroxides.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Karolina Orzel-Gajowik, Krzysztof Milewski, Magdalena Zielinska
Summary: Acute liver failure (ALF) is a life-threatening condition characterized by rapid loss of liver function. ALF can cause a range of neuropsychiatric symptoms called acute hepatic encephalopathy. Micro RNAs (miRNAs), small non-coding RNAs that regulate gene expression, have been identified as potential biomarkers for various diseases. In a systematic literature review of 852 ALF patients, 205 altered circulating miRNAs were identified, with 25 miRNAs consistently altered in the blood. These 25 miRNAs, primarily found in patients with acetaminophen overdose, show promise as potential biomarkers for diagnosing symptomatic ALF. The selected miRNAs are believed to play a role in blood-brain barrier function. Further research is needed to establish a causal relationship between differential expression of circulating miRNAs and specific clinical features of ALF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Jinrong Ning, Guodong Zheng, Yi Cai, Yunguang Hu, Yiqi Liu, Enping Lai, Baizhong Chen, Yujie Liu, Ziqi Liang, Jijun Fu, Minyan Wei
Summary: In this study, a novel self-assembly nano-drug delivery system of nobiletin (NOB/SD) was developed based on solid dispersion technology to improve the bioavailability and hepatoprotective ability of NOB for APAP-induced liver injury therapy. The results showed that NOB/SD exhibited enhanced solubility, improved release behavior, and promoted cellular uptake and anti-apoptosis in vitro, as well as significantly improved bioavailability and alleviated APAP-induced liver injury in vivo. NOB/SD could be considered as a promising hepatoprotective nano-drug delivery system for attenuating APAP-induced acute liver injury.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Environmental Sciences
Weishun Tian, Jing Zhao, Byung-Kil Choo, In-Shik Kim, Dongchoon Ahn, Hyun-Jin Tae, Md Sadikul Islam, Byung-Yong Park
Summary: This study revealed that Camellia japonica attenuated APAP-induced acute liver failure by inhibiting COX-2 activation, NF-kappa B, and JNK phosphorylation, while activating the AMPK signaling pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Congcong Zhang, Jiacheng Lin, Chao Zhen, Fang Wang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: In this study, the protective effect of Amygdalin in APAP-induced acute liver failure was investigated using a mouse model. Results showed that Amygdalin reduced liver injury and inflammation, possibly through modulation of oxidative stress and cell death signaling pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Lin Han, Ang Huang, Jinjun Chen, Guangju Teng, Ying Sun, Binxia Chang, Hong-Li Liu, Manman Xu, Xiaoqin Lan, Qingsheng Liang, Jun Zhao, Hui Tian, Songhai Chen, Yun Zhu, Huan Xie, Tong Dang, Jing Wang, Ning Li, Xiaoxia Wang, Yu Chen, Yong-Feng Yang, Dong Ji, Zhengsheng Zou
Summary: This study aims to identify high-risk factors for non-acetaminophen (APAP) drug-induced acute liver failure (ALF) and develop a predictive model for transplant-free survival (TFS). Analysis of 482 patients with non-APAP drug-induced ALF revealed herbal and dietary supplements (HDS) as the most common causative agents. The DIALF-5 model, based on easily identifiable clinical data, accurately predicts 21-day TFS.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Yeping Yu, Ling Chang, Qingluan Hu, Jianjun Zhu, Jianjun Zhang, Qiang Xia, Jie Zhao
Summary: This study revealed that P2RX1 is involved in mitochondria dysfunction and immune-mediated inflammation in acetaminophen-induced liver injury (AILI). P2RX1 depletion offers protection against AILI by inhibiting cell death and promoting inflammation resolution. The blockade of P2RX1 shows promise as a therapeutic approach for AILI.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Cell Biology
Bingrui Wang, Jichang Li, Junzhe Jiao, Min Xu, Yichun Luo, Fang Wang, Qiang Xia, Yueqiu Gao, Yu Feng, Xiaoni Kong, Xuehua Sun
Summary: The study demonstrates that deletion of DJ-1 protects against APAP-induced acute liver injury by reducing inflammatory response, potentially through modulating myeloid cell function.
Article
Biochemistry & Molecular Biology
Supachaya Sriphoosanaphan, Pakkapon Rattanachaisit, Kanjana Somanawat, Natcha Wanpiyarat, Piyawat Komolmit, Duangporn Werawatganon
Summary: This study found that calcitriol (VD3) can prevent acute liver injury induced by acetaminophen (APAP) and reduce mortality in mice through its anti-inflammatory and antioxidative activity. VD3 might be a novel treatment strategy for APAP-induced hepatotoxicity.
Article
Gastroenterology & Hepatology
Zhenzhen Sun, Qian Wang, Le Sun, Mengying Wu, Shuzhen Li, Hu Hua, Ying Sun, Tong Ni, Chunlei Zhou, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia
Summary: This study revealed the important role of NEK7 in acetaminophen-induced acute liver injury. Reduced NEK7 exacerbates liver damage and provides protection against APAP-induced injury by regulating the cell cycle progression.
Article
Cell Biology
Xin Hou, Qi Liu, Yimin Gao, Liang Yong, Huiyuan Xie, Wenting Li, Yuping Zhou, Jun Liu, Lijie Feng, Long Xu, Yuxian Shen, Hua Wang
Summary: The levels of mesencephalic astrocyte-derived neurotrophic factor (MANF) were found to be elevated in drug-induced liver injury, and MANF plays an important role in immune regulation and liver repair. MANF may enhance IL-10 expression and phagocytosis in macrophages via the p38 MAPK pathway, promoting the phenotype conversion of inflammatory macrophages to pro-restorative macrophages.
CELL DEATH & DISEASE
(2022)
Article
Gastroenterology & Hepatology
Ashwin Rao, Jody A. Rule, Giuliana Cerro-Chiang, Richard T. Stravitz, Brendan M. McGuire, Goo Lee, Robert J. Fontana, William M. Lee
Summary: While hepatitis A and B are well-known causes of acute liver failure (ALF), few cases of acute hepatitis C virus (HCV) infection leading to ALF have been documented. In this study, chronic HCV infection was found in at least 65 (2.2%) of ALI/ALF patients, and it contributed to more severe outcomes in APAP ALI/ALF.
DIGESTIVE DISEASES AND SCIENCES
(2023)