Review
Nutrition & Dietetics
Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar
Summary: Obesity and metabolic diseases are common in industrialized societies due to circadian disruption caused by shift work, jet lag, and social obligations. The circadian rhythm of the hypothalamic suprachiasmatic nucleus (SCN) plays a critical role in regulating physiological, metabolic, and behavioral processes. However, disruptions in external cues or metabolic flexibility can lead to the development of obesity and metabolic disease. This review explores the circadian rhythm of nutrient metabolism and discusses obesity as a circadian disease.
Article
Biochemistry & Molecular Biology
Luba Sominsky, Tamara Dangel, Sajida Malik, Simone N. De Luca, Nicolas Singewald, Sarah J. Spencer
Summary: Microglia play essential roles not only in immune defense but also in regulating satiety, memory, and pain responses. These functions are significantly influenced by circadian rhythmicity, impacting various physiological processes throughout the day.
Review
Pharmacology & Pharmacy
Hao-Ran Dai, Hong-Li Guo, Ya-Hui Hu, Jing Xu, Xuan-Sheng Ding, Rui Cheng, Feng Chen
Summary: This review focuses on the therapeutic effects of caffeine on apnea of prematurity (AOP) and the role of circadian rhythms in its response. The association between Clock gene polymorphisms and caffeine therapy response is discussed, along with the formation and characteristics of circadian rhythms in preterm infants. The potential of circadian-based therapeutic initiatives for precision caffeine therapy in managing AOP in preterm infants is also explored.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Evrim Yildirim, Rachel Curtis, Dae-Sung Hwangbo
Summary: Biological clocks are essential mechanisms that synchronize physiological and behavioral processes with external cues to ensure organisms' fitness and survival. While the central clock in the brain drives daily activity rhythms, peripheral tissues have their own clock systems generating metabolic and physiological rhythms. The fruit fly Drosophila melanogaster has been a widely studied model organism for investigating the mechanism and functions of circadian clocks.
Review
Pharmacology & Pharmacy
Meltem Weger, Benjamin D. Weger, Frederic Gachon
Summary: This review provides an overview of the current understanding of the time-of-day dependent aspects of drug metabolism and the significance of chronopharmacological strategies in drug development. The authors also highlight the factors that influence rhythmic drug pharmacokinetics, such as sex, metabolic diseases, feeding rhythms, and microbiota, which are often overlooked in the context of chronopharmacology. The review summarizes the molecular mechanisms and functions involved and emphasizes the importance of considering these parameters in the drug discovery process.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shigehiro Ohdo
Summary: This study focuses on the role of the molecular clock in regulating circadian rhythms and related disease treatments, emphasizing the importance of gene and antibody delivery as well as targeted therapy for specific disease molecules. New drugs targeting the molecular clock show potential in human disease treatments, and research on chronic kidney disease has revealed new molecular mechanisms.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Review
Cell Biology
Jonathan S. Yi, Nicolas M. Diaz, Shane D'Souza, Ethan D. Buhr
Summary: Most organisms have self-sustained circadian clocks that can be synchronized by environmental stimuli or oscillate indefinitely. In mammals, this is true at the molecular level for most cell types, with a core set of clock genes forming a transcriptional/translational feedback loop (TTFL) with a 24-hour period. The TTFL mechanism varies slightly in different cell types, but all involve similar core clock genes. The clock has unique outputs in different tissues, as cells convert the TTFL timing signals into orchestrated transcriptional oscillations of clock-controlled genes and cellular processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Physiology
Siska Wilantri, Hanna Grasshoff, Tanja Lange, Timo Gaber, Luciana Besedovsky, Frank Buttgereit
Summary: Research on 24-h rhythms over the past four decades has revealed their significance for immunity and various diseases through genetic, molecular, and physiological findings. Disruption and misalignment of circadian rhythms have been linked to diseases and abnormal physiological functioning, highlighting their fundamental importance to mammals. This article provides an overview of the molecular regulation of 24-h rhythms, their impact on immunity, the detrimental effects of misalignment, the association between pathological rhythms and rheumatoid arthritis (RA), and the potential use of chronobiological rhythms for chronotherapy in inflammatory autoimmune diseases like RA.
Article
Chemistry, Multidisciplinary
Shigehiro Ohdo, Satoru Koyanagi, Naoya Matsunaga
Summary: This article provides a critical summary of literature reports on the rationale/mechanisms for time-dependent dosing differences in therapeutic outcomes and safety, the molecular pathways underlying biological rhythms, and the possibility of pharmacotherapy based on intra- and inter-individual variabilities from the viewpoints of the clock genes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Charlotte von Gall
Summary: Life on earth has evolved with an internal clock that generates 24-hour rhythms to anticipate environmental changes. Light plays a crucial role in regulating rhythmic behavior and brain function, especially in nocturnal laboratory rodents. Research has made significant progress in understanding the molecular circadian clockwork and light perception, and the complex interaction between different components of the mammalian circadian system. This review also briefly discusses the impact of light at night, genetic manipulation, and neurodegenerative diseases on the circadian system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Xuemin Peng, Yong Chen
Summary: The relationship between circadian rhythms and thermogenic fat and its potential in treating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Review
Biochemistry & Molecular Biology
Sanjeev Kumar Soni, Priyoneel Basu, Muniyandi Singaravel, Ramaswamy Sharma, Seithikurippu R. Pandi-Perumal, Daniel. P. Cardinali, Russel J. Reiter
Summary: SIRT1 plays a crucial role in regulating cardioprotection through modulating the activity of CLOCK, a core clock gene. It has protective effects in preventing atherosclerotic plaque formation, shielding the heart from oxidative damage, but elevated levels may lead to cardiac hypertrophy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Anastasia O. Gkountidi, Laure Garnier, Juan Dubrot, Julien Angelillo, Guillaume Harle, Dale Brighouse, Ludovic J. Wrobel, Robert Pick, Christoph Scheiermann, Melody A. Swartz, Stephanie Hugues
Summary: This study demonstrates that tumoral lymphatic endothelial cells (LEC) can promote tumor growth by upregulating MHC class II and antigen-processing machinery, leading to Treg expansion and suppression of effector T-cell infiltration. Lack of MHC class II expression in LECs impairs tumor growth, increases effector T-cell infiltration, and alters Treg-suppressive functions. Antigen presentation by LECs locally in the tumor microenvironment is crucial for promoting Treg-mediated immunosuppression.
CANCER IMMUNOLOGY RESEARCH
(2021)
Editorial Material
Cell Biology
Coline Barnoud, Chen Wang, Christoph Scheiermann
Article
Cardiac & Cardiovascular Systems
Julia Hinterdobler, Simin Schott, Hong Jin, Almut Meesmann, Anna-Lena Steinsiek, Anna-Sophia Zimmermann, Jana Wobst, Philipp Mueller, Carina Mauersberger, Baiba Vilne, Alexandra Baecklund, Chien-Sin Chen, Aldo Moggio, Quinte Braster, Michael Molitor, Markus Krane, Wolfgang E. Kempf, Karl-Heinz Ladwig, Michael Hristov, Maarten Hulsmans, Ingo Hilgendorf, Christian Weber, Philip Wenzel, Christoph Scheiermann, Lars Maegdefessel, Oliver Soehnlein, Peter Libby, Matthias Nahrendorf, Heribert Schunkert, Thorsten Kessler, Hendrik B. Sager
Summary: This study reveals how acute mental stress exacerbates vascular inflammation and promotes plaque rupture. Acute stress increases the influx of inflammatory leucocytes into mouse atherosclerotic plaques by modulating endothelial cells. Chemical or surgical disruption of norepinephrine signaling reduces stress-induced leucocyte migration into mouse atherosclerotic plaques.
EUROPEAN HEART JOURNAL
(2021)
Article
Immunology
Chien-Sin Chen, Jasmin Weber, Stephan Jonas Holtkamp, Louise Madeleine Ince, Alba de Juan, Chen Wang, Lydia Lutes, Coline Barnoud, Burak Kizil, Sophia Martina Hergenhan, Johanna Salvermoser, Manuel Lasch, Elisabeth Deindl, Barbara Schraml, Dirk Baumjohann, Christoph Scheiermann
Summary: Peripheral nerve injury can cause immune cell-mediated destruction of the affected nerve, leading to pro-inflammatory effect on lymph node function and expansion. This effect can be rescued by beta 2 adrenergic receptor agonists.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Thomas Bromberger, Sarah Klapproth, Ina Rohwedder, Jasmin Weber, Robert Pick, Laura Mittmann, Soo Jin Min-Weissenhorn, Christoph A. Reichel, Christoph Scheiermann, Markus Sperandio, Markus Moser
Summary: Beta 2 integrins play a crucial role in leukocyte trafficking by mediating the processes of slow rolling and firm arrest through conformational changes, which are regulated by interactions with Rap1 and Riam. The loss of both pathways simultaneously results in a rolling phenotype similar to talin1 deficient neutrophils, suggesting that these two pathways primarily regulate beta 2 integrin.
FRONTIERS IN IMMUNOLOGY
(2021)
Biographical-Item
Cell Biology
Sandra Pinho, Daniel Lucas, Christoph Scheiermann, Andres Hidalgo
NATURE CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Alice Coillard, Lea Guyonnet, Alba De Juan, Adeline Cros, Elodie Segura
Summary: Monocytes are recruited to inflamed tissues where they encounter a broad range of microbial motifs, leading to differentiation into mo-mac or mo-DC. Viruses promote mo-mac differentiation via TLR signaling, while Mycobacteria favor mo-DC differentiation through NOD signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Chen Wang, Lydia Kay Lutes, Coline Barnoud, Christoph Scheiermann
Summary: The immune system is regulated by circadian rhythms, and recent advances have identified molecular factors governing these rhythms. The interconnectivity between immune cells and their environment has been found to be highly complex.
SCIENCE IMMUNOLOGY
(2022)
Meeting Abstract
Oncology
C. Wang, C. Barnoud, B. Kizil, C. Scheiermann
ANNALS OF ONCOLOGY
(2022)
Review
Neurosciences
Francesco De Virgiliis, Valeria Maria Oliva, Burak Kizil, Christoph Scheiermann
Summary: The nervous system communicates with immune cells through neurotransmitters and neuropeptides to respond to immune threats and maintain system homeostasis. Lymph nodes, as the sites of adaptive immune responses, are extensively innervated by peripheral nerves that secrete neurotransmitters and neuropeptides. Time-dependent fluctuations in nerve activity may play a role in coordinating immunity in a circadian fashion.
TRENDS IN NEUROSCIENCES
(2022)
Article
Immunology
Javiera Villar, Adeline Cros, Alba De Juan, Lamine Alaoui, Pierre-Emmanuel Bonte, Colleen M. Lau, Ioanna Tiniakou, Boris Reizis, Elodie Segura
Summary: In chronic nonresolving inflammation, the differentiation of monocytes into dendritic cells plays a major role in pathogenic events. This study reveals that the transcriptional repressors ETV3 and ETV6 control this differentiation process by repressing mo-Mac development and regulating MAFB expression. Mice lacking Etv6 show spontaneous expression of IFN-stimulated genes and impaired mo-DC differentiation, suggesting ETV6 as a potential therapeutic target for redirecting monocyte differentiation in inflammatory disorders.
Article
Multidisciplinary Sciences
Louise Madeleine Ince, Coline Barnoud, Lydia Kay Lutes, Robert Pick, Chen Wang, Flore Sinturel, Chien-Sin Chen, Alba de Juan, Jasmin Weber, Stephan J. Holtkamp, Sophia Martina Hergenhan, Jennifer Geddes-McAlister, Stefan Ebner, Paola Fontannaz, Benjamin Meyer, Maria Vono, Stephane Jemelin, Charna Dibner, Claire-Anne Siegrist, Felix Meissner, Frederik Graw, Christoph Scheiermann
Summary: The study shows that circadian rhythms affect immune responses, including responses to vaccines. Dendritic cells migrate in a time-of-day-dependent manner, altering interactions with T cells and influencing vaccine responses. The findings provide a mechanistic understanding of the development and maintenance of an adaptive immune response under circadian control, offering a strategy for optimizing vaccination regimes based on time-of-day.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Adeline Cros, Alba De Juan, Renaud Leclere, Julio L. Sampaio, Mabel San Roman, Mathieu Maurin, Sandrine Heurtebise-Chretien, Elodie Segura
Summary: Dietary agonists of aryl hydrocarbon receptor (AhR) have a regulatory role in allergic responses, with a lack of dietary AhR ligands exacerbating cutaneous allergic responses and asthma-like allergy. Mechanistically, dietary AhR ligands regulate the inflammatory profile of epidermal cells, without affecting barrier function. These findings highlight the importance of the gut-skin axis in the development of allergic diseases.
Article
Multidisciplinary Sciences
Laure Garnier, Robert Pick, Julien Montorfani, Mengzhu Sun, Dale Brighouse, Nicolas Liaudet, Thomas Kammertoens, Thomas Blankenstein, Nicolas Page, Jeremiah Bernier-Latamani, Ngoc Lan Tran, Tatiana Petrova, Doron Merkler, Christoph Scheiermann, Stephanie Hugues
Summary: A study found that cytotoxic T cells can reduce lymphatic flow and lymph node metastasis by affecting the tumor lymphatic vessel system. This is achieved through the induction of apoptosis in tumor-associated lymphatic endothelial cells (LECs) by T cells, which is triggered by the release of tumor antigens from dying tumor cells and cross-presentation by LECs.
Letter
Multidisciplinary Sciences
Lucrecia K. Aguilar
