Review
Biochemistry & Molecular Biology
Cindy Barnig, Gaetan Lutzweiler, Margherita Giannini, Anne Lejay, Anne-Laure Charles, Alain Meyer, Bernard Geny
Summary: This article discusses the inflammatory response and recent discoveries in resolution pathways during skeletal muscle ischemia reperfusion. Lipid mediators play an important role in regulating the inflammatory response, reducing damage caused by ischemia reperfusion, and have potential therapeutic applications.
Article
Chemistry, Multidisciplinary
Friedemann Boerner, Simona Pace, Paul M. Jordan, Jana Gerstmeier, Mario Gomez, Antonietta Rossi, Nathaniel C. Gilbert, Marcia E. Newcomer, Oliver Werz
Summary: This study reveals that 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) can activate cellular 15-LOX-1 and promote the formation of specialized pro-resolving mediators (SPM) for inflammation resolution. AKBA-induced LOX activation is independent of calcium and phosphorylation, with modest induction of 5-LOX products. The docking of AKBA with the R98 site of 15-LOX-1 is essential for its allosteric activation.
Article
Pharmacology & Pharmacy
Tran Thi Van Anh, Alilou Mostafa, Zhigang Rao, Simona Pace, Stefan Schwaiger, Christian Kretzer, Veronika Temml, Carsten Giesel, Paul M. Jordan, Rossella Bilancia, Christina Weinigel, Silke Rummler, Birgit Waltenberger, Tran Hung, Antonietta Rossi, Hermann Stuppner, Oliver Werz, Andreas Koeberle
Summary: The study identified a potential drug candidate from Vietnamese medicinal plant extracts to alleviate chronic inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile. This candidate showed promising activity in inhibiting leukotriene production and inducing specialized pro-resolving mediators, offering a new strategy to address chronic inflammatory conditions.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Biochemistry & Molecular Biology
Wheeler Torres, Jose Luis Perez, Maria P. Diaz, Luis D'Marco, Ana Checa-Ros, Ruben Carrasquero, Lisse Angarita, Yosselin Gomez, Maricarmen Chacin, Paola Ramirez, Nelson Villasmil, Samuel Duran-Aguero, Climaco Cano, Valmore Bermudez
Summary: Cancer is a major global health issue characterized by cell mutation, proliferation, invasion, and metastasis. The increasing incidence of cancer highlights the need for new approaches to understand the molecular changes involved in its development, including chronic inflammation. Specialized pro-resolving mediators (SPMs), bioactive lipids derived from polyunsaturated fatty acids (PUFAs), have shown potential as novel anti-inflammatory molecules that could improve anti-tumor immunity. This review aims to explore the effects of SPMs on carcinogenesis and their therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Physiology
Bohae Rachel Lee, May Hnin Paing, Neelam Sharma-Walia
Summary: Cyclopentenone prostaglandins (cyPGs) are biologically active lipid mediators with diverse functions, including anti-inflammatory, pro-apoptotic, anti-oxidant properties that can regulate cellular activities and combat pathogen infections. They have potential therapeutic value, especially in resolving inflammation.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Nutrition & Dietetics
Maria Paz Beyer, Luis A. Videla, Camila Farias, Rodrigo Valenzuela
Summary: This review discusses the therapeutic benefits of docosahexaenoic acid (DHA) and specialized pro-resolving lipid mediators (SPMs) on various diseases. DHA is the precursor of SPMs, which have been considered bioactive compounds for human health. Growing evidence suggests that DHA and SPMs have beneficial effects on the amelioration, regulation, and duration of inflammatory processes through different biological actions.
Article
Nutrition & Dietetics
Jiaqiang Deng, Lili Zhao, Xieyong Yuan, Yan Li, Junyang Shi, Hua Zhang, Yuxuan Zhao, Liping Han, Huani Wang, Yan Yan, Hong Zhao, Haojie Wang, Fangdong Zou
Summary: BBR has preventive effects in colon carcinogenesis by inhibiting inflammation and tumor proliferation, and maintaining intestinal homeostasis.
Article
Cell Biology
Yang Jiao, Ti Zhang, Mei Liu, Luyang Zhou, Mengzhi Qi, Xin Xie, Xueyin Shi, Xiaoping Gu, Zhengliang Ma
Summary: M2-Exos modulate PMN migration and NET formation through lipid mediator class switching, alleviating lung injury and reducing mortality in a sepsis mouse model. This study highlights the potential application of M2-Exos in controlling PMN-mediated tissue injury in sepsis patients.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Zhigang Rao, Diego Caprioglio, Andre Gollowitzer, Christian Kretzer, Daniela Imperio, Juan A. Collado, Lorenz Waltl, Sandra Lackner, Giovanni Appendino, Eduardo Munoz, Veronika Temml, Oliver Werz, Alberto Minassi, Andreas Koeberle
Summary: This study investigates the inhibitory effects of curcuminoid analogues on 5-LOX and mPGES-1, leading to the identification of potent and selective inhibitors for these enzymes.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Neurosciences
Santosh Anand, Mohammad Azam Ansari, Sambamurthy Kumaraswamy Sukrutha, Mohammad N. Alomary, Anmar Anwar Khan, Abozer Y. Elderdery
Summary: Inflammation and resolution are highly programmed processes involving immune cells and lipid mediators. Recent research focuses on understanding the resolution of inflammation, which is important for the treatment of chronic inflammation-related diseases.
Review
Immunology
David Shofler, Vikrant Rai, Sarah Mansager, Kira Cramer, Devendra K. Agrawal
Summary: Studies show that resolvins play a crucial role in diabetic wound healing by stimulating self-limited innate immune responses, promoting microbial killing and clearance, reducing cellular infiltration caused by inflammation, enhancing macrophage phagocytic activity, among other effects.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Melissa Simard, Sophie Morin, Zainab Ridha, Roxane Pouliot
Summary: The skin's barrier function is crucial for maintaining skin homeostasis. Bioactive lipid mediators derived from n-3 and n-6 PUFAs play complex roles in skin diseases, including psoriasis. High intake of n-3 PUFAs has been shown to reduce the severity and frequency of psoriatic plaques.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Laura Miek, Paul M. Jordan, Kerstin Guenther, Simona Pace, Timo Beyer, David Kowalak, Verena Hoerr, Bettina Loeffler, Lorena Tuchscherr, Charles N. Serhan, Jana Gerstmeier, Oliver Werz
Summary: The study reveals that S. aureus infection can modulate lipid mediator pathways involved in inflammatory processes, resulting in a shift from anti-inflammatory M2-like signature profiles to pro-inflammatory M1-like signature profiles.
Article
Biochemistry & Molecular Biology
Patrick Schaedel, Fabiana Troisi, Anna Czapka, Nadja Gebert, Simona Pace, Alessandro Ori, Oliver Werz
Summary: Aging is often accompanied by chronic systemic inflammation, referred to as inflammaging, which plays a major role in age-associated diseases. Research shows that different organs have organ-specific responses to inflammatory cytokines, chemokines, and lipid mediators, with varying levels of pro-inflammatory and pro-resolving mediators during the aging process.
Review
Immunology
Tobias Schmid, Bernhard Brune
Summary: Bioactive lipid mediators, such as prostanoids and specialized pro-resolving mediators, play key roles in regulating inflammatory processes. While prostanoids are known for their pro-inflammatory properties, they also contribute to the resolution of inflammation and return to homeostasis. Further research on the resolution-regulatory properties of prostanoids may have implications for anti-inflammatory therapeutic interventions targeting these lipid mediators.
FRONTIERS IN IMMUNOLOGY
(2021)