Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 32, Issue 3, Pages 227-238Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-010-0211-2
Keywords
Dendritic cells; T cells; Dynamic interactions; Priming; Tolerance; Lymph node
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Funding
- Swiss National Science Foundation [310030-127042]
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Antigen-specific dendritic cells (DC)-T cell encounters occur in lymph nodes (LNs) and are essential for the induction of both priming and tolerance. In both cases, T cells are rapidly activated and proliferate. However, the subsequent outcome of T cell activation depends on the modulation of different DC- and T cell-intrinsic signals. Recent advances in two-photon (2P) microscopy have furthered our understanding regarding the complex choreography of DCs and T cells in intact LNs, and established differences in the dynamics of DC-T cell contacts during priming and tolerance induction. The mechanisms that favour DC-T cell encounters, as well as the contribution of the frequency and the duration of such encounters in dictating the T cell response, are discussed in this review.
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