Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 30, Issue 4, Pages 457-477Publisher
SPRINGER
DOI: 10.1007/s00281-008-0140-5
Keywords
Thymus; Ageing; Regeneration; Stem cells; Immune reconstitution
Categories
Funding
- Australian Stem Cell Centre
- National Health and Medical Research Council of Australia and Norwood Immunology
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Poor immune recovery is characteristic of bone marrow transplantation and leads to high levels of morbidity and mortality. The primary underlying cause is a compromised thymic function, resulting from age-induced atrophy and further compounded by the damaging effects of cytoablative conditioning regimes on thymic epithelial cells (TEC). Several strategies have been proposed to enhance T cell reconstitution. Some, such as the use of single biological agents, are currently being tested in clinical trials. However, a more rational approach to immune restoration will be to leverage the evolving repertoire of new technologies. Specifically, the combined targeting of TEC, thymocytes and peripheral T cells, together with the bone marrow niches, promises a more strategic clinical therapeutic platform.
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