Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 19, Issue 6, Pages 349-356Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2014.09.007
Keywords
Congenital diaphragmatic hernia; Prenatal pharmacologic treatment; Prenatal stem cell therapy
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This review focuses on the emerging field of non-surgical in-utero therapies in the management of fetal pulmonary hypoplasia and pulmonary hypertension associated with congenital diaphragmatic hernia (CDH). These experimental approaches include pharmacologic as well as stem-cell-based strategies. Current barriers of non-surgical therapies toward clinical translation are emphasized. As the severity of CDH will likely influence the efficacy of any in-utero therapy, the current status of prenatal imaging and the role of novel biomarkers, especially those related to fetal inflammation, are also reviewed. (C) 2014 Elsevier Ltd. All rights reserved.
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