Review
Medicine, General & Internal
Jing Lin, Rong-zu Tu, Xun-yu Hong
Summary: This study aims to evaluate the efficacy and safety of glyburide, metformin, and insulin in the treatment of GDM. Through systematic review and meta-analysis, relevant literature will be screened and analyzed, and the results will be submitted to a peer-reviewed journal. This meta-analysis will provide valuable information for healthcare practitioners and policy makers in managing GDM.
Article
Multidisciplinary Sciences
Qinpei Zhao, Jinhao Zhu, Xuan Shen, Chuwen Lin, Yinjia Zhang, Yuxiang Liang, Baige Cao, Jiangfeng Li, Xiang Liu, Weixiong Rao, Congrong Wang
Summary: To promote research in diabetes management, the ShanghaiT1DM and ShanghaiT2DM datasets have been developed and made publicly available. These datasets include clinical characteristics, laboratory measurements, medications, continuous glucose monitoring readings, and daily dietary information of 12 Type 1 and 100 Type 2 diabetic patients in Shanghai, China. They can contribute to the development of data-driven algorithms/models and diabetes monitoring/managing technologies.
Review
Endocrinology & Metabolism
Ran Cheng, Nadine Taleb, Meggie Stainforth-Dubois, Remi Rabasa-Lhoret
Summary: The first therapeutic use of insulin in 1921 revolutionized diabetes management and significantly improved the lives of patients. Despite significant pharmacological advances, challenges such as increasing treatment flexibility, reducing iatrogenic hypoglycemia, and optimizing patient quality of life remain. Ongoing innovations in insulin therapy aim to overcome these hurdles and change the landscape of diabetes management.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Obstetrics & Gynecology
Kaat Beunen, Nancy Van Wilder, Dominique Ballaux, Gerd Vanhaverbeke, Youri Taes, Xavier-Philippe Aers, Frank Nobels, Joke Marlier, Dahae Lee, Joke Cuypers, Vanessa Preumont, Sarah E. Siegelaar, Rebecca C. Painter, Annouschka Laenen, Pieter Gillard, Chantal Mathieu, Katrien Benhalima
Summary: This study aims to evaluate the efficacy, safety and cost-effectiveness of the MiniMed (TM) 780G HCL system in pregnant women with T1D. It is an international, open-label, randomized controlled trial that will compare the MiniMed (TM) 780G HCL system to standard of care. The primary outcome is the time spent within the pregnancy glucose target range.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Fidelma Dunne, Christine Newman, Alberto Alvarez-Iglesias, John Ferguson, Andrew Smyth, Marie Browne, Paula O'Shea, Declan Devane, Paddy Gillespie, Delia Bogdanet, Oratile Kgosidialwa, Aoife Egan, Yvonne Finn, Geraldine Gaffney, Aftab Khattak, Derek O'Keeffe, Aaron Liew, Martin O'Donnell
Summary: Early initiation of metformin is not superior to placebo for the primary outcome of gestational diabetes. Further investigation of metformin in larger clinical trials is supported by the prespecified secondary outcome data.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Francesco Prendin, Jacopo Pavan, Giacomo Cappon, Simone Del Favero, Giovanni Sparacino, Andrea Facchinetti
Summary: Machine learning models are widely used in predicting glucose levels and suggesting therapeutic decisions for Type 1 Diabetes management. However, besides prediction accuracy, physiological soundness and explainability should also be considered. This paper discusses the importance of using interpretability tools for black-box models in diabetes management through a case study.
SCIENTIFIC REPORTS
(2023)
Review
Multidisciplinary Sciences
Jane L. Tarry-Adkins, Susan E. Ozanne, Catherine E. Aiken
Summary: Metformin use during pregnancy is associated with lower gestational weight gain and a modestly reduced risk of pre-eclampsia, but increased gastrointestinal side effects compared to other treatments.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Helene Affres, Marie-Victoire Senat, Alexandra Letourneau, Philippe Deruelle, Magali Coustols-Valat, Hanane Bouchghoul, Jean Bouyer
Summary: In women with gestational diabetes mellitus (GDM), glyburide is effective for reaching glycemic goals during pregnancy, but may increase the risk of maternal hypoglycemia. Switching to insulin therapy after glyburide treatment failure can improve glycemic control.
DIABETES & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Wenying Yang, Dalong Zhu, Shenglian Gan, Xiaolin Dong, Junping Su, Wenhui Li, Hongwei Jiang, Wenjuan Zhao, Minxiu Yao, Weihong Song, Yibing Lu, Xiuzhen Zhang, Huifang Li, Guixia Wang, Wei Qiu, Guoyue Yuan, Jianhua Ma, Wei Li, Ziling Li, Xiaoyue Wang, Jiao'e Zeng, Zhou Yang, Jingdong Liu, Yongqian Liang, Song Lu, Huili Zhang, Hui Liu, Ping Liu, Kuanlu Fan, Xiaozhen Jiang, Yufeng Li, Qing Su, Tao Ning, Huiwen Tan, Zhenmei An, Zhaoshun Jiang, Lijun Liu, Zunhai Zhou, Qiu Zhang, Xuefeng Li, Zhongyan Shan, Yaoming Xue, Hong Mao, Lixin Shi, Shandong Ye, Xiaomei Zhang, Jiao Sun, Ping Li, Tao Yang, Feng Li, Jingna Lin, Zhinong Zhang, Ying Zhao, Ruonan Li, Xiaohui Guo, Qi Yao, Weiping Lu, Shen Qu, Hongmei Li, Liling Tan, Wenbo Wang, Yongli Yao, Daoxiong Chen, Yulan Li, Jialin Gao, Wen Hu, Xiaoqiang Fei, Tianfeng Wu, Song Dong, Wenlong Jin, Chenzhong Li, Dong Zhao, Bo Feng, Yu Zhao, Yi Zhang, Xiaoying Li, Li Chen
Summary: In patients with inadequate glycemic control using metformin alone, dorzagliatin as an add-on therapy resulted in effective glycemic control with good tolerability and safety.
Review
Cell Biology
Caitlin L. Maikawa, Andrea d'Aquino, Rayhan A. Lal, Bruce A. Buckingham, Eric A. Appel
Summary: This review discusses the advantages and limitations of recent drug formulation technologies in improving protein stability, pharmacokinetics, prolonging drug delivery, and enabling alternative dosage forms for diabetes management. By providing controlled delivery, these formulations have the potential to enhance closed-loop glycemic control.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Carlos Palma, H. David McIntyre, Carlos Salomon
Summary: Research on extracellular vesicles (EVs) has provided insights into physiological and pathophysiological conditions, particularly during pregnancy. Gestational diabetes mellitus (GDM) is a common and influential complication that affects the miRNAs and proteins within EVs, leading to metabolic changes.
Article
Endocrinology & Metabolism
Ravi Retnakaran, Chang Ye, Anthony J. Hanley, Philip W. Connelly, Mathew Sermer, Bernard Zinman, Jill K. Hamilton
Summary: Despite reducing birth weight and macrosomia, the treatment of GDM does not have analogous effects on infant adiposity across the 1st year of life.
Review
Endocrinology & Metabolism
Carlos A. Diaz-Balzac, David Pillinger, Steven D. Wittlin
Summary: Continuous subcutaneous insulin infusions (CSIIs) and continuous glucose monitors (CGMs) have revolutionized the management of diabetes mellitus (DM). They provide an integrated system to maintain tight glycemic control and reduce episodes of hypoglycemia, while improving the quality of life for individuals with DM. Ongoing efforts to develop an artificial pancreas (AP) have created effective tools for managing DM, but cost and accessibility remain obstacles to wider application.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Fu-Shun Yen, James Cheng-Chung Wei, Ying-Hsiu Shih, Chih-Cheng Hsu, Chii-Min Hwu
Summary: In patients with type 2 diabetes, the use of metformin is associated with significantly lower risks of bacterial pneumonia, invasive mechanical ventilation, and respiratory cause of death. Longer duration of metformin use is also associated with lower hazard ratios for these risks.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Richard M. Bergenstal, Revital Nimri, Roy W. Beck, Amy Criego, Lori Laffel, Desmond Schatz, Tadej Battelino, Thomas Danne, Stuart A. Weinzimer, Judy Sibayan, Mary L. Johnson, Ryan J. Bailey, Peter Calhoun, Anders Carlson, Elvira Isganaitis, Rachel Bello, Anastasia Albanese-O'Neill, Klemen Dovc, Torben Biester, Kate Weyman, Korey Hood, Moshe Phillip
Summary: In adolescents and young adults with type 1 diabetes, the use of an investigational advanced hybrid closed-loop system was found to reduce hyperglycemia without increasing the occurrence of hypoglycemia compared to a commercially available MiniMed 670G system. Further testing of this technology in underserved populations and in individuals with impaired awareness of hypoglycemia could advance its effective use.
