Article
Medicine, General & Internal
Haiyan Zhu, Yian Tian, Huaiping Cheng, Yafei Zheng, Wei Wang, Tianping Bao, Rong Wu, Zhaofang Tian
Summary: This study found that elevated plasma LRP1 and S100A8 levels in BPD infants are correlated with the efficacy of dexamethasone, suggesting that they may serve as biomarkers for deciding the use of adjuvant corticosteroids therapy in BPD.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Pediatrics
Funda Yavanoglu Atay, Hayriye Gozde Kanmaz Kutman, Duygu Bidev, Ozlem Bozkurt Kalyoncu, Serife Suna Oguz
Summary: Caffeine, widely used in neonatal intensive care units (NICUs), is beneficial in reducing apnea of prematurity but does not prevent respiratory morbidity such as bronchopulmonary dysplasia (BPD). This retrospective cohort analysis of 475 premature infants found that caffeine prophylaxis significantly decreased the incidence of apnea attacks but did not affect the rates of BPD and other common morbidities.
FRONTIERS IN PEDIATRICS
(2023)
Review
Medicine, General & Internal
Yueqin Ding, Zhifeng Chen, Yanling Lu
Summary: Vitamin A supplementation is beneficial for the prophylaxis of bronchopulmonary dysplasia in premature infants, but no significant differences were found in the incidence of other complications such as retinopathy of prematurity, necrotizing enterocolitis, intraventricular hemorrhage, sepsis, and mortality. Further studies on administration approaches and dosages are warranted.
Article
Multidisciplinary Sciences
Andre Gie, Yannick Regin, Arianna Mersanne, Jaan Toelen
Summary: Intratracheal drug delivery provides a direct way to deliver pharmaceutical substances to the lungs of premature animals, with the transcutaneous technique being simple and effective. This method is well tolerated by newborn pups and can be repeated for multiple consecutive days without affecting survival.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Nutrition & Dietetics
Madelaine Eloranta Rossholt, Kristina Wendel, Marianne Bratlie, Marlen Fossan Aas, Gunnthorunn Gunnarsdottir, Drude Fugelseth, Are Hugo Pripp, Magnus Domellof, Ketil Stordal, Tom Stiris, Sissel Jennifer Moltu
Summary: Vitamin A deficiency is associated with an increased risk of bronchopulmonary dysplasia in preterm infants. This study analyzed the vitamin A status of infants <29 weeks gestation and found that dexamethasone exposure and inflammation can affect vitamin A concentrations. Infants exposed to dexamethasone had higher vitamin A concentrations, but lower pretreatment retinol levels, indicating a risk of deficiency.
Review
Respiratory System
Christopher Harris, Anne Greenough
Summary: Survival of premature infants has improved, but long-term respiratory morbidity from neonatal chronic lung disease (BPD) remains a problem. Infants with BPD require supplementary oxygen, have more hospital admissions, and experience troublesome respiratory symptoms. BPD also leads to poorer lung function and exercise capacity in adolescents and adults.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Medicine, Research & Experimental
Hong Zhen, Hongbo Hu, Guojie Rong, Xiuxiu Huang, Chang Tan, Xinyuan Yu
Summary: Administration of vitamin A or vitamin D can alleviate BPD-linked pulmonary injury induced by LPS and have a significant impact on macrophage polarization.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pediatrics
Vineet Lamba, Oscar Winners, Prem Fort
Summary: The study found that early high-dose caffeine (HD) therapy can reduce the duration of mechanical ventilation in premature infants and decrease the risk of bronchopulmonary dysplasia (BPD).
Article
Obstetrics & Gynecology
Caren Liviskie, Zachary Vesoulis, Brandy Zeller, Rakesh Rao, Christopher McPherson
Summary: This study found that prolonged prednisolone use in preterm infants was associated with a sustained decrease in pulmonary severity score without adverse effects on growth measurements. These results suggest potential benefit of prednisolone on respiratory outcomes in a subset of preterm infants.
EARLY HUMAN DEVELOPMENT
(2021)
Article
Pediatrics
V. M. Koenders, A. Appels, H. L. M. van Straaten, A. C. Dutman, M. A. C. Hemels
Summary: This study found that there was no significant difference in the short-term response to postnatal corticosteroids among premature neonates born after acute chorioamnionitis, maternal vascular malperfusion, or no placental pathology, which are associated with bronchopulmonary dysplasia. However, there was a slight trend of better corticosteroid response in neonates with maternal vascular malperfusion, potentially due to differences in prenatal pulmonary development and postnatal cortisol.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Yuan Yuan, Yang Yang, Xiaoping Lei, Wenbin Dong
Summary: Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease commonly associated with prematurity. Caffeine is used for the prevention of BPD and the treatment of apnea in premature infants, with multiple clinical benefits. However, the specific mechanisms by which caffeine protects against BPD are unclear.
PEDIATRIC PULMONOLOGY
(2022)
Article
Medicine, General & Internal
Shin Yun Byun, Mi Hye Bae, Na Rae Lee, Young Mi Han, Kyung Hee Park
Summary: Vitamin D deficiency is common in preterm infants and may be associated with bronchopulmonary dysplasia, with early monitoring of vitamin D levels at 1 month of age potentially predicting the risk of developing this condition.
Review
Pediatrics
Congliang Tian, Danni Li, Jianhua Fu
Summary: Bronchopulmonary dysplasia (BPD) is a common chronic respiratory complication in premature infants. Early prevention of BPD is emphasized due to its negative impact on the physical and mental health of children as well as the burden on families and society. Caffeine plays a significant role in the prevention and treatment of BPD, but its potential molecular mechanisms are not fully understood.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Qing Wang, Siyuan Jiang, Xuefeng Hu, Chao Chen, Yun Cao, Shoo Kim Lee, Jiang-Qin Liu
Summary: The rate of antenatal corticosteroid (ACS) exposure varies among tertiary maternal centers in China and is associated with perinatal factors. The highest ACS use was observed in the 28-31 weeks gestational age group, and the lowest in the under 26 weeks of gestational age group. ACS exposure was associated with lower odds of bronchopulmonary dysplasia or death, as well as invasive respiration requirement. Quality improvement of ACS administration is needed.
Article
Biochemistry & Molecular Biology
Shin Kato, Osuke Iwata, Hiroyuki Kato, Satoko Fukaya, Yukari Imai, Shinji Saitoh
Summary: This study reveals the involvement of furin in the alveolarization of immature lungs and its critical role in the pathogenesis of bronchopulmonary dysplasia (BPD). The findings highlight furin as a potential treatment target for ameliorating the impact of BPD.