Article
Engineering, Biomedical
Li Liu, Mengyu Chen, Junming Zhang, Haobo Li, Zhaoxia Li, Jianhao Song, Shutao Ma, Yingjie Wang, Xiangxin Lou
Summary: The present study used oriented nanofiber scaffolds to mimic the microenvironment of SGNs and promote neurite outgrowth. The results showed that the scaffolds can enhance SGN growth, with the 2% PANI/PLLA/Gel group exhibiting the best effects. These findings provide a feasible research direction for SGN regeneration and the treatment of SNHL in the future.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Cell Biology
Haiying Sun, Tian Wang, Patrick J. Atkinson, Sara E. Billings, Wuxing Dong, Alan G. Cheng
Summary: The study reveals that Gpr125 is dynamically expressed in various cell types in the developing and mature cochlea, but it is not essential for cochlear development and hearing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Kristy Truong, Braden Leigh, Joseph T. Vecchi, Reid Bartholomew, Linjing Xu, C. Allan Guymon, Marlan R. Hansen
Summary: The study investigates the impact of micropatterned biochemical and topographic guidance cues on the growth of spiral ganglion neuron (SGN) neurites, the target neurons of cochlear implants. Results suggest that the combination of topographical and biochemical cues enhances guided neurite growth.
Article
Nanoscience & Nanotechnology
Y. Hu, W. Chen, H. Yin, X. Chen, J. Cai, J. Guo, S. Zhou, R. Chai, M. Tang
Summary: This study presents a composite material, GelMA-SACNT, which can promote the growth of SGNs and the formation of anisotropic neural networks. The experimental results demonstrate that GelMA-SACNT can enhance the directional growth of SGNs and neural network activity, showing potential for the treatment of sensorineural hearing loss.
MATERIALS TODAY NANO
(2022)
Article
Chemistry, Multidisciplinary
Lin Xia, Xiaolong Zhao, Xiangyu Ma, Yangnan Hu, Yuan Zhang, Siyu Li, Jie Wang, Yuanjin Zhao, Renjie Chai
Summary: This paper introduces a novel neural regeneration guiding method based on magnetic colloidal nanochains, which can promote the oriented growth and synapse formation of seeded SGNs, facilitating nerve network reorganization and neural signal communication. Multidirectional nanochains can be constructed by adjusting the magnetic field, aiding the complex regenerate environment of the nervous system in vitro.
Article
Cell Biology
Kai Xu, Sen Chen, Xue Bai, Le Xie, Yue Qiu, Xiao-zhou Liu, Xiao-hui Wang, Wei-jia Kong, Yu Sun
Summary: The GJB2 gene mutation leads to congenital deafness or late-onset progressive hearing loss, and it has been found that deficiency of Cx26 accelerates age-related hearing loss. The expression of Cx26 is significantly reduced in the cochleae of aged mice, and it is degraded by lysosomes. Mice with Cx26 knockout in the cochlea show high-frequency hearing loss and degeneration of hair cells and spiral ganglions, similar to age-related hearing loss phenotype.
Article
Cell Biology
Xinyu Zhang, Ke Zhou, Keyong Tian, Qingwen Zhu, Wei Liu, Zhenzhen Liu, Xiaogang An, Chaoyong Tian, Yao Li, Fei Lu, Fei Sun, Dingjun Zha
Summary: This study discovered that the expression and function of brain natriuretic peptide (BNP) can be enhanced by the vitamin D receptor (VDR). In the inner ear of rats, BNP promotes neuron survival and prolongs neurite length through the cGMP-PKG signaling pathway. This finding may offer a new approach for neuronal regeneration therapy in the case of SGNs injury.
Article
Multidisciplinary Sciences
Jemma L. Webber, John C. Clancy, Yingjie Zhou, Natalia Yraola, Kazuaki Homma, Jaime Garcia-Anoveros
Summary: Through the use of an Insm1 mouse mutant with IHCs in the position of OHCs, a hierarchical sequence of instructions was discovered: first, IHCs attract and OHCs repel type I afferents; second, type II afferents innervate hair cells not contacted by type I afferents; and lastly, the type of afferent fiber determines how efferents innervate, whether axodendritically on the afferent, axosomatically on the hair cell, or not at all.
Article
Biochemistry & Molecular Biology
Dominik Schmidbauer, Stefan Fink, Francis Rousset, Hubert Loewenheim, Pascal Senn, Rudolf Glueckert
Summary: Neurotrophins can promote neurite outgrowth of auditory neurons and potentially improve electrical hearing with cochlear implants. However, the optimal concentrations and combinations of neurotrophins are still unknown. The effect of electrical stimulation during neurite outgrowth and its potential direction of axons are also open questions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Audiology & Speech-Language Pathology
Dalian Ding, Haiyan Jiang, Richard Salvi
Summary: Cyclodextrins have potential therapeutic benefits for diseases related to cholesterol metabolism, but the high doses required for treatment can cause hearing loss. Specifically, 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) has shown promising results in treating Niemann-Pick Type C1 disease, but at the cost of damaging cochlear cells.
Article
Neurosciences
Tyler T. Hickman, Ken Hashimoto, Leslie D. Liberman, M. Charles Liberman
Summary: The study indicates post-exposure neural regeneration in guinea pigs but not in CBA/CaJ mice, with this regenerative capacity extending into adulthood. It also reveals that acute synaptic loss is concentrated on the modiolar side of inner hair cells, consistent with a selective loss of high-threshold auditory-nerve fibers with low spontaneous rates.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Shimei Zheng, Chang Liu, Dongmei Tang, Zhiwei Zheng, Renchun Yan, Cheng Wu, Na Zuo, Jun Ma, Yingzi He, Shaofeng Liu
Summary: In this study, it was found that rutin could alleviate hair cell death in neonatal cochlear explants. The potential mechanism involved the mitigation of mitochondrial damage, scavenging of free radicals, and modulation of cellular signaling pathways.
Article
Cell Biology
Fei Sun, Ke Zhou, Ke-yong Tian, Xin-yu Zhang, Wei Liu, Jie Wang, Cui-ping Zhong, Jian-hua Qiu, Ding-jun Zha
Summary: Strategies using bioactive molecules that regulate neurite regeneration and neuronal survival to reestablish connections between auditory epithelium or implanted electrodes and SGN neurites would become attractive therapeutic candidates for sensorineural hearing loss.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Lutz Gaertner, Katharina Kloetzer, Thomas Lenarz, Verena Scheper
Summary: The ECAP AGF slope is negatively correlated with the duration of hearing loss and the age at implantation, supporting early implantation of a CI for sensorineural hearing loss. Additional factors such as cochlear coverage and insertion angle should be considered in future multifactorial analysis to study predictive parameters for the CI outcome.
Article
Neurosciences
Catherine J. C. Weisz, Sean-Paul G. Williams, Chad S. Eckard, Christopher B. Divito, David W. Ferreira, Kristen N. Fantetti, Shenin A. Dettwyler, Hou-Ming Cai, Maria E. Rubio, Karl Kandler, Rebecca P. Seal
Summary: The study reveals that cochlear outer hair cells, unlike inner hair cells, are capable of releasing glutamate and activating neurons in the cochlear nucleus at moderate sound levels.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Amber L. Jolly, Chi-Hao Luan, Brendon E. Dusel, Sara F. Dunne, Michael Winding, Vishrut J. Dixit, Chloe Robins, Jennifer L. Saluk, David J. Logan, Anne E. Carpenter, Manu Sharma, Deborah Dean, Andrew R. Cohen, Vladimir I. Gelfand
Article
Biochemistry & Molecular Biology
Che-Chien Chang, Song Cao, Soosung Kang, Li Kai, Xinyong Tian, Prativa Pandey, Sara Fernandez Dunne, Chi-Hao Luan, D. James Surmeier, Richard B. Silverman
BIOORGANIC & MEDICINAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Soosung Kang, Garry Cooper, Sara Fernandez Dunne, Chi-Hao Luan, D. James Surmeier, Richard B. Silverman
BIOORGANIC & MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Soosung Kang, Garry Cooper, Sara Fernandez Dunne, Chi-Hao Luan, D. James Surmeier, Richard B. Silverman
JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Geriatrics & Gerontology
Fernanda G. De Felice, Diana Wu, Mary P. Lambert, Sara J. Fernandez, Pauline T. Velasco, Pascale N. Lacor, Eileen H. Bigio, Jasna Jerecic, Paul J. Acton, Paul J. Shughrue, Elizabeth Chen-Dodson, Gene G. Kinney, William L. Klein
NEUROBIOLOGY OF AGING
(2008)
Article
Multidisciplinary Sciences
Soosung Kang, Garry Cooper, Sara F. Dunne, Brendon Dusel, Chi-Hao Luan, D. James Surmeier, Richard B. Silverman
NATURE COMMUNICATIONS
(2012)
Article
Virology
Jonathan Leis, Chi-Hao Luan, James E. Audia, Sara F. Dunne, Carissa M. Heath
Summary: The study found that the proton pump inhibitors tenatoprazole and ilaprazole can effectively block the release of both herpes simplex virus and human immunodeficiency virus from infected cells, potentially serving as broad-spectrum antiviral agents against enveloped viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ratika Kunder, Michelle Velyunskiy, Sara F. Dunne, Byoung-Kyu Cho, Deepak Kanojia, Lauren Begg, Adrienne M. Orriols, Erica Fleming-Trujillo, Pranathi Vadlamani, Alesia Vialichka, Rosemary Bolin, Jessica N. Perrino, Diane Roth, Matthew R. Clutter, Nicolette A. Zielinski-Mozny, Young Ah Goo, Massimo Cristofanilli, Marc L. Mendillo, Athanassios Vassilopoulos, Dai Horiuchi
Summary: Triple-negative breast cancer (TNBC) is a subtype with poor clinical outcomes, characterized by overexpression of PIM kinases. Preclinical data suggests sensitivity of TNBC with elevated MYC expression to PIM inhibition. Combination therapy of PIM and 20S proteasome inhibitors show synergistic antitumor effects against MYC-overexpressing TNBC.
CELL CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhiqiang Du, Stephanie Valtierra, Luzivette Robles Cardona, Sara Fernandez Dunne, Chi-Hao Luan, Liming Li
CELL CHEMICAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Fernanda G. De Felice, Pauline T. Velasco, Mary P. Lambert, Kirsten Viola, Sara J. Fernandez, Sergio T. Ferreira, William L. Klein
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
Article
Neurosciences
PN Lacor, MC Buniel, L Chang, SJ Fernandez, YS Gong, KL Viola, MP Lambert, PT Velasco, EH Bigio, CE Finch, GA Krafft, WL Klein
JOURNAL OF NEUROSCIENCE
(2004)
Article
Biochemistry & Molecular Biology
BA Chromy, RJ Nowak, MP Lambert, KL Viola, L Chang, PT Velasco, BW Jones, SJ Fernandez, PN Lacor, P Horowitz, CE Finch, GA Krafft, WL Klein