Article
Multidisciplinary Sciences
Eshetu Shiferaw Legesse, Oumer Sada Muhammed, Leja Hamza, Beshir Bedru Nasir, Teshome Nedi
Summary: This study aimed to assess medication-related problems (MRPs) and its associated factors among patients with chronic kidney disease (CKD). The study found that the most common MRP among CKD patients was the need for additional drug therapy.
Review
Biochemistry & Molecular Biology
Joanna Tracz, Magdalena Luczak
Summary: Patients with chronic kidney disease (CKD) face a higher risk of atherosclerosis and premature mortality due to cardiovascular events. The well-known risk factors for classical atherosclerosis do not fully explain the high prevalence of atherosclerosis in CKD. The complexity of the molecular mechanisms underlying the acceleration of CKD-related atherosclerosis remains to be fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Juliana Schneider, Engi Abd Elhady Algharably, Andrea Budnick, Arlett Wenzel, Dagmar Draeger, Reinhold Kreutz
Summary: The study found that multimorbidity and polypharmacy are highly prevalent in elderly outpatients receiving home care, with potential medication-related problems including potentially relevant drug interactions, overprescribing, and underuse.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Tasneem M. Shouqair, Syed Arman Rabbani, Sathvik B. Sridhar, Martin T. Kurian
Summary: This study investigated the occurrence of drug-drug interactions (DDIs) and adverse drug reactions (ADRs) in CKD patients. The results showed that polypharmacy and comorbidities such as dyslipidemia and diabetes were associated with the occurrence of DDIs. Furthermore, the study found a burden of ADRs in the CKD population, with most ADRs being of possible and mild to moderate severity.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yuping Wang, Jie Zhu, Luchen Shan, Ling Wu, Cunchuan Wang, Wah Yang
Summary: This study investigated the occurrence and risk factors of potentially inappropriate medications (PIM) in older diabetic kidney disease (DKD) patients during hospitalization, and explored the association with polypharmacy. The results showed that PIM was common during hospitalization and that polypharmacy was an independent risk factor for PIM.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ming-Tso Yan, Chia-Ter Chao, Shih-Hua Lin
Summary: Chronic kidney disease (CKD) is characterized by irreversible structural or functional kidney damages, increasing the risk of poor outcomes. Due to the heterogeneous origins and uncertain pathogenesis, efficacious therapies for CKD remain challenging. Therefore, prevention of CKD progression and complications, as well as controlling acute kidney injury, are crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Helene Dahl, Silje R. T. Sandblost, Natasha L. Welland, Kristina Sandnes, Ingegjerd Sekse, Kristin Soele, Hans-Peter Marti, Lone Holst, Jutta Dierkes
Summary: This study investigated the association between prescribed medication and nutritional status in patients with chronic kidney disease (CKD). The results showed that the number of prescribed medications was inversely associated with nutritional status, especially for medications with nausea and xerostomia as side-effects.
JOURNAL OF RENAL NUTRITION
(2022)
Article
Environmental Sciences
A. Jeong Kim, Hayeon Lee, Eun-Jeong Shin, Eun-Jung Cho, Yoon Sook Cho, Hajeong Lee, Ju-Yeun Lee
Summary: Inappropriate polypharmacy is common in older adults with chronic kidney disease, but pharmacist-led geriatric medication management service (MMS) can effectively improve the quality of medication use by reducing the total number of medications and potentially inappropriate medications.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Urology & Nephrology
Justine Marienne, Solene M. Laville, Pauline Caillard, Benjamin Batteux, Valerie Gras-Champel, Kamel Masmoudi, Gabriel Choukroun, Sophie Liabeuf
Summary: The study found that kidney transplant recipients had higher drug burden and MRCI at all time points after transplantation compared to before transplantation, with diabetes and dyslipidemia being associated with an elevated MRCI at M12.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Manon J. M. van Oosten, Susan J. J. Logtenberg, Marc H. Hemmelder, Martijn J. H. Leegte, Henk J. G. Bilo, Kitty J. Jager, Vianda S. Stel
Summary: Patients with CKD Stage G4/G5 and those on KRT have a high prevalence of polypharmacy, far exceeding that of the general population, due to their kidney disease and extensive comorbidities. An individualized approach to medication prescription, especially for medications like proton pump inhibitors and statins (in the dialysis population), could lead to more appropriate medication use.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Lina Naseralallah, Malkan Khatib, Azhar Al-Khulaifi, Mohammed Danjuma
Summary: Polypharmacy is common in patients with chronic kidney disease (CKD) due to an ageing population and multimorbidity. This systematic review and meta-analysis found a high prevalence of polypharmacy in CKD patients, with higher rates in North America and Europe compared to Asia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Transplantation
Samantha Hayward, Barnaby Hole, Rachel Denholm, Polly Duncan, James E. Morris, Simon D. S. Fraser, Rupert A. Payne, Paul Roderick, Nicholas C. Chesnaye, Christoph Wanner, Christiane Drechsler, Maurizio Postorino, Gaetana Porto, Maciej Szymczak, Marie Evans, Friedo W. Dekker, Kitty J. Jager, Fergus J. Caskey
Summary: Hyperpolypharmacy is common among older people with advanced CKD, with significant international differences in the number of prescribed medications. Practice variation may represent a lack of consensus regarding appropriate prescribing for this high-risk group for whom pharmacological treatment has great potential for harm as well as benefit.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Public, Environmental & Occupational Health
Xiaowen Wang, Chao Yang, Jie Jiang, Yonghua Hu, Yuantao Hao, Jia-Yi Dong
Summary: This study aimed to investigate the potential association between polypharmacy, chronic kidney disease (CKD), and mortality. The results showed that among individuals aged 65 years and older, polypharmacy was associated with increased rates of all-cause and cardiovascular disease (CVD) mortality, but not cancer mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Transplantation
Marco D. Boonstra, Sijmen A. Reijneveld, Elisabeth M. Foitzik, Ralf Westerhuis, Gerjan Navis, Andrea F. de Winter
Summary: This systematic review identified potential targets and strategies for improving limited health literacy in chronic kidney disease patients. Strong evidence was found for the association of limited health literacy with smoking and suboptimal transplantation process, while weak evidence was found for other factors related to self-care management, care utilization, patient-provider interaction, and social context. Interventions aimed at improving knowledge, decision-making, and health behaviors showed weak effectiveness, emphasizing the need for more and higher quality studies in earlier CKD stages. Healthcare organizations should focus on supporting limited health literacy patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Environmental Sciences
Gloria Liquori, Aurora De Leo, Emanuele Di Simone, Sara Dionisi, Noemi Giannetta, Elvira Ganci, Sherly Pia Trainito, Giovanni Battista Orsi, Marco Di Muzio, Christian Napoli
Summary: This study investigated the medication adherence levels of patients aged 65 years and older with chronic diseases. The majority of patients had good medication adherence. The study concluded that the MARS-5I is an effective tool for assessing medication adherence, but further research is needed to understand the factors influencing medication adherence.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
