Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Chang Min Heo, Won Ho Lee, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Byeong Cheol Yoo, Kang Min Park
Summary: This study compares glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls, and reveals the presence of glymphatic dysfunction in patients with ESRD as demonstrated by the DTI-ALPS index. Additionally, a significant positive correlation is found between the DTI-ALPS index and serum parathyroid hormone levels in ESRD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Malgorzata Maraj, Paulina Hetwer, Beata Kusnierz-Cabala, Barbara Maziarz, Paulina Dumnicka, Marek Kuzniewski, Piotr Ceranowicz
Summary: In hemodialyzed patients, serum AGP is weakly associated with the dietary intake of several nutrients, emphasizing the importance of patients consuming adequate nutrients for their overall health.
Article
Medicine, General & Internal
Elzbieta Dembowska, Aleksandra Jaron, Ewa Gabrysz-Trybek, Joanna Bladowska, Szymon Gacek, Grzegorz Trybek
Summary: Patients with end-stage renal disease undergoing hemodialysis experience lower quality of life, especially in the physical sphere, compared to healthy subjects. Comprehensive psychological care is indicated for hemodialysis patients due to their poor psychosocial status.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Chemistry, Analytical
Young-Seob Jeong, Juhyun Kim, Dahye Kim, Jiyoung Woo, Mun Gyu Kim, Hun Woo Choi, Ah Reum Kang, Sun Young Park
Summary: This study developed a model to predict major cardiac events in ESRD patients undergoing any type of surgery, and found that operation-related features have the biggest impact on model performance.
Article
Multidisciplinary Sciences
Jong Joo Moon, Yong Woo Kim, Baek-Lok Oh, Kyungdo Han, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Ki Ho Park, Hajeong Lee, Yong Chul Kim, Jin Wook Jeoung
Summary: This nationwide cohort study found that the incidence of primary open-angle glaucoma (POAG) was higher in patients with end stage renal disease (ESRD) and kidney transplantation recipients (KTRs) compared to healthy controls, but adjusting for confounding factors did not show a significant increase in risk. The incidence of primary angle-closure glaucoma (PACG) was higher in ESRD patients compared to healthy controls, while KTRs had a lower risk of PACG compared to ESRD patients.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Lina A. Dahabiyeh, Refat M. Nimer, Khalid M. Sumaily, Mohamad S. Alabdaljabar, Minnie Jacob, Essa M. Sabi, Maged H. Hussein, Anas Abdel Rahman
Summary: Chronic kidney disease (CKD) is a severe public health problem that can lead to end-stage renal disease (ESRD) requiring dialysis or transplantation. This study identified altered metabolites and biochemical reactions between ESRD and CKD, offering potential new biomarkers for monitoring CKD progression. Inhibition of the kynurenine pathway may be a promising target for delaying CKD progression, and metabolites with high discriminative ability could complement current markers to better indicate kidney damage status.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Xuekun Li, Ruifang Yan, Zheng Yue, Meng Zhang, Jipeng Ren, Baolin Wu
Summary: This study is the first to explore the dynamic aspects of whole-brain FC and topological properties in ESRD patients. The findings suggest impaired functional flexibility of network connections and state-specific FC disruptions in patients with ESRD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Rodolfo J. Galindo, Francisco J. Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury, Citlalli Perez-Guzman, Zheng Ziduo, Guillermo E. Umpierrez
Summary: This study revealed significant metabolic differences among DKA patients with different levels of renal function, with beta-hydroxybutyrate levels potentially assisting in confirming the diagnosis of DKA in ESKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Elzbieta Dembowska, Aleksandra Jaron, Joanna Raslawska-Socha, Ewa Gabrysz-Trybek, Joanna Bladowska, Szymon Gacek, Grzegorz Trybek
Summary: This study assessed the extent of gingivitis and periodontitis in hemodialysis patients compared to healthy subjects. The study found that hemodialysis patients had a higher incidence and severity of gingivitis and periodontitis than the control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Mark Sulkowski, Laura E. Telep, Massimo Colombo, Francois Durand, K. Rajender Reddy, Eric Lawitz, Marc Bourliere, Nelson Cheinquer, Stacey Scherbakovsky, Liyun Ni, Lindsey Force, Heribert Ramroth, Anuj Gaggar, Anand P. Chokkalingam, Meghan E. Sise
Summary: In clinical trials, patients with chronic kidney disease did not experience worsening of estimated glomerular filtration rate during treatment with sofosbuvir, and sofosbuvir was not associated with an increased risk of end-stage renal disease in patients with CKD in a nationally-representative administrative claims database.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Yue Peng, Yixi Li, Wei Zhang, Yu ShangGuan, Ting Xie, Kang Wang, Jing Qiu, Wenjun Pu, Biying Hu, Xinzhou Zhang, Lianghong Yin, Donge Tang, Yong Dai
Summary: This study identified and characterized extrachromosomal circular DNA (eccDNA) in end-stage renal disease (ESRD) patients. The distribution and motifs of eccDNA in ESRD patients were analyzed and compared to healthy individuals. Additionally, specific eccDNA-targeting genes associated with ESRD were identified, suggesting a potential mechanism for ESRD development.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Cristian Iorga, Cristina Raluca Iorga, Iuliana Andreiana, Iustinian Bengulescu, Traian Constantin, Victor Strambu
Summary: After analyzing the obtained results, it was concluded that total parathyroidectomy is the preferred intervention for patients with secondary hyperparathyroidism when pharmacotherapy fails, in order to prevent disease recurrence and correct metabolic parameters.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Siqing Wang, Aiya Qin, Lingqiu Dong, Jiaxing Tan, Xiaoyuan Zhou, Wei Qin
Summary: This retrospective study aimed to evaluate whether obesity is a risk factor for IgA nephropathy (IgAN) patients. The results showed that compared to patients with normal body weight, obese patients had more severe renal dysfunction, higher risk of metabolic disorders, and unhealthy behaviors. Although obesity was not confirmed as an independent risk factor for IgAN patients, it increased the risk when combined with hypertension. Therefore, the importance of obesity in IgAN patients needs to be emphasized.
FRONTIERS IN ENDOCRINOLOGY
(2023)