Article
Multidisciplinary Sciences
Yi-Kong Chen, Chih-Sheng Chu, Sheng-Wen Niu, Hugo You-Hsien Lin, Pei-Hua Yu, Feng-Ching Shen, Yu-Lin Chao, I-Ching Kuo, Chi-Chih Hung, Jer-Ming Chang
Summary: Kt/V and URR measurements are indicators of dialysis adequacy. Both URR and Kt/V are positively associated with nutritional factors and female sex, and negatively associated with body weight and heart failure. Higher URR and Kt/V values are associated with higher survival rates, but Kt/V may have weaker prognostic value in women.
SCIENTIFIC REPORTS
(2023)
Article
Hematology
Robert Ekart, Luka Varda, Nina Vodosek Hojs, Benjamin Dvorsak, Nejc Piko, Sebastjan Bevc, Radovan Hojs
Summary: In hemodialysis patients with AV fistula, routine measurement of Kt/V during online HDF procedures is beneficial for early detection of hemodynamically significant stenosis in AV fistula. After angioplasty, there was a significant improvement in Kt/V in the active group, with no statistically significant differences in Kt/V between the two groups at 3 and 8 weeks post-procedure.
BLOOD PURIFICATION
(2022)
Article
Urology & Nephrology
Shuang Liu, Lijie Zhang, Shuang Ma, Jing Xiao, Dong Liu, Rui Ding, Zhengyan Li, Zhanzheng Zhao
Summary: This study found that a higher Kt/V reach rate is associated with a better prognosis in incident PD patients. Patients in the dialysis adequacy group and dialysis intermittent adequacy group had significantly better clinical outcomes compared to the dialysis inadequacy group.
Article
Urology & Nephrology
Ali AlSahow, Daniel Muenz, Mohammed A. Al-Ghonaim, Issa Al Salmi, Mohamed Hassan, Ali H. Al Aradi, Abdullah Hamad, Saeed M. G. Al-Ghamdi, Faissal A. M. Shaheen, Anas Alyousef, Brian Bieber, Bruce M. Robinson, Ronald L. Pisoni
Summary: In the Gulf Cooperation Council, a relatively large proportion of hemodialysis patients have low Kt/V levels. Study findings suggest that increasing blood flow rate to equal or greater than 350 mL/min and dialysis time to equal or greater than 4 hours thrice weekly can reduce the prevalence of low Kt/V, particularly improving survival rates among women.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Urology & Nephrology
Chun-yan Su, Xin-hong Lu, Wen Tang, Pei-yu Wang, Tao Wang
Summary: This study suggests that anuric patients can achieve nitrogen balance and maintain good nutritional status with appropriate dietary protein intake, even with a low Kt/V.
CLINICAL NEPHROLOGY
(2022)
Article
Urology & Nephrology
Mauro Sergio Martins Marrocos, Christine Nastri Castro, Wilder Araujo Barbosa, Andressa Monteiro Sizo, Fernanda Teles Rodrigues, Rosemary Alves de Lima, Sandra Maria Rodrigues
Summary: This study compared different calculation methods by sex and age, showing that Kt/VOL can recognize real-time dialysis dose regardless of sex and age. Men and individuals above 65 years old received higher dialysis doses compared to females and those below 65 years old in the comparison between Kt/VOL and Kt/VII.
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Chemistry, Multidisciplinary
Vladimir G. Dubrovskii
Summary: A model for the nucleation of III-V nanowires in selective area growth is developed. The optimal SAG zone, with NW nucleation within the openings and the absence of parasitic III-V crystallites or group III droplets on the mask, is established. The SAG maps are plotted in terms of the material fluxes versus the temperature, and the correlation of the model with the experimental data is demonstrated.
Article
Urology & Nephrology
Hamid Tayebi-Khosroshahi, Arman Ghahremanzadeh, Morteza Ghojazedeh, Jeyran Dehgan
Summary: This study aimed to compare two methods for assessing hemodialysis adequacy in the largest dialysis center in Iran. The results showed that OCM can be used as an effective substitute for laboratory assessments in evaluating hemodialysis adequacy.
IRANIAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Engineering, Environmental
Po-Kai Chang, Stephen M. Griffith, Hsiao-Chi Chuang, Kai-Jen Chuang, Yu-Hui Wang, Kuo-En Chang, Ta-Chih Hsiao
Summary: This study established a measurement station at an urban roadside in northern Taiwan to investigate the contribution of traffic emissions to lung deposited surface area (LDSA) concentration. Through analysis, it was found that during rush hour, LDSA, particle number concentration (PNC), and LDSA ratio increased significantly.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Urology & Nephrology
Brian Mark Churchill, Pallavi Patri
Summary: In advanced Chronic Kidney Disease, patients require renal replacement therapy for clearance of toxins, electrolyte and acid-base balance and removal of excess fluid. Dialysis adequacy should be taken into consideration in the adjustment of the dialysis prescription, which involves factors such as Kt/V-urea measurement, nutritional parameters, gender, size, and mode of dialysis.
INDIAN JOURNAL OF NEPHROLOGY
(2021)
Article
Soil Science
Behzad Ghanbarian, Allen G. Hunt, Marco Bittelli, Markus Tuller, Emmanuel Arthur
Summary: In this study, the effects of surface roughness and probing molecule size on specific surface area estimation were investigated using concepts from fractals. The method proposed in this study theoretically estimates specific surface area from particle size distribution and water retention curve, with reasonably good estimation accuracy when compared with experimental results.
SOIL SCIENCE SOCIETY OF AMERICA JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Takayoshi Kiguchi, Hiromi Ito, Akihiro C. Yamashita
Summary: This study found that simulated membrane fouling in the dialyzer can decrease solute removal performance, especially in modules with smaller surface areas. Increasing the rate of internal filtration can help improve the solute removal performance of the dialyzer.
Article
Materials Science, Ceramics
Yang Wu, Yang Xu, Shanshan Li, Lin Zhong, Jianli Wang, Yaoqaing Chen
Summary: This study successfully developed high-surface-area yttria-zirconia materials through silicon modification, and investigated the distribution and role of silicon in the materials. The presence of silicon species, mainly in the form of silicates, hindered the migration of Y and Zr atoms, resulting in smaller crystallite size.
CERAMICS INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Min Wang, Hsin-Chiao Hsu, Mei-Ching Yu, I-Kuan Wang, Chien-Chang Huang, Ming-Jen Chan, Cheng-Hao Weng, Wen-Hung Huang, Ching-Wei Hsu, Lan-Mei Huang, Frederick W. K. Tam, Tzung-Hai Yen
Summary: This study found that small kidney size on starting hemodialysis is not associated with an increased risk of death in diabetic patients receiving hemodialysis.
Article
Chemistry, Analytical
Xiaowei Ma, Mao Huang, Juan Jia, Han Wang, Jing Wang, Yanyan Zhu
Summary: Rationally designing porous nanomaterials with high specific surface area (SSA) is an effective approach for improving their electrocatalytic activity and enhancing electrochemical sensing performance. However, increasing SSA often leads to an amplified background current signal, which hinders the achievement of optimal sensing performance. In this study, graphene frameworks (GFs) with different SSA and pore size were successfully synthesized and used as electrode materials for constructing a non-enzymatic electrochemical sensor. The findings suggest that GFs with abundant hierarchical pore structure and relatively large SSA exhibit the best performance, demonstrating the importance of considering both SSA and pore size for electrochemical sensing applications.
MICROCHEMICAL JOURNAL
(2023)
Article
Nutrition & Dietetics
Jorgen Hegbrant, Amparo Bernat, Domingo Del Castillo, Jose Luis Pizarro, Sonia Caparros, Mariano Gaspar, Carlos Jarava, Giovanni F. M. Strippoli, John T. Daugirdas
Summary: This study aimed to investigate the relationships between residual renal clearance and urine output in hemodialysis and hemodiafiltration patients. The results showed that the residual renal phosphate clearance was approximately 23% higher than residual renal urea clearance in these patients. Furthermore, urine volume was a moderately accurate surrogate for estimating residual renal phosphate clearance, but only when urine volume was above 300 mL/day.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Urology & Nephrology
John T. Daugirdas
Summary: Predictions of phosphate removal using a 2-pool kinetic model were compared with measured values, and the results showed similarity between the two. This is important for conventional 4-hour dialysis treatments.
SEMINARS IN DIALYSIS
(2023)
Article
Urology & Nephrology
Aileen X. Wang, Sai Liu, Maria E. Montez-Rath, Glenn M. Chertow, Colin R. Lenihan
Summary: This study aims to examine the incidence, associations, and outcomes of posttransplant parathyroidectomy and calcimimetic use in a cohort of Medicare-insured US kidney transplant recipients. The study found that the rate of posttransplant parathyroidectomy remained stable over time, while the use of calcimimetic increased during the study period. Long dialysis vintage and pre-transplant calcimimetic use were strongly associated with posttransplant parathyroidectomy and calcimimetic use. Roughly 1 in 4 patients were hospitalized within 90 days of posttransplant parathyroidectomy, with hypocalcemia-related diagnoses being the most common complication. Parathyroidectomy was not associated with an increase in acute kidney injury compared to calcimimetic initiation.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Jean-Claude Tardif, Jean Rouleau, Glenn M. Chertow, Ayman Al-Shurbaji, Vera Lisovskaja, Stephanie Gustavson, Yanli Zhao, Nadia Bouabdallaoui, Akshay S. Desai, Alexander Chernyavskiy, Maria Evsina, Bela Merkely, John J. V. McMurray, Marc A. Pfeffer
Summary: The PRIORITIZE-HF study, which aimed to evaluate the benefits and risks of using SZC to intensify RAAS inhibitor therapy in patients with heart failure and reduced ejection fraction (HFrEF), was prematurely terminated due to challenges related to the COVID-19 pandemic. The study did not demonstrate a statistically significant increase in the intensity of RAAS inhibitor therapies with SZC compared to placebo.
Article
Urology & Nephrology
Vikram Fielding-Singh, Glenn M. Chertow
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Urology & Nephrology
John T. Daugirdas, Christopher T. Chan
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Cynthia Delgado, Neil R. Powe, Glenn M. Chertow, Barbara Grimes, Kirsten L. Johansen
Summary: Among patients receiving dialysis, serum creatinine was higher in Black, Asian, and Hispanic patients than in non-Hispanic White patients. Differences in ICW did not explain the differences in serum creatinine concentration across race groups.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Robert A. Fletcher, Niels Jongs, Glenn M. Chertow, John J. V. Mcmurray, Clare Arnott, Meg J. Jardine, Kenneth W. Mahaffey, Vlado Perkovic, Patrick Rockenschaub, Peter Rossing, Ricardo Correa-Rotter, Robert D. Toto, Muthiah Vaduganathan, David C. Wheeler, Hiddo J. L. Heerspink, Brendon L. Neuen
Summary: This study analyzed the effect of SGLT2 inhibitors on the discontinuation of RAS blockade and found that patients receiving SGLT2 inhibitors had a lower risk of discontinuing RAS blockade. This effect was particularly pronounced in patients with a high baseline urinary albumin-to-creatinine ratio.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Hiddo J. L. Heerspink, Niels Jongs, Brendon L. Neuen, Patrick Schloemer, Muthiah Vaduganathan, Lesley A. Inker, Robert A. Fletcher, David C. Wheeler, George Bakris, Tom Greene, Glenn M. Chertow, Vlado Perkovic
Summary: The effects of newer kidney protective agents on smaller declines in eGFR have been assessed and found to be comparable to the effects on kidney failure or death due to kidney failure. This suggests that composite endpoints incorporating smaller declines in eGFR can reduce the required number of participants in clinical trials without compromising statistical power.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Patrick S. Parfrey, Steven K. Burke, Glenn M. Chertow, Kai-Uwe Eckardt, Alan G. Jardine, Eldrin F. Lewis, Wenli Luo, Kunihiro Matsushita, Peter A. McCullough, Todd Minga, Wolfgang C. Winkelmayer
Summary: In the PRO2TECT trials, vadadustat was found to be comparable to darbepoetin alfa in terms of hematologic efficacy but not in major adverse cardiovascular events (MACE) in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD). Regional differences were observed in the rates of MACE, with higher rates in Europe for both vadadustat and darbepoetin alfa groups.
Article
Urology & Nephrology
Wolfgang C. Winkelmayer, Susan Arnold, Steven K. Burke, Glenn M. Chertow, Kai-Uwe Eckardt, Alan G. Jardine, Eldrin F. Lewis, Wenli Luo, Kunihiro Matsushita, Peter A. McCullough, Todd Minga, Patrick S. Parfrey
Summary: The PRO2TECT trials compared the safety of vadadustat with darbepoetin alfa in patients with non-dialysis-dependent chronic kidney disease. The study found that there was no difference in major adverse cardiovascular events (MACE) among US patients, but a higher risk among patients treated with vadadustat outside the United States. Regional differences in MACE were observed, with higher rates in the non-US/non-Europe vadadustat group.
Article
Endocrinology & Metabolism
Calyani Ganesan, I-Chun Thomas, Maria E. Montez-Rath, Glenn M. Chertow, John T. Leppert, Alan C. Pao
Summary: Hypocitraturia is common in patients with kidney stone disease and is also a risk factor for incident bone disease. However, after adjusting for demographic factors, comorbid conditions, and laboratory abnormalities, the association between hypocitraturia and osteoporosis or fracture is no longer statistically significant.
Meeting Abstract
Surgery
M. Stedman, P. Ahearn, C. K. Liu, G. M. Chertow, J. C. Tan
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Thomas G. Peters, John J. Fung, Janet Radcliffe-Richards, Sally Satel, Alvin E. Roth, Frank McCormick, Martha Gershun, Arthur J. Matas, John P. Roberts, Josh Morrison, Glenn M. Chertow, Laurie D. Lee, Philip J. Held, Akinlolu Ojo
Summary: Living donor renal transplantation is considered the best treatment for permanent loss of kidney function, but it has not grown in the United States for over 20 years. A virtual symposium was held to address this issue, emphasizing the ethical principles and limitations of altruism as the sole motivation for donation. The potential of donor incentives to save lives and save taxpayer money was examined, with survey data showing support for donor compensation. The importance of removing barriers in donor evaluation, expanding living donor chains, ensuring the safety of live kidney donation, and relieving donors of financial burden was emphasized.
PROGRESS IN TRANSPLANTATION
(2023)
Letter
Medicine, General & Internal
Ogo Egbuna, Glenn M. Chertow
NEW ENGLAND JOURNAL OF MEDICINE
(2023)