Journal
SEMINARS IN DIAGNOSTIC PATHOLOGY
Volume 28, Issue 3, Pages 190-201Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.semdp.2011.03.002
Keywords
Anaplastic large-cell lymphoma (ALCL); Peripheral T-cell lymphoma (PTCL); Phenotype; Immunohistochemistry; Molecular biology; Targeted therapy; Anaplastic lymphoma kinase (ALK); Chimeric fusion proteins; Signaling pathways
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Funding
- Associazione Italiana per la Ricerca sul Cancro, Fondazione Guido Berlucchi
- Ministero dell'Universita e Ricerca Scientifica
- Regione Piemonte
- Compagnia di San Paolo, Torino (Progetto Oncologia)
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The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated. (C) 2011 Elsevier Inc. All rights reserved.
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