Journal
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
Volume 31, Issue 3, Pages S3-S5Publisher
FRONTLINE MEDICAL COMMUNICATIONS
DOI: 10.1016/j.sder.2012.07.002
Keywords
atopic dermatitis pathogenesis; barrier defects; epidermal skin barrier; filaggrin gene
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Funding
- University of Louisville Continuing Health Sciences Education
- Global Academy for Medical Education LLC
- Valeant Pharmaceuticals North America Inc.
- Astellas
- Skin Disease Education Foundation
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The prevalence of atopic dermatitis (AD) has increased markedly in the United States over the past 5 decades, with current reports varying from 10% to 20% prevalence in US children, and new diagnoses are estimated at almost 11% per year. Recent research in AD pathophysiology and pathogenesis has demonstrated that AD is associated with epidermal barrier dysfunction and that mutations in the filaggrin gene are implicated in barrier defects. These discoveries hold promise for future breakthroughs in the diagnosis and management of AD. Semin Cutan Med Surg 31(suppl 3):S3-S5 (C) 2012 Published by Elsevier Inc.
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