Article
Biochemical Research Methods
Shicheng Hao, Ying Xiong, Sisi Guo, Jing Gao, Xiaotong Chen, Ruoyu Zhang, Lihui Liu, Jianfeng Wang
Summary: This study reports the development and grading performance validation of a low-cost algorithms-based hyperspectral imaging (aHSI) system for radiodermatitis assessment. The system utilizes Monte Carlo simulations to derive hyper-spectra and physiological parameters of the skin, and achieves high classification accuracy using a one-dimensional convolutional neural network (CNN).
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Neurosciences
Canan Bagci, Melike Sever-Bahcekapili, Nevin Belder, Adam P. S. Bennett, Sefik Evren Erdener, Turgay Dalkara
Summary: Extracellular vesicles (EVs) are small nanoparticles that carry bioactive molecules between cells and participate in intercellular communication. This article discusses commonly used techniques for characterizing EVs, including dynamic light scattering, nanoparticle tracking analysis, flow cytometry, electron microscopy, and optical methods. It also introduces an innovative technique using confocal microscopy to identify molecular heterogeneity in EVs.
Article
Urology & Nephrology
Jesus Z. Villarreal, Javiera Perez-Anker, Susana Puig, Marc Xipell, Gerard Espinosa, Esther Barnadas, Ana B. Larque, J. Malvehy, Ricard Cervera, Arturo Pereira, Antonio Martinez-Pozo, Luis F. Quintana, Adriana Garcia-Herrera
Summary: This study demonstrates the feasibility of using ex vivo confocal microscopy for the analysis of basic patterns of lesion in nephropathology. FuCM proves to be as effective as conventional techniques in evaluating acute tubular necrosis and interstitial fibrosis changes, facilitating rapid evaluation of kidney biopsies and restructuring the clinical workflow in renal histopathology.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Microbiology
Sophie Soyeon Lim, Bo Ri Kim, Je-Ho Mun
Summary: Reflectance confocal microscopy (RCM) is valuable for the diagnosis of onychomycosis, rapidly identifying fungal lesions. Existing studies support the use of RCM in bedside diagnosis of onychomycosis and call for larger studies to further explore its diagnostic utility.
Article
Medicine, General & Internal
Mihai Lupu, Ana Maria Malciu, Elena Codruta Cozma, Madalina Laura Banciu, Vlad Mihai Voiculescu
Summary: This study aims to evaluate the healthy skin of different age groups, develop an easy-to-use confocal score for quantifying signs of skin aging, and test the correlation between this new score and the clinical score. The results showed a good correlation between the confocal score and clinical score.
Review
Medicine, General & Internal
Andrea De Pascalis, Jean Luc Perrot, Linda Tognetti, Pietro Rubegni, Elisa Cinotti
Summary: Mucosal melanoma is a rare tumor with aggressive behavior and poor prognosis, often diagnosed at an advanced stage. Dermoscopy and RCM are not well-established for mucosal lesions due to their rarity. Dermoscopic features include a structureless pattern and/or multiple colors, while RCM examination shows basal hyper-reflective dendritic cells and loss of normal lamina propria architecture. Limitations include the lack of large studies and standardized diagnostic criteria for both techniques.
Article
Urology & Nephrology
Jesus Z. Villarreal, J. Perez-Anker, S. Puig, G. Pellacani, M. Sole, J. Malvehy, Luis F. Quintana, A. Garcia-Herrera
Summary: This study evaluated the feasibility of using ex vivo confocal microscopy in non-neoplastic kidney biopsies, and found that confocal images correlated well with conventional histological sections without introducing artifacts to the samples. The ease and speed of image acquisition, along with the quality of digitally stained images obtained, suggest promise for clinical applications in nephrology and renal transplantation.
JOURNAL OF NEPHROLOGY
(2021)
Article
Optics
Jingxi Li, Jason Garfinkel, Xiaoran Zhang, Di Wu, Yijie Zhang, Kevin de Haan, Hongda Wang, Tairan Liu, Bijie Bai, Yair Rivenson, Gennady Rubinstein, Philip O. Scumpia, Aydogan Ozcan
Summary: The traditional pathological diagnosis of skin tumors involves invasive biopsies and histological staining, which can be cumbersome and result in unnecessary biopsies and scarring. Emerging noninvasive optical technologies, like reflectance confocal microscopy (RCM), offer label-free, cellular-level imaging of skin without the need for a biopsy, but require specialized training due to grayscale images lacking nuclear features.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Review
Medicine, General & Internal
Mehmet Fatih Atak, Banu Farabi, Cristian Navarrete-Dechent, Gennady Rubinstein, Milind Rajadhyaksha, Manu Jain
Summary: Cutaneous malignancies, including melanoma, are increasingly common worldwide and early diagnosis is crucial for successful treatment. Non-invasive skin imaging techniques, such as confocal microscopy, can aid in early detection and reduce unnecessary biopsies. This review article discusses the current applications of confocal microscopy in dermatology clinics and the advances in the field, including multi-modal approaches and the use of artificial intelligence.
Article
Dermatology
A. Pampin-Franco, R. Gamo-Villegas, U. Floristan-Muruzabal, F. J. Pinedo-Moraleda, E. Perez-Fernandez, J. L. Lopez-Estebaranz
Summary: This study evaluated the clinical, dermoscopic, and RCM features of MLPG under digital dermoscopic surveillance. It found that MLPGs with a diameter of 6 mm or more and asymmetry in two axes were associated with melanoma. Dermoscopy and confocal evaluation were able to diagnose 100% of melanomas and 84.21% of DNs, with a kappa coefficient of 0.76 between dermoscopy-RCM and histology.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
A. Rossi, F. Magri, G. Caro, S. Michelini, M. Di Fraia, M. C. Fortuna, G. Pellacani, M. Carlesimo
Summary: Non-invasive diagnostic methods such as dermoscopy and fluorescence advanced videodermoscopy (FAV) are widely used in clinical dermatology. FAV has shown promising results for the assessment of melanocytic and vascular lesions, and for the in vivo diagnosis of parasitosis. The study found that FAV provided more detailed observation than trichoscopy for scalp elementary lesions.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Medicine, General & Internal
Francesco Restelli, Bianca Pollo, Ignazio Gaspare Vetrano, Samuele Cabras, Morgan Broggi, Marco Schiariti, Jacopo Falco, Camilla de Laurentis, Gabriella Raccuia, Paolo Ferroli, Francesco Acerbi
Summary: Achieving complete resections in brain tumor surgery is crucial for postoperative survival, with histopathological analysis remaining the gold-standard for diagnosis. Confocal laser technology is suggested as a promising method for obtaining near real-time intraoperative histological data, showing potential in distinguishing between normal and pathologic tissue in clinical studies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Marissa D'Alonzo, Alican Bozkurt, Christi Alessi-Fox, Melissa Gill, Dana H. Brooks, Milind Rajadhyaksha, Kivanc Kose, Jennifer G. Dy
Summary: Reflectance confocal microscopy (RCM) is a non-invasive imaging tool that helps diagnose skin cancer by providing high-resolution mosaics of skin structures. This study introduces a weakly supervised machine learning model for semantic segmentation of architectural patterns in RCM mosaics, aiming to aid clinicians in interpreting diagnostic models with a focus on aspecific regions. The trained deep neural network achieved high accuracy in spatial localization of these regions, making the diagnostic decision model more interpretable to clinicians.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Marta Fusano, Simone Soglia, Raffaele Gianotti, Pier Luca Bencini
Summary: This study described a series of 10 BCNs with dermoscopic and RCM features, improving knowledge of this rare entity. Dermoscopy revealed unique patterns such as yellow and white globules, light-brown network, and a central hyperpigmented blotch. RCM examination showed dense nests at superficial dermis level and the presence of melanophages and epidermal dendritic cells in some cases, providing valuable insights for diagnosis and avoiding unnecessary surgical excision.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Biology
Veronica Rego Moraes, Maisa Oliveira Melo, Patricia M. B. G. Maia Campos
Summary: Diabetes leads to increased production of AGEs, causing irreversible damage to collagen fibers and accelerated signs of skin aging. This study aimed to evaluate diabetic skin's characteristics and compare them to healthy skin.
Meeting Abstract
Medicine, General & Internal
Silvia H. Koller
ANNALS OF MEDICINE
(2019)
Article
Psychology, Multidisciplinary
Paulo Sergio Boggio, Ana Carolina Alem Giglio, Caroline Kimie Nakao, Tanja Stefanie Helga Wingenbach, Lucas Murrins Marques, Silvia Koller, June Gruber
JOURNAL OF POSITIVE PSYCHOLOGY
(2020)
Meeting Abstract
Psychology, Clinical
Itala Raymundo Chinazzo, Maria Ines Rodrigues Lobato, Henrique Caetano Nardi, Silvia Helena Koller, Angelo Brandelli Costa
INTERNATIONAL JOURNAL OF SEXUAL HEALTH
(2019)
Article
Psychology, Developmental
G. Hapunda, S. Mahama, B. Mesurado, S. K. Verma, S. Koller
INTERNATIONAL JOURNAL OF ADOLESCENCE AND YOUTH
(2019)
Article
Psychology, Multidisciplinary
Alex Sandro Gomes Pessoa, Linda Liebenberg, Dorothy Bottrell, Silvia Helena Koller
ZEITSCHRIFT FUR PSYCHOLOGIE-JOURNAL OF PSYCHOLOGY
(2019)
Article
Family Studies
Guilherme Welter Wendt, Angelo Brandelli Costa, Michele Poletto, Vicente Cassepp-Borges, Debora D. Dellaglio, Silvia Helena Koller
CHILDREN AND YOUTH SERVICES REVIEW
(2019)
Article
Psychology, Developmental
Airi Macias Sacco, Maria Clara Pinheiro de Paula Couto, Yarrow Dunham, Juliana Prates Santana, Luciana Neves Nunes, Silvia Helena Koller
DEVELOPMENTAL PSYCHOLOGY
(2019)
Article
Psychology, Developmental
Luciana Dutra-Thome, Diogo DeSousa, Silvia Helena Koller
CHILD & YOUTH CARE FORUM
(2019)
Review
Public, Environmental & Occupational Health
Davi Manzini Macedo, Laura Nichele Foschiera, Thays Carolyna Pires Mazzini Bordini, Luisa Fernanda Habigzang, Silvia Helena Koller
CIENCIA & SAUDE COLETIVA
(2019)
Article
Psychology, Multidisciplinary
Clarissa Pinto Pizarro Freitas, Elif Merve Cankaya, Bruno Figueiredo Damasio, Emily Jean Haddad, Helder Hiroki Kamei, Patricia Renovato Tobo, Silvia Helena Koller
ACCION PSICOLOGICA
(2018)
Article
Public, Environmental & Occupational Health
Anderson Siqueira Pereira, Alice Rodrigues Willhelm, Silvia Helena Koller, Rosa Maria Martins de Almeida
CIENCIA & SAUDE COLETIVA
(2018)
Article
Public, Environmental & Occupational Health
Angelo Brandelli Costa, Anna Martha Vaitses Fontanari, Ramiro Figueiredo Catelan, Karine Schwarz, Juliana Ledur Stucky, Heitor Tome da Rosa Filho, Paola Fagundes Pase, Daniel Augusto Mori Gagliotti, Alexandre Saadeh, Maria Ines Rodrigues Lobato, Henrique Caetano Nardi, Silvia Helena Koller
Article
Education & Educational Research
Clarissa Tochetto de Oliveira, Emily Jean Haddad, Ana Cristina Garcia Dias, Marco Antonio Pereira Teixeira, Silvia Helena Koller
JOURNAL OF COLLEGE STUDENT DEVELOPMENT
(2018)
Article
Psychology, Multidisciplinary
Bruna L. Seibel, Bruno de Brito Silva, Anna M. V. Fontanari, Ramiro F. Catelan, Ana M. Bercht, Juliana L. Stucky, Diogo A. DeSousa, Elder Cerqueira-Santos, Henrique C. Nardi, Silvia H. Koller, Angelo B. Costa
FRONTIERS IN PSYCHOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Angelo Brandelli Costa, Heitor Tome da Rosa Filho, Paola Fagundes Pase, Anna Martha Vaitses Fontanari, Ramiro Figueiredo Catelan, Andressa Mueller, Dhiordan Cardoso, Bianca Soll, Karine Schwarz, Maiko Abel Schneider, Daniel Augusto Mori Gagliotti, Alexandre Saadeh, Maria Ines Rodrigues Lobato, Henrique Caetano Nardi, Silvia Helena Koller
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2018)